CH593912A5 - Pleuromutilin derivs. - prepd. by acylating derivs. contg. a (4)-hydroxyalkyl-(1)-piperazinyl gp. - Google Patents
Pleuromutilin derivs. - prepd. by acylating derivs. contg. a (4)-hydroxyalkyl-(1)-piperazinyl gp.Info
- Publication number
- CH593912A5 CH593912A5 CH842077A CH842077A CH593912A5 CH 593912 A5 CH593912 A5 CH 593912A5 CH 842077 A CH842077 A CH 842077A CH 842077 A CH842077 A CH 842077A CH 593912 A5 CH593912 A5 CH 593912A5
- Authority
- CH
- Switzerland
- Prior art keywords
- piperazinyl
- derivs
- formula
- hydroxyalkyl
- pleuromutilin
- Prior art date
Links
- ZRZNJUXESFHSIO-UHFFFAOYSA-N Pleuromutilin Natural products CC1C(O)C(C)(C=C)CC(OC(=O)CO)C2(C)C(C)CCC31C2C(=O)CC3 ZRZNJUXESFHSIO-UHFFFAOYSA-N 0.000 title abstract 3
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical compound C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 title abstract 3
- OBUUFWIMEGVAQS-UHFFFAOYSA-N Pleuromutenol Natural products CC1C(O)C(C)(C=C)CC(O)C2(C)C(C)CCC31C2C(=O)CC3 OBUUFWIMEGVAQS-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 abstract 2
- 229960002771 retapamulin Drugs 0.000 abstract 2
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005067 haloformyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 abstract 1
- STZYTFJPGGDRJD-NHUWBDDWSA-N retapamulin Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CS[C@@H]3C[C@H]4CC[C@H](N4C)C3)C)C[C@]32[C@H]1C(=O)CC3 STZYTFJPGGDRJD-NHUWBDDWSA-N 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Prepn. of new pleuromutilin derivs. of formula Q-O-CO-CH2-X-(CH2)n-NR2'R3' (I) comprises reacting a pleuromutilin deriv. of formula Q-O-CO-CH2-X-(CH2)n-NR2R3 (II) with an acylating agent of formula A-R5 (III) and opt. converting the prod. into an acid-addn. or quat. ammonium salt. In the formulae, Q is a gp. of formula (IV); R1 is ethyl or vinyl; n = 2-5; X is S, NR4 or Y-Ar-Z; R4 is H or QOCOCH2 Y and Z are both S or one is S and the other is O; Ar is phenylene; R2 and R3 form a 4-hydroxyalkyl-1-piperazinyl gp. or, when X = NR4 and n = 2, R2 and R4 form a piperazinyl gp. and R3 is lower hydroxyalkyl; R2' and R3' form a 4-acyloxyalkyl-1-piperazinyl gp. or, when X = NR4 and n = 2, R2' and R4 form a piperazinyl gp. and R3' is a lower (lower acyloxy) alkyl gp.; A is haloformyl or R5-CO-O-CO; R5 is lower alkyl. (I) have the same pharmacological properties as the cpds., described in the Parent Patent. A typical cpd. is 14-desoxy-14- 2- 4-(2-propionyloxyethyl)-1-piperazinyl -ethylthio- acetoxy mutilin. In an example, this is prepd. from 14-desoxy- 2- 4-(2-hydroxyethyl)-1-piperazinyl ethylthioacetoxy) mutilin and propionyl chloride.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1019772A CH593911A5 (en) | 1972-05-25 | 1972-07-07 | Pleuromutilin derivs. - prepd. by benzoylating derivs. contg. a (4)-hydroxyalkyl-(1)-piperazinyl gp. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH593912A5 true CH593912A5 (en) | 1977-12-30 |
Family
ID=4360474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH842077A CH593912A5 (en) | 1972-07-07 | 1977-07-07 | Pleuromutilin derivs. - prepd. by acylating derivs. contg. a (4)-hydroxyalkyl-(1)-piperazinyl gp. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH593912A5 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39128E1 (en) | 1997-10-29 | 2006-06-13 | Smithkline Beecham P.L.C. | Pleuromutilin derivatives as antimicrobials |
-
1977
- 1977-07-07 CH CH842077A patent/CH593912A5/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39128E1 (en) | 1997-10-29 | 2006-06-13 | Smithkline Beecham P.L.C. | Pleuromutilin derivatives as antimicrobials |
| USRE43390E1 (en) | 1997-10-29 | 2012-05-15 | Glaxosmithkline Llc | Pleuromutilin derivatives as antimicrobials |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |