CA2693390C - Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same - Google Patents

Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same Download PDF

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Publication number: CA2693390C
Authority: CA; Canada
Prior art keywords: phenyl; additional embodiments; compound; formula; alkyl
Prior art date: 2007-07-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2693390A

Other languages

English (en)

French (fr)

Other versions

CA2693390A1 (en

Inventor

Jean-Michel Vernier

Colin Edward Rowlings

Jean-Luc Girardet

Stuart Dimock

Barry Quart

Jeffrey N. Miner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ardea Biociences Inc

Original Assignee

Ardea Biociences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-30

Filing date

2008-07-28

Publication date

2017-01-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40304796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2693390(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-07-30 Priority claimed from US11/830,733 external-priority patent/US8101799B2/en

2008-07-28 Application filed by Ardea Biociences Inc filed Critical Ardea Biociences Inc

2008-07-28 Priority to CA2924436A priority Critical patent/CA2924436A1/en

2008-07-28 Priority to CA2924418A priority patent/CA2924418A1/en

2009-02-05 Publication of CA2693390A1 publication Critical patent/CA2693390A1/en

2017-01-17 Application granted granted Critical

2017-01-17 Publication of CA2693390C publication Critical patent/CA2693390C/en

Status Expired - Fee Related legal-status Critical Current

2028-07-28 Anticipated expiration legal-status Critical

Links

229940124530 sulfonamide Drugs 0.000 title claims description 27
239000000203 mixture Substances 0.000 title abstract description 266
238000000034 method Methods 0.000 title abstract description 129
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238000000634 powder X-ray diffraction Methods 0.000 claims abstract description 65
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 57
238000000113 differential scanning calorimetry Methods 0.000 claims abstract description 40
239000002904 solvent Substances 0.000 claims description 26
WMSPXQIQBQAWLL-UHFFFAOYSA-N cyclopropanesulfonamide Chemical compound NS(=O)(=O)C1CC1 WMSPXQIQBQAWLL-UHFFFAOYSA-N 0.000 claims description 17
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125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 13
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Classifications

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- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
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CA2693390A 2007-07-30 2008-07-28 Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same Expired - Fee Related CA2693390C (en)

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CA2924436A CA2924436A1 (en)	2007-07-30	2008-07-28	Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use
CA2924418A CA2924418A1 (en)	2007-07-30	2008-07-28	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same

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Application Number	Priority Date	Filing Date	Title
US11/830,733 US8101799B2 (en)	2005-07-21	2007-07-30	Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
US11/830,733		2007-07-30
US3446608P	2008-03-06	2008-03-06
US3446408P	2008-03-06	2008-03-06
US61/034,466		2008-03-06
US61/034,464		2008-03-06
US4488608P	2008-04-14	2008-04-14
US61/044,886		2008-04-14
PCT/US2008/071392 WO2009018233A1 (en)	2007-07-30	2008-07-28	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same

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Application Number	Title	Priority Date	Filing Date
CA2924418A Division CA2924418A1 (en)	2007-07-30	2008-07-28	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
CA2924436A Division CA2924436A1 (en)	2007-07-30	2008-07-28	Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use

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CA2693390A1 CA2693390A1 (en)	2009-02-05
CA2693390C true CA2693390C (en)	2017-01-17

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EP (1)	EP2184984A4 (ja)
JP (3)	JP2010535232A (ja)
KR (3)	KR20150091434A (ja)
CN (2)	CN101808516B (ja)
AP (1)	AP2817A (ja)
AU (2)	AU2008282338B2 (ja)
BR (1)	BRPI0815659A2 (ja)
CA (1)	CA2693390C (ja)
CO (1)	CO6470808A2 (ja)
CR (1)	CR11244A (ja)
DO (1)	DOP2010000045A (ja)
EA (2)	EA032294B1 (ja)
EC (1)	ECSP109910A (ja)
HN (1)	HN2010000203A (ja)
IL (1)	IL203296A (ja)
MA (1)	MA31881B1 (ja)
MX (1)	MX2010001244A (ja)
NZ (1)	NZ582929A (ja)
PH (1)	PH12015501914A1 (ja)
SV (1)	SV2010003469A (ja)
TN (1)	TN2010000049A1 (ja)
WO (1)	WO2009018233A1 (ja)

