CA1155140A - Production of thiophenol - Google Patents

Abstract

PRODUCTION OF THIOPHENOL

ABSTRACT OF THE INVENTION
A process for the production of a thiophenol which consists of reacting hydrogen sulfide and a source of hydrogen with a halogenated aromatic compound. The process produces high yields of thiophenol with low quantities of byproduct aromatic thioethers, particularly diphenyl disulfide.

Description

1155i40 PRODUCTION OF THIOPHENOL

BACKGROUND OF THE INVENTION

1. Fie}d of the Invention This invention relates to a process for the production of a thiophenol, and more particularly to the production of a thiophenol by the vapor phase reaction of hydrogen sulfide and a halogenated aromatic compound to produce high yields of thio-phenol with low quantities of byproduct aromatic thioethers.
Thiophenols are useful as additives to lubricating oils, as intermediates in organic synthesis, as insecticides, fungicides and para-siticides and as ingredients of insecticidal, fungicidal and parasiticidal compositions, and they are useful ~n the preparation of synthetic resinfi, rubber, vulcanization accelerators, and the like.

2. Prior Art .
U.S. Patent 2,490,257 to Crowley et al.
describes the production of thiophenols by the vapor phase reaction of chlorobenzene and hydrogen sulfide in the presence of a catalyst, such as wood charcoal or alumina.

.

:llS5140 Japanese Patent 1970-19046 describes the production of thiophenols by the vapor phase reaction of chlorobenzene with hydrogen sulfide in the presence of a catalyst of a sulfide of Cu, Ag, Zn, Cd, Pd, Bi, Co or Mo supported on activated carbon.
Both of these processes suffer from low yields of thiophenol due to the fact that by-product aromatic thioethers, such as diphenyl sulfide and diphenyl disulfide, are produced.
Attempts to reduce the amounts of such byproducts and increase thiophenol yields have been made.
For example, V.S. Patent 3,799,989 to Sherk et al.
describes the production of thiophenol by the vapor phase reaction of chlorobenzene and hydrogen sulfide in a reaction zone containing a non-catalytic filler. The byproduct diphenyl sulfide formed during the reaction is subsequently converted to additional quantities of thiophenol by separating the diphenyl sulfide from the product stream and returning it to the reaction zone for cleavage to thiophenol in the presence of the reactant hydrogen sulfide. Japanese Patent 1971-8293 also describes the vapor phase reaction of chlorobenzene with hydrogen sulfide, but in the presence of a cataly8t, suah as activated charcoal or alumina, and also recycles the diphenyl sulfide to the reaction zone.

llS5~40 -

3 --The aforementioned processes for increasing the yield of thiophenol and reducing the quantity of byproduct aromatic thioethers are not ideal for they involve the complex and costly separation of the byproduct diphenyl sulfide from the thiophenol, the constant recycling of such products, and such processes do not convert the byproduct diphenyl disulfide to thiophenol.
Attempts have been made to convert the byproduc~t diphenyl disulfide to thiophenol but such attempts generally require additional process equipment and result in disposal problems for other byproducts.
It is also known in the art from U.S.
Patent 2,402,686 to Signaiqo that aromatic thio-ethers in the presence of a sulphactive hydro-genation catalyst, e.g. sulphides of iron, nickel, cobalt, copper, etc. may be hydrogenated to thio-phenol. Si~n igo indicates that it is preferred to use hydrogen gas in substantially pure form as the reducing agent, however, hydrogen admixed with hydrogen sulfide may also be used. Additionally of interest is the fact that U.S. Patent 2,506,416 to Gilbert et al. describes the reduction of a diaryl polysulfide, i.e. diphenyl di~ulfide, by heating in the presence of a petroleum hydrocarbon to produce the thlophenolJ and U.S. Patent ~ .

3,994,980 to Kubicek describes a process for the preparation of a mercaptan by reacting an organic compound containing a carbonyl group with a sulfur source such as hydrogen sulfide in the presence of a specific catalyst. Kubicek states that "more satisfactory results are achieved when hydrogen is also used". None of these references, however, teach or suggest reacting hydrogen sulfide and a source of hydrogen with a halogenated aromatic compound, particularly chlorobenzene, preferably under vapor phase conditions, to produce a thiophenol.
SUMMARY OF THE INVENTION
_ Accordingly, it is an object of this invention to provide a process for the conversion of a halogenated aromatic compound, e.g. chloro-benzene, to a thiophenol, specifically thiophenol, in high yields and with low quantities of byproduct aromatic thioethers~ particularly diphenyl disulfide.
It is a further object of this invention to considerably reduce the cost and problems associated with the separation of byproduct aromatic thioethers, e.g. diphenyl sulfide and diphenyl disulfide, from the product stream produced from the reaction of a halogenated aromatic compound with hydrogen sulfide.
It i8 a further ob~ect of this invention to provide a process for the production of thio-phenols which can be conducted in a batch or continuous manner.

1155~40 " ( - s ~

These and other objects and advantages of this invention will become apparent from the following Detailed Description.
According to the present invention, hydrogen sulfide and a source of hydrogen are reacted with a halogenated aromatic compound to produce a thiophenol. The thiophenol is produced in high yields with low quantities of byproduct aromatic thioethers, particularly diphenyl disulfide.
DETAILED DESCRIPTION OF THE INVENTION
-The process of this invention, broadly, is an improvement over well known processes for producing a thiophenol by the reaction of a halogen-ated aromatic compound with hydrogen sulfide. The process of this invention may be accomplished with the same reactants, i.e. halogenated aromatic compounds, under the same conditions of reaction, e.g. temper-ature, pre~sure, etc., using the same catalysts to produce the same thiophenols as these well known processes. Preferably, the process of this invention is a vapor phase reaction process.
The proces~ of this invention may also be utilized in conjunction with any of the other well known processes which recycle the byproduct impur-itie~, e.g. byproduct aromatic thioether~, soe for ex~mple, U.S. Patent 3,799,989 to Sherk et ~ nd Japanese Patent 1971-8293. Ideally, the process of this inventlon may completely eliminate the necessity of recycling such byproducts, but this is highly dependent upon the hydrogen source, the amount of hydrogen produced, the specific reaction conditions, and the apparatus utilized. Thus, in its broadest, form the process of this invention will reduoe the quantity lS5140 ~

of byproduct aromatic thioethers which are recycled, and in its optimum form completely ellminate the necessity for recycling such products.
While this invention will be described primarily with respect to the formation of thio-phenol from chlorobenzene and hydrogen ~ulfide, the halogenated aromatic compound may include one or more alkyl or other non-reactive groups which are stable during the reaction. For example, the alkyl group substituent on the aromatic ring may have from one to about five or more carbons. Also, in lieu of one or more alkyl ~ubstituents, other non-reacti~ve sub6tituents may be included, e.g.
tolyl, xylyl and mesityl.
Crowley et al. exemplifies some of the thiophenols that may be produced and the corresponding halogenated aromatic compounds that may be utilized in the process of this invention. The halogenated aromatic compound may be selected from the group consisting of mono- and dihslo-genated benzenes, mono- and dihalogenated mono-and polyalkyl benzenes in which one or more of the alkyl group has up to 24 to 26 carbon atoms, mono- and dihalogenated polynuclear aromatic compounds and mono- and dihalogenated mono-and polyalkyl polynucle4r aromatic compounds in which one or more of tho alkyl sub~titutents has up to 24 to 26 carbon atoms. The reader i~
referred to Crowley et al., column 4, line 30 through column 6, line 10, for a more definitive explanation of the halogenated aromatic compounds which may be utilized in this invention.

