CA2899449A1 - Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement - Google Patents

Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement Download PDF

Info

Publication number: CA2899449A1
Authority: CA; Canada
Prior art keywords: less; antibody; composition; chromatography; low
Prior art date: 2013-03-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2899449A

Other languages

English (en)

Inventor

Chen Wang

Germano Coppola

Christopher Chumsae

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AbbVie Inc

Original Assignee

AbbVie Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-14

Filing date

2014-03-12

Publication date

2014-10-02

2013-03-14 Priority claimed from US13/803,808 external-priority patent/US9067990B2/en

2013-03-14 Priority claimed from PCT/US2013/031380 external-priority patent/WO2014142882A1/fr

2013-11-13 Priority claimed from US14/079,076 external-priority patent/US9017687B1/en

2014-03-12 Application filed by AbbVie Inc filed Critical AbbVie Inc

2014-10-02 Publication of CA2899449A1 publication Critical patent/CA2899449A1/fr

Status Abandoned legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 534
238000000034 method Methods 0.000 title claims abstract description 229
230000002378 acidificating effect Effects 0.000 title claims abstract description 158
238000002086 displacement chromatography Methods 0.000 title claims abstract description 92
108090000623 proteins and genes Proteins 0.000 claims abstract description 319
102000004169 proteins and genes Human genes 0.000 claims abstract description 286
239000000427 antigen Substances 0.000 claims abstract description 140
108091007433 antigens Proteins 0.000 claims abstract description 140
102000036639 antigens Human genes 0.000 claims abstract description 140
230000001627 detrimental effect Effects 0.000 claims abstract description 21
229960002964 adalimumab Drugs 0.000 claims description 108
210000004027 cell Anatomy 0.000 claims description 100
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 99
239000000872 buffer Substances 0.000 claims description 92
238000004587 chromatography analysis Methods 0.000 claims description 88
230000002829 reductive effect Effects 0.000 claims description 86
239000004472 Lysine Substances 0.000 claims description 69
241000894007 species Species 0.000 claims description 69
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 57
208000035475 disorder Diseases 0.000 claims description 49
230000001965 increasing effect Effects 0.000 claims description 41
125000003275 alpha amino acid group Chemical group 0.000 claims description 39
238000004519 manufacturing process Methods 0.000 claims description 38
238000002360 preparation method Methods 0.000 claims description 33
-1 wherein the antibody Substances 0.000 claims description 23
238000003860 storage Methods 0.000 claims description 19
210000000845 cartilage Anatomy 0.000 claims description 17
238000013467 fragmentation Methods 0.000 claims description 15
238000006062 fragmentation reaction Methods 0.000 claims description 15
239000012501 chromatography medium Substances 0.000 claims description 14
206010003246 arthritis Diseases 0.000 claims description 12
238000004113 cell culture Methods 0.000 claims description 12
208000011231 Crohn disease Diseases 0.000 claims description 11
208000003456 Juvenile Arthritis Diseases 0.000 claims description 11
102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 10
108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 10
206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 10
201000004681 Psoriasis Diseases 0.000 claims description 10
201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 10
230000006378 damage Effects 0.000 claims description 9
206010039073 rheumatoid arthritis Diseases 0.000 claims description 9
206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 8
230000035515 penetration Effects 0.000 claims description 8
206010051728 Bone erosion Diseases 0.000 claims description 7
206010009900 Colitis ulcerative Diseases 0.000 claims description 6
208000036824 Psoriatic arthropathy Diseases 0.000 claims description 6
201000006704 Ulcerative Colitis Diseases 0.000 claims description 6
230000002917 arthritic effect Effects 0.000 claims description 6
208000034967 Non-Radiographic Axial Spondyloarthritis Diseases 0.000 claims description 5
201000001263 Psoriatic Arthritis Diseases 0.000 claims description 5
210000001612 chondrocyte Anatomy 0.000 claims description 5
230000034994 death Effects 0.000 claims description 5
238000011161 development Methods 0.000 claims description 5
230000008595 infiltration Effects 0.000 claims description 5
238000001764 infiltration Methods 0.000 claims description 5
230000035755 proliferation Effects 0.000 claims description 5
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
238000010171 animal model Methods 0.000 claims description 4
208000025705 Axial Spondyloarthritis Diseases 0.000 claims description 3
201000002661 Spondylitis Diseases 0.000 claims description 3
235000018102 proteins Nutrition 0.000 description 280
238000009472 formulation Methods 0.000 description 130
239000000047 product Substances 0.000 description 121
239000000463 material Substances 0.000 description 96
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 78
235000018977 lysine Nutrition 0.000 description 77
230000008569 process Effects 0.000 description 73
239000000523 sample Substances 0.000 description 70
238000000926 separation method Methods 0.000 description 64
238000000746 purification Methods 0.000 description 56
239000012535 impurity Substances 0.000 description 51
230000009467 reduction Effects 0.000 description 42
239000011347 resin Substances 0.000 description 42
229920005989 resin Polymers 0.000 description 42
238000005341 cation exchange Methods 0.000 description 41
238000011084 recovery Methods 0.000 description 41
239000000126 substance Substances 0.000 description 40
235000002639 sodium chloride Nutrition 0.000 description 39
238000006073 displacement reaction Methods 0.000 description 38
238000011068 loading method Methods 0.000 description 37
239000012634 fragment Substances 0.000 description 36
210000004899 c-terminal region Anatomy 0.000 description 35
239000000546 pharmaceutical excipient Substances 0.000 description 35
238000005349 anion exchange Methods 0.000 description 34
102000007327 Protamines Human genes 0.000 description 33
108010007568 Protamines Proteins 0.000 description 33
238000010828 elution Methods 0.000 description 33
238000005516 engineering process Methods 0.000 description 31
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 30
230000000694 effects Effects 0.000 description 29
239000012528 membrane Substances 0.000 description 29
101100512078 Caenorhabditis elegans lys-1 gene Proteins 0.000 description 27
101100129088 Caenorhabditis elegans lys-2 gene Proteins 0.000 description 27
150000003839 salts Chemical class 0.000 description 27
230000006240 deamidation Effects 0.000 description 26
230000001225 therapeutic effect Effects 0.000 description 26
108091006629 SLC13A2 Proteins 0.000 description 25
235000001014 amino acid Nutrition 0.000 description 25
230000014509 gene expression Effects 0.000 description 25
230000036252 glycation Effects 0.000 description 25
229950008679 protamine sulfate Drugs 0.000 description 25
239000000243 solution Substances 0.000 description 25
239000013011 aqueous formulation Substances 0.000 description 23
150000001720 carbohydrates Chemical class 0.000 description 23
230000003993 interaction Effects 0.000 description 23
239000013604 expression vector Substances 0.000 description 22
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 21
235000014633 carbohydrates Nutrition 0.000 description 20
239000012669 liquid formulation Substances 0.000 description 20
239000012071 phase Substances 0.000 description 20
239000007787 solid Substances 0.000 description 20
238000005406 washing Methods 0.000 description 20
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 19
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 19
239000012615 aggregate Substances 0.000 description 19
229940024606 amino acid Drugs 0.000 description 19
239000006172 buffering agent Substances 0.000 description 19
125000002091 cationic group Chemical group 0.000 description 19
229960002885 histidine Drugs 0.000 description 19
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 19
150000001413 amino acids Chemical class 0.000 description 18
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 18
235000014304 histidine Nutrition 0.000 description 18
230000000670 limiting effect Effects 0.000 description 18
125000000129 anionic group Chemical group 0.000 description 17
230000002209 hydrophobic effect Effects 0.000 description 17
239000003795 chemical substances by application Substances 0.000 description 16
230000003247 decreasing effect Effects 0.000 description 16
229940048921 humira Drugs 0.000 description 16
238000004191 hydrophobic interaction chromatography Methods 0.000 description 16
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 15
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 15
150000001875 compounds Chemical class 0.000 description 15
238000004128 high performance liquid chromatography Methods 0.000 description 15
238000002347 injection Methods 0.000 description 15
239000007924 injection Substances 0.000 description 15
229940071643 prefilled syringe Drugs 0.000 description 15
238000012545 processing Methods 0.000 description 15
238000003259 recombinant expression Methods 0.000 description 15
238000011282 treatment Methods 0.000 description 15
239000013598 vector Substances 0.000 description 15
230000003612 virological effect Effects 0.000 description 15
239000011534 wash buffer Substances 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 14
239000011159 matrix material Substances 0.000 description 14
235000000346 sugar Nutrition 0.000 description 14
108060003951 Immunoglobulin Proteins 0.000 description 13
238000001042 affinity chromatography Methods 0.000 description 13
102000018358 immunoglobulin Human genes 0.000 description 13
239000011324 bead Substances 0.000 description 12
239000003814 drug Substances 0.000 description 12
230000013595 glycosylation Effects 0.000 description 12
238000006206 glycosylation reaction Methods 0.000 description 12
230000002779 inactivation Effects 0.000 description 12
239000003446 ligand Substances 0.000 description 12
108090000765 processed proteins & peptides Proteins 0.000 description 12
239000007983 Tris buffer Substances 0.000 description 11
238000005277 cation exchange chromatography Methods 0.000 description 11
239000012539 chromatography resin Substances 0.000 description 11
238000001914 filtration Methods 0.000 description 11
239000012160 loading buffer Substances 0.000 description 11
239000002609 medium Substances 0.000 description 11
239000012266 salt solution Substances 0.000 description 11
108010047041 Complementarity Determining Regions Proteins 0.000 description 10
108020004414 DNA Proteins 0.000 description 10
239000004471 Glycine Substances 0.000 description 10
208000002193 Pain Diseases 0.000 description 10
239000000654 additive Substances 0.000 description 10
238000005571 anion exchange chromatography Methods 0.000 description 10
238000013375 chromatographic separation Methods 0.000 description 10
229960004106 citric acid Drugs 0.000 description 10
235000015165 citric acid Nutrition 0.000 description 10
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 10
238000009826 distribution Methods 0.000 description 10
229940079593 drug Drugs 0.000 description 10
238000001727 in vivo Methods 0.000 description 10
230000036407 pain Effects 0.000 description 10
239000002953 phosphate buffered saline Substances 0.000 description 10
238000011176 pooling Methods 0.000 description 10
239000011780 sodium chloride Substances 0.000 description 10
150000008163 sugars Chemical class 0.000 description 10
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 10
238000000108 ultra-filtration Methods 0.000 description 10
