CL2007002196A1 - Compuestos heterociclicos nitrogenados, moduladores de la actividad del receptor de quimioquina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, obesidad, sindrome metabolico y dolor. - Google Patents

Compuestos heterociclicos nitrogenados, moduladores de la actividad del receptor de quimioquina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, obesidad, sindrome metabolico y dolor.

Info

Publication number: CL2007002196A1
Authority: CL; Chile
Prior art keywords: chemioquine; obesity; diabetes; pain; diseases
Prior art date: 2006-07-28

Application number

CL200702196A

Other languages

English (en)

Inventor

Michael G Cherney Robert Yang

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-28

Filing date

2007-07-26

Publication date

2008-05-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38823540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007002196(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-07-26 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2008-05-30 Publication of CL2007002196A1 publication Critical patent/CL2007002196A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Virology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Child & Adolescent Psychology (AREA)

CL200702196A 2006-07-28 2007-07-26 Compuestos heterociclicos nitrogenados, moduladores de la actividad del receptor de quimioquina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, obesidad, sindrome metabolico y dolor. CL2007002196A1 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US83423506P	2006-07-28	2006-07-28
US89602607P	2007-03-21	2007-03-21
US11/782,704 US7671062B2 (en)	2006-07-28	2007-07-25	Modulators of chemokine receptor activity, crystalline forms and process

Publications (1)

Publication Number	Publication Date
CL2007002196A1 true CL2007002196A1 (es)	2008-05-30

Family

ID=38823540

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CL200702195A CL2007002195A1 (es)	2006-07-28	2007-07-26	Compuesto n-((1r,2s,5r)-5-(isopropil(metil)amino)-2-((s)-2-oxo-3-(6-(trifluorometil)quinazolin-4-ilamino)pirrolidin-1-il)ciclohexil)acetamida; forma cristalina del compuesto; composicion farmaceutica; y uso en el tratamiento de enfermedades tales com
CL200702196A CL2007002196A1 (es)	2006-07-28	2007-07-26	Compuestos heterociclicos nitrogenados, moduladores de la actividad del receptor de quimioquina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, obesidad, sindrome metabolico y dolor.
CL200702194A CL2007002194A1 (es)	2006-07-28	2007-07-26	Compuesto n-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-2-oxo-3-(6-(trifluorometil)quinazolin-4-ilamino)pirrolidin-1-il)ciclohexil)-acetamida; forma cristalina del compuesto; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como dia

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CL200702195A CL2007002195A1 (es)	2006-07-28	2007-07-26	Compuesto n-((1r,2s,5r)-5-(isopropil(metil)amino)-2-((s)-2-oxo-3-(6-(trifluorometil)quinazolin-4-ilamino)pirrolidin-1-il)ciclohexil)acetamida; forma cristalina del compuesto; composicion farmaceutica; y uso en el tratamiento de enfermedades tales com

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CL200702194A CL2007002194A1 (es)	2006-07-28	2007-07-26	Compuesto n-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-2-oxo-3-(6-(trifluorometil)quinazolin-4-ilamino)pirrolidin-1-il)ciclohexil)-acetamida; forma cristalina del compuesto; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como dia

Country Status (29)

