CA2969545C - Method for reducing the phytotoxicity of tebuconazole or prothioconazole using mancozeb - Google Patents
Method for reducing the phytotoxicity of tebuconazole or prothioconazole using mancozeb Download PDFInfo
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- CA2969545C CA2969545C CA2969545A CA2969545A CA2969545C CA 2969545 C CA2969545 C CA 2969545C CA 2969545 A CA2969545 A CA 2969545A CA 2969545 A CA2969545 A CA 2969545A CA 2969545 C CA2969545 C CA 2969545C
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- tebuconazole
- prothioconazole
- mancozeb
- phytotoxicity
- soybean
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- 238000000034 method Methods 0.000 title claims abstract description 24
- 231100000674 Phytotoxicity Toxicity 0.000 title claims abstract description 22
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 239000005839 Tebuconazole Substances 0.000 title claims abstract description 19
- MNHVNIJQQRJYDH-UHFFFAOYSA-N 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione Chemical compound N1=CNC(=S)N1CC(C1(Cl)CC1)(O)CC1=CC=CC=C1Cl MNHVNIJQQRJYDH-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 239000005825 Prothioconazole Substances 0.000 title claims abstract description 16
- 239000005802 Mancozeb Substances 0.000 title claims abstract description 15
- 239000000417 fungicide Substances 0.000 claims abstract description 42
- 244000068988 Glycine max Species 0.000 claims abstract description 26
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 26
- 230000000855 fungicidal effect Effects 0.000 claims abstract description 20
- 239000007921 spray Substances 0.000 claims abstract description 8
- 229930182692 Strobilurin Natural products 0.000 claims abstract description 7
- 239000006188 syrup Substances 0.000 claims abstract description 6
- 235000020357 syrup Nutrition 0.000 claims abstract description 6
- 230000007423 decrease Effects 0.000 claims abstract 2
- 150000003852 triazoles Chemical class 0.000 description 22
- 239000000203 mixture Substances 0.000 description 9
- 230000009885 systemic effect Effects 0.000 description 9
- 241000196324 Embryophyta Species 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 241000233866 Fungi Species 0.000 description 5
- 229930182558 Sterol Natural products 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 150000003432 sterols Chemical class 0.000 description 5
- 235000003702 sterols Nutrition 0.000 description 5
- 238000009472 formulation Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- -1 ergosterol Chemical class 0.000 description 3
- 230000035784 germination Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- 241000682645 Phakopsora pachyrhizi Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000000243 photosynthetic effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- YAUCKEPYKXHCFF-UHFFFAOYSA-N 2-carbamothioylsulfanylethyl carbamodithioate;manganese Chemical compound [Mn].NC(=S)SCCSC(N)=S YAUCKEPYKXHCFF-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000862632 Soja Species 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001716 anti-fugal effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008238 biochemical pathway Effects 0.000 description 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 1
- 239000012677 causal agent Substances 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000012990 dithiocarbamate Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- AWYFNIZYMPNGAI-UHFFFAOYSA-N ethylenebis(dithiocarbamic acid) Chemical compound SC(=S)NCCNC(S)=S AWYFNIZYMPNGAI-UHFFFAOYSA-N 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
- A01N47/14—Di-thio analogues thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a method of reducing phytotoxicity of a fungicidal combination consisting of tebuconazole or prothioconazole and a strobilurin fungicide in soybean cultivars, the method comprising:
(i) adding to a spray tank 1.0 kg/ha to 5.0 kg/ha of mancozeb and premixed tebuconazole or prothioconazole and strobilurin fungicide;
(ii) triggering the spray tank agitator to produce a homogenized syrup; and (iii) applying the homogenized syrup to top leaves of a soybean crop, wherein adding mancozeb to the fungicidal combination consisting of tebuconazole or prothioconazole and a strobilurin fungicide decreases the phytotoxicity of the tebuconazole or prothioconazole to the soybean crop in comparison to a method lacking adding mancozeb.
(i) adding to a spray tank 1.0 kg/ha to 5.0 kg/ha of mancozeb and premixed tebuconazole or prothioconazole and strobilurin fungicide;
(ii) triggering the spray tank agitator to produce a homogenized syrup; and (iii) applying the homogenized syrup to top leaves of a soybean crop, wherein adding mancozeb to the fungicidal combination consisting of tebuconazole or prothioconazole and a strobilurin fungicide decreases the phytotoxicity of the tebuconazole or prothioconazole to the soybean crop in comparison to a method lacking adding mancozeb.
