BRPI1013956A2 - método para isolar uma proteína recombinante, partículas secas por aspersão, composição, e, método para reduzir a absorção de oxalato. - Google Patents
método para isolar uma proteína recombinante, partículas secas por aspersão, composição, e, método para reduzir a absorção de oxalato.Info
- Publication number
- BRPI1013956A2 BRPI1013956A2 BRPI1013956-7A BRPI1013956A BRPI1013956A2 BR PI1013956 A2 BRPI1013956 A2 BR PI1013956A2 BR PI1013956 A BRPI1013956 A BR PI1013956A BR PI1013956 A2 BRPI1013956 A2 BR PI1013956A2
- Authority
- BR
- Brazil
- Prior art keywords
- isolating
- oxalate
- composition
- recombinant protein
- dried particles
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 6
- 239000002245 particle Substances 0.000 title abstract 3
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 238000010521 absorption reaction Methods 0.000 title abstract 2
- 239000007921 spray Substances 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
método para isolar uma proteína recombinante, partículas secas por aspersão, composição, e, método para reduzir a absorção de oxalato a presente invenção compreende métodos e composições para a redução de oxalato em humanos, e métodos para a purificação e isolamento de proteínas de enzima de redução de oxalato recombinantes. a invenção fornece métodos e composições para a dispensação de enzimas que reduzem oxalato em composições de partícula. as composições da presente invenção são adequadas nos métodos de tratamento ou prevenção de condições relacionadas ao oxalato.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/497,275 US8431122B2 (en) | 2009-07-02 | 2009-07-02 | Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes |
| EP09164430.2 | 2009-07-02 | ||
| EP09164430.2A EP2270138B1 (en) | 2009-07-02 | 2009-07-02 | Purification and isolation of recombinant oxalate degrading enzymes |
| US12/497275 | 2009-07-02 | ||
| PCT/EP2010/003864 WO2011000523A1 (en) | 2009-07-02 | 2010-07-01 | Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI1013956A2 true BRPI1013956A2 (pt) | 2019-04-09 |
| BRPI1013956B1 BRPI1013956B1 (pt) | 2021-04-06 |
| BRPI1013956B8 BRPI1013956B8 (pt) | 2021-05-25 |
Family
ID=43028177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1013956A BRPI1013956B8 (pt) | 2009-07-02 | 2010-07-01 | método para isolar uma proteína recombinante, partículas secas por aspersão, composição, e, uso de partículas secas por aspersão |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120189604A1 (pt) |
| EP (1) | EP2449098B1 (pt) |
| JP (2) | JP2012531186A (pt) |
| CN (2) | CN104805067A (pt) |
| BR (1) | BRPI1013956B8 (pt) |
| CA (2) | CA3012811A1 (pt) |
| DK (1) | DK2449098T3 (pt) |
| ES (1) | ES2617917T3 (pt) |
| HK (1) | HK1210805A1 (pt) |
| HU (1) | HUE030905T2 (pt) |
| IL (1) | IL216873A (pt) |
| IN (1) | IN2012DN00592A (pt) |
| LT (1) | LT2449098T (pt) |
| PL (1) | PL2449098T3 (pt) |
| PT (1) | PT2449098T (pt) |
| WO (1) | WO2011000523A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8431122B2 (en) | 2009-07-02 | 2013-04-30 | Oxthera Intellectual Property Ab | Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes |
| US9714456B2 (en) * | 2013-01-18 | 2017-07-25 | Allena Pharmaceuticals, Inc. | Crystallized oxalate decarboxylase and methods of use |
| CN103540569A (zh) * | 2013-06-05 | 2014-01-29 | 黄虹寓 | 结石酶及其制备方法 |
| ES2875060T3 (es) * | 2013-06-07 | 2021-11-08 | Allena Pharmaceuticals Inc | Composiciones y dispositivos para diálisis |
| CN104673765B (zh) * | 2014-12-22 | 2017-11-17 | 武汉康复得生物科技股份有限公司 | 一组在生理pH条件下有活力的草酸氧化酶及其应用 |
