CL2007001961A1 - Composicion farmaceutica que contiene a) 2,0 mg de dienogest y 0,015 mg de etinilestradiol y (6s)-5-metil-tetrahidrofolato y uno o mas excipiente/vehiculos; kit; uso para la anticoncepcion femeneina y reducir el riesgo d malformaciones congenitas debidas a la falta de folato en el embarazo. - Google Patents
Composicion farmaceutica que contiene a) 2,0 mg de dienogest y 0,015 mg de etinilestradiol y (6s)-5-metil-tetrahidrofolato y uno o mas excipiente/vehiculos; kit; uso para la anticoncepcion femeneina y reducir el riesgo d malformaciones congenitas debidas a la falta de folato en el embarazo.Info
- Publication number
- CL2007001961A1 CL2007001961A1 CL2007001961A CL2007001961A CL2007001961A1 CL 2007001961 A1 CL2007001961 A1 CL 2007001961A1 CL 2007001961 A CL2007001961 A CL 2007001961A CL 2007001961 A CL2007001961 A CL 2007001961A CL 2007001961 A1 CL2007001961 A1 CL 2007001961A1
- Authority
- CL
- Chile
- Prior art keywords
- dienogest
- tetrahydrofolate
- methyl
- contraception
- risk
- Prior art date
Links
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 title abstract 3
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 title abstract 3
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 title abstract 3
- 229960003309 dienogest Drugs 0.000 title abstract 3
- 229960002568 ethinylestradiol Drugs 0.000 title abstract 3
- 239000011578 levomefolic acid Substances 0.000 title abstract 3
- 235000007635 levomefolic acid Nutrition 0.000 title abstract 3
- ZNOVTXRBGFNYRX-ABLWVSNPSA-N levomefolic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-ABLWVSNPSA-N 0.000 title abstract 3
- 206010010356 Congenital anomaly Diseases 0.000 title abstract 2
- 230000036244 malformation Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- VKEQBMCRQDSRET-UHFFFAOYSA-N Methylone Chemical compound CNC(C)C(=O)C1=CC=C2OCOC2=C1 VKEQBMCRQDSRET-UHFFFAOYSA-N 0.000 title 1
- 229940014144 folate Drugs 0.000 title 1
- 235000019152 folic acid Nutrition 0.000 title 1
- 239000011724 folic acid Substances 0.000 title 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 title 1
- 230000035935 pregnancy Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Composición farmacéutica que contiene a) 2,0 mg de dienogest y 0,015 mg de etinilestradiol y (6s)-5-metil-tetrahidrofolato o b) 1,5 mg de dienogest y 0,015 mg de etinilestradiol y(6s)-5-metil-tetrahidrofolato; kit que la contiene; y uso para la anticoncepción y para reducir el riesgo de malformación congénita.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06014002 | 2006-07-06 | ||
| EP06016950A EP1891959A1 (de) | 2006-08-14 | 2006-08-14 | Pharmazeutische Zusammensetzung zur Kontrazeption und zur Verminderung des Risikos angeborener Fehlbildungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007001961A1 true CL2007001961A1 (es) | 2008-01-11 |
Family
ID=38330771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2007001961A CL2007001961A1 (es) | 2006-07-06 | 2007-07-05 | Composicion farmaceutica que contiene a) 2,0 mg de dienogest y 0,015 mg de etinilestradiol y (6s)-5-metil-tetrahidrofolato y uno o mas excipiente/vehiculos; kit; uso para la anticoncepcion femeneina y reducir el riesgo d malformaciones congenitas debidas a la falta de folato en el embarazo. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080268048A1 (es) |
| EP (1) | EP2037935A1 (es) |
| JP (1) | JP2009542588A (es) |
| KR (1) | KR20090029824A (es) |
| AR (1) | AR061959A1 (es) |
| BR (1) | BRPI0713999A2 (es) |
| CA (1) | CA2665788A1 (es) |
| CL (1) | CL2007001961A1 (es) |
| DE (1) | DE112007001600A5 (es) |
| IL (1) | IL196154A0 (es) |
| MX (1) | MX2009000256A (es) |
| PE (1) | PE20080400A1 (es) |
| RU (1) | RU2009102443A (es) |
| TW (1) | TW200810764A (es) |
| UY (1) | UY30461A1 (es) |
| WO (1) | WO2008003363A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101489563A (zh) * | 2006-07-06 | 2009-07-22 | 拜耳先灵医药股份有限公司 | 用于避孕和预防先天性畸形风险的药物制剂 |
