BRPI1011206A2 - administração contínua de ligantes de integrina para tratar câncer - Google Patents
administração contínua de ligantes de integrina para tratar câncerInfo
- Publication number
- BRPI1011206A2 BRPI1011206A2 BRPI1011206A BRPI1011206A BRPI1011206A2 BR PI1011206 A2 BRPI1011206 A2 BR PI1011206A2 BR PI1011206 A BRPI1011206 A BR PI1011206A BR PI1011206 A BRPI1011206 A BR PI1011206A BR PI1011206 A2 BRPI1011206 A2 BR PI1011206A2
- Authority
- BR
- Brazil
- Prior art keywords
- treat cancer
- continuous administration
- integrin ligands
- integrin
- ligands
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09006941 | 2009-05-25 | ||
| PCT/EP2010/003162 WO2010136168A2 (en) | 2009-05-25 | 2010-05-25 | Continuous administration of integrin ligands for treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1011206A2 true BRPI1011206A2 (pt) | 2016-03-15 |
Family
ID=43223150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1011206A BRPI1011206A2 (pt) | 2009-05-25 | 2010-05-25 | administração contínua de ligantes de integrina para tratar câncer |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120130146A1 (pt) |
| EP (1) | EP2445534A2 (pt) |
| JP (1) | JP2012528079A (pt) |
| KR (1) | KR20120104491A (pt) |
| CN (1) | CN102448497A (pt) |
| AU (1) | AU2010252280A1 (pt) |
| BR (1) | BRPI1011206A2 (pt) |
| CA (1) | CA2763275A1 (pt) |
| CL (1) | CL2011002962A1 (pt) |
| EA (1) | EA201101651A1 (pt) |
| EC (1) | ECSP11011552A (pt) |
| IL (1) | IL216537A0 (pt) |
| MX (1) | MX2011012491A (pt) |
| NZ (1) | NZ597339A (pt) |
| SG (1) | SG176103A1 (pt) |
| WO (1) | WO2010136168A2 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9220771B2 (en) * | 2010-07-16 | 2015-12-29 | Merck Patent Gmbh | Peptide for use in the treatment of breast cancer and/or bone metastases |
| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| JP6426001B2 (ja) | 2011-11-17 | 2018-11-21 | グリア エスピー ゼット.オー.オー. | 神経膠腫を治療するための組成物および方法 |
| KR101470700B1 (ko) * | 2011-11-25 | 2014-12-12 | 서울대학교산학협력단 | 표적 항암제의 내성 극복 방법 |
| WO2015152407A1 (ja) * | 2014-04-04 | 2015-10-08 | 大鵬薬品工業株式会社 | 抗腫瘍性白金錯体を含有する抗腫瘍剤及び抗腫瘍効果増強剤 |
| MA42161A (fr) * | 2014-10-14 | 2017-08-23 | Univ Chicago | Nanoparticules pour thérapie photodynamique, thérapie photodynamique induite par rayons x, radiothérapie, chimiothérapie, immunothérapie, et toute combinaison de celles-ci |
| US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| JP7090034B2 (ja) | 2016-05-20 | 2022-06-23 | ザ ユニバーシティ オブ シカゴ | 化学療法、標的療法、光線力学療法、免疫療法及びそれらの任意の組み合わせのためのナノ粒子 |
| CN110831665B (zh) * | 2017-06-29 | 2022-03-04 | 医视特有限公司 | 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统 |
| WO2019028250A1 (en) | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
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| US4792525A (en) | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
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| US5780426A (en) | 1995-06-07 | 1998-07-14 | Ixsys, Incorporated | Fivemer cyclic peptide inhibitors of diseases involving αv β3 |
| ES2197950T3 (es) | 1995-06-29 | 2004-01-16 | Smithkline Beecham Corporation | Antagonistas del receptor de la integrina. |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| BR9612378A (pt) | 1995-12-29 | 1999-07-13 | Smithkline Beecham Corp | Antagonistas receptores de vitronectina |
| CA2241633A1 (en) | 1995-12-29 | 1997-07-10 | William Henry Miller | Vitronectin receptor antagonists |
| CN1209063A (zh) | 1995-12-29 | 1999-02-24 | 史密丝克莱恩比彻姆公司 | 玻连蛋白受体拮抗剂 |
| EP0888292B1 (fr) | 1996-03-20 | 2001-10-31 | Aventis Pharma S.A. | COMPOSES TRICYCLIQUES AYANT UNE ACTIVITE VIS-A-VIS DES INTEGRINES NOTAMMENT VIS-A-VIS DE L'INTEGRINE ALPHA vBETA3, LEUR PROCEDE DE PREPARATION ET LES INTERMEDIAIRES DE CE PROCEDE, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT |
| WO1997037655A1 (en) | 1996-04-10 | 1997-10-16 | Merck & Co., Inc. | αvβ3 ANTAGONISTS |
| US5925655A (en) | 1996-04-10 | 1999-07-20 | Merck & Co., Inc. | αv β3 antagonists |
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| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
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| DE19653645A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
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| DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
