CA2574124A1 - Vehicule permettant d'obtenir des medicaments a biodisponibilite orale - Google Patents
Vehicule permettant d'obtenir des medicaments a biodisponibilite orale Download PDFInfo
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- CA2574124A1 CA2574124A1 CA002574124A CA2574124A CA2574124A1 CA 2574124 A1 CA2574124 A1 CA 2574124A1 CA 002574124 A CA002574124 A CA 002574124A CA 2574124 A CA2574124 A CA 2574124A CA 2574124 A1 CA2574124 A1 CA 2574124A1
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- protein
- protein complex
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- polypeptide
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- 229940124736 hepatitis-B vaccine Drugs 0.000 description 1
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- 239000004030 hiv protease inhibitor Substances 0.000 description 1
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- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000004026 insulin derivative Substances 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
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- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 210000002161 motor neuron Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
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- 230000026792 palmitoylation Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229940127126 plasminogen activator Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229950010131 puromycin Drugs 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 239000002461 renin inhibitor Substances 0.000 description 1
- 229940086526 renin-inhibitors Drugs 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960002766 tetanus vaccines Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 229950009811 ubenimex Drugs 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004035606A DE102004035606A1 (de) | 2004-07-22 | 2004-07-22 | Carrier für Arzneimittel zur Gewinnung der oralen Bioverfügbarkeit |
| DE102004035606.8 | 2004-07-22 | ||
| PCT/DE2005/001290 WO2006010360A2 (fr) | 2004-07-22 | 2005-07-22 | Vehicule permettant d'obtenir des medicaments a biodisponibilite orale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2574124A1 true CA2574124A1 (fr) | 2006-02-02 |
Family
ID=35482323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002574124A Abandoned CA2574124A1 (fr) | 2004-07-22 | 2005-07-22 | Vehicule permettant d'obtenir des medicaments a biodisponibilite orale |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1768701A2 (fr) |
| JP (1) | JP2008506724A (fr) |
| KR (1) | KR20070047786A (fr) |
| CN (1) | CN101340932A (fr) |
| AU (1) | AU2005266739A1 (fr) |
| BR (1) | BRPI0513715A (fr) |
| CA (1) | CA2574124A1 (fr) |
| DE (1) | DE102004035606A1 (fr) |
| IL (1) | IL180229A0 (fr) |
| MX (1) | MX2007000421A (fr) |
| NO (1) | NO20070775L (fr) |
| RU (1) | RU2006147284A (fr) |
| WO (1) | WO2006010360A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9119274B2 (en) | 2011-07-15 | 2015-08-25 | Nxp B.V. | Resonant converter control |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008169166A (ja) * | 2007-01-14 | 2008-07-24 | Tokyo Univ Of Agriculture & Technology | 糖結合性ポリペプチド、複合材料、及び薬剤送達システム |
| JP2009132686A (ja) * | 2007-10-26 | 2009-06-18 | Okayama Univ | ボツリヌス毒素由来のポリペプチド及びボツリヌス毒素の検出方法 |
| WO2009131435A1 (fr) * | 2008-04-23 | 2009-10-29 | Erasmus University Medical Center Rotterdam | Lieur contenant de la bungarotoxine et un peptide de liaison |
| US20130085267A1 (en) * | 2009-12-18 | 2013-04-04 | Allergan, Inc. | Stabilization of Therapeutic Agents to Facilitate Administration |
| US10633643B2 (en) * | 2015-05-15 | 2020-04-28 | Board Of Regents Of The University Of Nebraska | Engineered Clostridium botulinum toxin adapted to deliver molecules into selected cells |
| CN115894719B (zh) * | 2022-11-24 | 2023-10-20 | 武汉禾元生物科技股份有限公司 | 一种人血清白蛋白胰岛素偶联物及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8914984D0 (en) * | 1989-06-29 | 1989-08-23 | Animal Health Inst | Nucleotide sequences |
| AU720857B2 (en) * | 1995-12-13 | 2000-06-15 | President And Fellows Of Harvard College | Use of toxin peptides and/or affinity handles for delivery compounds into cells |
| GB9617671D0 (en) * | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| GB9824282D0 (en) * | 1998-11-05 | 1998-12-30 | Microbiological Research Agenc | Delivery of superoxide dismutase to neuronal cells |
| DE19856052A1 (de) * | 1998-12-04 | 2000-06-08 | Deutsches Krebsforsch | Konjugat zur Anreicherung in neuronalen Zellen |
| US6776990B2 (en) * | 1999-04-08 | 2004-08-17 | Allergan, Inc. | Methods and compositions for the treatment of pancreatitis |
| US6500436B2 (en) * | 2000-01-19 | 2002-12-31 | Allergan, Inc. | Clostridial toxin derivatives and methods for treating pain |
| US6641820B1 (en) * | 2000-01-19 | 2003-11-04 | Allergan, Inc. | Clostridial toxin derivatives and methods to treat pain |
| US6670322B2 (en) * | 2000-06-01 | 2003-12-30 | Wisconsin Alumni Research Foundation | Method of targeting pharmaceuticals to motor neurons |
| DE10035156A1 (de) * | 2000-07-19 | 2002-02-07 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Proteinkomplex als Vehikel für oral verfügbare Protein-Arzneimittel |
| US20040220100A1 (en) * | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
| WO2003061694A1 (fr) * | 2001-05-10 | 2003-07-31 | Seattle Genetics, Inc. | Immunosuppression de la reponse immune humorale par des anticorps anti-cd20 |
| GB0112687D0 (en) * | 2001-05-24 | 2001-07-18 | Microbiological Res Authority | Pharmaceutical use of secreted bacterial effector proteins |
| US20040013687A1 (en) * | 2002-05-31 | 2004-01-22 | Thomas Jefferson University | Compositions and methods for transepithelial molecular transport |
| JP2007070225A (ja) * | 2003-07-25 | 2007-03-22 | Yukako Fujinaga | クロストリジウム属菌由来成分を含む医薬製剤 |
| US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
-
2004
- 2004-07-22 DE DE102004035606A patent/DE102004035606A1/de not_active Withdrawn
-
2005
- 2005-07-22 MX MX2007000421A patent/MX2007000421A/es not_active Application Discontinuation
- 2005-07-22 AU AU2005266739A patent/AU2005266739A1/en not_active Abandoned
- 2005-07-22 BR BRPI0513715-2A patent/BRPI0513715A/pt not_active IP Right Cessation
- 2005-07-22 KR KR1020077004107A patent/KR20070047786A/ko not_active Withdrawn
- 2005-07-22 CN CNA2005800244861A patent/CN101340932A/zh active Pending
- 2005-07-22 WO PCT/DE2005/001290 patent/WO2006010360A2/fr not_active Ceased
- 2005-07-22 RU RU2006147284/15A patent/RU2006147284A/ru not_active Application Discontinuation
- 2005-07-22 CA CA002574124A patent/CA2574124A1/fr not_active Abandoned
- 2005-07-22 JP JP2007521791A patent/JP2008506724A/ja active Pending
- 2005-07-22 EP EP05771235A patent/EP1768701A2/fr not_active Withdrawn
-
2006
- 2006-12-21 IL IL180229A patent/IL180229A0/en unknown
-
2007
- 2007-02-09 NO NO20070775A patent/NO20070775L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9119274B2 (en) | 2011-07-15 | 2015-08-25 | Nxp B.V. | Resonant converter control |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008506724A (ja) | 2008-03-06 |
| IL180229A0 (en) | 2007-07-04 |
| WO2006010360A3 (fr) | 2007-12-27 |
| NO20070775L (no) | 2007-04-18 |
| WO2006010360A2 (fr) | 2006-02-02 |
| EP1768701A2 (fr) | 2007-04-04 |
| BRPI0513715A (pt) | 2008-05-13 |
| AU2005266739A1 (en) | 2006-02-02 |
| DE102004035606A1 (de) | 2006-03-30 |
| MX2007000421A (es) | 2007-03-28 |
| CN101340932A (zh) | 2009-01-07 |
| KR20070047786A (ko) | 2007-05-07 |
| RU2006147284A (ru) | 2008-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |