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CH261812A - Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. - Google Patents

Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine.

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Publication number
CH261812A
CH261812A CH261812DA CH261812A CH 261812 A CH261812 A CH 261812A CH 261812D A CH261812D A CH 261812DA CH 261812 A CH261812 A CH 261812A
Authority
CH
Switzerland
Prior art keywords
triazine
amino
diamino
substituted
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH261812A publication Critical patent/CH261812A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines substituierten     2,4-Diamino-1,3,5.triazins.       Gegenstand vorliegenden Patentes bildet  ein Verfahren zur Herstellung eines neuen,  substituierten     2,4-Diamino-1,3,5-triazins.    Das  Verfahren ist dadurch gekennzeichnet, dass       man    im     2-Amino-4-allylamino-6-halogen-1,3,5-          triazin    das Halogenatom mit reduzierenden       Mitteln,    wie z. B. Jodwasserstoff oder Zink  staub, durch Wasserstoff ersetzt.

   Die erhal  tene neue Base, das     2-Amino-4-allylamino-          1,3,5-triazin,    ist ein farbloses Kristallpulver,  das bei 152,50 schmilzt und in Wasser von 370  zu ungefähr 1,5     %    mit neutraler Reaktion lös  lich ist. Sie soll als Heilmittel oder Zwischen  produkt für Heilmittel verwendet werden.  <I>Beispiel:</I>  9,2 Teile 2 -     Amino    -     4-allylamino    - 6 -     chlor-          1,3,5-triazin    werden mit 36 Teilen     Jodwasser-          atoffsäure    (d = 1,96) und 7 Teilen     Phos-          phoniumjodid    5 Stunden bei Zimmertempera  tur gerührt.

   Die Lösung wird hierauf in Was  ser gegossen und das gebildete     2-Amino-4-          allylamino-1,3,5-triazin    durch     Laugenzusatz     gefällt. Es wird durch Kristallisation aus  Wasser gereinigt, wobei man das 2-Amino-4-         allylamino-1,3,5-triazin    als farbloses Kristall  pulver vom Schmelzpunkt 152,50 erhält.  



  Als Reduktionsmittel kann ferner Zink  staub verwendet werden.



  Process for the preparation of a substituted 2,4-diamino-1,3,5.triazine. The present patent forms a process for the preparation of a new, substituted 2,4-diamino-1,3,5-triazine. The process is characterized in that in the 2-amino-4-allylamino-6-halogen-1,3,5-triazine the halogen atom with reducing agents, such as. B. hydrogen iodide or zinc dust, replaced by hydrogen.

   The new base obtained, the 2-amino-4-allylamino-1,3,5-triazine, is a colorless crystal powder that melts at 152.50 and about 1.5% soluble in water of 370 to about 1.5% with a neutral reaction is. It is intended to be used as a remedy or an intermediate product for remedies. <I> Example: </I> 9.2 parts of 2-amino-4-allylamino-6-chloro-1,3,5-triazine are mixed with 36 parts of hydriodic acid (d = 1.96) and 7 parts of phos - Phonium iodide stirred for 5 hours at room temperature.

   The solution is then poured into what water and the 2-amino-4-allylamino-1,3,5-triazine formed is precipitated by the addition of alkali. It is purified by crystallization from water, the 2-amino-4-allylamino-1,3,5-triazine being obtained as a colorless crystal powder with a melting point of 152.50.



  Zinc dust can also be used as a reducing agent.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines neuen, sub stituierten 2,4-Diamino-1,3,5-triazins, dadurch gekennzeichnet, dass man im 2-Amino-4-allyl- amino-6-halogen-1,3,5-triazin das Halogenatom mit reduzierenden Mitteln durch Wasserstoff ersetzt. Die erhaltene neue Base, das 2-Amino- 4-allylamino-1,3,5-triazin, ist ein farbloses Kristallpulver, das bei 152,50 schmilzt und in Wasser von 370 zu ungefähr 1,5 Jo mit neu traler Reaktion löslich ist. LNTERANSPRtCHE: 1. PATENT CLAIM: Process for the preparation of a new, substituted 2,4-diamino-1,3,5-triazine, characterized in that in the 2-amino-4-allyl-amino-6-halogen-1,3,5- triazine replaced the halogen atom with reducing agents by hydrogen. The new base obtained, the 2-amino-4-allylamino-1,3,5-triazine, is a colorless crystal powder which melts at 152.50 and is soluble in water of 370 to about 1.5 Jo with neutral reaction . SUBClaims: 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man als Reduk tionsmittel Jodwasserstoff verwendet. 2. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man als reduzie rendes Mittel Zinkstaub verwendet. Method according to claim, characterized in that hydrogen iodide is used as the reducing agent. 2. The method according to claim, characterized in that zinc dust is used as the reducing agent.
CH261812D 1946-08-16 1946-08-16 Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. CH261812A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH252530T 1946-08-16
CH261812T 1946-08-16

Publications (1)

Publication Number Publication Date
CH261812A true CH261812A (en) 1949-05-31

Family

ID=25729616

Family Applications (1)

Application Number Title Priority Date Filing Date
CH261812D CH261812A (en) 1946-08-16 1946-08-16 Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine.

Country Status (1)

Country Link
CH (1) CH261812A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658894A (en) * 1953-11-10 Formoguanamemes and their
WO2001025220A1 (en) * 1999-10-07 2001-04-12 Amgen Inc. Triazine kinase inhibitors
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
US6881737B2 (en) 2001-04-11 2005-04-19 Amgen Inc. Substituted triazinyl acrylamide derivatives and methods of use

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658894A (en) * 1953-11-10 Formoguanamemes and their
WO2001025220A1 (en) * 1999-10-07 2001-04-12 Amgen Inc. Triazine kinase inhibitors
AU770600B2 (en) * 1999-10-07 2004-02-26 Amgen, Inc. Triazine kinase inhibitors
US7074789B2 (en) 1999-10-07 2006-07-11 Amgen Inc. Kinase inhibitors
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
US6881737B2 (en) 2001-04-11 2005-04-19 Amgen Inc. Substituted triazinyl acrylamide derivatives and methods of use

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