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CA2332534A1 - Mass spectrometry with multipole ion guides - Google Patents

Mass spectrometry with multipole ion guides Download PDF

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Publication number
CA2332534A1
CA2332534A1 CA002332534A CA2332534A CA2332534A1 CA 2332534 A1 CA2332534 A1 CA 2332534A1 CA 002332534 A CA002332534 A CA 002332534A CA 2332534 A CA2332534 A CA 2332534A CA 2332534 A1 CA2332534 A1 CA 2332534A1
Authority
CA
Canada
Prior art keywords
ion
ion guide
fragmentation
mass
guide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002332534A
Other languages
French (fr)
Other versions
CA2332534C (en
Inventor
Craig M. Whitehouse
Bruce A. Andrien Jr.
Erol E. Gulcicek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2626383A priority Critical patent/CA2626383C/en
Publication of CA2332534A1 publication Critical patent/CA2332534A1/en
Application granted granted Critical
Publication of CA2332534C publication Critical patent/CA2332534C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A mass spectrometer (40) is configured with individual multipole ion guides (60, 62) configured in an assembly in alignment along a common centerline (5) wherein at least a portion of each multiple ion guide (60, 62) mounted in the assembly resides in a vacuum region (72, 73) with higher background pressure. Said multiple ion guides (60, 62) configured in a higher pressure vacuum region (72, 73) are operated in mass to charge selection and ion fragmentation modes.
Individual sets of RF, +/- DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multiple ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide (60, 62). The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multiple ion guide into an adjacent ion guide, analoguous to a triple quadruple ion function.
CA002332534A 1998-05-29 1999-05-29 Mass spectrometry with multipole ion guides Expired - Lifetime CA2332534C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2626383A CA2626383C (en) 1998-05-29 1999-05-29 Mass spectrometry with multipole ion guides

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8724698P 1998-05-29 1998-05-29
US60/087,246 1998-05-29
US23594699A 1999-01-22 1999-01-22
US09/235,946 1999-01-22
PCT/US1999/012169 WO1999062101A1 (en) 1998-05-29 1999-05-29 Mass spectrometry with multipole ion guides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2626383A Division CA2626383C (en) 1998-05-29 1999-05-29 Mass spectrometry with multipole ion guides

Publications (2)

Publication Number Publication Date
CA2332534A1 true CA2332534A1 (en) 1999-12-02
CA2332534C CA2332534C (en) 2008-07-22

Family

ID=26776766

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002332534A Expired - Lifetime CA2332534C (en) 1998-05-29 1999-05-29 Mass spectrometry with multipole ion guides
CA2626383A Expired - Lifetime CA2626383C (en) 1998-05-29 1999-05-29 Mass spectrometry with multipole ion guides

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2626383A Expired - Lifetime CA2626383C (en) 1998-05-29 1999-05-29 Mass spectrometry with multipole ion guides

Country Status (5)

Country Link
EP (1) EP1090412B1 (en)
JP (1) JP2002517070A (en)
AU (1) AU4326599A (en)
CA (2) CA2332534C (en)
WO (1) WO1999062101A1 (en)

