[go: up one dir, main page]

CH527181A - Procédé de préparation de composés à activité pharmaceutique - Google Patents

Procédé de préparation de composés à activité pharmaceutique

Info

Publication number
CH527181A
CH527181A CH1619769A CH1619769A CH527181A CH 527181 A CH527181 A CH 527181A CH 1619769 A CH1619769 A CH 1619769A CH 1619769 A CH1619769 A CH 1619769A CH 527181 A CH527181 A CH 527181A
Authority
CH
Switzerland
Prior art keywords
preparing compounds
pharmaceutical activity
pharmaceutical
activity
preparing
Prior art date
Application number
CH1619769A
Other languages
English (en)
Inventor
Cairns Hugh
Bennett Johnson Peter
Original Assignee
Fisons Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Pharmaceuticals Ltd filed Critical Fisons Pharmaceuticals Ltd
Priority to CH364271A priority Critical patent/CH534677A/fr
Publication of CH527181A publication Critical patent/CH527181A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH1619769A 1968-10-30 1969-10-30 Procédé de préparation de composés à activité pharmaceutique CH527181A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH364271A CH534677A (fr) 1968-10-30 1969-10-30 Procédé de préparation d'acides bis-chromone-carboxyliques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51421/68A GB1292601A (en) 1968-10-30 1968-10-30 Bis-(2-carboxy-chromone) compounds, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
CH527181A true CH527181A (fr) 1972-08-31

Family

ID=10459955

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1619769A CH527181A (fr) 1968-10-30 1969-10-30 Procédé de préparation de composés à activité pharmaceutique
CH364371A CH560210A5 (fr) 1968-10-30 1969-10-30

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH364371A CH560210A5 (fr) 1968-10-30 1969-10-30

Country Status (17)

Country Link
US (1) US3673218A (fr)
AT (3) AT301544B (fr)
BE (1) BE740548A (fr)
BR (1) BR6913699D0 (fr)
CA (1) CA948202A (fr)
CH (2) CH527181A (fr)
DE (1) DE1954266A1 (fr)
DK (1) DK128005B (fr)
ES (2) ES372916A1 (fr)
FR (1) FR2021874B1 (fr)
GB (1) GB1292601A (fr)
IL (1) IL33189A (fr)
IT (1) IT1035510B (fr)
LU (1) LU59707A1 (fr)
NL (1) NL6916387A (fr)
OA (1) OA03859A (fr)
SE (1) SE367403B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
GB1410588A (en) * 1971-08-10 1975-10-22 Fisons Ltd Composition
SU469247A3 (ru) * 1972-01-14 1975-04-30 Майлз Лабораториз Инк (Фирма) Способ получени производных хромона
US3953604A (en) * 1972-01-14 1976-04-27 Miles Laboratories, Inc. 1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
US4239748A (en) * 1977-11-30 1980-12-16 Fisons Limited Inorganic salts of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran useful for the treatment of asthma and hay fever
ZA786650B (en) * 1977-11-30 1980-07-30 Fisons Ltd Insoluble salts of benzodipyrans
US4447449A (en) * 1981-11-16 1984-05-08 The Upjohn Company Methods of treating ischemic states
US4584315A (en) * 1981-11-16 1986-04-22 The Upjohn Company Method of treating ischemic states
JP2868183B2 (ja) * 1988-02-29 1999-03-10 株式式社三和化学研究所 光学活性を有する４−オキソ−１−ベンゾピラン−２−カルボン酸誘導体の製法、その合成用中間体並びに該中間体の製法
EP0909258A1 (fr) * 1996-06-21 1999-04-21 Syntroleum Corporation Systeme et methode de production de gaz de synthese
MY118075A (en) 1996-07-09 2004-08-30 Syntroleum Corp Process for converting gas to liquids
US5950732A (en) * 1997-04-02 1999-09-14 Syntroleum Corporation System and method for hydrate recovery
AU9690298A (en) * 1997-10-10 1999-05-03 Syntroleum Corporation System and method for converting light hydrocarbons to heavier hydrocarbons withseparation of water into oxygen and hydrogen
US6794417B2 (en) 2002-06-19 2004-09-21 Syntroleum Corporation System and method for treatment of water and disposal of contaminants produced by converting lighter hydrocarbons into heavier hydrocarbon
US8754151B2 (en) 2010-12-21 2014-06-17 Basf Se Multistage polymer dispersions, processes for preparing them, and use thereof
WO2014030688A1 (fr) * 2012-08-24 2014-02-27 第一三共株式会社 Chromone à chaîne latérale linéaire
WO2014098597A1 (fr) * 2012-12-21 2014-06-26 Rijksuniversiteit Groningen Nouveaux dérivés de bis-chromone, leurs procédés de préparation et utilisations
JP6266940B2 (ja) * 2013-10-07 2018-01-24 マナック株式会社 アリーレンジオキシ−ビス（無水コハク酸）及びその製造方法
WO2019054386A1 (fr) * 2017-09-12 2019-03-21 学校法人工学院大学 Composé hétérocyclique ou sel de celui-ci, agoniste de gpr35 et composition pharmaceutique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1144905A (en) * 1965-03-25 1969-03-12 Fisons Pharmaceuticals Ltd Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof
FR1489749A (fr) * 1965-03-25 1967-07-28 Fisons Pharmaceuticals Ltd Procédé de préparation de composés bis-chromonylés et leurs dérivés
GB1190193A (en) * 1966-07-05 1970-04-29 Fisons Pharmaceuticals Ltd Bis-(2-Carboxy-Chromonyl-Oxy) Derivatives, their preparation, and Pharmaceutical Compositions thereof