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 9
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 9
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
239000003463 adsorbent Substances 0.000 description 9
239000003085 diluting agent Substances 0.000 description 9
239000002552 dosage form Substances 0.000 description 9
238000004255 ion exchange chromatography Methods 0.000 description 9
150000002669 lysines Chemical group 0.000 description 9
108020004707 nucleic acids Proteins 0.000 description 9
150000007523 nucleic acids Chemical class 0.000 description 9
102000039446 nucleic acids Human genes 0.000 description 9
239000003755 preservative agent Substances 0.000 description 9
230000001105 regulatory effect Effects 0.000 description 9
239000004094 surface-active agent Substances 0.000 description 9
PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 9
HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 8
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 8
229930195725 Mannitol Natural products 0.000 description 8
238000004458 analytical method Methods 0.000 description 8
230000015572 biosynthetic process Effects 0.000 description 8
201000010099 disease Diseases 0.000 description 8
210000004602 germ cell Anatomy 0.000 description 8
238000005342 ion exchange Methods 0.000 description 8
150000002500 ions Chemical class 0.000 description 8
239000000594 mannitol Substances 0.000 description 8
235000010355 mannitol Nutrition 0.000 description 8
238000012544 monitoring process Methods 0.000 description 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 8
229920001223 polyethylene glycol Polymers 0.000 description 8
102000004196 processed proteins & peptides Human genes 0.000 description 8
229940048914 protamine Drugs 0.000 description 8
238000004611 spectroscopical analysis Methods 0.000 description 8
239000003381 stabilizer Substances 0.000 description 8
241000894006 Bacteria Species 0.000 description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
239000002202 Polyethylene glycol Substances 0.000 description 7
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 7
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 7
229930006000 Sucrose Natural products 0.000 description 7
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 7
238000005119 centrifugation Methods 0.000 description 7
230000000295 complement effect Effects 0.000 description 7
239000003599 detergent Substances 0.000 description 7
239000003937 drug carrier Substances 0.000 description 7
230000006870 function Effects 0.000 description 7
238000000338 in vitro Methods 0.000 description 7
238000001990 intravenous administration Methods 0.000 description 7
238000001155 isoelectric focusing Methods 0.000 description 7
239000012931 lyophilized formulation Substances 0.000 description 7
229920001184 polypeptide Polymers 0.000 description 7
239000002904 solvent Substances 0.000 description 7
239000005720 sucrose Substances 0.000 description 7
150000005846 sugar alcohols Chemical class 0.000 description 7
229920000936 Agarose Polymers 0.000 description 6
208000023275 Autoimmune disease Diseases 0.000 description 6
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 6
238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 6
239000012515 MabSelect SuRe Substances 0.000 description 6
AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 description 6
241000699670 Mus sp. Species 0.000 description 6
229910019142 PO4 Inorganic materials 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
108010076504 Protein Sorting Signals Proteins 0.000 description 6
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
239000004480 active ingredient Substances 0.000 description 6
230000002776 aggregation Effects 0.000 description 6
125000000539 amino acid group Chemical group 0.000 description 6
238000001514 detection method Methods 0.000 description 6
238000011143 downstream manufacturing Methods 0.000 description 6
239000002158 endotoxin Substances 0.000 description 6
238000011067 equilibration Methods 0.000 description 6
239000001963 growth medium Substances 0.000 description 6
238000001802 infusion Methods 0.000 description 6
239000002502 liposome Substances 0.000 description 6
239000003550 marker Substances 0.000 description 6
230000003204 osmotic effect Effects 0.000 description 6
239000008194 pharmaceutical composition Substances 0.000 description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
239000010452 phosphate Substances 0.000 description 6
239000012521 purified sample Substances 0.000 description 6
239000006228 supernatant Substances 0.000 description 6
239000008181 tonicity modifier Substances 0.000 description 6
230000009261 transgenic effect Effects 0.000 description 6
230000014616 translation Effects 0.000 description 6
238000011144 upstream manufacturing Methods 0.000 description 6
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 5
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
229920002307 Dextran Polymers 0.000 description 5
102000009109 Fc receptors Human genes 0.000 description 5
108010087819 Fc receptors Proteins 0.000 description 5
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
241001465754 Metazoa Species 0.000 description 5
241001529936 Murinae Species 0.000 description 5
241000699666 Mus <mouse, genus> Species 0.000 description 5
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 5
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 5
238000004220 aggregation Methods 0.000 description 5
230000008901 benefit Effects 0.000 description 5
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
229920002678 cellulose Polymers 0.000 description 5
230000003196 chaotropic effect Effects 0.000 description 5
238000007385 chemical modification Methods 0.000 description 5
210000004978 chinese hamster ovary cell Anatomy 0.000 description 5
230000001684 chronic effect Effects 0.000 description 5
230000001143 conditioned effect Effects 0.000 description 5
230000001419 dependent effect Effects 0.000 description 5
238000011118 depth filtration Methods 0.000 description 5
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 5
239000003623 enhancer Substances 0.000 description 5
239000006167 equilibration buffer Substances 0.000 description 5
238000004108 freeze drying Methods 0.000 description 5
239000000499 gel Substances 0.000 description 5
210000004408 hybridoma Anatomy 0.000 description 5
239000008101 lactose Substances 0.000 description 5
239000007788 liquid Substances 0.000 description 5
244000005700 microbiome Species 0.000 description 5
230000004048 modification Effects 0.000 description 5
238000012986 modification Methods 0.000 description 5
229920000642 polymer Polymers 0.000 description 5
229920000136 polysorbate Polymers 0.000 description 5
239000011148 porous material Substances 0.000 description 5
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 5
239000002002 slurry Substances 0.000 description 5
208000024891 symptom Diseases 0.000 description 5
238000001890 transfection Methods 0.000 description 5
238000013060 ultrafiltration and diafiltration Methods 0.000 description 5
238000003989 weak cation exchange chromatography Methods 0.000 description 5
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
239000004475 Arginine Substances 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
241000701022 Cytomegalovirus Species 0.000 description 4
238000002965 ELISA Methods 0.000 description 4
241000588724 Escherichia coli Species 0.000 description 4
108010010803 Gelatin Proteins 0.000 description 4
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 4
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 4
108010029485 Protein Isoforms Proteins 0.000 description 4
102000001708 Protein Isoforms Human genes 0.000 description 4
238000001069 Raman spectroscopy Methods 0.000 description 4
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 4
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
241000700605 Viruses Species 0.000 description 4
MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 description 4
238000002835 absorbance Methods 0.000 description 4
238000013459 approach Methods 0.000 description 4
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
235000009697 arginine Nutrition 0.000 description 4
125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 4
238000003556 assay Methods 0.000 description 4
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 4
230000004071 biological effect Effects 0.000 description 4
239000008366 buffered solution Substances 0.000 description 4
239000004067 bulking agent Substances 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
239000002738 chelating agent Substances 0.000 description 4
239000003153 chemical reaction reagent Substances 0.000 description 4
238000011210 chromatographic step Methods 0.000 description 4
238000010367 cloning Methods 0.000 description 4
150000002016 disaccharides Chemical class 0.000 description 4
229910000397 disodium phosphate Inorganic materials 0.000 description 4
235000019800 disodium phosphate Nutrition 0.000 description 4
238000012377 drug delivery Methods 0.000 description 4
125000000524 functional group Chemical group 0.000 description 4
239000008273 gelatin Substances 0.000 description 4
229920000159 gelatin Polymers 0.000 description 4
235000019322 gelatine Nutrition 0.000 description 4
235000011852 gelatine desserts Nutrition 0.000 description 4
239000008103 glucose Substances 0.000 description 4
125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 4
230000036541 health Effects 0.000 description 4
210000003292 kidney cell Anatomy 0.000 description 4
RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 4
239000012516 mab select resin Substances 0.000 description 4
238000005259 measurement Methods 0.000 description 4
239000012092 media component Substances 0.000 description 4
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
239000000178 monomer Substances 0.000 description 4
238000002703 mutagenesis Methods 0.000 description 4
231100000350 mutagenesis Toxicity 0.000 description 4
238000010979 pH adjustment Methods 0.000 description 4
239000005022 packaging material Substances 0.000 description 4
238000007911 parenteral administration Methods 0.000 description 4
239000002245 particle Substances 0.000 description 4
239000000825 pharmaceutical preparation Substances 0.000 description 4
229920003023 plastic Polymers 0.000 description 4
239000004033 plastic Substances 0.000 description 4
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 4
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
229920000053 polysorbate 80 Polymers 0.000 description 4
229940068968 polysorbate 80 Drugs 0.000 description 4
239000012562 protein A resin Substances 0.000 description 4
238000001742 protein purification Methods 0.000 description 4
239000013017 sartobind Substances 0.000 description 4
239000011734 sodium Substances 0.000 description 4
229910052708 sodium Inorganic materials 0.000 description 4
229910052938 sodium sulfate Inorganic materials 0.000 description 4
235000011152 sodium sulphate Nutrition 0.000 description 4
238000001179 sorption measurement Methods 0.000 description 4
238000010561 standard procedure Methods 0.000 description 4
229920001059 synthetic polymer Polymers 0.000 description 4
230000008685 targeting Effects 0.000 description 4
238000013518 transcription Methods 0.000 description 4
230000035897 transcription Effects 0.000 description 4
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 4
229910052721 tungsten Inorganic materials 0.000 description 4
239000010937 tungsten Substances 0.000 description 4
NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 3
206010001052 Acute respiratory distress syndrome Diseases 0.000 description 3
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 3
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
241000233866 Fungi Species 0.000 description 3
230000005526 G1 to G0 transition Effects 0.000 description 3
238000012855 HCP-ELISA Methods 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 3