1155~40 Thus, the term "halogenated aromatic compound" includes all of the foregoing type compounds that one ~killed in the art would utilize in this type reaction, as well a6 chloro-benzene.
~ y the use of the term "source of hydrogen"
it i8 meant hydrogen or any composition when subjected to the conditions of the reaction release hydrogen which can be utilized in the reaction.
An example of such a source of hydrogen is methane.
It is preferred, however, to utilize hydrogen.
The process of this invention can proceed with or without a catalyst. It i8 preferred, however, to utilize the conventional catalysts, well known in the art, for this type process.
Crowley et al., for example, describes the use of a highly absorbent solid catalyst, such as ac-tivated alumina, silica, silica alumina, silica-alumina-iron gel and activated charcoal. Japanese Patent 1970-19046, describes the use of a sulfide of Cu, Ag, Zn, Cd, Pb, Bi, Co, or Mo supported on an acti-vated carbon. The process of this invention may utilize any of these type catalysts. It is highly preferred, however, to utilize activated carbon.
The reaction, for a given y$eld, may be carried out in the presence of a catalyst at lower temperatures than those at which the reaction takes place in the absence of a catalyst. For example, temperatures of about 400C. to about 600C. have been found to be satisfactory for the catalyzed reaction.

l~SS140 A particularly preferred manner of oper-ating the process of this invention is to increase the temperature as the total conversion decreases due to deactivation of the catalyst. This may be done in a gradual or stepwise manner. The rate of increase in the temperature i8 highly dependent on the catalyst, the halogenated aromatic compound used, the operating temperature, etc., but can readily be determined by simple experimentation by one skilled in the art. It has been found that about a 20C. increase in temper-ature for a drop of about 5% in yield has worked effectively to increase the yield by about 5%.
This process for increasing the temperature as the total conversion decreases due to deactivation of the catalyst may also be used in the broad process of reacting a halogenated aromatic compound with hydrogen sulfide, i.e. with or without a catalyst or hydrogen.
The reaction can be carried out at super-atmospheric, atmospheric or sub-atm~spheric pressures.
The reactants are passed through a heated reaction zone, preferably concurrently. Normally the reactants will be preheated before~being fed to the reaction zone. The feed i~ arranged 80 that there is efficient mixing of the reactant~
in a very short time, i.e. several seconds.
The liquid product, upon condensation, consists of the thiophenol and the unreacted halogenated aromatic compound. Any byproduct aromatic thioethers produced may be recycled with the unreacted halogenated aromatic compound in the conventional manner, i.e. as described in 1155~40 g _ Sherk et al. and Japanese Patent 1971-8293.
The hydrogen sulfide, source of hydrogen and halogenated aromatic compound may be reacted in any proportion. It is preferred, however, to employ an amount of hydrogen sulfide in excess of that required to satisfy the following equation:
Formula 1 RCl +H2S - RSH ~ HCl wherein ~'R" is an aromatic substituent.
That is to say, the hydrogen sulfide is prefèrably present in an amount in excess of equal molecular proportions. A mole ratio of hydrogen sulfide to halogenated aromatic compound of about 1:1 to about 10:1 will produce satisfactory results, although higher or lower molar ratios may be used if desired. Mole ratios greater than about 2:1 are preferred, with about 3:1 to about 5:1 having been found effective in producing substantial yields of thiophenol.
The mole ratio of hydrogen ~produced from the hydrogen source) to halogenated aromatic compound is not critical. It is preferred, however, to have present an amount of hydrogen which produces an increase in yield of thiophenol over that which would be produced without the hydrogen present.
A preferred mole ratio of hydrogen to halogenated aromatic compound is from about .05:1 to about 3:1, with about .05:1 to about .5:1 being highly preferred.
It is also within the scope of this invention to use a greater quantity of either the hydrogen sulfide, the source of hydrogen, e.g.

11551~0 hydrogen, or both should conditions of temperature, pressure, conversion or product distribution so require. In general, however, the amounts expressed above æhould be used.
The hydrogen sulfide, hydrogen source and halogenated aromatic compound may be passed over the catalyst at any convenient rate, depending upon the temperature, pressure, composition of the reactants and the products desired. A feed rate of hydrogen sulfide, hydrogen, and halogenated aromatic^compound of from about 1 to about 80 moles per liter of catalyst per hour will generally produce suitable results, although higher or lower rates may be used. A preferred feed rate is from about 5 to about lS moles per liter of catalyst per hour.
The reaction may be al-lowed to take place for any suitable length sf time. The duration of the run, i.e. residence time within the reaction zone, will depend upon feed rate, the reactant mixture utilized, temperature, pressure, catalyst used, and products desired. Residence times of from about 5 to about 60 seconds are generally suitable although longer or shorter runs may be desirable in some cases.
The products of reaction, i.e. thiophenol, any byproduct aromatic thioethers and any unreacted reactant mixture, can be recovered after one pass through the reaction or may be recycled.
The invention may be executed in any suitable type of apparatus and the process may be carried out in a batch-wise, intermittent or continuous manner, although a continuous process is preferred.

