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CL2008002243A1 - Compounds derived from 2-pyrazolamino-1,3,5-triazine, jak kinase inhibitors; preparation procedure; pharmaceutical composition; and use for the treatment of cancer. - Google Patents

Compounds derived from 2-pyrazolamino-1,3,5-triazine, jak kinase inhibitors; preparation procedure; pharmaceutical composition; and use for the treatment of cancer.

Info

Publication number
CL2008002243A1
CL2008002243A1 CL2008002243A CL2008002243A CL2008002243A1 CL 2008002243 A1 CL2008002243 A1 CL 2008002243A1 CL 2008002243 A CL2008002243 A CL 2008002243A CL 2008002243 A CL2008002243 A CL 2008002243A CL 2008002243 A1 CL2008002243 A1 CL 2008002243A1
Authority
CL
Chile
Prior art keywords
pyrazolamino
triazine
cancer
treatment
pharmaceutical composition
Prior art date
Application number
CL2008002243A
Other languages
Spanish (es)
Inventor
Stephanos Ioannidis
Lynsie Almeida
Michelle Lamb
Bo Peng
Huiping Guan
Shi
Brian Quila
Claudio Edmundo Chuaqui
Shan Huang
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40304964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008002243(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2008002243A1 publication Critical patent/CL2008002243A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos derivados de 2-pirazolamino-1,3,5-triazina, inhibidores de kinasa jak; procedimiento de preparación; composición farmacéutica; y uso para el tratamiento del cáncer.Compounds derived from 2-pyrazolamino-1,3,5-triazine, jak kinase inhibitors; preparation procedure; pharmaceutical composition; and use for the treatment of cancer.

CL2008002243A 2007-07-31 2008-07-30 Compounds derived from 2-pyrazolamino-1,3,5-triazine, jak kinase inhibitors; preparation procedure; pharmaceutical composition; and use for the treatment of cancer. CL2008002243A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95315807P 2007-07-31 2007-07-31

Publications (1)

Publication Number Publication Date
CL2008002243A1 true CL2008002243A1 (en) 2009-08-21

Family

ID=40304964

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002243A CL2008002243A1 (en) 2007-07-31 2008-07-30 Compounds derived from 2-pyrazolamino-1,3,5-triazine, jak kinase inhibitors; preparation procedure; pharmaceutical composition; and use for the treatment of cancer.

Country Status (6)

Country Link
AR (1) AR069899A1 (en)
CL (1) CL2008002243A1 (en)
PE (1) PE20090895A1 (en)
TW (1) TW200906818A (en)
UY (1) UY31254A1 (en)
WO (1) WO2009016410A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010223919B2 (en) 2009-03-13 2016-03-31 Les Laboratoires Servier Methods and compositions for cell-proliferation-related disorders
CN102573485B (en) * 2009-06-08 2014-11-26 加利福尼亚资本权益有限责任公司 Triazine derivatives and their therapeutic applications
CN102573484B (en) * 2009-06-09 2015-07-01 加利福尼亚资本权益有限责任公司 Benzyl substituted triazine derivatives and their therapeutical applications
DK2448582T3 (en) 2009-06-29 2017-07-17 Agios Pharmaceuticals Inc QUINOLIN-8 SULPHONAMIDE DERIVATIVES WITH ANTICANCER ACTIVITY
CA2793835C (en) 2009-10-21 2021-07-20 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
CA3088328A1 (en) 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
CN102827170A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Active treatment compositions and use method thereof
CN102827073A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Therapeutically active compositions and application methods thereof
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
AR091858A1 (en) 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc CISTATIONIN-g-LIASA INHIBITORS (CSE)
AU2013331626B2 (en) 2012-10-15 2018-08-02 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
CN105517996B (en) * 2013-07-11 2019-03-26 安吉奥斯医药品有限公司 Therapeutic active compounds and methods of use
EP3019480B1 (en) 2013-07-11 2020-05-06 Agios Pharmaceuticals, Inc. 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
NZ723859A (en) 2014-03-14 2023-01-27 Servier Lab Pharmaceutical compositions of therapeutically active compounds and their uses
DK3245190T3 (en) 2015-01-16 2019-02-18 Bayer Cropscience Ag METHOD FOR PREPARING 4-CYANOPIPERIDE HYDROCHLORIDE
MA44392B1 (en) 2015-06-11 2023-10-31 Agios Pharmaceuticals Inc METHODS OF USING PYRUVATE KINASE ACTIVATORS
JP7033061B2 (en) 2015-10-15 2022-03-09 アジオス ファーマシューティカルズ， インコーポレイテッド Combination therapy to treat malignant tumors
MA71411A (en) 2015-10-15 2025-04-30 Les Laboratoires Servier COMBINATION THERAPY FOR THE TREATMENT OF MALIGNANT TUMORS
EP3676264A1 (en) * 2017-08-28 2020-07-08 Acurastem Inc. Pikfyve kinase inhibitors
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
WO2019245910A1 (en) * 2018-06-22 2019-12-26 Aduro Biotech, Inc. Triazine compounds and uses thereof
CN109020951B (en) * 2018-08-24 2020-06-02 大连理工大学 Naphthalimide derivatives containing trisubstituted cyanuric chloride and their synthesis methods and applications
KR20220088699A (en) 2019-09-27 2022-06-28 디스크 메디슨, 인크. Methods of treating myelofibrosis and related conditions
AU2021207804A1 (en) 2020-01-13 2022-09-01 Verge Analytics, Inc. Substituted pyrazolo-pyrimidines and uses thereof
IL297437A (en) 2020-05-13 2022-12-01 Disc Medicine Inc Anti-hemoglobin (hjv) antibodies for the treatment of myelofibrosis
CN111454214B (en) * 2020-05-27 2023-04-07 龙曦宁（上海）医药科技有限公司 Synthetic method of 2-methoxy-1-pyrimidineethylamine hydrochloride

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60128709T2 (en) * 2000-09-15 2007-12-27 Vertex Pharmaceuticals Inc., Cambridge TRIAZOL COMPOUNDS AS PROTEIN KINASE INHIBITORS
MXPA03005608A (en) * 2000-12-21 2003-10-06 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors.
DE60327999D1 (en) * 2002-03-15 2009-07-30 Vertex Pharma AZOLYLAMINOAZINES AS INHIBITORS OF PROTEIN KINASES
KR20080015409A (en) * 2005-05-16 2008-02-19 아스트라제네카 아베 Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
WO2007049041A1 (en) * 2005-10-28 2007-05-03 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer

Also Published As

Publication number Publication date
TW200906818A (en) 2009-02-16
UY31254A1 (en) 2009-04-30
PE20090895A1 (en) 2009-08-08
WO2009016410A3 (en) 2009-07-02
WO2009016410A2 (en) 2009-02-05
AR069899A1 (en) 2010-03-03

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