Description
= a 1 METHOD FOR REDUCING THE PHYTOTOXICITY OF TEBUCONAZOLE OR
PROTHIOCONAZOLE USING MANCOZEB
Technical field of the invention.
The present invention relates to a method for reducing the phytotoxicity of systemic fungicides, especially triazoles in susceptible cultivars of soybeans, among others.
With this method it is unnecessary to innovate in diverse fungicide formulations and to add specific substances to alleviate the toxicity of systemic fungicides, especially triazoles.
Background of the Invention Fungicides are chemical compounds that kill or inhibit the growth of fungi and their spores. The use of fungicides to effectively control plant diseases have become essential to the farming system in recent decades, since the diseases in cultivars reduce in about 20% the world food production.
Due to its relatively low cost and effectiveness in the elimination of the diseases, fungicides have become the preferred means of control of plant diseases caused by fungi. However, it is known that its continued use and on a large scale leads to the emergence of new strains of fungi, which become resistant to the commercial products available. This can be exemplified by what is happening with the resistance of Phakopsora pachyrhizi (Pp), the causal agent of soybean rust, to the DMI
(demethylation inhibitors), Qol (quinone outside inhibitors) SDHI, and mixtures thereof.
Nevertheless, studies on the negative effects of fungicides to alter or inhibit the metabolic activity of healthy plants, as well as the effects of the application of some fungicides on photosynthesis, pigments content, growth and changes in the reproductive organs are still under explored. Some available data reported changes in CO2 assimilation and in the photosynthetic efficiency of the plant.
With respect to the soybean culture, it is known that the fungicides used on a large scale belong to two chemical groups, with site specific mechanism of action, which are: triazoles or DMIs; and strobilurins, or Qols. More recently a third chemical group started to being used, namely, the SDHI (succinate dehydrogenase enzyme inhibitors).
The combination of the DMIs with Qols has been used in more than 12 crops for the control of the FAS (Ferrugem-asiatica da soja or Asian soybean rust).
Additionally, reducing the sensitivity of Phakopsora pachyrhizi (Pp) to the DMI burdened the Qols antifungal action in the mixtures. From the 2012/13 crop it was observed that Pp had its sensitivity reduced to the mixtures of DMIs + Qols.
With respect to the triazoles (DMI), it is known that its action mechanism aims at inhibiting a specific enzyme, C14-demethylase, which plays a crucial role in sterol production. Sterols, such as ergosterol, are integral parts of the structure and function of
PROTHIOCONAZOLE USING MANCOZEB
Technical field of the invention.
The present invention relates to a method for reducing the phytotoxicity of systemic fungicides, especially triazoles in susceptible cultivars of soybeans, among others.
With this method it is unnecessary to innovate in diverse fungicide formulations and to add specific substances to alleviate the toxicity of systemic fungicides, especially triazoles.
Background of the Invention Fungicides are chemical compounds that kill or inhibit the growth of fungi and their spores. The use of fungicides to effectively control plant diseases have become essential to the farming system in recent decades, since the diseases in cultivars reduce in about 20% the world food production.
Due to its relatively low cost and effectiveness in the elimination of the diseases, fungicides have become the preferred means of control of plant diseases caused by fungi. However, it is known that its continued use and on a large scale leads to the emergence of new strains of fungi, which become resistant to the commercial products available. This can be exemplified by what is happening with the resistance of Phakopsora pachyrhizi (Pp), the causal agent of soybean rust, to the DMI
(demethylation inhibitors), Qol (quinone outside inhibitors) SDHI, and mixtures thereof.
Nevertheless, studies on the negative effects of fungicides to alter or inhibit the metabolic activity of healthy plants, as well as the effects of the application of some fungicides on photosynthesis, pigments content, growth and changes in the reproductive organs are still under explored. Some available data reported changes in CO2 assimilation and in the photosynthetic efficiency of the plant.
With respect to the soybean culture, it is known that the fungicides used on a large scale belong to two chemical groups, with site specific mechanism of action, which are: triazoles or DMIs; and strobilurins, or Qols. More recently a third chemical group started to being used, namely, the SDHI (succinate dehydrogenase enzyme inhibitors).
The combination of the DMIs with Qols has been used in more than 12 crops for the control of the FAS (Ferrugem-asiatica da soja or Asian soybean rust).
Additionally, reducing the sensitivity of Phakopsora pachyrhizi (Pp) to the DMI burdened the Qols antifungal action in the mixtures. From the 2012/13 crop it was observed that Pp had its sensitivity reduced to the mixtures of DMIs + Qols.