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CA2326514A1 (en) * 2000-01-10 2001-07-10 Mds Inc. An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices
US6720554B2 (en) * 2000-07-21 2004-04-13 Mds Inc. Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
US6642514B2 (en) 2000-11-29 2003-11-04 Micromass Limited Mass spectrometers and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6956205B2 (en) 2001-06-15 2005-10-18 Bruker Daltonics, Inc. Means and method for guiding ions in a mass spectrometer
JP3620479B2 (en) * 2001-07-31 2005-02-16 株式会社島津製作所 Method of ion selection in ion storage device
AU2002350343A1 (en) 2001-12-21 2003-07-15 Mds Inc., Doing Business As Mds Sciex Use of notched broadband waveforms in a linear ion trap
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
GB2391697B (en) * 2002-05-30 2004-07-28 Micromass Ltd Mass spectrometer
US7095013B2 (en) 2002-05-30 2006-08-22 Micromass Uk Limited Mass spectrometer
WO2003102508A1 (en) 2002-05-31 2003-12-11 Analytica Of Branford, Inc. Mass spectrometry with segmented rf multiple ion guides in various pressure regions
US7034292B1 (en) 2002-05-31 2006-04-25 Analytica Of Branford, Inc. Mass spectrometry with segmented RF multiple ion guides in various pressure regions
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
WO2004068523A2 (en) * 2003-01-24 2004-08-12 Thermo Finnigan Llc Controlling ion populations in a mass analyzer
US6977371B2 (en) 2003-06-10 2005-12-20 Micromass Uk Limited Mass spectrometer
DE10326156B4 (en) * 2003-06-10 2011-12-01 Micromass Uk Ltd. Mass spectrometer with gas collision cell and AC or RF ion guide with differential pressure ranges and associated methods for mass spectrometry
DE102004014582B4 (en) * 2004-03-25 2009-08-20 Bruker Daltonik Gmbh Ion optical phase volume compression
JP2005276787A (en) * 2004-03-26 2005-10-06 Tsutomu Masujima Mass spectrometer
US20050242281A1 (en) * 2004-04-30 2005-11-03 Gangqiang Li Unevenly segmented multipole
GB0416288D0 (en) 2004-07-21 2004-08-25 Micromass Ltd Mass spectrometer
JP4848657B2 (en) * 2005-03-28 2011-12-28 株式会社島津製作所 MS / MS mass spectrometer
GB0506288D0 (en) * 2005-03-29 2005-05-04 Thermo Finnigan Llc Improvements relating to mass spectrometry
GB2427067B (en) 2005-03-29 2010-02-24 Thermo Finnigan Llc Improvements relating to ion trapping
JP5252205B2 (en) * 2006-01-05 2013-07-31 エムディーエス インコーポレイテッド Information-dependent collection triggered by mass defect
US7378653B2 (en) * 2006-01-10 2008-05-27 Varian, Inc. Increasing ion kinetic energy along axis of linear ion processing devices
GB0624679D0 (en) * 2006-12-11 2007-01-17 Shimadzu Corp A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer
US8507850B2 (en) * 2007-05-31 2013-08-13 Perkinelmer Health Sciences, Inc. Multipole ion guide interface for reduced background noise in mass spectrometry
JP2008108739A (en) * 2007-11-26 2008-05-08 Hitachi High-Technologies Corp Mass spectrometer and measurement system using the same
EP2245650A4 (en) * 2008-01-30 2015-11-18 Dh Technologies Dev Pte Ltd Ion fragmentation in mass spectrometry
GB2484136B (en) * 2010-10-01 2015-09-16 Thermo Fisher Scient Bremen Method and apparatus for improving the throughput of a charged particle analysis system
US9202679B2 (en) 2010-11-26 2015-12-01 Analytik Jena Ag Electrically connected sample interface for mass spectrometer
JP2011119279A (en) * 2011-03-11 2011-06-16 Hitachi High-Technologies Corp Mass spectrometer, and measuring system using the same
CA2863300A1 (en) * 2012-02-01 2013-08-08 Dh Technologies Development Pte. Ltd. Method and apparatus for improved sensitivity in a mass spectrometer
WO2014197348A2 (en) * 2013-06-03 2014-12-11 Perkinelmer Health Sciences, Inc. Ion guide or filters with selected gas conductance
GB201715777D0 (en) * 2017-09-29 2017-11-15 Shimadzu Corp ION Trap
KR102305532B1 (en) * 2020-03-04 2021-09-27 한국원자력안전기술원 Qualitative and quantitative analysis apparatus and method for inert gas
CN111640646A (en) * 2020-06-15 2020-09-08 成都艾立本科技有限公司 High-sensitivity proton transfer time-of-flight mass spectrometer and method for measuring ion time-of-flight by using same
CN111613514B (en) * 2020-06-24 2023-11-03 成都艾立本科技有限公司 High-sensitivity ultraviolet ionization time-of-flight mass spectrometer and ion time-of-flight measurement method
WO2022239104A1 (en) * 2021-05-11 2022-11-17 株式会社島津製作所 Orthogonal acceleration time-of-flight mass spectrometer
US11501962B1 (en) * 2021-06-17 2022-11-15 Thermo Finnigan Llc Device geometries for controlling mass spectrometer pressures
GB202114780D0 (en) * 2021-10-15 2021-12-01 Thermo Fisher Scient Bremen Gmbh Ion transport between ion optical devices at different gas pressures

Family Cites Families (11)

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US4328420A (en) 1980-07-28 1982-05-04 French John B Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system
EP0237259A3 (en) * 1986-03-07 1989-04-05 Finnigan Corporation Mass spectrometer
US5179278A (en) * 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
CA2656956C (en) 1994-02-28 2011-10-11 Analytica Of Branford, Inc. Multipole ion guide for mass spectrometry
US6011259A (en) * 1995-08-10 2000-01-04 Analytica Of Branford, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSN analysis
DE19511333C1 (en) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer
JP3361528B2 (en) * 1995-07-03 2003-01-07 株式会社 日立製作所 Mass spectrometer
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AU2334199A (en) * 1998-01-23 1999-08-09 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guide

Also Published As

Publication number Publication date
CA2332534C (en) 2008-07-22
EP1090412A1 (en) 2001-04-11
WO1999062101A1 (en) 1999-12-02
CA2626383A1 (en) 1999-12-02
JP2002517070A (en) 2002-06-11
WO1999062101A9 (en) 2000-03-02
EP1090412B1 (en) 2014-03-05
AU4326599A (en) 1999-12-13
CA2626383C (en) 2011-07-19
EP1090412A4 (en) 2006-01-25

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Effective date: 20190529