The separation of the products of reaction from each other, i.e. the thiophenol from any byproducts and unreacted reactant mixture, may be accomplished by processes well known in the art, see for example, Sherk et al. and U.S. Patent

4,024,191 to Scoggin.
The reactions occurring within the reaction zone are believed to be as follows:
Formula 1 RCl +H2S 'RSH ~HCl Formula 2 H2S - H~ +-SH ~ H2 +S
Formula 3 RCl +H2 ~ R+HCl Formula 4 RCl ~RSH ~ R2S +HCl Formula 5 3 RSH +HCl ~ RCl +R2S +2H2S
Formula 6 R2S +S ' R-S-S-R
Formula 7 R-S~S-R +H2 ' 2RSH
Formula 8 R-S-R +H2 ~ RSH+ R
It is believed that the process of this invention produces high yields of thiophenol with low quantities of byproduct aromatic thioethers because the hydrogen in the reactant mixture either (a) prevents the formation of byproduct aromatic thioethers, i.e. Formulas 1 and 2 and/or (b) cleaves the byproduct aromatic thioethers to thiophenol, i.e.
Formulas 7 and 8.
The following examples serve to illustrate the invention and its advantages.

llS5140 EXaMPLE 1 A one inch (2,54 cm.) I.D. by 5 1/2 foot ~1.67 meters) high catalytic bed reactor was used for this test. The catalyst bed was 423 grams (5 feet--1.52 meters--in height), 3.08 liters of PPG
(6 X 16) activated carbon. The bed was brought to a temperature of 450C. by passing heated nitrogen therethrough.
Monochlorobenzene was uniformly fed to the oatalyst bed at a rate of 71 grams tO.63 moles) per hour.
The monochlorobenzene was vaporized and superhèated to 400C. prior to entry into the catalytic bed.
Hydrogen sulfide was uniformly fed to the catalyst bed at a rate of 64 grams (1.89moles) per hour. The hydrogen sulfide was preheated to to 400C. prior to entry into the catalytic bed. Hydrogen gas was added to the hydrogen sulfide stream prior to preheating at a rate of .38 grams (19 moles) per hour.
The mole ratio of hydrogen sulfide:
monochlorobenzene:hydrogen was 3:1:0.3.
The reaction was allowed to proceed continuously for 300 hours. The following results were obtained:

lSS140 TABLE I

Catalytic Bed Temp: 450C.
1 atmosphere pressure R s ~ % Mono-chlorobenzene Total Converted to: Conversion Process _ _ Per Time (hrs.) RSH R2S R2S2 Pass 4p 24.6 14.9 0 39.5 100 19.9 8.8 0 28.7 150 17~9 8.4 0 26.3 200 18.0 6.9 Trace 24.9 300 16.9 4.1 Trace 21.0 llS5140 COMPARATIVE EXAMPLES
_ __ The exact same test was performed as Example 1, except without injection of hydrogen into the catalytic bed. The following results were obtained:

llS55l40 TABLE II

_ _ _ _ _ _ Catalytic Bed Temp: 450C.
1 atmosp~ere pressure R = ~
Converted to- Total Process Conversion -- Per Time RSH R2S R2S2 Pass __ .