With respect to the triazoles (DMI), it is known that its action mechanism aims at inhibiting a specific enzyme, C14-demethylase, which plays a crucial role in sterol production. Sterols, such as ergosterol, are integral parts of the structure and function of
2 the membranes, becoming essential elements in its synthesis, and after the germination of the spores.
Although DMIs do not inhibit the germination of spores, they begin their antifungal action shortly after germination (elongation of germ tube), that is, the phase of the fungal life cycle that requires the formation of new membranes with consequent sterol production. The formation of such other structures that follow the elongation process of the germ tube, involves the infection structures like appressorium and penetration tube. All require the formation of new membranes and consequently the raw material for the sterols.
At the end, the antifugal activity results in the prevention of fungal tissue penetration of the hosts and the cessation of the infectious process. Therefore, triazoles cause abnormal growth of fungi and their eventual death, which is quite satisfactory.
It should be noted that each triazole compound (DMI) works slightly differently from the others, due to the use of different biochemical pathways in sterol synthesis. Although there are similarities between them, there are major differences in the spectrum of action of each.
It is known of reports of injuries in soybean cultivars associated with the application of DMIs, especially tebuconazole and prothioconazole. A known problem is the phytotoxicity of these fungicides such as, for example, tebuconazole, which usually occurs when spraying is done in a hot and dry environment and with the presence of surfactants added to the fungicide, which further increases the intensity of the injury.
In Brazil, little is known about the reaction of the Brazilian cultivars to triazoles.
What is known is that the application of mostly systemic fungicides especially triazoles with spray in soybean crops, results in bands of leaves with yellowing, light discoloration, death and detachment of the internervurais spaces of soybean leaflets. The soybean leaves also have symptoms which are mistaken with nutrient deficiency, secondary symptoms of disease and phytotoxicity of external chemical agents (such as, for example, triazoles fungicides).
This type of leaf symptoms receives the popular name in Brazil of carijo leaf.
It should be noted that the phytotoxicity occurs only at the top of the crop canopy, in the areas covered with the largest volume of product used in the spraying. The lower leaves have normal green color and the stem without evidence of injury.
Generally, the toxicity of systemic fungicides, especially triazoles, appears in crops under special conditions. For example, triazole fungicides can be used in soybean crops, with the proviso to avoid application to cultivars more sensitive to fungicides, or to avoid application at elevated temperatures above 35 C (or in the hottest time of the day) :3 and water stress (caused by drought). The most intense symptoms of phytotoxicity are observed in the areas of overlap of the fungicide spray bar and maneuver places to return.
The areas where the fungicide was not applied have superior leaves of normal green color, without the characteristic phytotoxicity. Under plant growth and normal environmental conditions there is no presence of phytotoxicity on the leaves.
This injury reduces the photosynthetic potential of the top of the canopy, which receives the largest amount of solar radiation. The production is a function of the duration of green healthy leaf area and the absorbed radiation.
The state of art to date has not solved the problems described here, so much that the nearest patent literature does not address the subject. As an example we can mention:
International application W02007/028388 entitled "Method of reducing phytotoxicity on plants susceptible to systemic fungicides Mainly triazoles"
which discloses that triazole fungicides can be applied to a cultivar susceptible to triazole fungicides, which is incorporated via a formulation that comprises certain solvents, which reduces or eliminates the phytotoxicity of the fungicide to said cultivar. As can be seen, this invention uses solvents in the formulation, which is a major problem for the producer when using the fungicide formulated in the soybean crop.
In order to solve the technique problem, the present invention describes a method aimed at reducing the phytotoxicity of systemic fungicides, especially triazoles in susceptible cultivars of soybeans, among others. The use of the method of the present invention allow the safe use of systemic fungicides, especially triazoles, in all cultures.
Summary of the Invention The present invention introduces in the Brazilian production system a method for reducing the phytotoxicity of systemic fungicides, especially triazoles, such as tebuconazole and prothioconazole in any crops.
Objects of the Invention It is the object of the present invention to reduce the phytotoxicity of systemic fungicides, especially triazoles, such as tebuconazole and prothioconazole, in cultures, more specifically in soybean cultivars.
Detailed Description of the Invention In order to solve one of the problems encountered in the state of art, the present invention developed a method for reducing the phytotoxicity of triazoles fungicides in soybean cultivars.
