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CA1338319C - Derives de la cyclosporine avec 8-aminoacide modifie - Google Patents

Derives de la cyclosporine avec 8-aminoacide modifie

Info

Publication number
CA1338319C
CA1338319C CA 585752 CA585752A CA1338319C CA 1338319 C CA1338319 C CA 1338319C CA 585752 CA585752 CA 585752 CA 585752 A CA585752 A CA 585752A CA 1338319 C CA1338319 C CA 1338319C
Authority
CA
Canada
Prior art keywords
alanine
fluoro
deutero
cyclosporin
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 585752
Other languages
English (en)
Inventor
Arthur A. Patchett
Raymond F. White
Robert T. Goegelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1338319C publication Critical patent/CA1338319C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA 585752 1987-06-22 1988-12-13 Derives de la cyclosporine avec 8-aminoacide modifie Expired - Fee Related CA1338319C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6467487A 1987-06-22 1987-06-22
US064,674 1987-06-22

Publications (1)

Publication Number Publication Date
CA1338319C true CA1338319C (fr) 1996-05-07

Family

ID=22057543

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 585752 Expired - Fee Related CA1338319C (fr) 1987-06-22 1988-12-13 Derives de la cyclosporine avec 8-aminoacide modifie

Country Status (2)

Country Link
CA (1) CA1338319C (fr)
GB (1) GB2206119B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
CH679119A5 (fr) * 1988-05-13 1991-12-31 Sandoz Ag
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2227244A (en) * 1989-01-19 1990-07-25 Merck & Co Inc Immunosuppressive fluorinated cyclosporin analogs
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (fr) 1992-05-13 1997-01-15 Sandoz Ltd. Compositions ophtalmiques contenant une cyclosporine
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
WO1994025606A2 (fr) * 1993-04-23 1994-11-10 Sandoz Ltd. Alanine racemase et gapdh du tolypocladium niveum recombines
EP0789580B1 (fr) 1994-11-03 2002-06-05 Novartis AG Nouvelles formes de preparations de cycylosporines pour administration par voie orale, de composition simple et haute biodisponibilite, et leur procede de production
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
KR20000069900A (ko) 1997-01-30 2000-11-25 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
ES2266564T3 (es) 2001-10-19 2007-03-01 Isotechnika Inc. Sintesis de analogos de cicloporinas.
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
AU2010208071C1 (en) 2009-01-30 2013-06-20 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
WO2012145426A1 (fr) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Procédés pour traiter un cancer utilisant la cyclosporine et des dérivés de cyclosporine
WO2014085623A1 (fr) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Nouveaux analogues de [n-me-4-hydroxyleucine]-9-cyclosporine
KR20160045136A (ko) 2013-08-26 2016-04-26 이난타 파마슈티칼스, 인코포레이티드 C형 간염을 예방 또는 치료하기 위한 사이클로스포린 유사체
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (fr) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporines

Also Published As

Publication number Publication date
GB2206119B (en) 1990-10-31
GB2206119A (en) 1988-12-29
GB8814598D0 (en) 1988-07-27

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