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CA2273322A1 - Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer - Google Patents

Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer Download PDF

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Publication number
CA2273322A1
CA2273322A1 CA002273322A CA2273322A CA2273322A1 CA 2273322 A1 CA2273322 A1 CA 2273322A1 CA 002273322 A CA002273322 A CA 002273322A CA 2273322 A CA2273322 A CA 2273322A CA 2273322 A1 CA2273322 A1 CA 2273322A1
Authority
CA
Canada
Prior art keywords
desolvating
mass spectrometer
ions
introduction
focussing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002273322A
Other languages
French (fr)
Other versions
CA2273322C (en
Inventor
Roger Guevremont
Randy W. Purves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2273322A1 publication Critical patent/CA2273322A1/en
Application granted granted Critical
Publication of CA2273322C publication Critical patent/CA2273322C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

This invention provides an apparatus and method for desolvating and selectively transmitting and focussing ions, including ions produced by electrospray ionization (ESI), based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry (FAIMS), for introduction into a mass spectrometer. The ion focussing, trapping and desolvating effects of FAIMS, as identified by the inventors, provides high ion transmission efficiency and high sensitivity for the detection of ions. An apparatus comprising an ESI source, a FAIMS device and a mass spectrometer provides a way of desolvating and selectively transmitting highly solvated ions for introduction into a mass spectrometer for analysis.
CA002273322A 1998-08-05 1999-05-28 Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer Expired - Fee Related CA2273322C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9548198P 1998-08-05 1998-08-05
US60/095,481 1998-08-05

Publications (2)

Publication Number Publication Date
CA2273322A1 true CA2273322A1 (en) 2000-02-05
CA2273322C CA2273322C (en) 2008-11-18

Family

ID=29581955

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002260572A Abandoned CA2260572A1 (en) 1998-08-05 1999-01-29 Apparatus and method for atmospheric pressure 3-dimensional ion trapping
CA002273322A Expired - Fee Related CA2273322C (en) 1998-08-05 1999-05-28 Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002260572A Abandoned CA2260572A1 (en) 1998-08-05 1999-01-29 Apparatus and method for atmospheric pressure 3-dimensional ion trapping

Country Status (1)

Country Link
CA (2) CA2260572A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006103465A3 (en) * 2005-04-01 2007-10-25 Micromass Ltd Mass spectrometer
WO2007123464A1 (en) * 2006-04-20 2007-11-01 Axel Mie Method for separation of molecules
US7820966B2 (en) 2005-04-01 2010-10-26 Waters Technologies Corporation Mass spectrometer
US10724990B2 (en) 2004-11-04 2020-07-28 Micromass Uk Limited Mass spectrometer

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113358943B (en) * 2021-04-30 2023-03-14 上海工程技术大学 Oil flow electrification measuring device and full-section charge measuring method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10724990B2 (en) 2004-11-04 2020-07-28 Micromass Uk Limited Mass spectrometer
WO2006103465A3 (en) * 2005-04-01 2007-10-25 Micromass Ltd Mass spectrometer
US7820966B2 (en) 2005-04-01 2010-10-26 Waters Technologies Corporation Mass spectrometer
WO2007123464A1 (en) * 2006-04-20 2007-11-01 Axel Mie Method for separation of molecules
US8563322B2 (en) 2006-04-20 2013-10-22 Axel Mie Method for separation of molecules

Also Published As

Publication number Publication date
CA2273322C (en) 2008-11-18
CA2260572A1 (en) 2000-02-05

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MKLA Lapsed

Effective date: 20140528