CL2007003262A1 - Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades. - Google Patents

Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades.

Info

Publication number: CL2007003262A1
Authority: CL; Chile
Prior art keywords: benzotiepina; hyperlipidemia; diabetes; diseases; dioxide
Prior art date: 2006-11-14

Application number

CL200703262A

Other languages

English (en)

Inventor

Heiner Frick Wendelin Glombik

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-14

Filing date

2007-11-13

Publication date

2008-05-30

2007-11-13 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2008-05-30 Publication of CL2007003262A1 publication Critical patent/CL2007003262A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)

CL200703262A 2006-11-14 2007-11-13 Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades. CL2007003262A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102006053635A DE102006053635B4 (de)	2006-11-14	2006-11-14	Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number	Publication Date
CL2007003262A1 true CL2007003262A1 (es)	2008-05-30

Family

ID=39092812

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200703262A CL2007003262A1 (es)	2006-11-14	2007-11-13	Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades.

Country Status (37)

Country	Link
US (1)	US7956085B2 (es)
EP (1)	EP2084172B1 (es)
JP (1)	JP5301453B2 (es)
KR (1)	KR101489168B1 (es)
CN (1)	CN101535326B (es)
AR (2)	AR063786A1 (es)
AT (1)	ATE492554T1 (es)
AU (1)	AU2007321496B2 (es)
BR (1)	BRPI0718813B8 (es)
CA (2)	CA2865332C (es)
CL (1)	CL2007003262A1 (es)
CO (1)	CO6190534A2 (es)
CR (1)	CR10733A (es)
CY (1)	CY1111166T1 (es)
DE (2)	DE102006053635B4 (es)
DK (1)	DK2084172T3 (es)
EC (1)	ECSP099327A (es)
ES (1)	ES2358371T3 (es)
GT (1)	GT200900125A (es)
HR (1)	HRP20110197T1 (es)
IL (1)	IL198718A (es)
MA (1)	MA30883B1 (es)
MX (1)	MX2009003958A (es)
MY (1)	MY148429A (es)
NI (1)	NI200900076A (es)
NO (2)	NO342236B1 (es)
NZ (1)	NZ576762A (es)
PE (1)	PE20081493A1 (es)
PL (1)	PL2084172T3 (es)
PT (1)	PT2084172E (es)
RU (1)	RU2456282C2 (es)
SI (1)	SI2084172T1 (es)
SV (1)	SV2009003216A (es)
TN (1)	TN2009000180A1 (es)
TW (1)	TWI414530B (es)
UY (1)	UY30709A1 (es)
WO (1)	WO2008058628A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8461312B2 (en) *	2008-05-02	2013-06-11	Sanofi	Method for the production of 1,4-benzothiepin-1,1-dioxide derivatives
WO2010062861A2 (en)	2008-11-26	2010-06-03	Satiogen Pharmaceuticals, Inc.	Bile acid recycling inhibitors for treatment of obesity and diabetes
EP2575821B1 (en) *	2010-05-26	2015-08-12	Satiogen Pharmaceuticals, Inc.	Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2612669A4 (en)	2010-08-31	2014-05-14	Snu R&Db Foundation	USING THE FÖTAL REPROGRAMMING OF A PPAR AGONIST
AU2011326871B2 (en)	2010-11-04	2015-02-12	Albireo Ab	IBAT inhibitors for the treatment of liver diseases
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2852957C (en) *	2011-10-28	2020-08-04	Lumena Pharmaceuticals, Inc.	Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
JP6217938B2 (ja)	2011-10-28	2017-10-25	ルメナファーマシューティカルズエルエルシー	小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
JO3301B1 (ar)	2013-04-26	2018-09-16	Albireo Ab	تعديلات بلورية على إيلوبيكسيبات
KR20220082931A (ko)	2014-06-25	2022-06-17	이에이 파마 가부시키가이샤	고형 제제 및 그의 착색 방지 또는 착색 감소 방법
EP3012252A1 (en)	2014-10-24	2016-04-27	Ferring BV	Crystal modifications of elobixibat
JP6954926B2 (ja)	2016-02-09	2021-10-27	アルビレオ・アクチボラグ	経口コレスチラミン製剤及びその使用
US10786529B2 (en)	2016-02-09	2020-09-29	Albireo Ab	Oral cholestyramine formulation and use thereof
US10441605B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Oral cholestyramine formulation and use thereof
US10441604B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Cholestyramine pellets and methods for preparation thereof
CN108601745B (zh)	2016-02-09	2021-12-07	阿尔比里奥公司	口服考来烯胺制剂及其用途
WO2019032026A1 (en)	2017-08-09	2019-02-14	Albireo Ab	CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
JP7328207B2 (ja)	2017-08-09	2023-08-16	アルビレオ・アクチボラグ	コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用
US10793534B2 (en)	2018-06-05	2020-10-06	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
EP3802504B1 (en)	2018-06-05	2023-01-18	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
MX2020013839A (es)	2018-06-20	2021-03-25	Albireo Ab	Formulacion farmaceutica de odevixibat.
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
CN112638944A (zh)	2018-08-23	2021-04-09	西进公司	抗tigit抗体
US10975045B2 (en)	2019-02-06	2021-04-13	Aibireo AB	Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en)	2019-02-06	2021-03-09	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
DK3921028T3 (da)	2019-02-06	2023-01-23	Albireo Ab	Benzothiadiazepinforbindelser og anvendelse deraf som galdesyremodulatorer
BR112021015815A2 (pt)	2019-02-12	2022-01-18	Mirum Pharmaceuticals Inc	Métodos para tratar colestase
JP7695242B2 (ja)	2019-12-04	2025-06-18	アルビレオ・アクチボラグ	ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
CA3158184A1 (en)	2019-12-04	2021-08-10	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
CN114786772B (zh)	2019-12-04	2024-04-09	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
CN114761080B (zh)	2019-12-04	2024-07-23	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
US11014898B1 (en)	2020-12-04	2021-05-25	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
JP7748451B2 (ja)	2020-08-03	2025-10-02	アルビレオ・アクチボラグ	ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
EP4243831A1 (en)	2020-11-12	2023-09-20	Albireo AB	Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
KR20230117393A (ko)	2020-12-04	2023-08-08	알비레오 에이비	벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의용도
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
EP4511038A1 (en)	2022-04-22	2025-02-26	Albireo AB	Subcutaneous administration of an asbt inhibitor
CA3257752A1 (en)	2022-06-09	2023-12-14	Albireo Ab	Treating hepatitis
JP2025539895A (ja)	2022-12-09	2025-12-09	アルビレオ・アクチボラグ	腎臓の疾患の治療におけるａｓｂｔ阻害剤
CN121175041A (zh) *	2023-05-19	2025-12-19	米鲁姆制药公司	包含2,3,4,5-四氢-苯并噻庚环-1,1-二氧化物衍生物的药物组合物和其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5994391A (en) *	1994-09-13	1999-11-30	G.D. Searle And Company	Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
DE19825804C2 (de) *	1998-06-10	2000-08-24	Aventis Pharma Gmbh	1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
WO2003018024A1 (de) *	2001-08-22	2003-03-06	Aventis Pharma Deutschland Gmbh	Kombinationspräparate von 1,4- benzothiepin-1,1-dioxidderivaten mit weiteren wirkstoffen und deren verwendung
GB0121621D0 (en) *	2001-09-07	2001-10-31	Astrazeneca Ab	Chemical compounds
US6740663B2 (en)	2001-11-02	2004-05-25	G.D. Searle, Llc	Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
GB0304194D0 (en)	2003-02-25	2003-03-26	Astrazeneca Ab	Chemical compounds
DE102005033099A1 (de)	2005-07-15	2007-01-18	Sanofi-Aventis Deutschland Gmbh	Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung

