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CA3038427C - Lieurs auto-immolables non lineaires et conjugues de ceux-ci - Google Patents

Lieurs auto-immolables non lineaires et conjugues de ceux-ci

Info

Publication number
CA3038427C
CA3038427C CA3038427A CA3038427A CA3038427C CA 3038427 C CA3038427 C CA 3038427C CA 3038427 A CA3038427 A CA 3038427A CA 3038427 A CA3038427 A CA 3038427A CA 3038427 C CA3038427 C CA 3038427C
Authority
CA
Canada
Prior art keywords
antibody
mmol
compound
linker
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3038427A
Other languages
English (en)
Other versions
CA3038427A1 (fr
Inventor
Ronald Christiaan Elgersma
Tijl Huijbregts
Rudy Gerardus Elisabeth Coumans
Original Assignee
Byondis BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byondis BV filed Critical Byondis BV
Priority claimed from PCT/EP2017/075896 external-priority patent/WO2018069375A1/fr
Publication of CA3038427A1 publication Critical patent/CA3038427A1/fr
Application granted granted Critical
Publication of CA3038427C publication Critical patent/CA3038427C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne des composés lieur-médicament (LD) et des conjugués anticorps-médicament (ADC) comprenant un lieur auto-immolable non linéaire, qui est clivable ou transformable dans des conditions appropriées et qui réduit l’hydrophobicité du conjugué anticorps-médicament (5). La présente invention concerne des composés lieur-médicament de la formule I, ou un sel de qualité pharmaceutique, un solvate ou un hydrate de celui-ci (voir la formule I).
CA3038427A 2016-10-11 2017-10-11 Lieurs auto-immolables non lineaires et conjugues de ceux-ci Active CA3038427C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16193337 2016-10-11
EP16193337.9 2016-10-11
PCT/EP2017/075896 WO2018069375A1 (fr) 2016-10-11 2017-10-11 Lieurs auto-immolables non linéaires et conjugués de ceux-ci

Publications (2)

Publication Number Publication Date
CA3038427A1 CA3038427A1 (fr) 2018-04-19
CA3038427C true CA3038427C (fr) 2026-01-13

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