Also Published As

Publication number Publication date
US3673218A (en) 1972-06-27
IT1035510B (it) 1979-10-20
IL33189A (en) 1974-01-14
NL6916387A (fr) 1970-05-04
GB1292601A (en) 1972-10-11
ES398029A1 (es) 1974-07-01
BR6913699D0 (pt) 1973-02-13
CH560210A5 (fr) 1975-03-27
DE1954266A1 (de) 1970-05-27
ES372916A1 (es) 1972-03-01
BE740548A (fr) 1970-04-20
CA948202A (en) 1974-05-28
DK128005B (da) 1974-02-18
LU59707A1 (fr) 1970-05-04
AT302299B (de) 1972-10-10
FR2021874A1 (fr) 1970-07-24
OA03859A (fr) 1971-12-24
SU365068A3 (fr) 1972-12-28
AT303037B (de) 1972-11-10
IL33189A0 (en) 1969-12-31
SE367403B (fr) 1974-05-27
FR2021874B1 (fr) 1974-08-09
AT301544B (de) 1972-09-11

Similar Documents

Publication Publication Date Title
CH527181A (fr) Procédé de préparation de composés à activité pharmaceutique
CH524593A (fr) Procédé de préparation de composés insecticides
CH486445A (fr) Procédé de préparation de composés bis-chromonylés
FR88358E (fr) Procédé de préparation de composés à groupements vinyloxysilane
CH493553A (fr) Procédé de préparation de composés thérapeutiquement actifs
OA01187A (fr) Procédé de préparation de nouveaux composés à activité antibiotique.
CH486475A (fr) Procédé de préparation d'un mitosan à activité antibiotique
FR1463651A (fr) Procédé de préparation de composés acylaminogènes
FR1503612A (fr) Procédé de préparation de composés azétidiniques
FR1506132A (fr) Procédé de préparation de composés à liaison alpha-beta-éthylénique
CH526533A (fr) Procédé de préparation de composés à activité antibiotique
FR1425950A (fr) Procédé de préparation de composés de 7-amino-3-phényl-coumarine
CH527813A (fr) Procédé de préparation de composés à activité antibiotique
CH491128A (fr) Procédé de préparation de nouvelles benzoxazines à activité pharmacologique
CH469784A (fr) Procédé de préparation de composés fluorindines
CH517056A (fr) Procédé de préparation de composés aromatiques substitués
CH500994A (fr) Procédé pour la préparation de composés à activité antihistamininique
CH514525A (fr) Procédé de préparation de nouveaux benzylphénols halogénés à activité bactériostatique
CH476720A (fr) Procédé de préparation de composés bis-chromonylés à activité pharmaceutique
CH513882A (fr) Procédé de préparation de composés ayant une activité anti-schistosomiase
CH473813A (fr) Procédé de préparation de composés à activité antibactérienne dérivés de la N-méthyl-pipérazine
FR1501631A (fr) Procédé de préparation de composés de caoutchouc-polysulfure
CH515865A (fr) Procédé de préparation de composés bis-cyclopentadiényliques
FR1413601A (fr) Procédé de préparation de composés organoétain
FR1491657A (fr) Procédé de préparation de composés uréthanne

Legal Events

Date Code Title Description
PL Patent ceased