108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 3
108700005091 Immunoglobulin Genes Proteins 0.000 description 3
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 3
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 3
108091028043 Nucleic acid sequence Proteins 0.000 description 3
108020004511 Recombinant DNA Proteins 0.000 description 3
208000013616 Respiratory Distress Syndrome Diseases 0.000 description 3
240000004808 Saccharomyces cerevisiae Species 0.000 description 3
229920002684 Sepharose Polymers 0.000 description 3
206010040070 Septic Shock Diseases 0.000 description 3
102000007562 Serum Albumin Human genes 0.000 description 3
108010071390 Serum Albumin Proteins 0.000 description 3
208000006045 Spondylarthropathies Diseases 0.000 description 3
108010022394 Threonine synthase Proteins 0.000 description 3
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
239000008351 acetate buffer Substances 0.000 description 3
201000000028 adult respiratory distress syndrome Diseases 0.000 description 3
150000001450 anions Chemical class 0.000 description 3
239000003963 antioxidant agent Substances 0.000 description 3
235000006708 antioxidants Nutrition 0.000 description 3
235000009582 asparagine Nutrition 0.000 description 3
229960001230 asparagine Drugs 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
230000003139 buffering effect Effects 0.000 description 3
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
239000000969 carrier Substances 0.000 description 3
230000015556 catabolic process Effects 0.000 description 3
208000019069 chronic childhood arthritis Diseases 0.000 description 3
238000004140 cleaning Methods 0.000 description 3
238000006731 degradation reaction Methods 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
206010012601 diabetes mellitus Diseases 0.000 description 3
238000011026 diafiltration Methods 0.000 description 3
230000004069 differentiation Effects 0.000 description 3
102000004419 dihydrofolate reductase Human genes 0.000 description 3
238000003113 dilution method Methods 0.000 description 3
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 3
238000011549 displacement method Methods 0.000 description 3
239000012149 elution buffer Substances 0.000 description 3
210000003527 eukaryotic cell Anatomy 0.000 description 3
230000007717 exclusion Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
230000004927 fusion Effects 0.000 description 3
235000011187 glycerol Nutrition 0.000 description 3
DXTIKTAIYCJTII-UHFFFAOYSA-N guanidine acetate Chemical compound CC([O-])=O.NC([NH3+])=N DXTIKTAIYCJTII-UHFFFAOYSA-N 0.000 description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
230000003053 immunization Effects 0.000 description 3
238000002649 immunization Methods 0.000 description 3
230000010354 integration Effects 0.000 description 3
125000003010 ionic group Chemical group 0.000 description 3
238000002955 isolation Methods 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
206010025135 lupus erythematosus Diseases 0.000 description 3
210000004962 mammalian cell Anatomy 0.000 description 3
229960000485 methotrexate Drugs 0.000 description 3
238000012434 mixed-mode chromatography Methods 0.000 description 3
238000010172 mouse model Methods 0.000 description 3
230000035772 mutation Effects 0.000 description 3
231100000252 nontoxic Toxicity 0.000 description 3
230000003000 nontoxic effect Effects 0.000 description 3
201000008482 osteoarthritis Diseases 0.000 description 3
238000002823 phage display Methods 0.000 description 3
229920005862 polyol Polymers 0.000 description 3
150000003077 polyols Chemical class 0.000 description 3
229920001296 polysiloxane Polymers 0.000 description 3
238000001556 precipitation Methods 0.000 description 3
230000002335 preservative effect Effects 0.000 description 3
230000000069 prophylactic effect Effects 0.000 description 3
238000003908 quality control method Methods 0.000 description 3
230000008929 regeneration Effects 0.000 description 3
238000011069 regeneration method Methods 0.000 description 3
230000004044 response Effects 0.000 description 3
230000000717 retained effect Effects 0.000 description 3
238000012216 screening Methods 0.000 description 3
238000000638 solvent extraction Methods 0.000 description 3
239000000600 sorbitol Substances 0.000 description 3
235000010356 sorbitol Nutrition 0.000 description 3
201000005671 spondyloarthropathy Diseases 0.000 description 3
230000000699 topical effect Effects 0.000 description 3
238000013519 translation Methods 0.000 description 3
239000008215 water for injection Substances 0.000 description 3
239000000811 xylitol Substances 0.000 description 3
235000010447 xylitol Nutrition 0.000 description 3
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
229960002675 xylitol Drugs 0.000 description 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 description 2
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
DIHXSRXTECMMJY-MURFETPASA-N 2-[dimethyl-[(9z,12z)-octadeca-9,12-dienyl]azaniumyl]acetate Chemical group CCCCC\C=C/C\C=C/CCCCCCCC[N+](C)(C)CC([O-])=O DIHXSRXTECMMJY-MURFETPASA-N 0.000 description 2
UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 2
LYUQWQRTDLVQGA-UHFFFAOYSA-N 3-phenylpropylamine Chemical compound NCCCC1=CC=CC=C1 LYUQWQRTDLVQGA-UHFFFAOYSA-N 0.000 description 2
CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 2
PVXPPJIGRGXGCY-TZLCEDOOSA-N 6-O-alpha-D-glucopyranosyl-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 PVXPPJIGRGXGCY-TZLCEDOOSA-N 0.000 description 2
208000030507 AIDS Diseases 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
206010002383 Angina Pectoris Diseases 0.000 description 2
241000194108 Bacillus licheniformis Species 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
241000283707 Capra Species 0.000 description 2
208000031229 Cardiomyopathies Diseases 0.000 description 2
241000282693 Cercopithecidae Species 0.000 description 2
229920001661 Chitosan Polymers 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
241000255925 Diptera Species 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
241000206602 Eukaryota Species 0.000 description 2
229930091371 Fructose Natural products 0.000 description 2
239000005715 Fructose Substances 0.000 description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
201000005569 Gout Diseases 0.000 description 2
206010018634 Gouty Arthritis Diseases 0.000 description 2
208000009329 Graft vs Host Disease Diseases 0.000 description 2
206010019280 Heart failures Diseases 0.000 description 2
241000238631 Hexapoda Species 0.000 description 2
241000282412 Homo Species 0.000 description 2
101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 2
102000008100 Human Serum Albumin Human genes 0.000 description 2
108091006905 Human Serum Albumin Proteins 0.000 description 2
206010020751 Hypersensitivity Diseases 0.000 description 2
108010067060 Immunoglobulin Variable Region Proteins 0.000 description 2
102000017727 Immunoglobulin Variable Region Human genes 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
244000285963 Kluyveromyces fragilis Species 0.000 description 2
241001138401 Kluyveromyces lactis Species 0.000 description 2
NBGXQZRRLOGAJF-UHFFFAOYSA-N Maltulose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)(CO)OCC1O NBGXQZRRLOGAJF-UHFFFAOYSA-N 0.000 description 2
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 2
206010029164 Nephrotic syndrome Diseases 0.000 description 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
206010035226 Plasma cell myeloma Diseases 0.000 description 2
229920001213 Polysorbate 20 Polymers 0.000 description 2
229920001219 Polysorbate 40 Polymers 0.000 description 2
206010037660 Pyrexia Diseases 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
206010039710 Scleroderma Diseases 0.000 description 2
206010040047 Sepsis Diseases 0.000 description 2
241000607720 Serratia Species 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
241000256251 Spodoptera frugiperda Species 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
101710120037 Toxin CcdB Proteins 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
208000025865 Ulcer Diseases 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 2
230000002411 adverse Effects 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
208000026935 allergic disease Diseases 0.000 description 2
230000007815 allergy Effects 0.000 description 2
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
229910052921 ammonium sulfate Inorganic materials 0.000 description 2
235000011130 ammonium sulphate Nutrition 0.000 description 2
230000003321 amplification Effects 0.000 description 2
239000003957 anion exchange resin Substances 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
235000010323 ascorbic acid Nutrition 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
230000001363 autoimmune Effects 0.000 description 2
201000004982 autoimmune uveitis Diseases 0.000 description 2
239000008228 bacteriostatic water for injection Substances 0.000 description 2
229960000686 benzalkonium chloride Drugs 0.000 description 2
229960001950 benzethonium chloride Drugs 0.000 description 2
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 2
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
239000013060 biological fluid Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
230000037396 body weight Effects 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
229960001714 calcium phosphate Drugs 0.000 description 2
229910000389 calcium phosphate Inorganic materials 0.000 description 2
235000011010 calcium phosphates Nutrition 0.000 description 2
239000013019 capto adhere Substances 0.000 description 2
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
239000012876 carrier material Substances 0.000 description 2
YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
230000008859 change Effects 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
238000002983 circular dichroism Methods 0.000 description 2
238000005352 clarification Methods 0.000 description 2
238000013329 compounding Methods 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
208000029078 coronary artery disease Diseases 0.000 description 2
238000009295 crossflow filtration Methods 0.000 description 2
238000012258 culturing Methods 0.000 description 2
230000003013 cytotoxicity Effects 0.000 description 2
231100000135 cytotoxicity Toxicity 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
238000010494 dissociation reaction Methods 0.000 description 2
230000005593 dissociations Effects 0.000 description 2
238000002296 dynamic light scattering Methods 0.000 description 2
230000002526 effect on cardiovascular system Effects 0.000 description 2
239000012636 effector Substances 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
239000013020 final formulation Substances 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
239000011521 glass Substances 0.000 description 2
150000004676 glycans Chemical class 0.000 description 2
229930182470 glycoside Natural products 0.000 description 2
208000024908 graft versus host disease Diseases 0.000 description 2
230000012010 growth Effects 0.000 description 2
230000009931 harmful effect Effects 0.000 description 2
238000003306 harvesting Methods 0.000 description 2
238000000265 homogenisation Methods 0.000 description 2
102000057041 human TNF Human genes 0.000 description 2
238000009396 hybridization Methods 0.000 description 2
229920001477 hydrophilic polymer Polymers 0.000 description 2
125000001165 hydrophobic group Chemical group 0.000 description 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
230000016784 immunoglobulin production Effects 0.000 description 2
239000007943 implant Substances 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
230000001939 inductive effect Effects 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
208000028774 intestinal disease Diseases 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000010829 isocratic elution Methods 0.000 description 2
