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CL2007000396A1 - Compuestos derivados de benzoil-piperidina, moduladores del receptor 5ht2/d3; composicion farmaceutica que los comprende;y su uso en el tratamiento y/o prevencion de patologias delsnc, tales como psicosis, esquizofrenia, depresion, ansiedad,adiccion a drogas y problemas cognitivos. - Google Patents

Compuestos derivados de benzoil-piperidina, moduladores del receptor 5ht2/d3; composicion farmaceutica que los comprende;y su uso en el tratamiento y/o prevencion de patologias delsnc, tales como psicosis, esquizofrenia, depresion, ansiedad,adiccion a drogas y problemas cognitivos.

Info

Publication number
CL2007000396A1
CL2007000396A1 CL2007000396A CL2007000396A CL2007000396A1 CL 2007000396 A1 CL2007000396 A1 CL 2007000396A1 CL 2007000396 A CL2007000396 A CL 2007000396A CL 2007000396 A CL2007000396 A CL 2007000396A CL 2007000396 A1 CL2007000396 A1 CL 2007000396A1
Authority
CL
Chile
Prior art keywords
schizophrenia
anxiety
depression
prevention
treatment
Prior art date
Application number
CL2007000396A
Other languages
English (en)
Inventor
Jaeschke Georg
Maria Rodriguez Sarmiento Rosa
Luebbers Thomas
Steward Lucinda
Roche Olivier
Gobbi Tuca
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38091740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007000396(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2007000396A1 publication Critical patent/CL2007000396A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compuestos derivados de piperidina sustituida, moduladores de los receptores 5-ht2a y d3; composición farmacéutica; y uso en el tratamiento y/o prevención de trastornos cognitivos, adicción a drogas, ansiedad, depresión, esquizofrenia, entre otros.
CL2007000396A 2006-02-17 2007-02-14 Compuestos derivados de benzoil-piperidina, moduladores del receptor 5ht2/d3; composicion farmaceutica que los comprende;y su uso en el tratamiento y/o prevencion de patologias delsnc, tales como psicosis, esquizofrenia, depresion, ansiedad,adiccion a drogas y problemas cognitivos. CL2007000396A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06110112 2006-02-17
EP06112464 2006-04-11

Publications (1)

Publication Number Publication Date
CL2007000396A1 true CL2007000396A1 (es) 2008-01-04

Family

ID=38091740

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2007000396A CL2007000396A1 (es) 2006-02-17 2007-02-14 Compuestos derivados de benzoil-piperidina, moduladores del receptor 5ht2/d3; composicion farmaceutica que los comprende;y su uso en el tratamiento y/o prevencion de patologias delsnc, tales como psicosis, esquizofrenia, depresion, ansiedad,adiccion a drogas y problemas cognitivos.

Country Status (15)