Country	Link
US (1)	US7671062B2 (es)
EP (2)	EP2049477B1 (es)
JP (1)	JP2009544758A (es)
KR (1)	KR20090035036A (es)
CN (1)	CN101511822A (es)
AR (1)	AR062114A1 (es)
AT (1)	ATE471928T1 (es)
AU (1)	AU2007279256A1 (es)
BR (1)	BRPI0715066A2 (es)
CA (1)	CA2659259A1 (es)
CL (3)	CL2007002195A1 (es)
CO (1)	CO6190527A2 (es)
CY (1)	CY1110785T1 (es)
DE (1)	DE602007007335D1 (es)
DK (1)	DK2049477T3 (es)
EA (1)	EA014960B1 (es)
ES (1)	ES2346591T3 (es)
HR (1)	HRP20100371T1 (es)
IL (1)	IL196518A0 (es)
MX (1)	MX2009000803A (es)
NO (1)	NO20090256L (es)
NZ (1)	NZ574656A (es)
PE (1)	PE20080838A1 (es)
PL (1)	PL2049477T3 (es)
PT (1)	PT2049477E (es)
SG (1)	SG158925A1 (es)
SI (1)	SI2049477T1 (es)
TW (1)	TW200823203A (es)
WO (1)	WO2008014381A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7687508B2 (en) *	2006-07-28	2010-03-30	Bristol-Myers Squibb Company	Cyclic derivatives as modulators of chemokine receptor activity
US8383812B2 (en) *	2009-10-13	2013-02-26	Bristol-Myers Squibb Company	N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
PT3297438T (pt) *	2015-05-21	2022-01-25	Chemocentryx Inc	Moduladores de ccr2
US11254679B2 (en) *	2017-07-20	2022-02-22	Bristol-Myers Squibb Company	Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide
CN111712242B (zh)	2017-09-25	2023-11-24	凯莫森特里克斯股份有限公司	使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
AU2019205784B2 (en)	2018-01-08	2024-07-25	Chemocentryx, Inc.	Methods of treating solid tumors with CCR2 antagonists
US20190269664A1 (en)	2018-01-08	2019-09-05	Chemocentryx, Inc.	Methods of treating solid tumors with ccr2 antagonists
CN115494184B (zh) *	2022-05-09	2023-07-28	浙江海正药业股份有限公司	一种同时检测药物中异丙苯磺酸甲酯、异丙苯磺酸乙酯的方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6383082A (ja)	1986-09-26	1988-04-13	Takeda Chem Ind Ltd	テトラヒドロフランカルボン酸誘導体の製造法
CA2084800A1 (en)	1991-12-16	1993-06-17	Joseph P. Vacca	Hiv protease inhibitors with an internal lactam ring
GB9515411D0 (en)	1995-07-27	1995-09-27	Pharmacia Spa	N-(4-substituted-benzyl)-2-aminolactam derivatives
US5827875A (en)	1996-05-10	1998-10-27	Bristol-Myers Squibb Company	Inhibitors of microsomal triglyceride transfer protein and method
UA51716C2 (uk)	1996-07-08	2002-12-16	Авентіс Фармасьютікалз Продактс Інк.	Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
US6054579A (en)	1997-06-26	2000-04-25	Leukosite, Inc.	Synthesis of substituted lactams
GB9716656D0 (en)	1997-08-07	1997-10-15	Zeneca Ltd	Chemical compounds
BR9907300A (pt)	1998-01-27	2000-10-24	Aventis Pharm Prod Inc	Inibidores do fator xa oxoaza-heterociclila substituìdos
US6492553B1 (en)	1998-01-29	2002-12-10	Aventis Pharamaceuticals Inc.	Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds
SK10642000A3 (sk)	1998-01-29	2001-07-10	Aventis Pharmaceuticals Products Inc.	Spôsob prípravy n-[(alifatickej alebo aromatickej)karbonyl)]-2- aminoacetamidovej zlúčeniny a cyklizovanej formy tejto zlúčeniny
GB9803228D0 (en)	1998-02-17	1998-04-08	Zeneca Ltd	Chemical compounds
US6541208B1 (en)	1998-03-17	2003-04-01	University Of Maryland Biotechnology Institute	Diagnostic method for distinguishing HIV-associated dementia from other forms of dementia
AU7354900A (en)	1999-09-09	2001-04-10	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
US6620823B2 (en)	2000-07-11	2003-09-16	Bristol-Myers Squibb Pharme Company	Lactam metalloprotease inhibitors
JP2005506949A (ja)	2000-12-20	2005-03-10	ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー	ケモカイン受容体の調節剤としてのジアミン
CA2432369A1 (en)	2000-12-20	2002-08-08	Bristol-Myers Squibb Pharma Company	Cyclic derivatives as modulators of chemokine receptor activity
DE60209471D1 (de)	2001-03-29	2006-04-27	Topo Target As Copenhagen Koeb	Succinimid- und maleimidderivate und ihre verwendung als katalytische inhibitoren der topoisomerase ii
GB0114867D0 (en)	2001-06-18	2001-08-08	Merck Sharp & Dohme	Therapeutic agents
DE10135043A1 (de)	2001-07-11	2003-01-30	Bayer Cropscience Gmbh	Substituierte 3-Heteroaryl(amino- oder oxy)-pyrrolidin-2-one, Verfahren zu deren Herstellung und Verwendung als Herbizide oder als Pflanzenwachstumsregulatoren
US7087604B2 (en)	2002-03-08	2006-08-08	Bristol-Myers Squibb Company	Cyclic derivatives as modulators of chemokine receptor activity
TW200307667A (en)	2002-05-06	2003-12-16	Bristol Myers Squibb Co	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
WO2004022536A1 (en)	2002-09-04	2004-03-18	Glenmark Pharmaceuticals Limited	New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
US7338975B2 (en)	2003-02-12	2008-03-04	Bristol-Myers Squibb Co.	Lactams as modulators of chemokine receptor activity
TW200508224A (en)	2003-02-12	2005-03-01	Bristol Myers Squibb Co	Cyclic derivatives as modulators of chemokine receptor activity
US7291615B2 (en)	2003-05-01	2007-11-06	Bristol-Myers Squibb Company	Cyclic derivatives as modulators of chemokine receptor activity
US7230133B2 (en)	2003-05-01	2007-06-12	Bristol-Myers Squibb Company	Malonamides and malonamide derivatives as modulators of chemokine receptor activity
WO2004110376A2 (en)	2003-06-06	2004-12-23	Merck & Co., Inc.	Ccr-2 antagonists for treatment of neuropathic pain
US7863317B2 (en)	2003-08-21	2011-01-04	Bristol-Myers Squibb Company	Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity
US7378409B2 (en)	2003-08-21	2008-05-27	Bristol-Myers Squibb Company	Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
US7163937B2 (en)	2003-08-21	2007-01-16	Bristol-Myers Squibb Company	Cyclic derivatives as modulators of chemokine receptor activity
US7317019B2 (en)	2003-08-21	2008-01-08	Bristol Myers Squibb Co.	N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity
US20050043392A1 (en)	2003-08-21	2005-02-24	Carter Percy H.	Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity
BRPI0513953A (pt)	2004-07-30	2008-05-20	Pfizer Prod Inc	métodos para tratamento de doenças ou distúrbios mediados pela ccr2
EP1802602A1 (en)	2004-09-28	2007-07-04	Janssen Pharmaceutica N.V.	Substituted dipiperdine ccr2 antagonists