2006
- 2006-11-14 DE DE102006053635A patent/DE102006053635B4/de not_active Expired - Fee Related
2007
- 2007-10-30 PT PT07819434T patent/PT2084172E/pt unknown
- 2007-10-30 HR HR20110197T patent/HRP20110197T1/hr unknown
- 2007-10-30 NZ NZ576762A patent/NZ576762A/en unknown
- 2007-10-30 MY MYPI20091688A patent/MY148429A/en unknown
- 2007-10-30 CA CA2865332A patent/CA2865332C/en active Active
- 2007-10-30 JP JP2009536625A patent/JP5301453B2/ja active Active
- 2007-10-30 ES ES07819434T patent/ES2358371T3/es active Active
- 2007-10-30 AT AT07819434T patent/ATE492554T1/de active
- 2007-10-30 NO NO20091893A patent/NO342236B1/no unknown
- 2007-10-30 KR KR1020097009914A patent/KR101489168B1/ko active Active
- 2007-10-30 CN CN2007800424399A patent/CN101535326B/zh active Active
- 2007-10-30 DE DE502007006055T patent/DE502007006055D1/de active Active
- 2007-10-30 EP EP07819434A patent/EP2084172B1/de active Active
- 2007-10-30 SI SI200730487T patent/SI2084172T1/sl unknown
- 2007-10-30 CA CA2669230A patent/CA2669230C/en active Active
- 2007-10-30 BR BRPI0718813A patent/BRPI0718813B8/pt active IP Right Grant
- 2007-10-30 PL PL07819434T patent/PL2084172T3/pl unknown
- 2007-10-30 RU RU2009122470/04A patent/RU2456282C2/ru active
- 2007-10-30 DK DK07819434.7T patent/DK2084172T3/da active
- 2007-10-30 WO PCT/EP2007/009393 patent/WO2008058628A1/de not_active Ceased
- 2007-10-30 MX MX2009003958A patent/MX2009003958A/es active IP Right Grant
- 2007-10-30 AU AU2007321496A patent/AU2007321496B2/en active Active
- 2007-11-12 UY UY30709A patent/UY30709A1/es unknown
- 2007-11-12 PE PE2007001553A patent/PE20081493A1/es not_active Application Discontinuation
- 2007-11-12 AR ARP070105027A patent/AR063786A1/es active IP Right Grant
- 2007-11-12 TW TW096142599A patent/TWI414530B/zh active
- 2007-11-13 CL CL200703262A patent/CL2007003262A1/es unknown
2009
- 2009-04-03 SV SV2009003216A patent/SV2009003216A/es unknown
- 2009-04-20 CR CR10733A patent/CR10733A/es not_active Application Discontinuation
- 2009-05-04 NI NI200900076A patent/NI200900076A/es unknown
- 2009-05-06 CO CO09045559A patent/CO6190534A2/es not_active Application Discontinuation
- 2009-05-08 TN TNP2009000180A patent/TN2009000180A1/fr unknown
- 2009-05-12 MA MA31864A patent/MA30883B1/fr unknown
- 2009-05-12 IL IL198718A patent/IL198718A/en active IP Right Grant
- 2009-05-13 EC EC2009009327A patent/ECSP099327A/es unknown
- 2009-05-13 GT GT200900125A patent/GT200900125A/es unknown
- 2009-05-14 US US12/465,911 patent/US7956085B2/en active Active
2011
- 2011-02-04 CY CY20111100133T patent/CY1111166T1/el unknown
2017
- 2017-07-12 AR ARP170101938A patent/AR109033A2/es unknown
2018
- 2018-04-11 NO NO20180497A patent/NO344589B1/no unknown