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2008
- 2008-07-28 BR BRPI0815659-0A2A patent/BRPI0815659A2/pt not_active Application Discontinuation
- 2008-07-28 CA CA2693390A patent/CA2693390C/en not_active Expired - Fee Related
- 2008-07-28 KR KR1020157020493A patent/KR20150091434A/ko not_active Ceased
- 2008-07-28 CN CN2008801088296A patent/CN101808516B/zh not_active Expired - Fee Related
- 2008-07-28 AU AU2008282338A patent/AU2008282338B2/en not_active Ceased
- 2008-07-28 MX MX2010001244A patent/MX2010001244A/es active IP Right Grant
- 2008-07-28 JP JP2010520118A patent/JP2010535232A/ja active Pending
- 2008-07-28 EP EP08796733.7A patent/EP2184984A4/en not_active Ceased
- 2008-07-28 KR KR1020147017261A patent/KR20140098185A/ko not_active Ceased
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- 2008-07-28 CN CN201310317815.8A patent/CN103479604B/zh not_active Expired - Fee Related
- 2008-07-28 WO PCT/US2008/071392 patent/WO2009018233A1/en not_active Ceased
- 2008-07-28 AP AP2010005134A patent/AP2817A/xx active
- 2008-07-28 EA EA201400552A patent/EA032294B1/ru not_active IP Right Cessation
- 2008-07-28 KR KR1020107004742A patent/KR20100092424A/ko not_active Ceased
- 2008-07-28 EA EA201000268A patent/EA020624B1/ru not_active IP Right Cessation
2010
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- 2010-01-29 CR CR11244A patent/CR11244A/es not_active Application Discontinuation
- 2010-01-29 SV SV2010003469A patent/SV2010003469A/es unknown
- 2010-01-29 CO CO10009526A patent/CO6470808A2/es not_active Application Discontinuation
- 2010-01-29 TN TNP2010000049A patent/TN2010000049A1/fr unknown
- 2010-01-29 DO DO2010000045A patent/DOP2010000045A/es unknown
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2014
- 2014-11-14 JP JP2014231450A patent/JP6309880B2/ja not_active Expired - Fee Related
2015
- 2015-01-28 AU AU2015200390A patent/AU2015200390B2/en not_active Ceased
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Publication number	Publication date
EP2184984A4 (en)	2013-07-24
MA31881B1 (fr)	2010-12-01
EA201400552A1 (ru)	2014-09-30
PH12015501914A1 (en)	2017-07-31
AP2817A (en)	2013-12-31
EP2184984A1 (en)	2010-05-19
KR20150091434A (ko)	2015-08-10
SV2010003469A (es)	2010-04-30
JP2015078199A (ja)	2015-04-23
AU2015200390B2 (en)	2017-02-23
TN2010000049A1 (en)	2011-09-26
JP6309880B2 (ja)	2018-04-11
AU2008282338B2 (en)	2015-02-12
DOP2010000045A (es)	2010-10-31
JP2010535232A (ja)	2010-11-18
EA020624B1 (ru)	2014-12-30
CA2693390A1 (en)	2009-02-05
EA201000268A1 (ru)	2010-08-30
HK1147396A1 (en)	2011-08-12
CR11244A (es)	2010-05-20
CN103479604A (zh)	2014-01-01
IL203296A (en)	2017-06-29
KR20140098185A (ko)	2014-08-07
ECSP109910A (es)	2010-04-30
HN2010000203A (es)	2012-11-19
NZ582929A (en)	2012-03-30
KR20100092424A (ko)	2010-08-20
CN103479604B (zh)	2016-08-10
MX2010001244A (es)	2010-08-31
CO6470808A2 (es)	2012-06-29
AP2010005134A0 (en)	2010-02-28
AU2008282338A1 (en)	2009-02-05
BRPI0815659A2 (pt)	2014-09-30
EA032294B1 (ru)	2019-05-31
CN101808516A (zh)	2010-08-18
WO2009018233A1 (en)	2009-02-05
CN101808516B (zh)	2013-08-28
JP2017125021A (ja)	2017-07-20

Publication	Publication Date	Title
CA2693390C (en)	2017-01-17	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
US8648116B2 (en)	2014-02-11	Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same
US8808742B2 (en)	2014-08-19	Compositions and methods for preparing and using same
US8829052B2 (en)	2014-09-09	Derivatives of N-(arylamino)sulfonamides as inhibitors of MEK
US8044240B2 (en)	2011-10-25	Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof
HK1147396B (en)	2014-05-16	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
TWI481590B (zh)	2015-04-21	作為ｍｅｋ抑制劑之ｎ－（芳胺基）磺醯胺（包括多晶型）衍生物及組合物，使用方法及其製備方法
HK1193032A (en)	2014-09-12	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
HK1193032B (en)	2017-10-20	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
HK1157738A (en)	2012-07-06	Compositions and methods for preparing and using same

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