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
239000000832 lactitol Substances 0.000 description 2
235000010448 lactitol Nutrition 0.000 description 2
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 2
229960003451 lactitol Drugs 0.000 description 2
JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 2
229960000511 lactulose Drugs 0.000 description 2
PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 2
238000011031 large-scale manufacturing process Methods 0.000 description 2
125000005647 linker group Chemical group 0.000 description 2
210000005229 liver cell Anatomy 0.000 description 2
239000008176 lyophilized powder Substances 0.000 description 2
229910001629 magnesium chloride Inorganic materials 0.000 description 2
229910052943 magnesium sulfate Inorganic materials 0.000 description 2
235000019341 magnesium sulphate Nutrition 0.000 description 2
230000014759 maintenance of location Effects 0.000 description 2
239000000845 maltitol Substances 0.000 description 2
235000010449 maltitol Nutrition 0.000 description 2
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
229940035436 maltitol Drugs 0.000 description 2
JCQLYHFGKNRPGE-HFZVAGMNSA-N maltulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-HFZVAGMNSA-N 0.000 description 2
238000013327 media filtration Methods 0.000 description 2
230000001404 mediated effect Effects 0.000 description 2
QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 2
238000001823 molecular biology technique Methods 0.000 description 2
150000002772 monosaccharides Chemical class 0.000 description 2
201000006417 multiple sclerosis Diseases 0.000 description 2
201000000050 myeloid neoplasm Diseases 0.000 description 2
208000004296 neuralgia Diseases 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
238000003199 nucleic acid amplification method Methods 0.000 description 2
239000002773 nucleotide Substances 0.000 description 2
125000003729 nucleotide group Chemical group 0.000 description 2
QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 2
238000005457 optimization Methods 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 2
230000007310 pathophysiology Effects 0.000 description 2
AQIXEPGDORPWBJ-UHFFFAOYSA-N pentan-3-ol Chemical compound CCC(O)CC AQIXEPGDORPWBJ-UHFFFAOYSA-N 0.000 description 2
210000001322 periplasm Anatomy 0.000 description 2
239000008177 pharmaceutical agent Substances 0.000 description 2
229940127557 pharmaceutical product Drugs 0.000 description 2
239000008180 pharmaceutical surfactant Substances 0.000 description 2
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
238000005498 polishing Methods 0.000 description 2
229920001993 poloxamer 188 Polymers 0.000 description 2
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 2
235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
239000005017 polysaccharide Substances 0.000 description 2
229950008882 polysorbate Drugs 0.000 description 2
229940068977 polysorbate 20 Drugs 0.000 description 2
229940101027 polysorbate 40 Drugs 0.000 description 2
229940068965 polysorbates Drugs 0.000 description 2
239000000843 powder Substances 0.000 description 2
230000002265 prevention Effects 0.000 description 2
238000011027 product recovery Methods 0.000 description 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
230000002685 pulmonary effect Effects 0.000 description 2
230000001698 pyrogenic effect Effects 0.000 description 2
238000011002 quantification Methods 0.000 description 2
150000003242 quaternary ammonium salts Chemical group 0.000 description 2
208000002574 reactive arthritis Diseases 0.000 description 2
238000010188 recombinant method Methods 0.000 description 2
239000012557 regeneration buffer Substances 0.000 description 2
230000010076 replication Effects 0.000 description 2
GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
238000005185 salting out Methods 0.000 description 2
230000028327 secretion Effects 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
230000035939 shock Effects 0.000 description 2
208000017520 skin disease Diseases 0.000 description 2
JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
239000001488 sodium phosphate Substances 0.000 description 2
229910000162 sodium phosphate Inorganic materials 0.000 description 2
235000011008 sodium phosphates Nutrition 0.000 description 2
210000001082 somatic cell Anatomy 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
238000001370 static light scattering Methods 0.000 description 2
238000007920 subcutaneous administration Methods 0.000 description 2
238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 2
210000001179 synovial fluid Anatomy 0.000 description 2
230000004797 therapeutic response Effects 0.000 description 2
WRCITXQNXAIKLR-UHFFFAOYSA-N tiadenol Chemical compound OCCSCCCCCCCCCCSCCO WRCITXQNXAIKLR-UHFFFAOYSA-N 0.000 description 2
230000000451 tissue damage Effects 0.000 description 2
231100000827 tissue damage Toxicity 0.000 description 2
238000012448 transchromosomic mouse model Methods 0.000 description 2
230000002103 transcriptional effect Effects 0.000 description 2
238000012546 transfer Methods 0.000 description 2
238000011830 transgenic mouse model Methods 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 2
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
230000036269 ulceration Effects 0.000 description 2
241000701161 unidentified adenovirus Species 0.000 description 2
238000011100 viral filtration Methods 0.000 description 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
AYRXSINWFIIFAE-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal Chemical compound OCC1OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C1O AYRXSINWFIIFAE-UHFFFAOYSA-N 0.000 description 1
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
WOUANPHGFPAJCA-UHFFFAOYSA-N 2-[benzyl(methyl)amino]ethanol Chemical compound OCCN(C)CC1=CC=CC=C1 WOUANPHGFPAJCA-UHFFFAOYSA-N 0.000 description 1
LMVGXBRDRZOPHA-UHFFFAOYSA-N 2-[dimethyl-[3-(16-methylheptadecanoylamino)propyl]azaniumyl]acetate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O LMVGXBRDRZOPHA-UHFFFAOYSA-N 0.000 description 1
TYIOVYZMKITKRO-UHFFFAOYSA-N 2-[hexadecyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O TYIOVYZMKITKRO-UHFFFAOYSA-N 0.000 description 1
SNQVCAOGQHOSEN-UHFFFAOYSA-N 2-[methyl(octadecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCCCCCN(C)CC(O)=O SNQVCAOGQHOSEN-UHFFFAOYSA-N 0.000 description 1
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 description 1
125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
DIROHOMJLWMERM-UHFFFAOYSA-N 3-[dimethyl(octadecyl)azaniumyl]propane-1-sulfonate Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O DIROHOMJLWMERM-UHFFFAOYSA-N 0.000 description 1
HVCNXQOWACZAFN-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound CCN1CCOCC1 HVCNXQOWACZAFN-UHFFFAOYSA-N 0.000 description 1
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
206010069754 Acquired gene mutation Diseases 0.000 description 1
206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 description 1
206010059193 Acute hepatitis B Diseases 0.000 description 1
206010067484 Adverse reaction Diseases 0.000 description 1
241000256118 Aedes aegypti Species 0.000 description 1
241000256173 Aedes albopictus Species 0.000 description 1
206010049589 Afterbirth pain Diseases 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
244000247812 Amorphophallus rivieri Species 0.000 description 1
235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
206010003225 Arteriospasm coronary Diseases 0.000 description 1
208000006820 Arthralgia Diseases 0.000 description 1
206010003253 Arthritis enteropathic Diseases 0.000 description 1
206010003267 Arthritis reactive Diseases 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
241000351920 Aspergillus nidulans Species 0.000 description 1
241000228245 Aspergillus niger Species 0.000 description 1
241000408939 Atalopedes campestris Species 0.000 description 1
201000001320 Atherosclerosis Diseases 0.000 description 1
241000972773 Aulopiformes Species 0.000 description 1
241001203868 Autographa californica Species 0.000 description 1
239000007989 BIS-Tris Propane buffer Substances 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
208000009137 Behcet syndrome Diseases 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
241000255789 Bombyx mori Species 0.000 description 1
241000409811 Bombyx mori nucleopolyhedrovirus Species 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
239000002126 C01EB10 - Adenosine Substances 0.000 description 1
206010006895 Cachexia Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
241000222120 Candida <Saccharomycetales> Species 0.000 description 1
241000282465 Canis Species 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
208000020446 Cardiac disease Diseases 0.000 description 1
206010007559 Cardiac failure congestive Diseases 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
241000282552 Chlorocebus aethiops Species 0.000 description 1
206010008609 Cholangitis sclerosing Diseases 0.000 description 1
208000005590 Choroidal Neovascularization Diseases 0.000 description 1
206010060823 Choroidal neovascularisation Diseases 0.000 description 1
208000000094 Chronic Pain Diseases 0.000 description 1
206010009208 Cirrhosis alcoholic Diseases 0.000 description 1
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
208000006561 Cluster Headache Diseases 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
108020004635 Complementary DNA Proteins 0.000 description 1
208000003890 Coronary Vasospasm Diseases 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
241000699802 Cricetulus griseus Species 0.000 description 1
206010063075 Cryptogenic cirrhosis Diseases 0.000 description 1
201000003883 Cystic fibrosis Diseases 0.000 description 1
102000004127 Cytokines Human genes 0.000 description 1
108090000695 Cytokines Proteins 0.000 description 1
GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Chemical class OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
206010011878 Deafness Diseases 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
206010012438 Dermatitis atopic Diseases 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
208000032131 Diabetic Neuropathies Diseases 0.000 description 1
206010012689 Diabetic retinopathy Diseases 0.000 description 1
241000255601 Drosophila melanogaster Species 0.000 description 1
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 1
201000009273 Endometriosis Diseases 0.000 description 1
206010014824 Endotoxic shock Diseases 0.000 description 1
241000588914 Enterobacter Species 0.000 description 1
241000588921 Enterobacteriaceae Species 0.000 description 1
102400001368 Epidermal growth factor Human genes 0.000 description 1
101800003838 Epidermal growth factor Proteins 0.000 description 1
YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241000588698 Erwinia Species 0.000 description 1
206010015150 Erythema Diseases 0.000 description 1
206010015226 Erythema nodosum Diseases 0.000 description 1
239000004386 Erythritol Substances 0.000 description 1
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
241001522878 Escherichia coli B Species 0.000 description 1
241001302584 Escherichia coli str. K-12 substr. W3110 Species 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 1
108091029865 Exogenous DNA Proteins 0.000 description 1
208000004930 Fatty Liver Diseases 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
206010016654 Fibrosis Diseases 0.000 description 1
206010016717 Fistula Diseases 0.000 description 1
229920002148 Gellan gum Polymers 0.000 description 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
229930182566 Gentamicin Natural products 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
229920002527 Glycogen Polymers 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
241000219146 Gossypium Species 0.000 description 1
239000007995 HEPES buffer Substances 0.000 description 1
208000010496 Heart Arrest Diseases 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
208000005176 Hepatitis C Diseases 0.000 description 1