Also Published As

Publication number	Publication date
MX2009003958A (es)	2009-04-27
AU2007321496B2 (en)	2012-07-26
US7956085B2 (en)	2011-06-07
NI200900076A (es)	2010-01-29
AR063786A1 (es)	2009-02-18
IL198718A (en)	2012-12-31
IL198718A0 (en)	2010-02-17
SI2084172T1 (sl)	2011-03-31
EP2084172B1 (de)	2010-12-22
EP2084172A1 (de)	2009-08-05
DE102006053635A1 (de)	2008-05-15
KR20090082396A (ko)	2009-07-30
PL2084172T3 (pl)	2011-06-30
AR109033A2 (es)	2018-10-24
KR101489168B1 (ko)	2015-02-03
BRPI0718813B8 (pt)	2021-05-25
CA2669230C (en)	2015-01-13
BRPI0718813A2 (pt)	2013-12-03
CY1111166T1 (el)	2015-06-11
MA30883B1 (fr)	2009-11-02
NO20091893L (no)	2009-07-09
JP2010509379A (ja)	2010-03-25
PE20081493A1 (es)	2008-11-24
GT200900125A (es)	2011-06-23
DE102006053635B4 (de)	2011-06-30
HRP20110197T1 (hr)	2011-04-30
DK2084172T3 (da)	2011-04-04
ES2358371T3 (es)	2011-05-10
UY30709A1 (es)	2008-07-03
HK1137762A1 (en)	2010-08-06
CN101535326A (zh)	2009-09-16
CR10733A (es)	2009-05-25
JP5301453B2 (ja)	2013-09-25
CO6190534A2 (es)	2010-08-19
ATE492554T1 (de)	2011-01-15
RU2009122470A (ru)	2010-12-20
NO342236B1 (no)	2018-04-23
CA2865332C (en)	2016-03-29
NO344589B1 (no)	2020-02-03
BRPI0718813B1 (pt)	2020-12-08
TN2009000180A1 (en)	2010-10-18
TWI414530B (zh)	2013-11-11
TW200837072A (en)	2008-09-16
DE502007006055D1 (de)	2011-02-03
ECSP099327A (es)	2009-06-30
AU2007321496A1 (en)	2008-05-22
CA2865332A1 (en)	2008-05-22
RU2456282C2 (ru)	2012-07-20
US20100035961A1 (en)	2010-02-11
CN101535326B (zh)	2012-10-31
CA2669230A1 (en)	2008-05-22
WO2008058628A1 (de)	2008-05-22
MY148429A (en)	2013-04-30
PT2084172E (pt)	2011-02-10
NZ576762A (en)	2010-11-26
NO20180497A1 (no)	2009-07-09
SV2009003216A (es)	2010-05-26

