CA2942568A1 - Formulations de progesterone - Google Patents
Formulations de progesterone Download PDFInfo
- Publication number
- CA2942568A1 CA2942568A1 CA2942568A CA2942568A CA2942568A1 CA 2942568 A1 CA2942568 A1 CA 2942568A1 CA 2942568 A CA2942568 A CA 2942568A CA 2942568 A CA2942568 A CA 2942568A CA 2942568 A1 CA2942568 A1 CA 2942568A1
- Authority
- CA
- Canada
- Prior art keywords
- progesterone
- pharmaceutical composition
- capsule
- solubilized
- gelucire
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title claims abstract description 620
- 229960003387 progesterone Drugs 0.000 title claims abstract description 296
- 239000000186 progesterone Substances 0.000 title claims abstract description 296
- 239000000203 mixture Substances 0.000 title claims abstract description 162
- 238000009472 formulation Methods 0.000 title abstract description 97
- 238000000034 method Methods 0.000 claims abstract description 48
- 239000008194 pharmaceutical composition Substances 0.000 claims description 117
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- 125000005456 glyceride group Chemical group 0.000 claims description 31
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 29
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 19
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- 239000000047 product Substances 0.000 description 49
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- 230000002062 proliferating effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940026235 propylene glycol monolaurate Drugs 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229940100459 steareth-20 Drugs 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- YOEWQQVKRJEPAE-UHFFFAOYSA-L succinylcholine chloride (anhydrous) Chemical compound [Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C YOEWQQVKRJEPAE-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000000979 synthetic dye Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 208000022934 urinary frequency Diseases 0.000 description 1
- 230000036318 urination frequency Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
L'invention concerne des formulations de progestérone, des méthodes pour utiliser ces formulations et leur paramètres pharmacocinétiques associés, dans des modes de réalisation particuliers. Les formulations selon l'invention permettent de réduire la quantité de progestérone administrée à un patient en ayant besoin tout en procurant les avantages d'une plus grande dose.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461972068P | 2014-03-28 | 2014-03-28 | |
| US61/972,068 | 2014-03-28 | ||
| PCT/US2015/023041 WO2015148952A1 (fr) | 2014-03-28 | 2015-03-27 | Formulations de progestérone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2942568A1 true CA2942568A1 (fr) | 2015-10-01 |
Family
ID=54196452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2942568A Abandoned CA2942568A1 (fr) | 2014-03-28 | 2015-03-27 | Formulations de progesterone |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3122364A4 (fr) |
| JP (2) | JP2017509630A (fr) |
| KR (1) | KR20160137597A (fr) |
| AR (1) | AR099872A1 (fr) |
| AU (1) | AU2015237243A1 (fr) |
| CA (1) | CA2942568A1 (fr) |
| IL (1) | IL247828A0 (fr) |
| MX (1) | MX2016011706A (fr) |
| RU (1) | RU2016136666A (fr) |
| WO (1) | WO2015148952A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020081726A1 (fr) * | 2018-10-17 | 2020-04-23 | Stadler Sarah Sheehan | Procédés de traitement de symptômes de la ménopause en utilisant de la progestérone à faible dose |
| CN112336699A (zh) * | 2019-08-09 | 2021-02-09 | 南京科宁检测科技有限公司 | 一种黄体酮阴道缓释软胶囊及其制备方法 |
| US20220105107A1 (en) * | 2020-10-01 | 2022-04-07 | Michael Liguori | Bioidentical progesterone cream infused with nanoemulsified cbd |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| EP1303261B1 (fr) * | 2000-07-24 | 2005-03-09 | Pharmacia & Upjohn Company | Systemes auto-emulsifiant d'administration de medicaments lipophiles extremement insolubles dans l'eau |
| CN1622810A (zh) * | 2002-03-14 | 2005-06-01 | 华生制药公司 | 孕酮口服药物传输系统 |
| EA015155B1 (ru) * | 2005-05-26 | 2011-06-30 | Тева Вуменс Хелс, Инк. | Дозированные формы для перорального применения, содержащие прогестерон, и способы их изготовления и использования |
| US20110312928A1 (en) * | 2010-06-18 | 2011-12-22 | Lipocine Inc. | Progesterone Containing Oral Dosage Forms and Related Methods |
| US20110312927A1 (en) * | 2010-06-18 | 2011-12-22 | Satish Kumar Nachaegari | Progesterone Containing Oral Dosage Forms and Related Methods |
| US9301920B2 (en) * | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) * | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) * | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
-
2015
- 2015-03-27 CA CA2942568A patent/CA2942568A1/fr not_active Abandoned
- 2015-03-27 WO PCT/US2015/023041 patent/WO2015148952A1/fr not_active Ceased
- 2015-03-27 AR ARP150100920A patent/AR099872A1/es unknown
- 2015-03-27 AU AU2015237243A patent/AU2015237243A1/en not_active Abandoned
- 2015-03-27 RU RU2016136666A patent/RU2016136666A/ru not_active Application Discontinuation
- 2015-03-27 MX MX2016011706A patent/MX2016011706A/es unknown
- 2015-03-27 KR KR1020167029519A patent/KR20160137597A/ko not_active Withdrawn
- 2015-03-27 EP EP15768772.4A patent/EP3122364A4/fr not_active Withdrawn
- 2015-03-27 JP JP2016557059A patent/JP2017509630A/ja active Pending
-
2016
- 2016-09-14 IL IL247828A patent/IL247828A0/en unknown
-
2019
- 2019-07-05 JP JP2019126362A patent/JP2019206540A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017509630A (ja) | 2017-04-06 |
| JP2019206540A (ja) | 2019-12-05 |
| MX2016011706A (es) | 2017-05-01 |
| RU2016136666A (ru) | 2018-05-03 |
| IL247828A0 (en) | 2016-11-30 |
| RU2016136666A3 (fr) | 2018-11-07 |
| KR20160137597A (ko) | 2016-11-30 |
| AR099872A1 (es) | 2016-08-24 |
| EP3122364A4 (fr) | 2017-10-25 |
| WO2015148952A1 (fr) | 2015-10-01 |
| EP3122364A1 (fr) | 2017-02-01 |
| AU2015237243A1 (en) | 2016-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211123 |
|
| FZDE | Discontinued |
Effective date: 20211123 |