206010019728 Hepatitis alcoholic Diseases 0.000 description 1
206010019799 Hepatitis viral Diseases 0.000 description 1
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
238000011993 High Performance Size Exclusion Chromatography Methods 0.000 description 1
238000012450 HuMAb Mouse Methods 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
208000001953 Hypotension Diseases 0.000 description 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 1
108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 1
102000013463 Immunoglobulin Light Chains Human genes 0.000 description 1
108010065825 Immunoglobulin Light Chains Proteins 0.000 description 1
208000022559 Inflammatory bowel disease Diseases 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
208000029523 Interstitial Lung disease Diseases 0.000 description 1
241000588748 Klebsiella Species 0.000 description 1
241000235649 Kluyveromyces Species 0.000 description 1
241000235058 Komagataella pastoris Species 0.000 description 1
229920002752 Konjac Polymers 0.000 description 1
238000012449 Kunming mouse Methods 0.000 description 1
LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
229930064664 L-arginine Natural products 0.000 description 1
235000014852 L-arginine Nutrition 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
241000481961 Lachancea thermotolerans Species 0.000 description 1
241000235651 Lachancea waltii Species 0.000 description 1
208000008930 Low Back Pain Diseases 0.000 description 1
208000019693 Lung disease Diseases 0.000 description 1
208000005777 Lupus Nephritis Diseases 0.000 description 1
235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
208000002720 Malnutrition Diseases 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
208000001940 Massive Hepatic Necrosis Diseases 0.000 description 1
201000009906 Meningitis Diseases 0.000 description 1
208000019695 Migraine disease Diseases 0.000 description 1
KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
241001045988 Neogene Species 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
241000221960 Neurospora Species 0.000 description 1
241000221961 Neurospora crassa Species 0.000 description 1
244000061176 Nicotiana tabacum Species 0.000 description 1
235000002637 Nicotiana tabacum Nutrition 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
208000008589 Obesity Diseases 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
239000012606 POROS 50 HQ resin Substances 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
241001494479 Pecora Species 0.000 description 1
201000011152 Pemphigus Diseases 0.000 description 1
241000228143 Penicillium Species 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
240000007377 Petunia x hybrida Species 0.000 description 1
206010057249 Phagocytosis Diseases 0.000 description 1
208000004983 Phantom Limb Diseases 0.000 description 1
206010056238 Phantom pain Diseases 0.000 description 1
241000276498 Pollachius virens Species 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
208000004550 Postoperative Pain Diseases 0.000 description 1
208000002389 Pouchitis Diseases 0.000 description 1
208000012654 Primary biliary cholangitis Diseases 0.000 description 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
239000004365 Protease Substances 0.000 description 1
241000588769 Proteus <enterobacteria> Species 0.000 description 1
241000589516 Pseudomonas Species 0.000 description 1
208000020410 Psoriasis-related juvenile idiopathic arthritis Diseases 0.000 description 1
206010037575 Pustular psoriasis Diseases 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
241000700159 Rattus Species 0.000 description 1
241000700157 Rattus norvegicus Species 0.000 description 1
208000033464 Reiter syndrome Diseases 0.000 description 1
208000017442 Retinal disease Diseases 0.000 description 1
206010038923 Retinopathy Diseases 0.000 description 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
238000011579 SCID mouse model Methods 0.000 description 1
241000607142 Salmonella Species 0.000 description 1
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
241000235347 Schizosaccharomyces pombe Species 0.000 description 1
241000311088 Schwanniomyces Species 0.000 description 1
241001123650 Schwanniomyces occidentalis Species 0.000 description 1
208000008765 Sciatica Diseases 0.000 description 1
206010053879 Sepsis syndrome Diseases 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
241000607768 Shigella Species 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
201000010001 Silicosis Diseases 0.000 description 1
208000021386 Sjogren Syndrome Diseases 0.000 description 1
206010061363 Skeletal injury Diseases 0.000 description 1
239000004288 Sodium dehydroacetate Substances 0.000 description 1
239000004280 Sodium formate Substances 0.000 description 1
240000003768 Solanum lycopersicum Species 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
108010090804 Streptavidin Proteins 0.000 description 1
241000187747 Streptomyces Species 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
206010042496 Sunburn Diseases 0.000 description 1
208000010265 Sweet syndrome Diseases 0.000 description 1
206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
241000255588 Tephritidae Species 0.000 description 1
241001149964 Tolypocladium Species 0.000 description 1
206010044248 Toxic shock syndrome Diseases 0.000 description 1
231100000650 Toxic shock syndrome Toxicity 0.000 description 1
102000004338 Transferrin Human genes 0.000 description 1
108090000901 Transferrin Proteins 0.000 description 1
206010052779 Transplant rejections Diseases 0.000 description 1
241000223259 Trichoderma Species 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
206010046851 Uveitis Diseases 0.000 description 1
244000000188 Vaccinium ovalifolium Species 0.000 description 1
206010047112 Vasculitides Diseases 0.000 description 1
206010047115 Vasculitis Diseases 0.000 description 1
206010047642 Vitiligo Diseases 0.000 description 1
208000000208 Wet Macular Degeneration Diseases 0.000 description 1
238000012452 Xenomouse strains Methods 0.000 description 1
241000235013 Yarrowia Species 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
206010000269 abscess Diseases 0.000 description 1
TYEPEWHRNANQOJ-UHFFFAOYSA-N acetic acid guanidine sulfuric acid Chemical compound NC(=N)N.C(C)(=O)O.S(=O)(=O)(O)O TYEPEWHRNANQOJ-UHFFFAOYSA-N 0.000 description 1
PZAGQUOSOTUKEC-UHFFFAOYSA-N acetic acid;sulfuric acid Chemical compound CC(O)=O.OS(O)(=O)=O PZAGQUOSOTUKEC-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000003926 acrylamides Chemical class 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
230000009471 action Effects 0.000 description 1
208000005298 acute pain Diseases 0.000 description 1
229960005305 adenosine Drugs 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
230000006838 adverse reaction Effects 0.000 description 1
238000001261 affinity purification Methods 0.000 description 1
239000008272 agar Substances 0.000 description 1
206010064930 age-related macular degeneration Diseases 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
208000002353 alcoholic hepatitis Diseases 0.000 description 1
208000010002 alcoholic liver cirrhosis Diseases 0.000 description 1
229940072056 alginate Drugs 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
LHAOFBCHXGZGOR-NAVBLJQLSA-N alpha-D-Manp-(1->3)-alpha-D-Manp-(1->2)-alpha-D-Manp Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1 LHAOFBCHXGZGOR-NAVBLJQLSA-N 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000001412 amines Chemical group 0.000 description 1
238000012870 ammonium sulfate precipitation Methods 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
239000003011 anion exchange membrane Substances 0.000 description 1
239000003945 anionic surfactant Substances 0.000 description 1
238000011091 antibody purification Methods 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
230000003078 antioxidant effect Effects 0.000 description 1
239000002216 antistatic agent Substances 0.000 description 1
239000008365 aqueous carrier Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
206010003119 arrhythmia Diseases 0.000 description 1
230000006793 arrhythmia Effects 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
229960005261 aspartic acid Drugs 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
201000008937 atopic dermatitis Diseases 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
229960003237 betaine Drugs 0.000 description 1
230000001588 bifunctional effect Effects 0.000 description 1
108091008324 binding proteins Proteins 0.000 description 1
239000012620 biological material Substances 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
229940126587 biotherapeutics Drugs 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 1
HHKZCCWKTZRCCL-UHFFFAOYSA-N bis-tris propane Chemical compound OCC(CO)(CO)NCCCNC(CO)(CO)CO HHKZCCWKTZRCCL-UHFFFAOYSA-N 0.000 description 1
HUTDDBSSHVOYJR-UHFFFAOYSA-H bis[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphaplumbetan-2-yl)oxy]lead Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O HUTDDBSSHVOYJR-UHFFFAOYSA-H 0.000 description 1
230000008499 blood brain barrier function Effects 0.000 description 1
210000001218 blood-brain barrier Anatomy 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000012512 bulk drug substance Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical class O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
LRHPLDYGYMQRHN-UHFFFAOYSA-N butyl alcohol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229960005069 calcium Drugs 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
239000013622 capto Q Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
206010007625 cardiogenic shock Diseases 0.000 description 1
210000000748 cardiovascular system Anatomy 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
239000003518 caustics Substances 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
238000012832 cell culture technique Methods 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
230000005889 cellular cytotoxicity Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
201000008191 cerebritis Diseases 0.000 description 1
208000019065 cervical carcinoma Diseases 0.000 description 1
238000010382 chemical cross-linking Methods 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
229960002242 chlorocresol Drugs 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
238000011098 chromatofocusing Methods 0.000 description 1
230000007882 cirrhosis Effects 0.000 description 1
208000019425 cirrhosis of liver Diseases 0.000 description 1
229960002303 citric acid monohydrate Drugs 0.000 description 1
206010009887 colitis Diseases 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
BPLKXBNWXRMHRE-UHFFFAOYSA-N copper;1,10-phenanthroline Chemical compound [Cu].C1=CN=C2C3=NC=CC=C3C=CC2=C1 BPLKXBNWXRMHRE-UHFFFAOYSA-N 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
201000011634 coronary artery vasospasm Diseases 0.000 description 1
239000003246 corticosteroid Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
239000002577 cryoprotective agent Substances 0.000 description 1
230000001186 cumulative effect Effects 0.000 description 1
230000001351 cycling effect Effects 0.000 description 1
HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
201000003146 cystitis Diseases 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
229940127089 cytotoxic agent Drugs 0.000 description 1
239000002254 cytotoxic agent Substances 0.000 description 1
231100000599 cytotoxic agent Toxicity 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
239000000412 dendrimer Substances 0.000 description 1
229920000736 dendritic polymer Polymers 0.000 description 1
238000013461 design Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
229940061607 dibasic sodium phosphate Drugs 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
238000001085 differential centrifugation Methods 0.000 description 1
238000000113 differential scanning calorimetry Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