Publication	Publication Date	Title
CL2007003262A1 (es)	2008-05-30	Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades.
CL2007003261A1 (es)	2008-05-30	Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, tales como esquizofrenia,
CL2008000691A1 (es)	2008-09-12	Compuestos derivados de dihidro y tetrahidro oxazolopirimidinonas sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de la esquizofrenia, epilepsia, entre otras enfermedades.
CL2007003440A1 (es)	2008-04-04	Compuestos derivados de azacicloalcanos, inhibidores de estearoil-coenzima a delta-9 desaturasa; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como diabetes tipo 2, resistencia a la insulina, trastornos de lipidos, obesida
CL2007002641A1 (es)	2008-06-20	Compuestos derivados de pirimidinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos alergicos, autoinmunes, enfermedades inflamatorias.
CL2007003341A1 (es)	2008-04-18	Compuestos derivados de imidazotriazinas; composicion farmaceutica, util para el tratamiento del cancer, arteroesclerosis y enfermedades cardiovasculares entre otras.
CL2007003183A1 (es)	2008-06-27	Compuestos biciclicos puenteados; y composicion farmaceutica, util para el tratamiento de trastornos del apetito, diabetes y obesidad entre otros.
CL2007003797A1 (es)	2008-07-18	Compuestos derivados de pirrolo piridina; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de la enfermedad de alzheimer, parkinson, cancer, entre otras enfermedades.
BRPI0810390A2 (pt)	2014-11-25	Película, composição, e, métodos para administrar um material ativo, para melhorar a estabilidade de uma película e para manter a saúde sistêmica de um mamífero
BRPI0810646A2 (pt)	2014-11-04	" compostos farmacêuticos ".
CL2007001778A1 (es)	2008-05-23	Compuestos derivados de 2-pirazinacarboxamida, antagonistas/agonistas inversos selectivos de cb1; proceso de preparacion; composiciones farmaceuticas; y uso para el tratamiento y/o profilaxis de trastornos de ingestion de comida, diabetes tipo ii y a
NO20070046L (no)	2007-04-26	Nytt cykloheksanderivat, prodrug derav og salt derav, og terapeutisk middel inneholdende de samme for diabetes
CL2007003263A1 (es)	2008-05-30	Compuestos derivados de 1,4-benzotiepina 1,1-dioxido; producto farmaceutico; procedimiento de preparacion; y uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, e
BRPI0820868A2 (pt)	2019-09-24	composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado
CL2008000198A1 (es)	2008-05-30	Compuestos derivados de azacicloalcanos, inhibidores de estearoil-coenzima a delta-9; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como diabetes tipo 2, trastorno de lipidos, obesidad y aterosclerosis.
CL2007003583A1 (es)	2008-07-18	Formulacion farmaceutica estable, parenteral, del anticuerpo contra el peptido beta amiloide (abeta); y uso de la formulacion para el tratamiento de la enfermedad de alzheimer.
BRPI0811267A2 (pt)	2014-10-07	Variante de fenilanina amônia-liase procariótica, composição farmacêutica, método para o tratamento de uma doença, uso de uma variante de fenilalanina amônia-liase procariótica, método para o tratamento de uma condição, e, variante de fenilalanina amônia-liase de anabaena variabilis.
IL185277A0 (en)	2008-02-09	Pharmaceutical compositions containing roflumilast for the treatment of diabetes
CL2007002187A1 (es)	2008-02-01	Compuestos derivados espirocetal sustituidos; composicion farmaceutica que comprende a dicho compuesto; y su uso para el tratamiento de la diabetes, hiperglicemia, complicaciones diabeticas y obesidad.
CL2009000173A1 (es)	2010-02-12	Compuestos derivados de urea-tetrahidroxiquinoxalina; procedimiento de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento y la prevencion de la obesidad y la diabetes, resistencia a la insulina, sindrome metabolico, entre otros.
CL2007002186A1 (es)	2008-02-01	Compuestos derivados espirocetal sustituidos de anillo fusionado; composicion farmaceutica que comprende a dicho compuesto; y uso de la composicion para el tratamiento de la diabetes, hiperglicemia, complicaciones diabeticas y obesidad.
BRPI0807807A2 (pt)	2014-06-17	" composição farmacêutica de liberação modificada e um processo para fabricar a mesma ".
CL2007003049A1 (es)	2008-05-16	Compuestos derivados de 2,4-diaminopirimidina; composicion farmaceutica, utiles para tratar trastornos proliferativos.
EP2162003A4 (en)	2010-08-11	THERAPEUTIC TREATMENT OF METABOLIC SYNDROME, TYPE 2 DIABETES, OBESITY OR PRE-DIABETES
CL2007003202A1 (es)	2008-03-07	Compuestos derivados de espiroindolinona; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos de proliferacion celular.