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CL2008002038A1 - Compounds derived from 3-phenyl-1,2-oxazole, sodium channel inhibitors; and its use for the treatment of a pain disorder. - Google Patents

Compounds derived from 3-phenyl-1,2-oxazole, sodium channel inhibitors; and its use for the treatment of a pain disorder.

Info

Publication number
CL2008002038A1
CL2008002038A1 CL2008002038A CL2008002038A CL2008002038A1 CL 2008002038 A1 CL2008002038 A1 CL 2008002038A1 CL 2008002038 A CL2008002038 A CL 2008002038A CL 2008002038 A CL2008002038 A CL 2008002038A CL 2008002038 A1 CL2008002038 A1 CL 2008002038A1
Authority
CL
Chile
Prior art keywords
oxazole
phenyl
treatment
compounds derived
sodium channel
Prior art date
Application number
CL2008002038A
Other languages
Spanish (es)
Inventor
Yevgeni Besidski
Alf Claesson
Istvan Macsari
Lars Sandberg
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2008002038A1 publication Critical patent/CL2008002038A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos derivados de fenil 1,2 oxazol y su uso para el tratamiento de un trastorno del dolor.Compounds derived from phenyl 1,2 oxazole and their use for the treatment of a pain disorder.

CL2008002038A 2007-07-13 2008-07-11 Compounds derived from 3-phenyl-1,2-oxazole, sodium channel inhibitors; and its use for the treatment of a pain disorder. CL2008002038A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94966507P 2007-07-13 2007-07-13

Publications (1)

Publication Number Publication Date
CL2008002038A1 true CL2008002038A1 (en) 2009-07-17

Family

ID=39709355

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002038A CL2008002038A1 (en) 2007-07-13 2008-07-11 Compounds derived from 3-phenyl-1,2-oxazole, sodium channel inhibitors; and its use for the treatment of a pain disorder.

Country Status (6)

Country Link
AR (1) AR067513A1 (en)
CL (1) CL2008002038A1 (en)
PE (1) PE20090477A1 (en)
TW (1) TW200911766A (en)
UY (1) UY31219A1 (en)
WO (1) WO2009010784A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20160094T1 (en) * 2010-09-13 2016-02-26 Novartis Ag Triazine-oxadiazoles
BR112014010271A2 (en) 2011-10-31 2017-04-18 Xenon Pharmaceuticals Inc benzenesulfonamide compounds and their use as therapeutic agents
KR20140105445A (en) 2011-10-31 2014-09-01 제논 파마슈티칼스 인크. Biaryl ether sulfonamides and their use as therapeutic agents
PE20150400A1 (en) 2012-05-22 2015-03-27 Genentech Inc N-SUBSTITUTED BENZAMIDES AND ITS USE IN THE TREATMENT OF PAIN
CA2878478A1 (en) 2012-07-06 2014-01-09 Genentech, Inc. N-substituted benzamides and methods of use thereof
JP6096370B2 (en) 2013-03-14 2017-03-15 ジェネンテック， インコーポレイテッド Substituted triazolopyridines and methods of use
JP6227112B2 (en) 2013-03-15 2017-11-08 ジェネンテック， インコーポレイテッド Substituted benzoxazole and methods of use
WO2015078374A1 (en) 2013-11-27 2015-06-04 Genentech, Inc. Substituted benzamides and methods of use thereof
WO2015102929A1 (en) 2013-12-30 2015-07-09 Novartis Ag Tricyclic sulfonamide derivatives
CN106715418A (en) 2014-07-07 2017-05-24 基因泰克公司 Therapeutic compounds and methods of use thereof
AU2016268120A1 (en) 2015-05-22 2017-11-30 Genentech, Inc. Substituted benzamides and methods of use thereof
JP2018526371A (en) 2015-08-27 2018-09-13 ジェネンテック， インコーポレイテッド Therapeutic compounds and methods of use thereof
WO2017058821A1 (en) 2015-09-28 2017-04-06 Genentech, Inc. Therapeutic compounds and methods of use thereof
EP3380466A1 (en) 2015-11-25 2018-10-03 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
JP2019513714A (en) 2016-03-30 2019-05-30 ジェネンテック， インコーポレイテッド Substituted benzamides and methods of use thereof
CA3039853A1 (en) 2016-10-17 2018-04-26 Genentech, Inc. Therapeutic compounds and methods of use thereof
WO2018175707A1 (en) 2017-03-24 2018-09-27 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
WO2019165290A1 (en) 2018-02-26 2019-08-29 Genentech, Inc. Pyridine-sulfonamide compounds and their use against pain and related conditions
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
TW202003490A (en) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075896A2 (en) * 2005-12-22 2007-07-05 Kemia, Inc. Heterocyclic cytokine inhibitors

Also Published As

Publication number Publication date
UY31219A1 (en) 2009-03-02
AR067513A1 (en) 2009-10-14
PE20090477A1 (en) 2009-05-24
TW200911766A (en) 2009-03-16
WO2009010784A1 (en) 2009-01-22

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