22 15.4 1.6 39 100 18 9.0 1.4 28.4 150 16.3 8.8 1.4 26.5 200 16.2 7.1 1.3. 24.6 300 14.8 4.2 1.0 20.0 115S140 ,~

~ his Example was performed in a bench scale hot tube static bed reaction system consisting of two (2) 1 inch by 6 foot long schedule 40 pipes, constructed of 310 stainless steel and Incolo ~ 825 alloy. The gas distributor was a circular 316 stainless steel disk with 21-1/16 inch holes.
~ eat was supplied by externally wound beaded nichrome wire heaters. The temperature of the bed was maintained constant by adjusting the power i,nput to wire heaters. Each reactor was equipped with 5 thermocouples for recording and controlling temperatures. Reactants were fed through separate feed lines entering through the side of the wind box which promoted intimate contact of the preheated hydrogen sulfide and chlorobenzene before passing through the distributor plate and activated carbon bed.
Reactor off-gases were condensed in a two pass stainless steel condenser and collected in a glass receiver. The vent lines of both reactors had a valve arrangement that allowed condensate collection from both or individual reactors.
In one run lasting only 32 hours, methane was substituted for hydrogen as a source o~ hydrogen:

l~S5~40 TABLE III

M E T H A N E
_ Catalytic Bed Temp: 450C.
1 atmosphere pressure R = ~

% Mono-chlorobenzene Total Pro-cess Converted to: Conversion Per Time RSH R2S R2S2 Pass j . . .
6 `I 44.3 ' 8.1 0 1 52.4 ' 38.6 1 7.4 0 46.0 32.2 j 7.6 0 39.8 30.2 ~ 7.5 Tr 37.7 28.1 1 7.1 Tr 1 35.2 Small amounts of methyl mercaptan appeared in the product which was probably produced according to the following formulas:
CH4 - CH3- + H-H2S ~-- H- ~ SH
CH3- ~ ~SH ---~ CH3SH
H- ~ H- - H~

~1551~0 The exact same test as Example 1 was performed except as indicated herein.
A fresh activated carbon catalyst bed was placed in the reactor. The reaction was initially conducted at 4Q0C. The reactor was divided into three heating zones of equal height. Each zone was composed of a nichrome resistance wire wound around the reactor. Since the reaction was only slightly exothermic, isothermal reaction condi-tions were maintained by adjusting the electrical power fed to each heating zone. It was found that by adjusting power input the temperature in the reaction zone could be maintained within ~ 5C.
With a fresh bed of activated carbon the initial total conversion per pass was about 41%.
The total conversion then gradually decreased to about 20% over the next 240 hours. It had been found from past tests that if the reaction were allowed to proceed at 400C. the total conversion would have been about 5% to 7% within an additional 60 hours, i.e. 300 hours total time.
Total conversions below 14% are considered un-economical.
The temperature of the bed was increased at 240 hours total time, to about 420C. by increasing the power input to each heating zone. The total conversion increased over the next 16 hours to about 25%. After about 80 hours, the total conversion again dropped to 20%.
The temperature of the bed was then increased to 440C. The total conversion subsequently ~ 1155140 increased to about 25%. After about 80 hours the total conversion again dropped to about 20%.
This process was repeated several more times until the temperature of the bed was 520C.
This temperature was determined to be the maximum temperature for conducting this reaction under these conditions.

.. . ..

`` 115S140 Although this invention has been described in terms of specific embodiments, it should be understood that these embodiments are by way of illustration only and that this invention is not to be limited thereto since alternative embodiments and operating techniques will become apparent to those skilled in the art. Accordingly, modifications are contemplated which can be made without departing from the spirit of the invention.

Claims (6)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. In a process for producing a thiophenol of the type which consists of reacting a halogenated aromatic compound with hydrogen sulfide at a temperature of reaction, the improvement comprising increasing the total conversion by increasing the temperature as the total conversion decreases.

2. The process of Claim 1, wherein the halogenated aromatic compound is chlorobenzene.

3. The process of Claim 1, wherein the temperature is between about 400°C and about 600°C.

4. The process of Claim 1, wherein the reaction takes place in the presence of an effective catalyst for the reaction.

5. The process of Claim 1, wherein increasing the tem-perature is accomplished gradually to maintain the total con-version substantially constant.

6. The process of Claim 1, wherein increasing the tem-perature is accomplished in a stepwise manner.