CL2011001879A1 - Compounds derived from 6- (6-o-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, met inhibitors; preparation procedure; pharmaceutical composition; and its use for the treatment or prevention of diseases such as blood vessel proliferation disorders, asthma, rheumatoid arthritis and cancer. - Google Patents
Compounds derived from 6- (6-o-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, met inhibitors; preparation procedure; pharmaceutical composition; and its use for the treatment or prevention of diseases such as blood vessel proliferation disorders, asthma, rheumatoid arthritis and cancer.Info
- Publication number
- CL2011001879A1 CL2011001879A1 CL2011001879A CL2011001879A CL2011001879A1 CL 2011001879 A1 CL2011001879 A1 CL 2011001879A1 CL 2011001879 A CL2011001879 A CL 2011001879A CL 2011001879 A CL2011001879 A CL 2011001879A CL 2011001879 A1 CL2011001879 A1 CL 2011001879A1
- Authority
- CL
- Chile
- Prior art keywords
- triazolopyridazine
- benzothiazoles
- benzimidazoles
- sulfanyl
- asthma
- Prior art date
Links
- 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 208000006673 asthma Diseases 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title abstract 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title abstract 2
- 210000004204 blood vessel Anatomy 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000006806 disease prevention Effects 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000035755 proliferation Effects 0.000 title abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos derivados de 6-(6-o-sustituido-triazolopiridazina-sulfanil) benzotiazoles y bencimidazoles, inhibidores de met; procedimiento de preparación; composición farmacéutica; y su uso para el tratamiento o prevención de enfermedades tales como trastornos de la proliferación de vasos sanguíneos, asmas, artritis reumatoide y cáncer.Compounds derived from 6- (6-o-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, met inhibitors; preparation procedure; pharmaceutical composition; and its use for the treatment or prevention of diseases such as blood vessel proliferation disorders, asthma, rheumatoid arthritis and cancer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0900512A FR2941950B1 (en) | 2009-02-06 | 2009-02-06 | 6- (6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011001879A1 true CL2011001879A1 (en) | 2012-01-06 |
Family
ID=40872767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011001879A CL2011001879A1 (en) | 2009-02-06 | 2011-08-04 | Compounds derived from 6- (6-o-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, met inhibitors; preparation procedure; pharmaceutical composition; and its use for the treatment or prevention of diseases such as blood vessel proliferation disorders, asthma, rheumatoid arthritis and cancer. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP2393791A1 (en) |
| JP (1) | JP2012517408A (en) |
| KR (1) | KR20110132560A (en) |
| CN (1) | CN102378759A (en) |
| AR (1) | AR075249A1 (en) |
| AU (1) | AU2010212232A1 (en) |
| BR (1) | BRPI1008232A2 (en) |
| CA (1) | CA2750875A1 (en) |
| CL (1) | CL2011001879A1 (en) |
| CO (1) | CO6400223A2 (en) |
| EA (1) | EA201171011A1 (en) |
| FR (1) | FR2941950B1 (en) |
| IL (1) | IL214406A0 (en) |
| MA (1) | MA33107B1 (en) |
| MX (1) | MX2011008319A (en) |
| SG (1) | SG173559A1 (en) |
| TW (1) | TW201031670A (en) |
| UY (1) | UY32420A (en) |
| WO (1) | WO2010089507A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA026655B1 (en) | 2011-09-15 | 2017-05-31 | Новартис Аг | 6-SUBSTITUTED 3-(QUINOLIN-6-YLTHIO)[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS c-Met TYROSINE KINASE INHIBITORS |
| AU2012314501B2 (en) * | 2011-09-27 | 2017-02-16 | Genfit | Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists |
| GB201321745D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| AU2024241633A1 (en) | 2023-03-30 | 2025-11-06 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| TW202530228A (en) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1298125A1 (en) | 2001-09-26 | 2003-04-02 | Aventis Pharma S.A. | Substituted benzimidazole compounds and their use for the treatment of cancer |
| US7728017B2 (en) * | 2005-11-30 | 2010-06-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met and uses thereof |
| WO2007075567A1 (en) * | 2005-12-21 | 2007-07-05 | Janssen Pharmaceutica, N.V. | Triazolopyridazines as tyrosine kinase modulators |
| EP2032578A2 (en) * | 2006-05-30 | 2009-03-11 | Pfizer Products Incorporated | Triazolopyridazine derivatives |
| PE20080403A1 (en) * | 2006-07-14 | 2008-04-25 | Amgen Inc | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE |
| EA200970403A1 (en) * | 2006-10-23 | 2009-10-30 | ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. | BICYCLIC TRIAZOLES AS PROTEINKINASE MODULATORS |
| PA8792501A1 (en) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS. |
-
2009
- 2009-02-06 FR FR0900512A patent/FR2941950B1/en not_active Expired - Fee Related
-
2010
- 2010-02-04 CA CA2750875A patent/CA2750875A1/en not_active Abandoned
- 2010-02-04 BR BRPI1008232A patent/BRPI1008232A2/en not_active IP Right Cessation
- 2010-02-04 EP EP10708278A patent/EP2393791A1/en not_active Withdrawn
- 2010-02-04 EA EA201171011A patent/EA201171011A1/en unknown
- 2010-02-04 SG SG2011056488A patent/SG173559A1/en unknown
- 2010-02-04 MA MA34152A patent/MA33107B1/en unknown
- 2010-02-04 KR KR1020117020677A patent/KR20110132560A/en not_active Withdrawn
- 2010-02-04 JP JP2011548751A patent/JP2012517408A/en not_active Withdrawn
- 2010-02-04 CN CN2010800155375A patent/CN102378759A/en active Pending
- 2010-02-04 MX MX2011008319A patent/MX2011008319A/en not_active Application Discontinuation
- 2010-02-04 WO PCT/FR2010/050178 patent/WO2010089507A1/en not_active Ceased
- 2010-02-04 AU AU2010212232A patent/AU2010212232A1/en not_active Abandoned
- 2010-02-05 AR ARP100100317A patent/AR075249A1/en unknown
- 2010-02-05 TW TW099103579A patent/TW201031670A/en unknown
- 2010-02-05 UY UY0001032420A patent/UY32420A/en not_active Application Discontinuation
-
2011
- 2011-08-02 IL IL214406A patent/IL214406A0/en unknown
- 2011-08-04 CL CL2011001879A patent/CL2011001879A1/en unknown
- 2011-08-05 CO CO11099127A patent/CO6400223A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR075249A1 (en) | 2011-03-16 |
| UY32420A (en) | 2010-09-30 |
| CO6400223A2 (en) | 2012-03-15 |
| EP2393791A1 (en) | 2011-12-14 |
| CN102378759A (en) | 2012-03-14 |
| AU2010212232A1 (en) | 2011-08-25 |
| FR2941950B1 (en) | 2011-04-01 |
| WO2010089507A1 (en) | 2010-08-12 |
| FR2941950A1 (en) | 2010-08-13 |
| IL214406A0 (en) | 2011-09-27 |
| MA33107B1 (en) | 2012-03-01 |
| SG173559A1 (en) | 2011-09-29 |
| EA201171011A1 (en) | 2012-03-30 |
| JP2012517408A (en) | 2012-08-02 |
| KR20110132560A (en) | 2011-12-08 |
| BRPI1008232A2 (en) | 2016-03-08 |
| MX2011008319A (en) | 2012-01-25 |
| CA2750875A1 (en) | 2010-08-12 |
| TW201031670A (en) | 2010-09-01 |
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