150000002019 disulfides Chemical class 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
229940126534 drug product Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
238000004520 electroporation Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
206010014599 encephalitis Diseases 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
229940116977 epidermal growth factor Drugs 0.000 description 1
230000003628 erosive effect Effects 0.000 description 1
235000019414 erythritol Nutrition 0.000 description 1
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
229940009714 erythritol Drugs 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
238000012869 ethanol precipitation Methods 0.000 description 1
229940031098 ethanolamine Drugs 0.000 description 1
UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical class NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
230000029142 excretion Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000000605 extraction Methods 0.000 description 1
208000003816 familial cirrhosis Diseases 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000000945 filler Substances 0.000 description 1
230000003890 fistula Effects 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
229940014144 folate Drugs 0.000 description 1
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
235000019152 folic acid Nutrition 0.000 description 1
239000011724 folic acid Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
238000007710 freezing Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
238000001879 gelation Methods 0.000 description 1
239000000174 gluconic acid Chemical class 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
229950006191 gluconic acid Drugs 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
235000004554 glutamine Nutrition 0.000 description 1
229960002449 glycine Drugs 0.000 description 1
229940096919 glycogen Drugs 0.000 description 1
150000002338 glycosides Chemical class 0.000 description 1
108091005608 glycosylated proteins Proteins 0.000 description 1
102000035122 glycosylated proteins Human genes 0.000 description 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
206010018797 guttate psoriasis Diseases 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
230000010370 hearing loss Effects 0.000 description 1
231100000888 hearing loss Toxicity 0.000 description 1
208000016354 hearing loss disease Diseases 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
206010073071 hepatocellular carcinoma Diseases 0.000 description 1
150000004687 hexahydrates Chemical class 0.000 description 1
208000002557 hidradenitis Diseases 0.000 description 1
239000013628 high molecular weight specie Substances 0.000 description 1
125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
229940014041 hyaluronate Drugs 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
150000002433 hydrophilic molecules Chemical class 0.000 description 1
238000012872 hydroxylapatite chromatography Methods 0.000 description 1
230000036543 hypotension Effects 0.000 description 1
210000002865 immune cell Anatomy 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000001114 immunoprecipitation Methods 0.000 description 1
230000001506 immunosuppresive effect Effects 0.000 description 1
230000006872 improvement Effects 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
208000027866 inflammatory disease Diseases 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000002484 inorganic compounds Chemical class 0.000 description 1
229910010272 inorganic material Inorganic materials 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
208000003243 intestinal obstruction Diseases 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000007913 intrathecal administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
239000000252 konjac Substances 0.000 description 1
235000010485 konjac Nutrition 0.000 description 1
238000002372 labelling Methods 0.000 description 1
238000002386 leaching Methods 0.000 description 1
230000003902 lesion Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
208000019423 liver disease Diseases 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000013627 low molecular weight specie Substances 0.000 description 1
210000005265 lung cell Anatomy 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
230000002535 lyotropic effect Effects 0.000 description 1
229960003646 lysine Drugs 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229960002337 magnesium chloride Drugs 0.000 description 1
229940091250 magnesium supplement Drugs 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
201000004792 malaria Diseases 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
150000008146 mannosides Chemical class 0.000 description 1
FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
238000002483 medication Methods 0.000 description 1
238000011140 membrane chromatography Methods 0.000 description 1
108020004999 messenger RNA Proteins 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Chemical class 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
CRVGTESFCCXCTH-UHFFFAOYSA-N methyl diethanolamine Chemical compound OCCN(C)CCO CRVGTESFCCXCTH-UHFFFAOYSA-N 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
238000001471 micro-filtration Methods 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
206010027599 migraine Diseases 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
239000004223 monosodium glutamate Substances 0.000 description 1
235000013923 monosodium glutamate Nutrition 0.000 description 1
238000012433 multimodal chromatography Methods 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
NZXVYLJKFYSEPO-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]-16-methylheptadecanamide Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)NCCCN(C)C NZXVYLJKFYSEPO-UHFFFAOYSA-N 0.000 description 1
208000026721 nail disease Diseases 0.000 description 1
101150091879 neo gene Proteins 0.000 description 1
208000021722 neuropathic pain Diseases 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
235000018343 nutrient deficiency Nutrition 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
235000020824 obesity Nutrition 0.000 description 1
230000000414 obstructive effect Effects 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000002674 ointment Substances 0.000 description 1
238000006384 oligomerization reaction Methods 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
230000006548 oncogenic transformation Effects 0.000 description 1
230000010494 opalescence Effects 0.000 description 1
230000014207 opsonization Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
239000003002 pH adjusting agent Substances 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
239000006072 paste Substances 0.000 description 1
238000009928 pasteurization Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
201000001976 pemphigus vulgaris Diseases 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
239000012466 permeate Substances 0.000 description 1
230000008782 phagocytosis Effects 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229960005323 phenoxyethanol Drugs 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
229940044519 poloxamer 188 Drugs 0.000 description 1
230000008488 polyadenylation Effects 0.000 description 1
229920000867 polyelectrolyte Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920002704 polyhistidine Polymers 0.000 description 1
239000002952 polymeric resin Substances 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
229940113124 polysorbate 60 Drugs 0.000 description 1
229920001289 polyvinyl ether Polymers 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
201000000742 primary sclerosing cholangitis Diseases 0.000 description 1
210000001236 prokaryotic cell Anatomy 0.000 description 1
230000009465 prokaryotic expression Effects 0.000 description 1
235000013930 proline Nutrition 0.000 description 1
239000003380 propellant Substances 0.000 description 1
229960000380 propiolactone Drugs 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
201000007094 prostatitis Diseases 0.000 description 1
239000013636 protein dimer Substances 0.000 description 1
208000005069 pulmonary fibrosis Diseases 0.000 description 1
201000003651 pulmonary sarcoidosis Diseases 0.000 description 1
238000011403 purification operation Methods 0.000 description 1
239000012264 purified product Substances 0.000 description 1
208000009954 pyoderma gangrenosum Diseases 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000002510 pyrogen Substances 0.000 description 1
230000005855 radiation Effects 0.000 description 1
231100000336 radiotoxic Toxicity 0.000 description 1
230000001690 radiotoxic effect Effects 0.000 description 1
238000002708 random mutagenesis Methods 0.000 description 1
230000001172 regenerating effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
208000037803 restenosis Diseases 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
239000012723 sample buffer Substances 0.000 description 1
201000000306 sarcoidosis Diseases 0.000 description 1
208000010157 sclerosing cholangitis Diseases 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
230000036303 septic shock Effects 0.000 description 1
229960001153 serine Drugs 0.000 description 1
210000000717 sertoli cell Anatomy 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000021309 simple sugar Nutrition 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
229960002668 sodium chloride Drugs 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000019259 sodium dehydroacetate Nutrition 0.000 description 1
229940079839 sodium dehydroacetate Drugs 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
235000019254 sodium formate Nutrition 0.000 description 1
229940074404 sodium succinate Drugs 0.000 description 1
ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
HSFQBFMEWSTNOW-UHFFFAOYSA-N sodium;carbanide Chemical group [CH3-].[Na+] HSFQBFMEWSTNOW-UHFFFAOYSA-N 0.000 description 1
VBJGJHBYWREJQD-UHFFFAOYSA-M sodium;dihydrogen phosphate;dihydrate Chemical compound O.O.[Na+].OP(O)([O-])=O VBJGJHBYWREJQD-UHFFFAOYSA-M 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
230000000392 somatic effect Effects 0.000 description 1
230000037439 somatic mutation Effects 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
210000004988 splenocyte Anatomy 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
239000008107 starch Substances 0.000 description 1
SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
150000003440 styrenes Chemical class 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
125000000185 sucrose group Chemical group 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000013589 supplement Substances 0.000 description 1
108010033090 surfactant protein A receptor Proteins 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000004114 suspension culture Methods 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000013076 target substance Substances 0.000 description 1
239000011975 tartaric acid Chemical class 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940104261 taurate Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
230000014723 transformation of host cell by virus Effects 0.000 description 1
125000000647 trehalose group Chemical group 0.000 description 1
239000013638 trimer Substances 0.000 description 1
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
229940073585 tromethamine hydrochloride Drugs 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
108700026220 vif Genes Proteins 0.000 description 1
229920001567 vinyl ester resin Polymers 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
201000001862 viral hepatitis Diseases 0.000 description 1
208000009935 visceral pain Diseases 0.000 description 1
238000012784 weak cation exchange Methods 0.000 description 1
230000003313 weakening effect Effects 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000001262 western blot Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000002023 wood Substances 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)

