CA2566655C - Formulations pharmaceutiques utiles pour inhiber la secretion d'acides et procedes correspondants de fabrication et d'utilisation - Google Patents

Formulations pharmaceutiques utiles pour inhiber la secretion d'acides et procedes correspondants de fabrication et d'utilisation Download PDF

Info

Publication number: CA2566655C
Authority: CA; Canada
Prior art keywords: pharmaceutical formulation; proton pump; meq; pump inhibitor; formulation according
Prior art date: 2004-05-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2566655A

Other languages

English (en)

Other versions

CA2566655A1 (fr

Inventor

Kay Olmstead

Warren Hall

Gerald T. Proehl

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Santarus Inc

Original Assignee

Santarus Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-25

Filing date

2005-05-25

Publication date

2013-04-16

2005-05-25 Application filed by Santarus Inc filed Critical Santarus Inc

2005-12-08 Publication of CA2566655A1 publication Critical patent/CA2566655A1/fr

2013-04-16 Application granted granted Critical

2013-04-16 Publication of CA2566655C publication Critical patent/CA2566655C/fr

2025-05-25 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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239000003795 chemical substances by application Substances 0.000 claims abstract description 57
102100021904 Potassium-transporting ATPase alpha chain 1 Human genes 0.000 claims abstract description 45
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239000000612 proton pump inhibitor Substances 0.000 claims description 255
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SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 102
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125000003396 thiol group Chemical group [H]S* 0.000 description 1
206010043554 thrombocytopenia Diseases 0.000 description 1
229960001312 tiaprofenic acid Drugs 0.000 description 1
229950010302 tiaramide Drugs 0.000 description 1
HTJXMOGUGMSZOG-UHFFFAOYSA-N tiaramide Chemical compound C1CN(CCO)CCN1C(=O)CN1C(=O)SC2=CC=C(Cl)C=C21 HTJXMOGUGMSZOG-UHFFFAOYSA-N 0.000 description 1
229950010298 tinoridine Drugs 0.000 description 1
PFENFDGYVLAFBR-UHFFFAOYSA-N tinoridine Chemical compound C1CC=2C(C(=O)OCC)=C(N)SC=2CN1CC1=CC=CC=C1 PFENFDGYVLAFBR-UHFFFAOYSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
229960002905 tolfenamic acid Drugs 0.000 description 1
YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
229960001017 tolmetin Drugs 0.000 description 1
UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
230000032258 transport Effects 0.000 description 1
229960003991 trazodone Drugs 0.000 description 1
PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
229960003386 triazolam Drugs 0.000 description 1
JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
229940117013 triethanolamine oleate Drugs 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
ZSCDBOWYZJWBIY-UHFFFAOYSA-N trimipramine Chemical compound C1CC2=CC=CC=C2N(CC(CN(C)C)C)C2=CC=CC=C21 ZSCDBOWYZJWBIY-UHFFFAOYSA-N 0.000 description 1
229960002431 trimipramine Drugs 0.000 description 1
238000001665 trituration Methods 0.000 description 1
229950002470 tropesin Drugs 0.000 description 1
UCCJWNPWWPJKGL-UHFFFAOYSA-N tropesin Chemical compound CC1=C(CC(=O)OCC(C(O)=O)C=2C=CC=CC=2)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 UCCJWNPWWPJKGL-UHFFFAOYSA-N 0.000 description 1
229950004147 ufiprazole Drugs 0.000 description 1
235000020767 valerian extract Nutrition 0.000 description 1
229940087652 vioxx Drugs 0.000 description 1
229940063674 voltaren Drugs 0.000 description 1
239000002023 wood Substances 0.000 description 1
229950005298 xenbucin Drugs 0.000 description 1
IYEPZNKOJZOGJG-UHFFFAOYSA-N xenbucin Chemical compound C1=CC(C(C(O)=O)CC)=CC=C1C1=CC=CC=C1 IYEPZNKOJZOGJG-UHFFFAOYSA-N 0.000 description 1
229950000707 ximoprofen Drugs 0.000 description 1
229960004010 zaleplon Drugs 0.000 description 1
HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 1
229950004227 zaltoprofen Drugs 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
229960001475 zolpidem Drugs 0.000 description 1
229960003414 zomepirac Drugs 0.000 description 1
ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
229960000820 zopiclone Drugs 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2566655A 2004-05-25 2005-05-25 Formulations pharmaceutiques utiles pour inhiber la secretion d'acides et procedes correspondants de fabrication et d'utilisation Expired - Fee Related CA2566655C (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US57464604P	2004-05-25	2004-05-25
US57466304P	2004-05-25	2004-05-25
US60/574,663		2004-05-25
US60/574,646		2004-05-25
PCT/US2005/018585 WO2005115474A1 (fr)	2004-05-25	2005-05-25	Formulations pharmaceutiques utiles pour inhiber la secretion d'acides et procedes correspondants de fabrication et d'utilisation

Publications (2)

Publication Number	Publication Date
CA2566655A1 CA2566655A1 (fr)	2005-12-08
CA2566655C true CA2566655C (fr)	2013-04-16

Family

ID=35450661

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2566655A Expired - Fee Related CA2566655C (fr)	2004-05-25	2005-05-25	Formulations pharmaceutiques utiles pour inhiber la secretion d'acides et procedes correspondants de fabrication et d'utilisation

Country Status (5)

Country	Link
EP (1)	EP1750767A4 (fr)
JP (1)	JP2008500365A (fr)
CA (1)	CA2566655C (fr)
MX (1)	MXPA06013585A (fr)
WO (1)	WO2005115474A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2444593B (en) *	2006-10-05	2010-06-09	Santarus Inc	Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations
CA2819460C (fr) *	2010-12-03	2017-08-01	Takeda Pharmaceutical Company Limited	Comprime a desintegration orale
JP6641626B2 (ja) *	2015-12-25	2020-02-05	エスエス製薬株式会社	制酸用医薬組成物
ES2926192T3 (es) *	2017-07-07	2022-10-24	Dsm Ip Assets Bv	Tabletas comprimidas que comprenden nitrooxicompuestos
KR102080023B1 (ko)	2018-01-29	2020-02-21	주식회사 종근당	에스오메프라졸 및 탄산수소나트륨을 포함하는 안정한 약제학적 조성물
KR102006777B1 (ko)	2018-01-29	2019-10-08	주식회사 종근당	에스오메프라졸 및 탄산수소나트륨을 포함하는 약제학적 제제
WO2020040438A1 (fr)	2018-08-23	2020-02-27	주식회사 종근당	Préparation pharmaceutique ayant d'excellentes propriétés de dissolution, contenant de l'ésoméprazole et du bicarbonate de sodium
BR112022001287A2 (pt) *	2019-07-26	2022-04-12	Chong Kun Dang Pharmaceutical Corp	Composição farmacêutica
KR102573842B1 (ko) *	2020-02-21	2023-09-01	주식회사 종근당	방출특성이 우수한 에스오메프라졸 및 탄산수소나트륨의 약제학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2189698A (en) *	1986-04-30	1987-11-04	Haessle Ab	Coated omeprazole tablets
US5622719A (en)	1993-09-10	1997-04-22	Fuisz Technologies Ltd.	Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
US6645988B2 (en) *	1996-01-04	2003-11-11	Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) *	1996-01-04	2004-03-02	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) *	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
DE60237087D1 (de) *	2001-06-01	2010-09-02	Pozen Inc	Pharmazeutische zusammensetzungen für die koordinierte abgabe von nsaid
AR045062A1 (es) *	2003-07-18	2005-10-12	Santarus Inc	Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas
US20050249806A1 (en) *	2004-02-10	2005-11-10	Santarus, Inc.	Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory drug
MXPA06011820A (es) *	2004-04-16	2006-12-15	Santarus Inc	Combinacion de inhibidor de bomba de proton, agente regulador del ph y agente procinetico.

2005
- 2005-05-25 CA CA2566655A patent/CA2566655C/fr not_active Expired - Fee Related
- 2005-05-25 JP JP2007515351A patent/JP2008500365A/ja active Pending
- 2005-05-25 EP EP05755940A patent/EP1750767A4/fr not_active Withdrawn
- 2005-05-25 MX MXPA06013585A patent/MXPA06013585A/es active IP Right Grant
- 2005-05-25 WO PCT/US2005/018585 patent/WO2005115474A1/fr not_active Ceased

Also Published As

Publication number	Publication date
JP2008500365A (ja)	2008-01-10
WO2005115474B1 (fr)	2006-02-23
MXPA06013585A (es)	2009-07-22
EP1750767A4 (fr)	2010-09-22
WO2005115474A1 (fr)	2005-12-08
EP1750767A1 (fr)	2007-02-14
CA2566655A1 (fr)	2005-12-08

Publication	Publication Date	Title
US20220133778A1 (en)	2022-05-05	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2005076987A2 (fr)	2005-08-25	Combinaison d'un inhibiteur de la pompe a protons, d'un tampon et d'un medicament anti-inflammatoire non steroidien
US20050239845A1 (en)	2005-10-27	Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US8906940B2 (en)	2014-12-09	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2531564C (fr)	2016-01-19	Formulations pharmaceutiques utilisees pour inhiber une secretion acide et procede de fabrication associe
US20050244517A1 (en)	2005-11-03	Combination of proton pump inhibitor and sleep aid
US20150202226A1 (en)	2015-07-23	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2004073654A2 (fr)	2004-09-02	Liberation immediate d'un complexe antacide d'omeprazole presentant une nouvelle formulation pour une elimination rapide et prolongee d'acide gastrique
CA2579177A1 (fr)	2006-03-23	Nouvelle formulation de complexe antiacide d'omeprazole a liberation immediate pour inhibition rapide et prolongee de la production d'acide gastrique
US20070292498A1 (en)	2007-12-20	Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
CA2566655C (fr)	2013-04-16	Formulations pharmaceutiques utiles pour inhiber la secretion d'acides et procedes correspondants de fabrication et d'utilisation
AU2011265561B2 (en)	2012-11-08	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2005331781B2 (en)	2011-09-29	Pharmaceutical formulations useful for inhibiting acid secretion
MXPA06009036A (en)	2007-04-10	Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent
AU2005204242A1 (en)	2005-09-29	A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid

Legal Events

Date	Code	Title	Description
2010-05-17	EEER	Examination request
2019-07-08	MKLA	Lapsed	Effective date: 20190527