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CA2299300C - Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase - Google Patents

Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase Download PDF

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Publication number
CA2299300C
CA2299300C CA002299300A CA2299300A CA2299300C CA 2299300 C CA2299300 C CA 2299300C CA 002299300 A CA002299300 A CA 002299300A CA 2299300 A CA2299300 A CA 2299300A CA 2299300 C CA2299300 C CA 2299300C
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Canada
Prior art keywords
phenyl
pharmaceutically acceptable
group
ester
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA002299300A
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English (en)
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CA2299300A1 (fr
Inventor
Lawrence A. Black
Anwer Basha
Teodozyj Kolasa
Michael E. Kort
Huaqing Liu
Catherine M. Mccarty
Meena V. Patel
Jeffrey J. Rohde
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Abbott Laboratories
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Abbott Laboratories
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Priority to CA002578858A priority Critical patent/CA2578858A1/fr
Publication of CA2299300A1 publication Critical patent/CA2299300A1/fr
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Publication of CA2299300C publication Critical patent/CA2299300C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur des composés de pyridazinone inhibiteurs de la cyclo-oxygénase (COX) et en particulier inhibiteurs sélectifs de la cyclo-oxygénase-2 (COX-2), laquelle représente l'isoforme inductible associée à l'inflammation par opposition à l'isoforme constitutive, la cyclo-oxygénase-1 (COX-1), qui est une importante enzyme "ménagère" présente dans beaucoup de tissus, y compris les voies digestives (GI) et les reins. La sélectivité desdits composés vis-à-vis du COX-2 réduit les effets secondaires indésirables affectant les voies digestives (GI) et les reins observés avec les anti-inflammatoires non stéroïdiens (NSAID) actuellement sur le marché.
CA002299300A 1997-08-22 1998-08-10 Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase Expired - Fee Related CA2299300C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002578858A CA2578858A1 (fr) 1997-08-22 1998-08-10 Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91702397A 1997-08-22 1997-08-22
US08/917,023 1997-08-22
PCT/US1998/016479 WO1999010331A1 (fr) 1997-08-22 1998-08-10 Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002578858A Division CA2578858A1 (fr) 1997-08-22 1998-08-10 Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase

Publications (2)

Publication Number Publication Date
CA2299300A1 CA2299300A1 (fr) 1999-03-04
CA2299300C true CA2299300C (fr) 2007-04-17

Family

ID=25438243

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002299300A Expired - Fee Related CA2299300C (fr) 1997-08-22 1998-08-10 Arylpyridazinones inhibitrices de la biosynthese de la prostaglandine endoperoxyde h synthase

Country Status (8)

Country Link
EP (1) EP1007515A1 (fr)
BR (1) BR9812127A (fr)
CA (1) CA2299300C (fr)
CO (1) CO4970740A1 (fr)
SA (1) SA98190764B1 (fr)
TW (1) TWI232216B (fr)
WO (1) WO1999010331A1 (fr)
ZA (1) ZA987555B (fr)

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US6307047B1 (en) * 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) * 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
AU738595B2 (en) 1997-11-19 2001-09-20 Kowa Co., Ltd. Novel pyridazine derivatives and medicines containing the same as effective ingredients
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
AU756275B2 (en) 1998-08-14 2003-01-09 Nihon Nohyaku Co., Ltd. Pyridazinone derivatives
HUP0105248A3 (en) * 1998-10-27 2002-09-30 Abbott Lab Prostaglandin endoperoxide h synthase biosynthesis inhibitors pyridazinone-derivatives, pharmaceutical compositions containing them as active inaredient and process for preparation the compounds
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
JP2000247959A (ja) 1999-02-26 2000-09-12 Kowa Co ピリダジン−３−オン誘導体及びこれを含有する医薬
PT1175214E (pt) 1999-12-08 2005-04-29 Pharmacia Corp Composicoes de inibidor de ciclo-oxigenase-2 com um inicio rapido do seu efito terapeutico
CA2393724A1 (fr) 1999-12-23 2001-06-28 Nitromed, Inc. Inhibiteurs de cyclooxygenase-2 nitroses et nitrosyles, compositions et procedes d'utilisation
US6664256B1 (en) 2000-07-10 2003-12-16 Kowa Co., Ltd. Phenylpyridazine compounds and medicines containing the same
ITMI20010733A1 (it) 2001-04-05 2002-10-05 Recordati Chem Pharm Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
JP2005519895A (ja) * 2002-01-18 2005-07-07 ファルマシア・コーポレーション Ｐ３８阻害剤としての置換ピリダジノン
WO2004002420A2 (fr) 2002-06-28 2004-01-08 Nitromed, Inc. Inhibiteurs a selectivite cyclooxygenase-2 nitrosiles et/ou nitroses contenant une oxime et/ou une hydrazone, compositions et methodes d'utilisation correspondantes
EP1604984A1 (fr) 2003-03-18 2005-12-14 Kowa Co., Ltd. Derive de phenylpyridazine soluble dans l'eau et medicament contenant ce derive
PL1534305T3 (pl) 2003-05-07 2007-03-30 Osteologix As Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
WO2005007632A1 (fr) * 2003-07-18 2005-01-27 Pharmacia Corporation Pyridazinones substituees utiles comme inhibiteurs de p38
WO2005121104A1 (fr) 2004-06-09 2005-12-22 Sumitomo Chemical Company, Limited Composé pyridazine et utilisation de celui-ci
EP1775290B1 (fr) 2004-06-28 2010-11-17 Sumitomo Chemical Company, Limited Compose de pyridazine et son utilisation
EP1928454B1 (fr) 2005-05-10 2014-09-24 Intermune, Inc. Derives du pyridone destines a la modulation du systeme de kinase proteinique active par le stress
BRPI0616655A2 (pt) 2005-10-03 2011-06-28 Ono Pharmaceutical Co composto heterocìclico contendo nitrogênio e aplicação farmacêutica do mesmo
DK1958948T3 (da) 2005-12-07 2011-10-31 Sumitomo Chemical Co Pyridazinforbindelse og anvendelse deraf
WO2007066601A1 (fr) 2005-12-07 2007-06-14 Sumitomo Chemical Company, Limited Compose de pyridazine et son emploi
DE102007008840A1 (de) * 2007-02-23 2008-08-28 Bayer Healthcare Ag Neue polymorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-methyl-1-butoxy)-5-[4-methylsulfonyl)phenyl]-3(2H)-pyridazinon (FHMP)
DE102007008843A1 (de) 2007-02-23 2008-08-28 Bayer Healthcare Ag Verfahren zur Herstellung von 4,5-Dihalogen-2-aryl-2H-pyridazin-3-onen
DE102007008839A1 (de) 2007-02-23 2008-08-28 Bayer Healthcare Ag Verfahren zur Herstellung von 4-(3-Hydroxy-3-methyl-butoxy)-5-[4-(methylsulfonyl)phenyl]-2-arylpyridazin-3(2H)-onen
DE102007020690A1 (de) * 2007-05-03 2008-11-06 Bayer Healthcare Ag Neue amorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-mehtyl-1-butoxy)-6[4-methylsulfonyl)phenyl]-3(2H)-pyridazinon (FHMP)
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IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES

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Also Published As

Publication number Publication date
CA2299300A1 (fr) 1999-03-04
BR9812127A (pt) 2000-07-18
TWI232216B (en) 2005-05-11
EP1007515A1 (fr) 2000-06-14
CO4970740A1 (es) 2000-11-07
SA98190764B1 (ar) 2006-08-06
WO1999010331A1 (fr) 1999-03-04
ZA987555B (en) 1999-02-23

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