CH535201A - Process for the resolution of racemic 2- (o-chlorophenyl) -2-methylaminocyclohexanone into the optically active isomers - Google Patents
Process for the resolution of racemic 2- (o-chlorophenyl) -2-methylaminocyclohexanone into the optically active isomersInfo
- Publication number
- CH535201A CH535201A CH1836870A CH1836870A CH535201A CH 535201 A CH535201 A CH 535201A CH 1836870 A CH1836870 A CH 1836870A CH 1836870 A CH1836870 A CH 1836870A CH 535201 A CH535201 A CH 535201A
- Authority
- CH
- Switzerland
- Prior art keywords
- methylaminocyclohexanone
- racemic
- chlorophenyl
- resolution
- optically active
- Prior art date
Links
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 title 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88679969A | 1969-12-19 | 1969-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH535201A true CH535201A (en) | 1973-03-31 |
Family
ID=25389797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1836870A CH535201A (en) | 1969-12-19 | 1970-12-11 | Process for the resolution of racemic 2- (o-chlorophenyl) -2-methylaminocyclohexanone into the optically active isomers |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4948542B1 (en) |
| BE (1) | BE760492A (en) |
| CH (1) | CH535201A (en) |
| DE (1) | DE2062620A1 (en) |
| ES (1) | ES386601A1 (en) |
| FR (1) | FR2081388B1 (en) |
| GB (1) | GB1330878A (en) |
| NL (1) | NL7018334A (en) |
| ZA (1) | ZA708468B (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5875614A (en) * | 1981-10-28 | 1983-05-07 | Matsushita Electric Ind Co Ltd | Incinerator exhaust gas purification device |
| DE4312016A1 (en) * | 1993-04-13 | 1994-10-20 | Goedecke Ag | Stable ketamine solutions |
| DE19619665C2 (en) * | 1996-05-15 | 2001-03-08 | Goedecke Ag | Racemate separation of ketamine |
| BRPI0002693B8 (en) * | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | process for obtaining the enantiomers of ketamine and its pharmaceutically acceptable salts |
| US7273889B2 (en) * | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| EP2792347A1 (en) | 2005-09-28 | 2014-10-22 | Auris Medical AG | Pharmaceutical compositions for the treatment of inner ear disorders |
| US20150044200A1 (en) | 2011-12-12 | 2015-02-12 | Otolanum Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
| SG10201802104QA (en) | 2013-03-15 | 2018-05-30 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| CA3143962A1 (en) | 2013-09-13 | 2015-03-19 | National University Corporation Chiba University | Application of r-ketamine and salt thereof as pharmaceuticals |
| EP3179993B1 (en) | 2014-08-13 | 2021-01-20 | Janssen Pharmaceutica NV | Esketamine for use in a method for the treatment of depression |
| US20160074340A1 (en) | 2014-09-15 | 2016-03-17 | Janssen Pharmaceutica Nv | VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| US11707440B2 (en) | 2017-12-22 | 2023-07-25 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| BR112020016500A2 (en) | 2018-02-15 | 2020-12-15 | National University Corporation Chiba University | PREVENTIVE OR THERAPEUTIC AGENT AND PHARMACEUTICAL COMPOSITION FOR INFLAMMATORY DISEASE OR BONE DISEASE |
| CN110218157B (en) * | 2018-03-01 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | Preparation method of R-ketamine and its medicinal salt |
| EP3813808A4 (en) | 2018-05-04 | 2022-01-26 | Perception Neuroscience, Inc. | DRUG TREATMENT METHODS |
| BR112020023882A2 (en) | 2018-06-27 | 2021-02-09 | Clexio Biosciences Ltd. | method to treat major depressive disorder |
| WO2020070706A1 (en) | 2018-10-05 | 2020-04-09 | Clexio Biosciences Ltd. | Dosage regime of esketamine for treating major depressive disorder |
| EP3860579A1 (en) | 2018-10-05 | 2021-08-11 | Clexio Biosciences Ltd. | Dosage regime of esketamine for treating major depressive disorder |
| WO2020070547A1 (en) | 2018-10-05 | 2020-04-09 | Clexio Biosciences Ltd. | Dosage regime of esketamine for treating major depressive disorder |
| EP3863617A1 (en) | 2018-10-11 | 2021-08-18 | Clexio Biosciences Ltd. | Esketamine for use in treating major depressive disorder |
| BR112021017457A2 (en) | 2019-03-05 | 2021-11-16 | Janssen Pharmaceuticals Inc | Esketamine for the treatment of depression |
| WO2021137148A1 (en) | 2019-12-30 | 2021-07-08 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating neuropsychiatric or neurological conditions |
| US12268658B2 (en) | 2019-12-30 | 2025-04-08 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating major depressive disorder |
| US12478592B2 (en) | 2019-12-30 | 2025-11-25 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating neuropsychiatric or neurological conditions |
| MX2022009050A (en) | 2020-01-22 | 2022-10-27 | Seelos Therapeutics Inc | REDUCTION OF THE SIDE EFFECTS OF NMDA ANTAGONISTS. |
| CN112125816A (en) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | A kind of racemization method of ketamine, its derivative or its salt |
| US20250082587A1 (en) | 2023-09-12 | 2025-03-13 | Clexio Biosciences Ltd. | Method Of Treating Major Depressive Disorder |
-
1970
- 1970-12-11 CH CH1836870A patent/CH535201A/en not_active IP Right Cessation
- 1970-12-15 ZA ZA708468A patent/ZA708468B/en unknown
- 1970-12-16 NL NL7018334A patent/NL7018334A/xx unknown
- 1970-12-17 BE BE760492A patent/BE760492A/en unknown
- 1970-12-18 ES ES386601A patent/ES386601A1/en not_active Expired
- 1970-12-18 DE DE19702062620 patent/DE2062620A1/en active Pending
- 1970-12-18 FR FR7045893A patent/FR2081388B1/fr not_active Expired
- 1970-12-18 GB GB6017370A patent/GB1330878A/en not_active Expired
- 1970-12-19 JP JP11363170A patent/JPS4948542B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES386601A1 (en) | 1974-01-16 |
| DE2062620A1 (en) | 1971-07-15 |
| GB1330878A (en) | 1973-09-19 |
| BE760492A (en) | 1971-06-17 |
| JPS4948542B1 (en) | 1974-12-21 |
| ZA708468B (en) | 1972-02-23 |
| NL7018334A (en) | 1971-06-22 |
| FR2081388B1 (en) | 1974-06-21 |
| FR2081388A1 (en) | 1971-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |