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CA2411660C - Composes de promedicament a clivage enzymatique - Google Patents

Composes de promedicament a clivage enzymatique Download PDF

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Publication number
CA2411660C
CA2411660C CA2411660A CA2411660A CA2411660C CA 2411660 C CA2411660 C CA 2411660C CA 2411660 A CA2411660 A CA 2411660A CA 2411660 A CA2411660 A CA 2411660A CA 2411660 C CA2411660 C CA 2411660C
Authority
CA
Canada
Prior art keywords
seq
beta
leu
ala
oligopeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2411660A
Other languages
English (en)
Other versions
CA2411660A1 (fr
Inventor
Matthew H. Nieder
Vincent Dubois
Sanjeev Gangwar
Thomas J. Lobl
Lesley B. Pickford
Andre Trouet
Geoffrey T. Yarranton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
Medarex LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medarex LLC filed Critical Medarex LLC
Publication of CA2411660A1 publication Critical patent/CA2411660A1/fr
Application granted granted Critical
Publication of CA2411660C publication Critical patent/CA2411660C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ce promédicament est une forme modifiée d'un agent thérapeutique et comprend un agent thérapeutique, un oligopeptide, un groupe de stabilisation et éventuellement un groupe de liaison. Ce promédicament peut être clivé par la Thimet oligopeptidase, ou TOP. L'invention concerne également des procédés de conception de promédicaments comprenant l'introduction de séquences de clivage par TOP dans le conjugué, ainsi que des traitements comprenant l'administration des promédicaments décrits à des patients.
CA2411660A 2000-06-14 2001-06-11 Composes de promedicament a clivage enzymatique Expired - Fee Related CA2411660C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21188700P 2000-06-14 2000-06-14
US60/211,887 2000-06-14
US29044801P 2001-05-11 2001-05-11
US60/290,448 2001-05-11
PCT/US2001/018903 WO2001095945A2 (fr) 2000-06-14 2001-06-11 Composes de promedicament a clivage enzymatique

Publications (2)

Publication Number Publication Date
CA2411660A1 CA2411660A1 (fr) 2001-12-20
CA2411660C true CA2411660C (fr) 2011-03-01

Family

ID=26906558

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2411660A Expired - Fee Related CA2411660C (fr) 2000-06-14 2001-06-11 Composes de promedicament a clivage enzymatique

Country Status (5)

Country Link
EP (1) EP1294405A2 (fr)
JP (1) JP2004510703A (fr)
AU (2) AU2001271301B2 (fr)
CA (1) CA2411660C (fr)
WO (1) WO2001095945A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129261B2 (en) 2001-05-31 2006-10-31 Medarex, Inc. Cytotoxic agents
EP1404356B1 (fr) * 2001-06-11 2011-04-06 Medarex, Inc. Méthode pour concevoir des promédicaments activés par cd10
FR2858936A1 (fr) * 2003-08-22 2005-02-25 Diatos Potentialisation de l'activation de prodrogues de haut poids moleculaire
CA2564076C (fr) 2004-05-19 2014-02-18 Medarex, Inc. Bras de liaison chimiques et conjugues associes
EP2097097B1 (fr) 2006-12-01 2018-05-30 E. R. Squibb & Sons, L.L.C. Anticorps, en particulier anticorps humains, se liant a cd22 et utilisations de ceux-ci
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
NZ578354A (en) 2006-12-14 2012-01-12 Medarex Inc Antibody-partner molecule conjugates that bind cd70 and uses thereof
US9662308B2 (en) 2008-02-01 2017-05-30 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Orally bioavailable pentamidine prodrugs for the treatment of diseases
DE102008007381A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten
MX363522B (es) 2013-03-21 2019-03-26 Sanofi Aventis Deutschland Síntesis de productos peptídicos que contienen hidantoína.
MX365465B (es) 2013-03-21 2019-06-04 Sanofi Aventis Deutschland Sintesis de productos peptidicos que contienen imida ciclica.
EP4267188A1 (fr) 2020-12-22 2023-11-01 Cobiores NV Composés comprenant une fraction tétrapeptidique
WO2022167664A1 (fr) 2021-02-07 2022-08-11 Cobiores Nv Composés comprenant une fraction tétrapeptidique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT769967E (pt) * 1994-08-19 2008-02-18 Univ Catholique Louvain Conjugados que compreendem um agente antitumoral e a sua utilização
DE69942128D1 (de) * 1998-12-11 2010-04-22 Coulter Pharm Inc Prodrugs und verfahren zu deren herstellung

Also Published As

Publication number Publication date
AU7130101A (en) 2001-12-24
WO2001095945A2 (fr) 2001-12-20
AU2001271301B2 (en) 2006-08-31
WO2001095945A3 (fr) 2002-08-15
JP2004510703A (ja) 2004-04-08
CA2411660A1 (fr) 2001-12-20
EP1294405A2 (fr) 2003-03-26

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Legal Events

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EEER Examination request
MKLA Lapsed