CA2349069C - Accumulateur cryogenique pour xenon 129 polarise par spin - Google Patents
Accumulateur cryogenique pour xenon 129 polarise par spin Download PDFInfo
- Publication number
- CA2349069C CA2349069C CA002349069A CA2349069A CA2349069C CA 2349069 C CA2349069 C CA 2349069C CA 002349069 A CA002349069 A CA 002349069A CA 2349069 A CA2349069 A CA 2349069A CA 2349069 C CA2349069 C CA 2349069C
- Authority
- CA
- Canada
- Prior art keywords
- gas
- hyperpolarized
- accumulation
- polarization
- xenon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- FHNFHKCVQCLJFQ-YPZZEJLDSA-N xenon-129 atom Chemical compound [129Xe] FHNFHKCVQCLJFQ-YPZZEJLDSA-N 0.000 title abstract 7
- 238000000034 method Methods 0.000 claims abstract description 84
- 230000002102 hyperpolarization Effects 0.000 claims abstract description 64
- 238000003384 imaging method Methods 0.000 claims abstract description 10
- 239000007789 gas Substances 0.000 claims description 212
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 32
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
- 230000005291 magnetic effect Effects 0.000 claims description 21
- 238000011049 filling Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 3
- 238000009825 accumulation Methods 0.000 abstract description 92
- 238000003860 storage Methods 0.000 abstract description 20
- 238000002595 magnetic resonance imaging Methods 0.000 abstract description 10
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- 241001465754 Metazoa Species 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 230000010287 polarization Effects 0.000 description 82
- 238000005086 pumping Methods 0.000 description 73
- 229910052724 xenon Inorganic materials 0.000 description 69
- 210000004027 cell Anatomy 0.000 description 68
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 67
- 150000001340 alkali metals Chemical class 0.000 description 52
- 229910052783 alkali metal Inorganic materials 0.000 description 48
- 229910052756 noble gas Inorganic materials 0.000 description 47
- 230000003287 optical effect Effects 0.000 description 44
- 229910052734 helium Inorganic materials 0.000 description 26
- 229910052701 rubidium Inorganic materials 0.000 description 26
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 26
- 238000005481 NMR spectroscopy Methods 0.000 description 23
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 22
- 239000001307 helium Substances 0.000 description 21
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
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- 239000012535 impurity Substances 0.000 description 7
- 239000006200 vaporizer Substances 0.000 description 7
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 6
- 230000028161 membrane depolarization Effects 0.000 description 6
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000004429 atom Chemical group 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- 230000000155 isotopic effect Effects 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 238000000711 polarimetry Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
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- 230000003647 oxidation Effects 0.000 description 2
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- 239000001301 oxygen Substances 0.000 description 2
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- 229920006395 saturated elastomer Polymers 0.000 description 2
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- XMTQQYYKAHVGBJ-UHFFFAOYSA-N 3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA Chemical compound CN(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1 XMTQQYYKAHVGBJ-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000005354 aluminosilicate glass Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
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- 239000005388 borosilicate glass Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
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- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
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- 230000002999 depolarising effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
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- 239000007792 gaseous phase Substances 0.000 description 1
- 238000005247 gettering Methods 0.000 description 1
- 238000007511 glassblowing Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
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- 230000031700 light absorption Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
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- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
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- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012549 training Methods 0.000 description 1
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Landscapes
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/622,865 US5809801A (en) | 1996-03-29 | 1996-03-29 | Cryogenic accumulator for spin-polarized xenon-129 |
| US08/622,865 | 1996-03-29 | ||
| CA002250167A CA2250167C (fr) | 1996-03-29 | 1997-03-27 | Accumulateur cryogenique pour xenon 129 polarise par spin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002250167A Division CA2250167C (fr) | 1996-03-29 | 1997-03-27 | Accumulateur cryogenique pour xenon 129 polarise par spin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2349069A1 CA2349069A1 (fr) | 1997-10-09 |
| CA2349069C true CA2349069C (fr) | 2002-09-24 |
Family
ID=25680562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002349069A Expired - Fee Related CA2349069C (fr) | 1996-03-29 | 1997-03-27 | Accumulateur cryogenique pour xenon 129 polarise par spin |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2349069C (fr) |
-
1997
- 1997-03-27 CA CA002349069A patent/CA2349069C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2349069A1 (fr) | 1997-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130327 |