| CN114903985A (zh) * | 2021-02-10 | 2022-08-16 | 宁波倍益嘉生物科技有限公司 | 一种组合物及其在防治高草酸尿症方面的应用 |
| CN116124853B (zh) * | 2022-11-07 | 2024-01-16 | 东北农业大学 | 一种检测草酸的电化学生物传感器、制备方法及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8486389B2 (en) * | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
| AU2003274918A1 (en) * | 2002-08-20 | 2004-03-11 | University Of Florida | Polynucleotide encoding oxalate decarboxylase from aspergillus niger and methods of use |
| US6929940B1 (en) * | 2002-08-20 | 2005-08-16 | University Of Florida Research Foundation, Inc. | Polynucleotides encoding oxalate decarboxylase from Aspergillus niger and methods of use |
| PT1962873E (pt) * | 2005-12-14 | 2013-08-29 | Oxthera Inc | Composições farmacêuticas compreendendo bactérias redutoras de oxalato |
| CN101405022A (zh) | 2005-12-16 | 2009-04-08 | 奥克斯赛拉公司 | 用于减少草酸盐的组合物和方法 |
| PT2046373E (pt) * | 2006-08-02 | 2013-05-06 | Althea Technologies Inc | Oxalato descarboxilase cristalizada e métodos de utilização |
-
2010
- 2010-07-01 BR BRPI1013956A patent/BRPI1013956B8/pt not_active IP Right Cessation
- 2010-07-01 CN CN201510140451.XA patent/CN104805067A/zh active Pending
- 2010-07-01 IN IN592DEN2012 patent/IN2012DN00592A/en unknown
- 2010-07-01 LT LTEP10744865.6T patent/LT2449098T/lt unknown
- 2010-07-01 CN CN201080029636.9A patent/CN102597225B/zh not_active Expired - Fee Related
- 2010-07-01 ES ES10744865.6T patent/ES2617917T3/es active Active
- 2010-07-01 HU HUE10744865A patent/HUE030905T2/en unknown
- 2010-07-01 CA CA3012811A patent/CA3012811A1/en not_active Abandoned
- 2010-07-01 DK DK10744865.6T patent/DK2449098T3/en active
- 2010-07-01 JP JP2012516581A patent/JP2012531186A/ja active Pending
- 2010-07-01 PL PL10744865T patent/PL2449098T3/pl unknown
- 2010-07-01 PT PT107448656T patent/PT2449098T/pt unknown
- 2010-07-01 CA CA2767039A patent/CA2767039C/en not_active Expired - Fee Related
- 2010-07-01 WO PCT/EP2010/003864 patent/WO2011000523A1/en not_active Ceased
- 2010-07-01 EP EP10744865.6A patent/EP2449098B1/en not_active Not-in-force
- 2010-07-01 US US13/381,430 patent/US20120189604A1/en not_active Abandoned
-
2011
- 2011-12-08 IL IL216873A patent/IL216873A/en active IP Right Grant
-
2015
- 2015-11-19 HK HK15111425.5A patent/HK1210805A1/xx unknown
- 2015-12-17 JP JP2015246402A patent/JP6220845B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IN2012DN00592A (pt) | 2015-06-12 |
| JP6220845B2 (ja) | 2017-10-25 |
| CA3012811A1 (en) | 2011-01-06 |
| HK1210805A1 (en) | 2016-05-06 |
| CA2767039A1 (en) | 2011-01-06 |
| CN102597225B (zh) | 2015-04-29 |
| ES2617917T3 (es) | 2017-06-20 |
| CN104805067A (zh) | 2015-07-29 |
| CA2767039C (en) | 2018-09-04 |
| WO2011000523A1 (en) | 2011-01-06 |
| HUE030905T2 (en) | 2017-06-28 |
| EP2449098B1 (en) | 2016-12-07 |
| EP2449098A1 (en) | 2012-05-09 |
| PT2449098T (pt) | 2017-03-10 |
| US20120189604A1 (en) | 2012-07-26 |
| CN102597225A (zh) | 2012-07-18 |
| IL216873A (en) | 2017-07-31 |
| JP2012531186A (ja) | 2012-12-10 |
| DK2449098T3 (en) | 2017-03-06 |
| IL216873A0 (en) | 2012-02-29 |
| PL2449098T3 (pl) | 2017-06-30 |
| BRPI1013956B1 (pt) | 2021-04-06 |
| JP2016121138A (ja) | 2016-07-07 |
| LT2449098T (lt) | 2017-05-25 |
| BRPI1013956B8 (pt) | 2021-05-25 |
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| Date | Code | Title | Description |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: OXTHERA INTELLECTUAL PROPERTY AB (SE) |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/04/2021, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/07/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2677 DE 26-04-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |