BRPI1012219A2 - produto, substrato, composição farmacêutica, usos de um produto, e de um peptídeo antimicrobiano, métodos para prevenir formação de biofilme em um ambiente, para tratar uma infecção microbiana por profilaxia ou terapia, e para tratar ou prevenir formação de biofilme em um ambiente, e, uso de uma cisteamina - Google Patents

produto, substrato, composição farmacêutica, usos de um produto, e de um peptídeo antimicrobiano, métodos para prevenir formação de biofilme em um ambiente, para tratar uma infecção microbiana por profilaxia ou terapia, e para tratar ou prevenir formação de biofilme em um ambiente, e, uso de uma cisteamina

Info

Publication number: BRPI1012219A2
Authority: BR; Brazil
Prior art keywords: treating; environment; product; biofilm formation; preventing biofilm
Prior art date: 2009-03-31

Application number

BRPI1012219A

Other languages

English (en)

Inventor

Cedric Charrier

Deborah O' Neil

Derry Mercer

Original Assignee

Novabiotics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-31

Filing date

2010-03-31

Publication date

2016-03-29

2010-03-31 Application filed by Novabiotics Ltd filed Critical Novabiotics Ltd

2016-03-29 Publication of BRPI1012219A2 publication Critical patent/BRPI1012219A2/pt

2020-05-12 Publication of BRPI1012219B8 publication Critical patent/BRPI1012219B8/pt

2021-05-25 Publication of BRPI1012219C1 publication Critical patent/BRPI1012219C1/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/424—Anti-adhesion agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Materials Engineering (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Marine Sciences & Fisheries (AREA)
Heart & Thoracic Surgery (AREA)
Surgery (AREA)
Transplantation (AREA)
Environmental Sciences (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI1012219A 2009-03-31 2010-03-31 produto, substrato, composição farmacêutica, usos de um produto, e de um peptídeo antimicrobiano, métodos para prevenir formação de biofilme em um ambiente, para tratar uma infecção microbiana por profilaxia ou terapia, e para tratar ou prevenir formação de biofilme em um ambiente, e, uso de uma cisteamina BRPI1012219C1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US16539609P	2009-03-31	2009-03-31
GBGB0905451.1A GB0905451D0 (en)	2009-03-31	2009-03-31	Biofilms
PCT/GB2010/000631 WO2010112848A2 (en)	2009-03-31	2010-03-31	Inhibition of biofilm organisms

Publications (3)

Publication Number	Publication Date
BRPI1012219A2 true BRPI1012219A2 (pt)	2016-03-29
BRPI1012219B8 BRPI1012219B8 (pt)	2020-05-12
BRPI1012219C1 BRPI1012219C1 (pt)	2021-05-25

Family

ID=40671951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1012219A BRPI1012219C1 (pt)	2009-03-31	2010-03-31	produto, substrato, composição farmacêutica, usos de um produto, e de um peptídeo antimicrobiano, métodos para prevenir formação de biofilme em um ambiente, para tratar uma infecção microbiana por profilaxia ou terapia, e para tratar ou prevenir formação de biofilme em um ambiente, e, uso de uma cisteamina

Country Status (21)

Country	Link
US (3)	US9339525B2 (pt)
EP (1)	EP2413949B1 (pt)
JP (1)	JP5727994B2 (pt)
KR (1)	KR101852784B1 (pt)
CN (2)	CN102387794B (pt)
AU (2)	AU2010231136B2 (pt)
BR (1)	BRPI1012219C1 (pt)
CA (1)	CA2755878C (pt)
CY (1)	CY1121175T1 (pt)
GB (1)	GB0905451D0 (pt)
IL (1)	IL215369B2 (pt)
MX (1)	MX358018B (pt)
NZ (1)	NZ595037A (pt)
PL (1)	PL2413949T3 (pt)
RU (1)	RU2548786C2 (pt)
SG (2)	SG174278A1 (pt)
SI (1)	SI2413949T1 (pt)
TR (1)	TR201821161T4 (pt)
UA (1)	UA106743C2 (pt)
WO (1)	WO2010112848A2 (pt)
ZA (1)	ZA201107140B (pt)

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GB0905451D0 (en) *	2009-03-31	2009-05-13	Novabiotics Ltd	Biofilms
TWI403330B (zh) *	2010-03-29	2013-08-01	Rise technology co ltd	低血球溶解性之抗微生物胜肽、醫藥組成物及其用途
GB201016733D0 (en) *	2010-10-05	2010-11-17	Novabiotics Ltd	Compounds and their use
CN103119158B (zh)	2010-04-27	2015-04-08	莱桑多公司	减少生物膜的方法
GB201021186D0 (en) *	2010-12-14	2011-01-26	Novabiotics Ltd	Composition
US20140154235A1 (en)	2011-05-12	2014-06-05	Smith & Nephew Orthopaedics Ag	Wound debridement compositions containing seaprose and methods of wound treatment using same
TWI415572B (zh)	2011-06-17	2013-11-21	Univ Chang Gung	利用１，２，３，４，６－五－ｏ－沒食子醯基－ｄ－葡哌喃糖來抑制生物膜形成
US20140315789A1 (en) *	2011-11-23	2014-10-23	Newsouth Innovations Pty Limited	Antimicrobial peptides and uses thereof
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US20160102052A1 (en) *	2014-09-22	2016-04-14	Novabiotics Limited	Use of Cysteamine in Treating Infections caused by Yeasts/Moulds
GB201416727D0 (en) *	2014-09-22	2014-11-05	Novabiotics Ltd	Use
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WO2017134661A1 (en) *	2016-02-04	2017-08-10	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	Methods for disrupting biofilms
ES3036077T3 (en) *	2016-02-19	2025-09-12	Klaus Brandenburg	Means and methods for treating bacterial infections
WO2017176796A1 (en)	2016-04-04	2017-10-12	University Of Virginia Patent Foundation	Compositions and methods for preventing and treating disease
EP3241570A1 (en) *	2016-05-02	2017-11-08	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Polypeptide and hyaluronic acid coatings
CN117224709A (zh) *	2016-05-12	2023-12-15	宾夕法尼亚州立大学托管会	用于抑制生物膜沉积和产生的组合物和方法
WO2017212239A1 (en) *	2016-06-07	2017-12-14	Novabiotics Limited	Treatment of drug-resistant microbial infections
US11628207B2 (en)	2016-07-27	2023-04-18	Smith & Nephew, Inc.	Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
CN110049761A (zh)	2016-12-15	2019-07-23	萨宝公司	N-乙酰半胱氨酸作为抗菌剂的用途
WO2018112511A1 (en) *	2016-12-22	2018-06-28	Whiteley Corporation Pty Ltd	Biofilm disrupting composition
CA3052784A1 (en) *	2017-01-05	2018-07-12	Cormedix Inc.	Antimicrobial compositions, including antimicrobial hydrogels, effective against mature biofilms
WO2018140707A1 (en)	2017-01-30	2018-08-02	Smith & Nephew, Inc.	Synergistic combination of thermolysin and an antibacterial agent to reduce eliminate bacterial biofilms from surfaces
US11285189B2 (en)	2017-04-06	2022-03-29	Amicrobe, Inc.	Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety
RU2664708C1 (ru) *	2017-06-08	2018-08-21	Сергей Иванович Черныш	Способ разрушения и предотвращения образования бактериальных биопленок комплексом антимикробных пептидов насекомых
CN108048359B (zh) *	2017-12-27	2020-12-01	广州立白企业集团有限公司	一种牙菌斑生物膜模型的培养方法和优化的生物膜活菌计数法及应用
US20220249599A1 (en) *	2018-03-13	2022-08-11	Peptilogics, Inc.	Treatment of implants with engineered antimicrobial amphiphilic peptides
CN108753632A (zh) *	2018-05-25	2018-11-06	安徽中医药大学	一种溶解白念珠菌生物被膜胞外基质的方法
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PL3866775T3 (pl) *	2018-10-17	2025-07-07	Novabiotics Limited	Cysteamina do zastosowania w leczeniu chorób płuc
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2009
- 2009-03-31 GB GBGB0905451.1A patent/GB0905451D0/en not_active Ceased
2010
- 2010-03-31 NZ NZ595037A patent/NZ595037A/xx unknown
- 2010-03-31 UA UAA201110832A patent/UA106743C2/uk unknown
- 2010-03-31 CN CN201080014896.9A patent/CN102387794B/zh not_active Expired - Fee Related
- 2010-03-31 SG SG2011064417A patent/SG174278A1/en unknown
- 2010-03-31 MX MX2011010258A patent/MX358018B/es active IP Right Grant
- 2010-03-31 CN CN201410419543.7A patent/CN104257645A/zh active Pending
- 2010-03-31 WO PCT/GB2010/000631 patent/WO2010112848A2/en not_active Ceased
- 2010-03-31 SG SG10201400926VA patent/SG10201400926VA/en unknown
- 2010-03-31 EP EP10715573.1A patent/EP2413949B1/en active Active
- 2010-03-31 BR BRPI1012219A patent/BRPI1012219C1/pt active IP Right Grant
- 2010-03-31 TR TR2018/21161T patent/TR201821161T4/tr unknown
- 2010-03-31 CA CA2755878A patent/CA2755878C/en active Active
- 2010-03-31 SI SI201031825T patent/SI2413949T1/sl unknown
- 2010-03-31 KR KR1020117024561A patent/KR101852784B1/ko active Active
- 2010-03-31 PL PL10715573T patent/PL2413949T3/pl unknown
- 2010-03-31 JP JP2012502770A patent/JP5727994B2/ja active Active
- 2010-03-31 AU AU2010231136A patent/AU2010231136B2/en not_active Ceased
- 2010-03-31 RU RU2011143399/15A patent/RU2548786C2/ru active
- 2010-03-31 US US13/260,547 patent/US9339525B2/en active Active
2011
- 2011-09-25 IL IL215369A patent/IL215369B2/en unknown
- 2011-09-29 ZA ZA2011/07140A patent/ZA201107140B/en unknown
2016
- 2016-03-28 US US15/082,976 patent/US20160206575A1/en not_active Abandoned
- 2016-08-05 AU AU2016210742A patent/AU2016210742B2/en active Active
2019
- 2019-01-09 CY CY20191100019T patent/CY1121175T1/el unknown
- 2019-02-13 US US16/274,896 patent/US20190175528A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ZA201107140B (en)	2012-06-27
BRPI1012219B8 (pt)	2020-05-12
EP2413949A2 (en)	2012-02-08
AU2010231136B2 (en)	2016-08-04
MX2011010258A (es)	2011-10-19
CY1121175T1 (el)	2020-05-29
UA106743C2 (uk)	2014-10-10
SI2413949T1 (sl)	2019-02-28
US9339525B2 (en)	2016-05-17
JP5727994B2 (ja)	2015-06-03
WO2010112848A3 (en)	2011-01-27
SG174278A1 (en)	2011-10-28
SG10201400926VA (en)	2014-10-30
US20160206575A1 (en)	2016-07-21
TR201821161T4 (tr)	2019-01-21
KR101852784B1 (ko)	2018-04-30
WO2010112848A2 (en)	2010-10-07
BRPI1012219C1 (pt)	2021-05-25
GB0905451D0 (en)	2009-05-13
RU2548786C2 (ru)	2015-04-20
KR20120003893A (ko)	2012-01-11
IL215369A (en)	2013-02-03
AU2016210742B2 (en)	2017-08-10
CN102387794A (zh)	2012-03-21
PL2413949T3 (pl)	2019-04-30
US20190175528A1 (en)	2019-06-13
EP2413949B1 (en)	2018-10-10
NZ595037A (en)	2013-07-26
CN102387794B (zh)	2015-11-25
AU2016210742A1 (en)	2016-08-25
MX358018B (es)	2018-08-02
CA2755878A1 (en)	2010-10-07
CN104257645A (zh)	2015-01-07
JP2012522037A (ja)	2012-09-20
IL215369B2 (en)	2023-02-01
CA2755878C (en)	2018-04-24
AU2010231136A1 (en)	2011-09-29
IL215369B (en)	2022-10-01
US20120189682A1 (en)	2012-07-26

Publication	Publication Date	Title
BRPI1012219A2 (pt)	2016-03-29	produto, substrato, composição farmacêutica, usos de um produto, e de um peptídeo antimicrobiano, métodos para prevenir formação de biofilme em um ambiente, para tratar uma infecção microbiana por profilaxia ou terapia, e para tratar ou prevenir formação de biofilme em um ambiente, e, uso de uma cisteamina
BR112013015010A2 (pt)	2016-08-09	produto, substrato, composição farmacêutica, uso de um produto, e, método para tratar uma infecção microbiana
BRPI1007379A2 (pt)	2016-02-16	composições e métodos para o tratamento ou a prevenção de infecções orais por e. coli
BRPI1013984A2 (pt)	2018-06-19	composto , composição farmacêutica, método para tratamento ou profilaxia de uma doença ou condição, e, uso de um composto.
BR112013011737A2 (pt)	2016-08-09	composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv
EA033311B1 (ru)	2019-09-30	Производные бензоксаборола в качестве антибактериальных средств
BR112014000665A2 (pt)	2017-01-10	composto, uso do mesmo, composição farmacêutica, agente antimicrobiano, e, método para previnir ou tratar uma infecção bacteriana
BRPI0807487A8 (pt)	2016-02-10	Uso de antagonistas de il-23 para o tratamento de infecção
BR112012002992A2 (pt)	2016-04-19	composição para cuidado oral, composição, método para inibir formação de biopelícula e/ou degradar uma biopelícula em um paciente, uso de um sesquiterpenóide.
BR112014010179A8 (pt)	2018-01-09	composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição
CL2009000426A1 (es)	2011-02-11	Compuestos derivados de carbociclil/heterociclil-piridin-2-il-urea, inhibidores de topoisomerasa iv bacteriana; composicion farmaceutica; y su uso para el tratamiento de infecciones bacterianas
BR112014010177A2 (pt)	2017-04-25	composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou tratamento de um estado ou uma condição de doença
BRPI0916235A2 (pt)	2018-03-13	composto, composição farmacêutica, uso do composto ou da composição, e, método para tratar um paciente infectado com hcv
BRPI1013705A2 (pt)	2016-04-05	compostos, composição farmacêutica, método de tratamento de doença ou condição associada com função de trap1 e usos de compostos e de composição farmacêutica
IL211120A (en)	2014-09-30	Compound, tetracycline converted at position 7c with fluorine, a pharmaceutical preparation containing it and its use in the preparation of drugs for the treatment of bacteria-caused infection
BRPI0813450A2 (pt)	2014-12-30	Composto, composição, combinação, formulação farmacêutica, e, métodos para inibir uma enzima, para exterminar ou prevenir o crescimento de um microorganismo e para tratar e/ou prevenir uma doença em um animal
IL221940A (en)	2017-03-30	Small anti-infective compounds, pharmaceutical preparations containing them and their use in the preparation of drugs for the treatment of bacterial infections
BRPI0908021A2 (pt)	2015-07-21	Composto, composição farmacêutica, e, usos do composto ou da composição farmacêutica
BRPI0820568A2 (pt)	2015-06-16	Composto, composição farmacêutica, uso de um composto ou uma composição farmacêutica, e, método de tratamento de um humano ou animal
BRPI1013763A2 (pt)	2015-08-25	Composto ou sal do mesmo, prodroga, composição farmacêutica, agente diminuidor da proteína de ligação de retinol 4, agente para a profilaxia ou tratamento de diabetes, e, uso de um composto
CL2011001299A1 (es)	2012-01-13	Compuestos derivados de benzotiazoles; composicion farmaceutica; y su uso como inhibidores de raf para el tratamiento o profilaxis del cancer.
BRPI0813001A2 (pt)	2019-09-24	composto, método de tratamento ou profilaxia de dor neuropática e composição farmacêutica
BRPI1012951A2 (pt)	2016-07-26	"administração de interferon para profilaxia ou tratamento de infecção por patôgeno"
BR112012020719A2 (pt)	2017-05-30	formulação herbicida método de tratamento de plantas com herbicida método de aumento da eficácia de uma formulação herbicida, e, uso de uma composição
BR112014006420A2 (pt)	2017-04-11	compostos, composição farmacêutica, uso de um composto e mètodo para o tratamento ou profilaxia

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