2007
- 2007-07-25 US US11/782,704 patent/US7671062B2/en active Active
- 2007-07-26 PT PT07799831T patent/PT2049477E/pt unknown
- 2007-07-26 SI SI200730305T patent/SI2049477T1/sl unknown
- 2007-07-26 EA EA200900244A patent/EA014960B1/ru not_active IP Right Cessation
- 2007-07-26 CL CL200702195A patent/CL2007002195A1/es unknown
- 2007-07-26 AR ARP070103321A patent/AR062114A1/es not_active Application Discontinuation
- 2007-07-26 CL CL200702196A patent/CL2007002196A1/es unknown
- 2007-07-26 SG SG201000704-5A patent/SG158925A1/en unknown
- 2007-07-26 HR HR20100371T patent/HRP20100371T1/hr unknown
- 2007-07-26 DE DE602007007335T patent/DE602007007335D1/de active Active
- 2007-07-26 ES ES07799831T patent/ES2346591T3/es active Active
- 2007-07-26 CA CA002659259A patent/CA2659259A1/en not_active Abandoned
- 2007-07-26 CN CNA2007800327628A patent/CN101511822A/zh active Pending
- 2007-07-26 EP EP07799831A patent/EP2049477B1/en not_active Not-in-force
- 2007-07-26 WO PCT/US2007/074438 patent/WO2008014381A2/en not_active Ceased
- 2007-07-26 PL PL07799831T patent/PL2049477T3/pl unknown
- 2007-07-26 KR KR1020097004327A patent/KR20090035036A/ko not_active Withdrawn
- 2007-07-26 TW TW096127306A patent/TW200823203A/zh unknown
- 2007-07-26 DK DK07799831.8T patent/DK2049477T3/da active
- 2007-07-26 EP EP10001344A patent/EP2184283A1/en not_active Withdrawn
- 2007-07-26 JP JP2009522956A patent/JP2009544758A/ja not_active Withdrawn
- 2007-07-26 BR BRPI0715066-0A patent/BRPI0715066A2/pt not_active IP Right Cessation
- 2007-07-26 AT AT07799831T patent/ATE471928T1/de active
- 2007-07-26 MX MX2009000803A patent/MX2009000803A/es active IP Right Grant
- 2007-07-26 CL CL200702194A patent/CL2007002194A1/es unknown
- 2007-07-26 PE PE2007000968A patent/PE20080838A1/es not_active Application Discontinuation
- 2007-07-26 NZ NZ574656A patent/NZ574656A/en not_active IP Right Cessation
- 2007-07-26 AU AU2007279256A patent/AU2007279256A1/en not_active Abandoned
2009
- 2009-01-15 IL IL196518A patent/IL196518A0/en unknown
- 2009-01-16 NO NO20090256A patent/NO20090256L/no not_active Application Discontinuation
- 2009-01-27 CO CO09007271A patent/CO6190527A2/es not_active Application Discontinuation
2010
- 2010-09-22 CY CY20101100852T patent/CY1110785T1/el unknown

