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CL2007001733A1 - Compounds derived from condensed imidazole with nitrogen heterocycles; pharmaceutical composition; and use to treat or prevent a disorder associated with cognitive impairment, Alzheimer's disease, senile dementia and dementia associated with parkinson's disease among others. - Google Patents

Compounds derived from condensed imidazole with nitrogen heterocycles; pharmaceutical composition; and use to treat or prevent a disorder associated with cognitive impairment, Alzheimer's disease, senile dementia and dementia associated with parkinson's disease among others.

Info

Publication number
CL2007001733A1
CL2007001733A1 CL2007001733A CL2007001733A CL2007001733A1 CL 2007001733 A1 CL2007001733 A1 CL 2007001733A1 CL 2007001733 A CL2007001733 A CL 2007001733A CL 2007001733 A CL2007001733 A CL 2007001733A CL 2007001733 A1 CL2007001733 A1 CL 2007001733A1
Authority
CL
Chile
Prior art keywords
disease
dementia
alzheimer
pharmaceutical composition
parkinson
Prior art date
Application number
CL2007001733A
Other languages
Spanish (es)
Inventor
Stefan Berg
Katharina Hogdin
Jacob Kihlstrom
Niklas Plobeck
Fernando Sehgelmeble
Maria Wirstam
Original Assignee
Astrazeneca Ab
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38831992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007001733(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Astex Therapeutics Ltd filed Critical Astrazeneca Ab
Publication of CL2007001733A1 publication Critical patent/CL2007001733A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos derivados de imidazo[1,5-a]pirimidina; composición farmacéutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del síndrome de Down, angiopatía amiloide cerebral, Alzheimer.Compounds derived from imidazo [1,5-a] pyrimidine; pharmaceutical composition comprising said compound; and use of the compound in the treatment of Down syndrome, cerebral amyloid angiopathy, Alzheimer's.

CL2007001733A 2006-06-14 2007-06-13 Compounds derived from condensed imidazole with nitrogen heterocycles; pharmaceutical composition; and use to treat or prevent a disorder associated with cognitive impairment, Alzheimer's disease, senile dementia and dementia associated with parkinson's disease among others. CL2007001733A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81372806P 2006-06-14 2006-06-14
US89699407P 2007-03-26 2007-03-26

Publications (1)

Publication Number Publication Date
CL2007001733A1 true CL2007001733A1 (en) 2008-01-25

Family

ID=38831992

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2007001733A CL2007001733A1 (en) 2006-06-14 2007-06-13 Compounds derived from condensed imidazole with nitrogen heterocycles; pharmaceutical composition; and use to treat or prevent a disorder associated with cognitive impairment, Alzheimer's disease, senile dementia and dementia associated with parkinson's disease among others.

Country Status (7)

Country Link
EP (1) EP2035423A1 (en)
JP (1) JP2009539973A (en)
AR (1) AR061369A1 (en)
CL (1) CL2007001733A1 (en)
TW (1) TW200815443A (en)
UY (1) UY30407A1 (en)
WO (1) WO2007145568A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
CA2575340A1 (en) 2004-07-28 2006-02-09 Schering Corporation Macrocyclic beta-secretase inhibitors
JP2008543849A (en) 2005-06-14 2008-12-04 シェーリング コーポレイション Aspartyl protease inhibitor
BRPI0612545A2 (en) 2005-06-14 2010-11-23 Schering Corp protease inhibiting compounds, pharmaceutical compositions and their use
TW200815349A (en) 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
WO2008063114A1 (en) * 2006-11-20 2008-05-29 Astrazeneca Ab Amino- imidazolones and their use as medicament for treating cognitive impairment alzheimer disease, neurodegeneration and dementia
MX2010011563A (en) 2008-04-22 2010-11-12 Schering Corp Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use.
TW201020244A (en) 2008-11-14 2010-06-01 Astrazeneca Ab New compounds
EP2485920B1 (en) 2009-10-08 2016-04-27 Merck Sharp & Dohme Corp. Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
US8563543B2 (en) 2009-10-08 2013-10-22 Merck Sharp & Dohme Corp. Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
UA108363C2 (en) 2009-10-08 2015-04-27 IMINOTIADIASIADIOXIDE OXIDES AS BACE INHIBITORS, COMPOSITIONS THEREOF AND THEIR APPLICATIONS
US8557826B2 (en) 2009-10-08 2013-10-15 Merck Sharp & Dohme Corp. Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use
HUE026338T2 (en) * 2011-03-01 2016-05-30 Janssen Pharmaceutica Nv Beta-secretase (BACE) inhibitors 6,7-dihydro-pyrazolo [1,5-a] pyrazin-4-ylamine derivatives
US9221839B2 (en) 2011-04-07 2015-12-29 Merck Sharp & Dohme Corp. C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
US9145426B2 (en) 2011-04-07 2015-09-29 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
BR112014004181A2 (en) 2011-08-22 2017-06-13 Merck Sharp & Dohme compound, pharmaceutical composition, and method of treating, preventing, and / or delaying the onset of a disease or condition
CA2867891C (en) 2012-03-19 2021-09-14 Buck Institute For Research On Aging App specific bace inhibitors (asbis) and uses thereof
US9422277B2 (en) 2012-10-17 2016-08-23 Merck Sharp & Dohme Corp. Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use
WO2014062553A1 (en) 2012-10-17 2014-04-24 Merck Sharp & Dohme Corp. Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
JP6471100B2 (en) 2013-02-12 2019-02-13 バック・インスティテュート・フォー・リサーチ・オン・エイジング Hydantoins that regulate BACE-mediated APP processing
JP7419865B2 (en) * 2020-02-17 2024-01-23 東ソー株式会社 Aromatic halogen compounds, their uses, and manufacturing methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070026811A (en) * 2004-06-16 2007-03-08 와이어쓰 Diphenylimidazopyrimidine and diphenylimidazole amines as beta-secretase inhibitors
EP2264036A1 (en) * 2005-01-14 2010-12-22 Wyeth LLC (Formerly Known As Wyeth) Amino-imidazolones for the inhibition of beta-secretase

Also Published As

Publication number Publication date
EP2035423A1 (en) 2009-03-18
WO2007145568A9 (en) 2008-12-11
UY30407A1 (en) 2008-01-31
WO2007145568A1 (en) 2007-12-21
TW200815443A (en) 2008-04-01
JP2009539973A (en) 2009-11-19
AR061369A1 (en) 2008-08-20

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