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| JP2002510328A (ja) | 1997-07-25 | 2002-04-02 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体アンタゴニスト |
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| WO1999011626A1 (en) | 1997-09-04 | 1999-03-11 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| DZ2609A1 (fr) | 1997-09-19 | 2003-03-01 | Smithkline Beecham Corp | Composés nouveaux antagonistes des récepteurs de vitronectine et compositions pharmaceutiques les contenant. |
| FR2768736B1 (fr) | 1997-09-24 | 2000-05-26 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| TR200000786T2 (tr) | 1997-09-24 | 2000-08-21 | Smithkline Beecham Corporation | Vitronektin reseptör antagonisti |
| CN1273529A (zh) | 1997-09-24 | 2000-11-15 | 史密丝克莱恩比彻姆公司 | 玻连蛋白受体拮抗剂 |
| FR2768734B1 (fr) | 1997-09-24 | 2000-01-28 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
| JP3589633B2 (ja) | 1997-12-17 | 2004-11-17 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
| ATE294163T1 (de) | 1997-12-17 | 2005-05-15 | Merck & Co Inc | Integrin-rezeptor-antagonisten |
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| DE69830806T2 (de) | 1997-12-17 | 2006-04-27 | Merck & Co., Inc. | Integrinrezeptor antagonisten |
| AU736026B2 (en) | 1997-12-17 | 2001-07-26 | Merck & Co., Inc. | Integrin receptor antagonists |
| DE69930723T2 (de) | 1998-01-23 | 2006-11-16 | Merck Patent Gmbh | Verwendung des antikörpers 271.14d9.f8 (dsm acc2331) um die bindung zwischen alphavbeta6-integrin und fibronectin in vitro zu hemmen |
| AU747784B2 (en) | 1998-07-29 | 2002-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
| CA2338878A1 (en) | 1998-08-13 | 2000-02-24 | Merck & Co., Inc. | Integrin receptor antagonists |
| DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
| IL143901A0 (en) | 1998-12-23 | 2002-04-21 | Searle & Co | Use of cyclooxygenase-2- inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia |
| DE60035779T2 (de) | 1999-06-02 | 2008-04-30 | Merck & Co., Inc. | Alpha v integrin-rezeptor antagonisten |
| US6773897B2 (en) | 2000-09-29 | 2004-08-10 | The Johns Hopkins University School Of Medicine | Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents |
| CN101370522A (zh) * | 2006-01-18 | 2009-02-18 | 默克专利有限公司 | 使用整联蛋白配体治疗癌症的特别疗法 |
| ES2472450T3 (es) * | 2007-01-18 | 2014-07-01 | Merck Patent Gmbh | Ligandos de integrinas para su uso en el tratamiento del cáncer de colon |
-
2010
- 2010-05-25 NZ NZ597339A patent/NZ597339A/xx not_active IP Right Cessation
- 2010-05-25 BR BRPI1011206A patent/BRPI1011206A2/pt not_active Application Discontinuation
- 2010-05-25 KR KR1020117030945A patent/KR20120104491A/ko not_active Withdrawn
- 2010-05-25 MX MX2011012491A patent/MX2011012491A/es not_active Application Discontinuation
- 2010-05-25 WO PCT/EP2010/003162 patent/WO2010136168A2/en not_active Ceased
- 2010-05-25 AU AU2010252280A patent/AU2010252280A1/en not_active Abandoned
- 2010-05-25 JP JP2012511202A patent/JP2012528079A/ja active Pending
- 2010-05-25 EP EP20100721342 patent/EP2445534A2/en not_active Withdrawn
- 2010-05-25 CA CA2763275A patent/CA2763275A1/en not_active Abandoned
- 2010-05-25 SG SG2011084381A patent/SG176103A1/en unknown
- 2010-05-25 US US13/322,391 patent/US20120130146A1/en not_active Abandoned
- 2010-05-25 EA EA201101651A patent/EA201101651A1/xx unknown
- 2010-05-25 CN CN2010800227000A patent/CN102448497A/zh active Pending
-
2011
- 2011-11-22 IL IL216537A patent/IL216537A0/en unknown
- 2011-11-24 CL CL2011002962A patent/CL2011002962A1/es unknown
- 2011-12-23 EC EC2011011552A patent/ECSP11011552A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010252280A1 (en) | 2012-01-19 |
| SG176103A1 (en) | 2011-12-29 |
| NZ597339A (en) | 2013-10-25 |
| EP2445534A2 (en) | 2012-05-02 |
| CA2763275A1 (en) | 2010-12-02 |
| WO2010136168A3 (en) | 2011-07-07 |
| KR20120104491A (ko) | 2012-09-21 |
| JP2012528079A (ja) | 2012-11-12 |
| MX2011012491A (es) | 2011-12-14 |
| US20120130146A1 (en) | 2012-05-24 |
| ECSP11011552A (es) | 2012-01-31 |
| EA201101651A1 (ru) | 2012-08-30 |
| WO2010136168A2 (en) | 2010-12-02 |
| CN102448497A (zh) | 2012-05-09 |
| CL2011002962A1 (es) | 2012-06-01 |
| WO2010136168A8 (en) | 2011-09-22 |
| IL216537A0 (en) | 2012-02-29 |
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