Although the triazoles, such as tebuconazole and prothioconazole, are fungicides commonly used in the control of fungal diseases on soybean crops, they are also causing more toxic effect on plants (phytotoxicity) even at normal doses used for the control of diseases. In the specific case of tebuconazole, both the EC and SC
formulations can cause serious injuries in plants; however, in soybean crops, which causes more injury is the EC.
The present invention solves the problem of tebuconazole with the mixture thereof with a multi site fungicide, especially a dithiocarbamate, specifically mancozeb, which has the purpose of increasing the tolerance to the triazoles fungicides.
Therefore, the present invention enables the safe use of triazoles fungicides, especially tebuconazole and prothioconazole, in all soybean cultivars. The process consists of:
add the spray tank, mancozeb (manganese ethylene bis(dithiocarbamate) + Zn) in an amount ranging from 1.0 kg/ha and 5.0 kg/ha, preferably 1.0 to 4.0 kg/ha, more preferably between 1.0 and 3.0 kg / ha, together with the fungicide (mixture of prefab "DMI + Qol" or "SDHI + DMI");
trigger the spray tank agitator; and once the syrup is homogenized, apply the syrup in the soybean crop.
The advantage of the method of the present invention is to use the multi site fungicide mancozeb, since so far there are not known cases of fungi resistant to it.
The mancozeb is shown therefore as broad-spectrum fungicide highly important for eliminating undesirable phytotoxicity on soybean caused by triazoles fungicides, more precisely by the tebuconazole and prothioconazole.
It should be noted that mancozeb has never before been used for this purpose.
Therefore, the present invention, despite being represented by an extremely simple method, it should be seen as innovative and very important for the soybean crop sustainability in Brazil and worldwide. This is because this method has never been used to fight phytotoxicity in crops (this includes the soybean culture).
It will be readily understood by those skilled in the art that modifications can be made herein without thereby departing from the concepts set forth in the above description.
These modifications are to be considered comprised by the scope of the present invention.
Although DMIs do not inhibit the germination of spores, they begin their antifungal action shortly after germination (elongation of germ tube), that is, the phase of the fungal life cycle that requires the formation of new membranes with consequent sterol production. The formation of such other structures that follow the elongation process of the germ tube, involves the infection structures like appressorium and penetration tube. All require the formation of new membranes and consequently the raw material for the sterols.
At the end, the antifugal activity results in the prevention of fungal tissue penetration of the hosts and the cessation of the infectious process. Therefore, triazoles cause abnormal growth of fungi and their eventual death, which is quite satisfactory.
It should be noted that each triazole compound (DMI) works slightly differently from the others, due to the use of different biochemical pathways in sterol synthesis. Although there are similarities between them, there are major differences in the spectrum of action of each.
It is known of reports of injuries in soybean cultivars associated with the application of DMIs, especially tebuconazole and prothioconazole. A known problem is the phytotoxicity of these fungicides such as, for example, tebuconazole, which usually occurs when spraying is done in a hot and dry environment and with the presence of surfactants added to the fungicide, which further increases the intensity of the injury.
In Brazil, little is known about the reaction of the Brazilian cultivars to triazoles.
What is known is that the application of mostly systemic fungicides especially triazoles with spray in soybean crops, results in bands of leaves with yellowing, light discoloration, death and detachment of the internervurais spaces of soybean leaflets. The soybean leaves also have symptoms which are mistaken with nutrient deficiency, secondary symptoms of disease and phytotoxicity of external chemical agents (such as, for example, triazoles fungicides).
This type of leaf symptoms receives the popular name in Brazil of carijo leaf.
It should be noted that the phytotoxicity occurs only at the top of the crop canopy, in the areas covered with the largest volume of product used in the spraying. The lower leaves have normal green color and the stem without evidence of injury.
Generally, the toxicity of systemic fungicides, especially triazoles, appears in crops under special conditions. For example, triazole fungicides can be used in soybean crops, with the proviso to avoid application to cultivars more sensitive to fungicides, or to avoid application at elevated temperatures above 35 C (or in the hottest time of the day) :3 and water stress (caused by drought). The most intense symptoms of phytotoxicity are observed in the areas of overlap of the fungicide spray bar and maneuver places to return.
The areas where the fungicide was not applied have superior leaves of normal green color, without the characteristic phytotoxicity. Under plant growth and normal environmental conditions there is no presence of phytotoxicity on the leaves.
This injury reduces the photosynthetic potential of the top of the canopy, which receives the largest amount of solar radiation. The production is a function of the duration of green healthy leaf area and the absorbed radiation.