Country Link
US (2) US8039490B2 (es)
EP (1) EP1987019B1 (es)
JP (1) JP4855485B2 (es)
KR (1) KR101062513B1 (es)
AR (1) AR059513A1 (es)
AU (1) AU2007216563B2 (es)
BR (1) BRPI0707960A2 (es)
CA (1) CA2640807A1 (es)
CL (1) CL2007000396A1 (es)
ES (1) ES2399447T3 (es)
IL (1) IL193176A (es)
NO (1) NO20083584L (es)
RU (1) RU2396265C2 (es)
TW (1) TWI329107B (es)
WO (1) WO2007093540A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101169518B1 (ko) * 2007-07-26 2012-07-27 에프. 호프만-라 로슈 아게 5-ｈｔ2ａ 및 ｄ3 수용체의 이중 조절제
KR101171467B1 (ko) * 2007-08-09 2012-08-07 에프. 호프만-라 로슈 아게 5-ｈｔ2ａ 및 ｄ3 수용체의 이중 조절제로서 벤조일-피페리딘 유도체
AU2009294695B2 (en) 2008-09-22 2012-09-13 F. Hoffmann-La Roche Ag Piperazine D3 and 5-HT2a receptor modulators
US8586579B2 (en) 2010-06-21 2013-11-19 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8470828B2 (en) 2010-07-06 2013-06-25 Hoffmann-La Roche Inc. Anellated pyridine compounds
SG190819A1 (en) * 2010-11-15 2013-07-31 Abbvie Inc Nampt and rock inhibitors
US8877778B2 (en) * 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8722683B2 (en) 2011-02-17 2014-05-13 Hoffmann La-Roche Inc. Benzodioxole piperazine compounds
US8598357B2 (en) 2011-03-03 2013-12-03 Hoffmann-La Roche Inc. Benzodioxole piperidine compounds
US8921397B2 (en) * 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
AU2016258192B2 (en) 2015-05-06 2021-07-29 Leidos Biomedical Research, Inc. K-Ras modulators
AU2018255413A1 (en) 2017-04-20 2019-12-05 Leidos Biomedical Research, Inc. K-Ras modulators
JP6948830B2 (ja) * 2017-05-17 2021-10-13 花王株式会社 乳化化粧料
FI3651766T3 (fi) 2017-07-10 2024-11-18 Celgene Corp 4-(4-(4-(((2-(2,6-dioksopiperidin-3-yyli)-l-oksoisoindolin-4-yyli)oksi)metyyli)bentsyyli)piperatsin-1-yyli)-3-fluoribentsonitriili antiproliferatiivisena yhdisteenä
BR112022007238A2 (pt) * 2019-10-29 2022-07-05 Shanghai Hansoh Biomedical Co Ltd Compostos modificadores derivados de anel de quatro membros, métodos para preparar os referidos compostos, composição e uso
KR20220119013A (ko) 2019-11-05 2022-08-26 상하이 한서 바이오메디컬 컴퍼니 리미티드 벤조티오펜 유도체 조절제, 그의 제조 방법 및 그의 용도
CN113277974B (zh) * 2020-02-20 2023-04-07 上海科技大学 2-苯基环丙基甲基胺衍生物及其制备方法和用途
CA3216904A1 (en) 2021-04-28 2022-11-03 Jinyao CHEN Salt containing piperazine polycyclic derivative, crystal form thereof, preparation method therefor, and use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1514718A (en) 1974-08-15 1978-06-21 Ferrosan Ab Diphenyl-butylpiperidines
US4024264A (en) 1974-08-15 1977-05-17 Ab Ferrosan Diphenylbutylpiperidines
JP2860689B2 (ja) 1990-03-14 1999-02-24 第一製薬株式会社 ピリミジン誘導体
US5229400A (en) * 1990-10-05 1993-07-20 Ajinomoto Co., Inc. Piperidine compounds and their use as antiarrhythmic agents
PL350904A1 (en) * 1999-03-26 2003-02-10 Astrazeneca Ab Novel compounds
GB0117577D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
HUP0103986A2 (hu) * 2001-09-28 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
SI1499607T1 (sl) * 2001-12-04 2006-06-30 Actelion Pharmaceuticals Ltd 4-(piperidil- in pirolidil-alkil-ureido)-kinolinikot antagonisti receptorja urotensina II
EP1348434A1 (en) * 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
TWI263497B (en) * 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
US6770659B2 (en) * 2002-08-26 2004-08-03 Sk Corporation Benzoyl piperidine compounds
US7186725B2 (en) * 2003-01-03 2007-03-06 Genzyme Corporation Anti-inflammatory compositions and methods
KR101169518B1 (ko) * 2007-07-26 2012-07-27 에프. 호프만-라 로슈 아게 5-ｈｔ2ａ 및 ｄ3 수용체의 이중 조절제
KR101171467B1 (ko) * 2007-08-09 2012-08-07 에프. 호프만-라 로슈 아게 5-ｈｔ2ａ 및 ｄ3 수용체의 이중 조절제로서 벤조일-피페리딘 유도체

Also Published As

Publication number Publication date
RU2396265C2 (ru) 2010-08-10
AU2007216563B2 (en) 2012-08-09
IL193176A (en) 2013-01-31
EP1987019B1 (en) 2012-11-28
NO20083584L (no) 2008-11-14
KR101062513B1 (ko) 2011-09-06
ES2399447T3 (es) 2013-04-01
CA2640807A1 (en) 2007-08-23
IL193176A0 (en) 2009-02-11
EP1987019A1 (en) 2008-11-05
US20070197531A1 (en) 2007-08-23
KR20080095899A (ko) 2008-10-29
US8039490B2 (en) 2011-10-18
RU2008133322A (ru) 2010-03-27
BRPI0707960A2 (pt) 2011-05-10
AR059513A1 (es) 2008-04-09
TW200808758A (en) 2008-02-16
TWI329107B (en) 2010-08-21
US20120004208A1 (en) 2012-01-05
WO2007093540A1 (en) 2007-08-23
AU2007216563A1 (en) 2007-08-23
JP4855485B2 (ja) 2012-01-18
JP2009526807A (ja) 2009-07-23
US8415350B2 (en) 2013-04-09

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