Also Published As

Publication number	Publication date
PL2049477T3 (pl)	2010-11-30
EA200900244A1 (ru)	2009-08-28
TW200823203A (en)	2008-06-01
CO6190527A2 (es)	2010-08-19
US7671062B2 (en)	2010-03-02
US20080027083A1 (en)	2008-01-31
MX2009000803A (es)	2009-01-29
AR062114A1 (es)	2008-10-15
HK1125931A1 (en)	2009-08-21
CL2007002195A1 (es)	2008-02-08
KR20090035036A (ko)	2009-04-08
CL2007002194A1 (es)	2008-02-08
PE20080838A1 (es)	2008-06-14
JP2009544758A (ja)	2009-12-17
DK2049477T3 (da)	2010-10-25
ES2346591T3 (es)	2010-10-18
CN101511822A (zh)	2009-08-19
EP2049477B1 (en)	2010-06-23
AU2007279256A1 (en)	2008-01-31
HRP20100371T1 (hr)	2010-08-31
CY1110785T1 (el)	2015-06-10
EA014960B1 (ru)	2011-04-29
EP2184283A1 (en)	2010-05-12
IL196518A0 (en)	2009-11-18
NO20090256L (no)	2009-02-25
ATE471928T1 (de)	2010-07-15
PT2049477E (pt)	2010-08-27
NZ574656A (en)	2011-12-22
SG158925A1 (en)	2010-02-26
BRPI0715066A2 (pt)	2013-05-28
WO2008014381A3 (en)	2008-12-31
SI2049477T1 (sl)	2010-09-30
EP2049477A2 (en)	2009-04-22
WO2008014381A2 (en)	2008-01-31
CA2659259A1 (en)	2008-01-31
DE602007007335D1 (de)	2010-08-05