The state of art to date has not solved the problems described here, so much that the nearest patent literature does not address the subject. As an example we can mention:
International application W02007/028388 entitled "Method of reducing phytotoxicity on plants susceptible to systemic fungicides Mainly triazoles"
which discloses that triazole fungicides can be applied to a cultivar susceptible to triazole fungicides, which is incorporated via a formulation that comprises certain solvents, which reduces or eliminates the phytotoxicity of the fungicide to said cultivar. As can be seen, this invention uses solvents in the formulation, which is a major problem for the producer when using the fungicide formulated in the soybean crop.
In order to solve the technique problem, the present invention describes a method aimed at reducing the phytotoxicity of systemic fungicides, especially triazoles in susceptible cultivars of soybeans, among others. The use of the method of the present invention allow the safe use of systemic fungicides, especially triazoles, in all cultures.
Summary of the Invention The present invention introduces in the Brazilian production system a method for reducing the phytotoxicity of systemic fungicides, especially triazoles, such as tebuconazole and prothioconazole in any crops.
Objects of the Invention It is the object of the present invention to reduce the phytotoxicity of systemic fungicides, especially triazoles, such as tebuconazole and prothioconazole, in cultures, more specifically in soybean cultivars.
Detailed Description of the Invention In order to solve one of the problems encountered in the state of art, the present invention developed a method for reducing the phytotoxicity of triazoles fungicides in soybean cultivars.
Although the triazoles, such as tebuconazole and prothioconazole, are fungicides commonly used in the control of fungal diseases on soybean crops, they are also causing more toxic effect on plants (phytotoxicity) even at normal doses used for the control of diseases. In the specific case of tebuconazole, both the EC and SC
formulations can cause serious injuries in plants; however, in soybean crops, which causes more injury is the EC.
The present invention solves the problem of tebuconazole with the mixture thereof with a multi site fungicide, especially a dithiocarbamate, specifically mancozeb, which has the purpose of increasing the tolerance to the triazoles fungicides.
Therefore, the present invention enables the safe use of triazoles fungicides, especially tebuconazole and prothioconazole, in all soybean cultivars. The process consists of:
add the spray tank, mancozeb (manganese ethylene bis(dithiocarbamate) + Zn) in an amount ranging from 1.0 kg/ha and 5.0 kg/ha, preferably 1.0 to 4.0 kg/ha, more preferably between 1.0 and 3.0 kg / ha, together with the fungicide (mixture of prefab "DMI + Qol" or "SDHI + DMI");
trigger the spray tank agitator; and once the syrup is homogenized, apply the syrup in the soybean crop.
The advantage of the method of the present invention is to use the multi site fungicide mancozeb, since so far there are not known cases of fungi resistant to it.
The mancozeb is shown therefore as broad-spectrum fungicide highly important for eliminating undesirable phytotoxicity on soybean caused by triazoles fungicides, more precisely by the tebuconazole and prothioconazole.
It should be noted that mancozeb has never before been used for this purpose.
Therefore, the present invention, despite being represented by an extremely simple method, it should be seen as innovative and very important for the soybean crop sustainability in Brazil and worldwide. This is because this method has never been used to fight phytotoxicity in crops (this includes the soybean culture).
It will be readily understood by those skilled in the art that modifications can be made herein without thereby departing from the concepts set forth in the above description.
These modifications are to be considered comprised by the scope of the present invention.
Claims (3)
We Claim:
1. A method of reducing phytotoxicity of a fungicidal combination consisting of tebuconazole or prothioconazole and a strobilurin fungicide in soybean cultivars, the method comprising:
(i) adding to a spray tank 1.0 kg/ha to 5.0 kg/ha of mancozeb and premixed tebuconazole or prothioconazole and strobilurin fungicide;
(ii) triggering the spray tank agitator to produce a homogenized syrup; and (iii) applying the homogenized syrup to top leaves of a soybean crop, wherein adding mancozeb to the fungicidal combination consisting of tebuconazole or prothioconazole and a strobilurin fungicide decreases the phytotoxicity of the tebuconazole or prothioconazole to the soybean crop in comparison to a method lacking adding mancozeb.
(i) adding to a spray tank 1.0 kg/ha to 5.0 kg/ha of mancozeb and premixed tebuconazole or prothioconazole and strobilurin fungicide;
(ii) triggering the spray tank agitator to produce a homogenized syrup; and (iii) applying the homogenized syrup to top leaves of a soybean crop, wherein adding mancozeb to the fungicidal combination consisting of tebuconazole or prothioconazole and a strobilurin fungicide decreases the phytotoxicity of the tebuconazole or prothioconazole to the soybean crop in comparison to a method lacking adding mancozeb.
2. The method according to claim 1, wherein the mancozeb is added in an amount of 1.0 to 4.0 kg/ha.
3. The method according to claim 1, wherein the mancozeb is added in an amount ranging from between 1.0 and 3.0 kg/ha.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRBR1020140312528 | 2014-12-12 | ||
| BR102014031252A BR102014031252A2 (en) | 2014-12-12 | 2014-12-12 | method for reducing phytotoxicity of fungicides |
| PCT/BR2015/050241 WO2016090446A1 (en) | 2014-12-12 | 2015-12-10 | Method for reducing phytotoxicity of fungicides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2969545A1 CA2969545A1 (en) | 2016-06-16 |
| CA2969545C true CA2969545C (en) | 2022-02-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2969545A Active CA2969545C (en) | 2014-12-12 | 2015-12-10 | Method for reducing the phytotoxicity of tebuconazole or prothioconazole using mancozeb |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10537101B2 (en) |
| AP (1) | AP2016009392A0 (en) |
| AR (1) | AR102959A1 (en) |
| BR (1) | BR102014031252A2 (en) |
| CA (1) | CA2969545C (en) |
| LU (1) | LU93173B1 (en) |
| WO (1) | WO2016090446A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3534711A4 (en) | 2016-11-04 | 2020-11-18 | UPL Ltd | FUNGICIDAL COMBINATIONS |
| EP4555862A3 (en) | 2017-03-07 | 2025-10-15 | UPL Ltd | Fungicidal combinations |
| US11272706B2 (en) * | 2017-06-12 | 2022-03-15 | Upl Limited | Anti-resistance method |
| US20190116793A1 (en) * | 2017-10-25 | 2019-04-25 | Pbi-Gordon Corporation | Fungicidal formulation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394966A (en) * | 1978-05-09 | 1983-07-26 | Snyder Industries, Inc. | Spraying apparatus having a fluid storage tank with agitator and anti-vortex tank fittings |
| MA19798A1 (en) | 1982-06-08 | 1983-12-31 | Novartis Ag | PLANT DISEASE CONTROL AGENT; ITS PREPARATION AND ITS APPLICATION TO THE PROTECTION OF PLANTS. |
| EA200801774A1 (en) * | 2006-02-14 | 2009-02-27 | Басф Се | METHOD OF APPLICATION OF MICRONUTRIENT AS SAFENER FOR TRIAZOLE FOR THE FIGHT AGAINST HARMFUL MUSHRIA |
| BR112012015154B1 (en) * | 2009-12-21 | 2017-05-09 | Bayer Cropscience Ag | combination of active compounds, mixture, formulation or agrochemical composition, use of the mixture and method of using protioconazole and metominostrobin to control plant and plant fungal and / or plant pathogenic microorganisms |
| EP2612554A1 (en) * | 2012-01-09 | 2013-07-10 | Bayer CropScience AG | Fungicide compositions comprising fluopyram, at least one succinate dehydrogenase (SDH) inhibitor and optionally at least one triazole fungicide |
| CN114557361A (en) | 2013-11-26 | 2022-05-31 | Upl 有限公司 | Method for controlling rust |
-
2014
- 2014-12-12 BR BR102014031252A patent/BR102014031252A2/en not_active Application Discontinuation
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2015
- 2015-12-10 LU LU93173A patent/LU93173B1/en active
- 2015-12-10 AR ARP150104020A patent/AR102959A1/en active IP Right Grant
- 2015-12-10 AP AP2016009392A patent/AP2016009392A0/en unknown
- 2015-12-10 US US15/535,290 patent/US10537101B2/en active Active
- 2015-12-10 CA CA2969545A patent/CA2969545C/en active Active
- 2015-12-10 WO PCT/BR2015/050241 patent/WO2016090446A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| BR102014031252A2 (en) | 2016-06-14 |
| US10537101B2 (en) | 2020-01-21 |
| US20170367337A1 (en) | 2017-12-28 |
| CA2969545A1 (en) | 2016-06-16 |
| LU93173B1 (en) | 2016-12-11 |
| AR102959A1 (en) | 2017-04-05 |
| AP2016009392A0 (en) | 2016-08-31 |
| WO2016090446A1 (en) | 2016-06-16 |
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