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CA1114381A - Process for production of indole derivatives - Google Patents

Process for production of indole derivatives

Info

Publication number
CA1114381A
CA1114381A CA307,174A CA307174A CA1114381A CA 1114381 A CA1114381 A CA 1114381A CA 307174 A CA307174 A CA 307174A CA 1114381 A CA1114381 A CA 1114381A
Authority
CA
Canada
Prior art keywords
alkyl
formula
compound
hydrogen
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA307,174A
Other languages
English (en)
French (fr)
Inventor
Franz Troxler
Paul Stadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1114381A publication Critical patent/CA1114381A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA307,174A 1977-07-12 1978-07-11 Process for production of indole derivatives Expired CA1114381A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH858977 1977-07-12
CH8589/77 1977-07-12
CH300878 1978-03-20
CH3008/78 1978-03-20

Publications (1)

Publication Number Publication Date
CA1114381A true CA1114381A (en) 1981-12-15

Family

ID=25691930

Family Applications (1)

Application Number Title Priority Date Filing Date
CA307,174A Expired CA1114381A (en) 1977-07-12 1978-07-11 Process for production of indole derivatives

Country Status (14)

Country Link
EP (1) EP0000355B1 (da)
JP (1) JPS5436259A (da)
AU (1) AU521641B2 (da)
CA (1) CA1114381A (da)
DE (1) DE2861502D1 (da)
DK (1) DK300978A (da)
ES (1) ES471593A1 (da)
FI (1) FI782138A7 (da)
IE (1) IE47209B1 (da)
IL (1) IL55116A (da)
IT (1) IT7850140A0 (da)
NZ (1) NZ187813A (da)
PH (1) PH14993A (da)
PT (1) PT68270A (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003901B1 (en) * 1978-02-24 1981-08-05 Pfizer Limited 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
US4634713A (en) * 1982-05-28 1987-01-06 Ciba-Geigy Corporation Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives
JPH0283380A (ja) * 1988-09-21 1990-03-23 Kotobuki Seiyaku Kk 新規ジアミン誘導体、抗不整脈剤及びその製法
FR2642422A1 (fr) * 1988-12-22 1990-08-03 Roussel Uclaf Nouvelles polyamines acylees, leur procede de preparation et leur application comme fongicides
DE69430861T2 (de) * 1993-04-07 2003-01-23 Otsuka Pharmaceutical Co., Ltd. N-acylierte 4-aminopiperidin derivate als aktive bestandteile von peripher gefässerweiternden wikstoffen
MY142362A (en) 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
US11764679B2 (en) 2020-01-15 2023-09-19 Solaredge Technologies Ltd. Power device
CN116478134B (zh) * 2022-01-17 2025-07-25 上海医药工业研究院有限公司 Ssri/5-ht1a双靶点抗抑郁甲酰哌啶类化合物及其制备方法和应用
CN115433164B (zh) * 2022-09-14 2023-12-12 南京师范大学 烟酰胺衍生物及其制备方法和在抗衰老延长寿命中的应用

Also Published As

Publication number Publication date
PH14993A (en) 1982-03-22
DK300978A (da) 1979-01-13
IL55116A (en) 1982-02-28
IT7850140A0 (it) 1978-07-03
AU3793978A (en) 1980-01-17
ES471593A1 (es) 1979-10-01
DE2861502D1 (en) 1982-02-25
IL55116A0 (en) 1978-09-29
NZ187813A (en) 1981-03-16
PT68270A (en) 1978-08-01
FI782138A7 (fi) 1979-01-13
JPS5436259A (en) 1979-03-16
IE781382L (en) 1979-01-12
AU521641B2 (en) 1982-04-22
EP0000355A1 (en) 1979-01-24
IE47209B1 (en) 1984-01-11
EP0000355B1 (en) 1982-01-06

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Legal Events

Date Code Title Description
MKEX Expiry