Publication	Publication Date	Title
CL2008001125A1 (es)	2008-10-24	Compuestos derivados de pirimidinona condensada con heterociclos; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, sindrome metabolico y obesidad.
CL2008001126A1 (es)	2008-10-24	Compuestos derivados de pirimidinona condensada con heterociclos; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, sindrome metabolico y obesidad.
CL2008002111A1 (es)	2008-10-24	Compuestos derivados de piridona, agonistas del receptor acoplado a proteina g gpr119; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, sindrome metabolico, cancer, entre otras.
CL2007002196A1 (es)	2008-05-30	Compuestos heterociclicos nitrogenados, moduladores de la actividad del receptor de quimioquina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, obesidad, sindrome metabolico y dolor.
CL2008003116A1 (es)	2010-02-05	Compuestos heterocíclicos bicíclicos; composición farmacéutica que comprende a dichos compuestos; y su uso en el tratamiento o prevención de enfermedades tales como diabetes, obesidad, trastorno metabólico, enfermedad cardiovascular entre otras.
CL2008001994A1 (es)	2008-09-22	Compuestos derivados de pirazin-2-ona; combinacion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, aterosclerosis, hipertension, entre otras.
CL2007003629A1 (es)	2008-08-08	Compuestos heterociclicos aril-sustituidos, moduladores del receptor de cannabinoides tipo i (cb1); proceso de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como trastornos metabolicos y trastornos cognitivos.
CL2007002610A1 (es)	2008-02-01	Compuestos derivados de bipiridina sustituida; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento y/o la profilaxis de enfermedades tales como hipertonia, diabetes, infarto de miocardio, entre otras.
CL2008001114A1 (es)	2008-12-19	Compuestos derivados de bencimidazol; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como vejiga sobreactiva, dolor, obesidad, convulsiones, entre otras.
CL2009000173A1 (es)	2010-02-12	Compuestos derivados de urea-tetrahidroxiquinoxalina; procedimiento de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento y la prevencion de la obesidad y la diabetes, resistencia a la insulina, sindrome metabolico, entre otros.
CL2008001215A1 (es)	2008-09-22	Compuestos derivados de heterociclos nitrogenados condensados; composicion farmaceutica; procedimiento para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, dislipidemia, obesidad y alzheimer.
CL2008000198A1 (es)	2008-05-30	Compuestos derivados de azacicloalcanos, inhibidores de estearoil-coenzima a delta-9; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como diabetes tipo 2, trastorno de lipidos, obesidad y aterosclerosis.
CL2008000690A1 (es)	2008-09-12	Compuestos derivados del acido indol-3-propionico; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hiperlipidemia, hipertension; entre otras.
CL2007003766A1 (es)	2008-08-08	Compuestos derivados de heterociclos de nitrogeno y oxigeno; composicion farmaceutica; y uso del compuesto en el tratamiento de diabetes mellitus, artritis, obesidad, insuficiencia cardiaca, enfermedades neurodegenerativas, cardiovasculares, dislipid
CL2008001197A1 (es)	2008-12-19	Compuestos derivados de amidas sustituidas, moduladoras de la actividad de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo i; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como sindrome metabolico, resistencia a la insulina, dislipidemia, entre otras.
CL2007002996A1 (es)	2008-06-13	Compuestos derivados de quinolina sustituido, moduladores de los receptores x del higado; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como sindrome coronario agudo, alzheimer, diabetes y aterosclerosis.
CL2008000434A1 (es)	2008-08-22	Compuestos derivados de 2-amino-oxazolinas; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como depresion, ansiedad, estres, trastorno bipolar, entre otros.
CL2007003440A1 (es)	2008-04-04	Compuestos derivados de azacicloalcanos, inhibidores de estearoil-coenzima a delta-9 desaturasa; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como diabetes tipo 2, resistencia a la insulina, trastornos de lipidos, obesida
CL2011000663A1 (es)	2011-07-29	Compuestos derivados de n-heterociclil-2-sulfonil acetamida, moduladores del receptor cb2, utiles para el tratamiento del dolor, enfermedad pulmonar, reumatica, autoinmune, entre otras.
CL2008000791A1 (es)	2008-05-30	Compuestos derivados de 2-amino-5-(4-difluorometoxi-fenil)-5-fenil-imidazolidin-4-ona; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de una enfermedad asociada con la actividad bace excesiva, tales como enferm
CL2007003640A1 (es)	2008-07-11	Compuestos derivados de benzamida; composicion farmaceutica que comprende dichos compuestos; y su uso para el tratamiento en que la afeccion es dolor, tales como dolor lumbar y cervical, migrana, dismenorrea, dolor de muelas, entre otros.
CL2008000875A1 (es)	2008-10-03	Compuestos derivados de imidazolidin-2-ona; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento y/o profilaxis de enfermedades tales como dislipidemia, diabetes, enfermedades inflamatorias, entre otras.
CL2007002513A1 (es)	2008-04-04	Compuestos derivados de isoindolina sustituidos, compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento y prevencion de enfermedades tales como cancer, dolor, degeneracion macular, entre otras.
CL2007002348A1 (es)	2008-08-08	Compuestos heterociclicos, moduladores de la actividad de la estearoil-coa-desaturasa; composicion farmaceutica, util para el tratamiento de enfermedades tales como diabetes, dislipidemias, obesidad, anorexia y acne.
CL2007003879A1 (es)	2008-07-04	Compuestos derivados de aril-carboxamida; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como alzheimer, epilepsia y parkinson.