CA2899449A 2013-03-14 2014-03-12 Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement Abandoned CA2899449A1 (fr)

Applications Claiming Priority (11)

Application Number	Priority Date	Filing Date	Title
US13/803,808 US9067990B2 (en)	2013-03-14	2013-03-14	Protein purification using displacement chromatography
US13/803,808		2013-03-14
PCT/US2013/031380 WO2014142882A1 (fr)	2013-03-14	2013-03-14	Purification de protéine utilisant une chromatographie de déplacement
USPCT/US2013/031380		2013-03-14
US201361892833P	2013-10-18	2013-10-18
US61/892,833		2013-10-18
US201314077576A	2013-11-12	2013-11-12
US14/077,576		2013-11-12
US14/079,076 US9017687B1 (en)	2013-10-18	2013-11-13	Low acidic species compositions and methods for producing and using the same using displacement chromatography
US14/079,076		2013-11-13
PCT/US2014/024151 WO2014159554A1 (fr)	2013-03-14	2014-03-12	Composition d'espèces faiblement acides et leurs méthodes de production utilisant la chromatographie de déplacement

Publications (1)

Publication Number	Publication Date
CA2899449A1 true CA2899449A1 (fr)	2014-10-02

Family

ID=50439505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2899449A Abandoned CA2899449A1 (fr)	2013-03-14	2014-03-12	Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement

Country Status (6)

Country	Link
EP (1)	EP2970375A1 (fr)
AU (1)	AU2014240431A1 (fr)
CA (1)	CA2899449A1 (fr)
HK (1)	HK1213919A1 (fr)
SG (1)	SG11201507365VA (fr)
WO (1)	WO2014159554A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI4209499T1 (sl)	2015-08-13	2025-01-31	Amgen Inc.	Globinsko nabito filtriranje proteinov, ki vežejo antigen
WO2018027195A1 (fr) *	2016-08-05	2018-02-08	Abbvie Biotherapeutics Inc.	Compositions contenant des quantités réduites d'isoformes acides de daclizumab et procédés de préparation associés