| US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| HUE054551T2 (hu) | 2015-06-18 | 2021-09-28 | Estetra Sprl | Ösztetrolt tartalmazó, szájban diszpergálódó tabletta |
| MA44205B1 (fr) | 2015-06-18 | 2021-04-30 | Estetra Sprl | Comprimé orodispersible comprenant estetrol |
| SMT201800232T1 (it) | 2015-06-18 | 2018-07-17 | Mithra Pharmaceuticals S A | Unita' di dosaggio orodispersibile contenente un componente di estetrolo |
| EP3310333B1 (en) | 2015-06-18 | 2020-04-29 | Estetra SPRL | Orodispersible dosage unit containing an estetrol component |
| KR102712911B1 (ko) | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633011A (en) * | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| CH693255A5 (de) * | 1997-06-13 | 2003-05-15 | Eprova Ag | Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels. |
| TR200002995T2 (tr) * | 1998-04-17 | 2001-01-22 | Ortho-Mcneil Pharmaceutical,Inc. | Folik asit ihtiva eden farmasötik bileşimler, bununla ilgili yöntemler ve uygulama sistemleri |
| CH693905A5 (de) * | 1999-04-15 | 2004-04-15 | Eprova Ag | Stabile kristalline Salze von 5-Methyltetrahydrofolsäure. |
| US7696219B2 (en) * | 2000-09-27 | 2010-04-13 | Everett Laboratories, Inc. | Method and composition for supplementation of nutritional deficiences in renal patients |
| US20020147155A1 (en) * | 2001-04-06 | 2002-10-10 | Foster Warren G. | Prevention and treatment of endometriosis with aryl hydrocarbon receptor binding ligands |
| US20050164977A1 (en) * | 2002-02-21 | 2005-07-28 | Coelingh Bennink Herman J.T. | Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12 |
| WO2005115349A1 (de) * | 2004-05-28 | 2005-12-08 | Grünenthal GmbH | Folsäurehaltiges kontrazeptivum |
| DE102004026671A1 (de) * | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Darreichungsform zur hormonalen Kontrazeption |
| UY29527A1 (es) * | 2005-05-13 | 2006-12-29 | Schering Ag | Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato. |
-
2007
- 2007-05-05 RU RU2009102443/15A patent/RU2009102443A/ru not_active Application Discontinuation
- 2007-05-05 MX MX2009000256A patent/MX2009000256A/es not_active Application Discontinuation
- 2007-05-05 WO PCT/EP2007/003982 patent/WO2008003363A1/de not_active Ceased
- 2007-05-05 EP EP07724906A patent/EP2037935A1/de not_active Withdrawn
- 2007-05-05 JP JP2009516918A patent/JP2009542588A/ja active Pending
- 2007-05-05 DE DE112007001600T patent/DE112007001600A5/de not_active Withdrawn
- 2007-05-05 CA CA002665788A patent/CA2665788A1/en not_active Abandoned
- 2007-05-05 KR KR1020097002387A patent/KR20090029824A/ko not_active Ceased
- 2007-05-05 BR BRPI0713999-3A patent/BRPI0713999A2/pt not_active Application Discontinuation
- 2007-07-03 US US11/773,037 patent/US20080268048A1/en not_active Abandoned
- 2007-07-04 UY UY30461A patent/UY30461A1/es not_active Application Discontinuation
- 2007-07-05 PE PE2007000865A patent/PE20080400A1/es not_active Application Discontinuation
- 2007-07-05 CL CL2007001961A patent/CL2007001961A1/es unknown
- 2007-07-06 TW TW096124769A patent/TW200810764A/zh unknown
- 2007-07-06 AR ARP070103017A patent/AR061959A1/es not_active Application Discontinuation
-
2008
- 2008-12-24 IL IL196154A patent/IL196154A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL196154A0 (en) | 2009-09-22 |
| CA2665788A1 (en) | 2008-01-10 |
| TW200810764A (en) | 2008-03-01 |
| WO2008003363A1 (de) | 2008-01-10 |
| DE112007001600A5 (de) | 2009-04-30 |
| UY30461A1 (es) | 2008-02-29 |
| RU2009102443A (ru) | 2010-08-20 |
| PE20080400A1 (es) | 2008-07-04 |
| JP2009542588A (ja) | 2009-12-03 |
| MX2009000256A (es) | 2009-02-18 |
| US20080268048A1 (en) | 2008-10-30 |
| BRPI0713999A2 (pt) | 2012-11-20 |
| AR061959A1 (es) | 2008-08-10 |
| KR20090029824A (ko) | 2009-03-23 |
| EP2037935A1 (de) | 2009-03-25 |
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