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CA2283210A1 - Method and apparatus for removal of non-uniformities in an electrophoresis apparatus - Google Patents

Method and apparatus for removal of non-uniformities in an electrophoresis apparatus Download PDF

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Publication number
CA2283210A1
CA2283210A1 CA002283210A CA2283210A CA2283210A1 CA 2283210 A1 CA2283210 A1 CA 2283210A1 CA 002283210 A CA002283210 A CA 002283210A CA 2283210 A CA2283210 A CA 2283210A CA 2283210 A1 CA2283210 A1 CA 2283210A1
Authority
CA
Canada
Prior art keywords
uniformities
removal
another aspect
electrophoresis
electrophoresis apparatus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002283210A
Other languages
French (fr)
Other versions
CA2283210C (en
Inventor
David M. Heffelfinger
Craig Van Horn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/814,125 external-priority patent/US5799773A/en
Priority claimed from US08/814,812 external-priority patent/US5891314A/en
Priority claimed from US08/814,127 external-priority patent/US5897760A/en
Application filed by Individual filed Critical Individual
Priority to CA002509470A priority Critical patent/CA2509470C/en
Priority to CA002509461A priority patent/CA2509461C/en
Publication of CA2283210A1 publication Critical patent/CA2283210A1/en
Application granted granted Critical
Publication of CA2283210C publication Critical patent/CA2283210C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A method and apparatus for correcting the non-uniformities in the lens assembly of an electrophoresis apparatus is provided.
In one aspect, a look-up table is created based on non-uniformities at different aperture and magnification settings (Figure 5). In another aspect, a calibration standard with a uniform emittance is used to correct non-uniformities. In yet another aspect, a beam splitter or minor is used to create a correction data file for non-uniformities in the light source.
CA002283210A 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus Expired - Fee Related CA2283210C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002509470A CA2509470C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus
CA002509461A CA2509461C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/814,812 1997-03-10
US08/814,127 1997-03-10
US08/814,125 US5799773A (en) 1997-03-10 1997-03-10 Method and apparatus for correcting lens and detector non-uniformities
US08/814,125 1997-03-10
US08/814,812 US5891314A (en) 1997-03-10 1997-03-10 Method and apparatus for correcting lens non-uniformities in an electrophoresis apparatus
US08/814,127 US5897760A (en) 1997-03-10 1997-03-10 Method and apparatus for the removal of non-uniformities in an electrophoresis apparatus
PCT/US1998/003872 WO1998040730A1 (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA002509470A Division CA2509470C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus
CA002509461A Division CA2509461C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus

Publications (2)

Publication Number Publication Date
CA2283210A1 true CA2283210A1 (en) 1998-09-17
CA2283210C CA2283210C (en) 2006-07-04

Family

ID=27420092

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002509461A Expired - Fee Related CA2509461C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus
CA002283210A Expired - Fee Related CA2283210C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus
CA002509470A Expired - Fee Related CA2509470C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002509461A Expired - Fee Related CA2509461C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002509470A Expired - Fee Related CA2509470C (en) 1997-03-10 1998-02-26 Method and apparatus for removal of non-uniformities in an electrophoresis apparatus

Country Status (4)

Country Link
EP (1) EP0966674A4 (en)
JP (4) JP3696624B2 (en)
CA (3) CA2509461C (en)
WO (1) WO1998040730A1 (en)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5582025A (en) * 1978-12-16 1980-06-20 Japan Spectroscopic Co Spectrophotometer of sample alternate measurement type
JPS6250641A (en) * 1985-08-30 1987-03-05 Hitachi Ltd Analyzing instrument having absorption spectrophotometer
US4737464A (en) * 1985-09-26 1988-04-12 Molecular Devices Corporation Solid-state optical assay imaging apparatus
US4781464A (en) * 1986-04-14 1988-11-01 Isco, Inc. Gel scanner
US5147522A (en) * 1987-03-16 1992-09-15 Helena Laboratories Corporation Automatic electrophoresis apparatus and method
US4960999A (en) * 1989-02-13 1990-10-02 Kms Fusion, Inc. Scanning and storage of electrophoretic records
US5307148A (en) * 1990-04-05 1994-04-26 Hitachi, Ltd. Fluorescence detection type electrophoresis apparatus
WO1993018182A1 (en) * 1992-03-09 1993-09-16 Difco Laboratories Diagnostic microbiological testing apparatus and method
DE4244825C2 (en) * 1992-06-06 1997-06-05 Hermann Prof Dr Bauer Electrophoretic capillary appts. for analysing protein fractions, etc.
EP0626578B1 (en) * 1993-05-26 1998-07-29 Hitachi Electronics Engineering Co., Ltd. Apparatus for gel electrophoresis
US5672881A (en) * 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
US5670375A (en) * 1996-02-21 1997-09-23 Biomerieux Vitek, Inc. Sample card transport method for biological sample testing machine

Also Published As

Publication number Publication date
JP2004163441A (en) 2004-06-10
JP2004163440A (en) 2004-06-10
CA2509461C (en) 2007-07-31
JP2004226414A (en) 2004-08-12
WO1998040730A1 (en) 1998-09-17
JP4119383B2 (en) 2008-07-16
CA2283210C (en) 2006-07-04
JP3696624B2 (en) 2005-09-21
CA2509470C (en) 2006-11-07
JP4119384B2 (en) 2008-07-16
CA2509470A1 (en) 1998-09-17
CA2509461A1 (en) 1998-09-17
EP0966674A1 (en) 1999-12-29
EP0966674A4 (en) 2001-09-12
JP4119382B2 (en) 2008-07-16
JP2001514758A (en) 2001-09-11

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EEER Examination request
MKLA Lapsed

Effective date: 20180226