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE30985E (en)	1978-01-01	1982-06-29		Serum-free cell culture media
US5179017A (en)	1980-02-25	1993-01-12	The Trustees Of Columbia University In The City Of New York	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en)	1980-02-25	1987-01-06	The Trustees Of Columbia University In The City Of New York	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en)	1980-02-25	1983-08-16	The Trustees Of Columbia University	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4475196A (en)	1981-03-06	1984-10-02	Zor Clair G	Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en)	1981-04-10	1984-05-08	Parker-Hannifin Corporation	Medication infusion pump
US4439196A (en)	1982-03-18	1984-03-27	Merck & Co., Inc.	Osmotic drug delivery system
US4522811A (en)	1982-07-08	1985-06-11	Syntex (U.S.A.) Inc.	Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en)	1982-09-20	1984-05-08	Infusaid Corporation	Variable flow implantable infusion apparatus
US4510245A (en)	1982-11-18	1985-04-09	Chiron Corporation	Adenovirus promoter system
US4487603A (en)	1982-11-26	1984-12-11	Cordis Corporation	Implantable microinfusion pump system
US4560655A (en)	1982-12-16	1985-12-24	Immunex Corporation	Serum-free cell culture medium and process for making same
US4657866A (en)	1982-12-21	1987-04-14	Sudhir Kumar	Serum-free, synthetic, completely chemically defined tissue culture media
GB8308235D0 (en)	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US4534972A (en)	1983-03-29	1985-08-13	Miles Laboratories, Inc.	Protein compositions substantially free from infectious agents
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
DD266710A3 (de)	1983-06-06	1989-04-12	Ve Forschungszentrum Biotechnologie	Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4486194A (en)	1983-06-08	1984-12-04	James Ferrara	Therapeutic device for administering medicaments through the skin
US4767704A (en)	1983-10-07	1988-08-30	Columbia University In The City Of New York	Protein-free culture medium
US4879231A (en)	1984-10-30	1989-11-07	Phillips Petroleum Company	Transformation of yeasts of the genus pichia
US5168062A (en)	1985-01-30	1992-12-01	University Of Iowa Research Foundation	Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4596556A (en)	1985-03-25	1986-06-24	Bioject, Inc.	Hypodermic injection apparatus
US5374548A (en)	1986-05-02	1994-12-20	Genentech, Inc.	Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es)	1985-06-26	1992-08-01	Liposome Co Inc	Metodo para acoplamiento de liposomas.
GB8516415D0 (en)	1985-06-28	1985-07-31	Celltech Ltd	Culture of animal cells
US4968615A (en)	1985-12-18	1990-11-06	Ciba-Geigy Corporation	Deoxyribonucleic acid segment from a virus
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
US4927762A (en)	1986-04-01	1990-05-22	Cell Enterprises, Inc.	Cell culture medium with antioxidant
GB8610600D0 (en)	1986-04-30	1986-06-04	Novo Industri As	Transformation of trichoderma
DE3631229A1 (de)	1986-09-13	1988-03-24	Basf Ag	Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
US4941880A (en)	1987-06-19	1990-07-17	Bioject, Inc.	Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en)	1987-06-19	1988-12-13	Bioject, Inc.	Non-invasive hypodermic injection device
US5476996A (en)	1988-06-14	1995-12-19	Lidak Pharmaceuticals	Human immune system in non-human animal
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
EP0435911B1 (fr)	1988-09-23	1996-03-13	Cetus Oncology Corporation	Milieu de culture de cellules pour l'amelioration de la croissance des cellules, de la longivite de la culture et de l'expression du produit
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
US5108921A (en)	1989-04-03	1992-04-28	Purdue Research Foundation	Method for enhanced transmembrane transport of exogenous molecules
EP0402226A1 (fr)	1989-06-06	1990-12-12	Institut National De La Recherche Agronomique	Vecteurs de transformation de la levure yarrowia
US5064413A (en)	1989-11-09	1991-11-12	Bioject, Inc.	Needleless hypodermic injection device
US5312335A (en)	1989-11-09	1994-05-17	Bioject Inc.	Needleless hypodermic injection device
US5427908A (en)	1990-05-01	1995-06-27	Affymax Technologies N.V.	Recombinant library screening methods
US5110913A (en) *	1990-05-25	1992-05-05	Miles Inc.	Antibody purification method
EP0585287B1 (fr)	1990-07-10	1999-10-13	Cambridge Antibody Technology Limited	Methode de production de chainons de paires de liaison specifique
GB9015198D0 (en)	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
US5122469A (en)	1990-10-03	1992-06-16	Genentech, Inc.	Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
DE69129154T2 (de)	1990-12-03	1998-08-20	Genentech, Inc., South San Francisco, Calif.	Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
ES2330052T3 (es)	1991-03-01	2009-12-03	Dyax Corporation	Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas.
ATE414768T1 (de)	1991-04-10	2008-12-15	Scripps Research Inst	Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE4122599C2 (de)	1991-07-08	1993-11-11	Deutsches Krebsforsch	Phagemid zum Screenen von Antikörpern
US5383851A (en)	1992-07-24	1995-01-24	Bioject Inc.	Needleless hypodermic injection device
AU682670B2 (en)	1993-02-05	1997-10-16	Becton Dickinson & Company	Syringe needle isolation device
US5607400A (en)	1995-05-19	1997-03-04	Becton, Dickinson And Company	Pre-fillable syringe and stopper assembly therefor
US6685940B2 (en)	1995-07-27	2004-02-03	Genentech, Inc.	Protein formulation
US6090382A (en)	1996-02-09	2000-07-18	Basf Aktiengesellschaft	Human antibodies that bind human TNFα
JPH09173450A (ja)	1995-12-26	1997-07-08	Nissho Corp	プレフィルドシリンジ
ATE239041T1 (de)	1996-02-09	2003-05-15	Basf Ag	Humane antikörper welche an humanen tnfalpha binden
JP3293122B2 (ja)	1996-12-13	2002-06-17	ニプロ株式会社	プレフィルドシリンジ
SE9703425D0 (sv)	1997-09-23	1997-09-23	Pharmacia & Upjohn Ab	Prefilled ampooules and manufacture thereof
DE19751219A1 (de)	1997-11-19	1999-05-27	Vetter & Co Apotheker	Spritze, insbesondere vorgefüllte Spritze, oder Karpule
AU3001299A (en)	1998-03-13	1999-09-27	Becton Dickinson & Company	Method for manufacturing, filling and packaging medical containers
EP0943632A1 (fr)	1998-03-18	1999-09-22	Ecole Polytechnique Federale De Lausanne	Polymère d'ammonium quaternaire, sa préparation et son usage dans la séparation de biomolécules
US6914128B1 (en)	1999-03-25	2005-07-05	Abbott Gmbh & Co. Kg	Human antibodies that bind human IL-12 and methods for producing
US6881540B2 (en)	2000-02-23	2005-04-19	Rensselaer Polytechnic Institute	High throughtput screening of potential displacer molecules
JP3591636B2 (ja)	2000-04-03	2004-11-24	ニプロ株式会社	プレフィルドシリンジ
DE60227067D1 (de)	2001-05-11	2008-07-24	Kirin Pharma Kk	Künstliches menschliches chromosom mit dem gen für die lambda-leichte kette menschlicher antikörper
US6929747B2 (en)	2002-02-28	2005-08-16	Renesselaer Polytechnic Institute	High-affinity, low-molecular-mass displacers for ion-exchange chromatography
JP4141156B2 (ja)	2002-03-15	2008-08-27	日本ベクトン・ディッキンソン株式会社	プランジャ後退制限機構付きプレフィルドシリンジ
AU2003221888B2 (en)	2002-04-11	2008-11-06	Medimmune, Llc	Preservation of bioactive materials by spray drying
US20040042972A1 (en)	2002-04-11	2004-03-04	Medimmune Vaccines, Inc.	Spray freeze dry of compositions for intranasal administration
US7135180B2 (en)	2002-04-11	2006-11-14	Medimmune Vaccines, Inc.	Preservation of bioactive materials by freeze dried foam
WO2003087339A2 (fr)	2002-04-11	2003-10-23	Medimmune Vaccines, Inc.	Lyophilisation par pulverisation de compositions a administration pulmonaire
EP2386326B1 (fr)	2002-07-02	2013-01-09	Terumo Kabushiki Kaisha	Seringue et seringue préremplie
US20040033228A1 (en)	2002-08-16	2004-02-19	Hans-Juergen Krause	Formulation of human antibodies for treating TNF-alpha associated disorders
DE10254321A1 (de)	2002-11-21	2004-06-17	Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg	Vorgefüllte Spritze
EP1581639A4 (fr)	2002-12-17	2006-03-08	Medimmune Vaccines Inc	Pulv risation haute pression de mat riaux bioactifs
JP2004229750A (ja)	2003-01-28	2004-08-19	Nipro Corp	プレフィルドシリンジ及びそのバレルの製造方法
AR044302A1 (es)	2003-05-13	2005-09-07	Ares Trading Sa	Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos
US20050075611A1 (en)	2003-10-01	2005-04-07	Hetzler Kevin G.	Low extractable, thermoplastic syringe and tip cap
TWI424161B (zh)	2005-11-01	2014-01-21	Abbvie Biotechnology Ltd	利用生物標記診斷關節黏連脊椎炎之方法及組合物
WO2007053235A1 (fr)	2005-11-04	2007-05-10	Sachem, Inc.	Processus chromatographie par deplacement a echange de cations et composes cationiques organiques servant de composes deplaceurs dans un tel processus
CN101336124B (zh)	2005-12-02	2012-06-13	塞克姆公司	阴离子交换顶替色谱法及在阴离子交换顶替色谱法中作为置换剂化合物的阴离子有机化合物
US7988675B2 (en)	2005-12-08	2011-08-02	West Pharmaceutical Services Of Delaware, Inc.	Automatic injection and retraction devices for use with pre-filled syringe cartridges
JP4682850B2 (ja)	2006-01-12	2011-05-11	ニプロ株式会社	プレフィルドシリンジ
TWI392684B (zh)	2006-04-05	2013-04-11	亞培生物科技公司	抗體之純化
CA2842964A1 (fr)	2006-09-13	2008-03-20	Abbvie Inc.	Ameliorations a la culture de cellules
CN104072612A (zh) *	2006-10-27	2014-10-01	艾伯维生物技术有限公司	结晶型抗-hTNFα抗体
US8092998B2 (en)	2007-05-31	2012-01-10	Abbott Laboratories	Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders
KR20210049186A (ko)	2007-11-30	2021-05-04	애브비 바이오테크놀로지 리미티드	단백질 제형 및 이의 제조방법
US8187836B2 (en)	2008-01-15	2012-05-29	Abbott Laboratories	Mammalian expression vectors and uses thereof
WO2009135656A1 (fr) *	2008-05-06	2009-11-12	Lonza Biologics Plc.	Procédé de purification d’anticorps à l’aide de la chromatographie de déplacement
RU2520838C2 (ru) *	2008-10-20	2014-06-27	Эббви Инк	Выделение и очистка антител с использованием аффинной хроматографии на основе белка а
LT2637690T (lt)	2010-11-11	2016-10-25	Abbvie Biotechnology Ltd	Didelės koncentracijos anti-tnfalfa antikūno skystos kompozicijos

2014
- 2014-03-12 CA CA2899449A patent/CA2899449A1/fr not_active Abandoned
- 2014-03-12 EP EP14715500.6A patent/EP2970375A1/fr not_active Withdrawn
- 2014-03-12 AU AU2014240431A patent/AU2014240431A1/en not_active Abandoned
- 2014-03-12 HK HK16101855.4A patent/HK1213919A1/zh unknown
- 2014-03-12 SG SG11201507365VA patent/SG11201507365VA/en unknown
- 2014-03-12 WO PCT/US2014/024151 patent/WO2014159554A1/fr not_active Ceased

Also Published As

Publication number	Publication date
WO2014159554A1 (fr)	2014-10-02
HK1213919A1 (zh)	2016-07-15
SG11201507365VA (en)	2015-10-29
EP2970375A1 (fr)	2016-01-20
AU2014240431A1 (en)	2015-08-27

Publication	Publication Date	Title
US9688752B2 (en)	2017-06-27	Low acidic species compositions and methods for producing and using the same using displacement chromatography
US8946395B1 (en)	2015-02-03	Purification of proteins using hydrophobic interaction chromatography
US9522953B2 (en)	2016-12-20	Low acidic species compositions and methods for producing and using the same
CA2899308C (fr)	2017-04-18	Compositions d'especes d'adalimumab a faible teneur en acide et utilisations associees
WO2014143185A1 (fr)	2014-09-18	Purification de protéines au moyen de la chromatographie d'interaction hydrophobe
AU2013381759B2 (en)	2016-12-08	Modulated lysine variant species compositions and methods for producing and using the same
US9499616B2 (en)	2016-11-22	Modulated lysine variant species compositions and methods for producing and using the same
US20140154270A1 (en)	2014-06-05	Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
AU2015207915A1 (en)	2015-08-20	Isolation and purification of antibodies using Protein A affinity chromatography
EP2968532A1 (fr)	2016-01-20	Purification de protéines au moyen de la chromatographie d'interaction hydrophobe
CA2899449A1 (fr)	2014-10-02	Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement

Legal Events

Date	Code	Title	Description
2019-04-23	FZDE	Dead	Effective date: 20190312