BRPI1010885A2 - motivos de modificação química para inibidores mirna e miméticos. - Google Patents
motivos de modificação química para inibidores mirna e miméticos.Info
- Publication number
- BRPI1010885A2 BRPI1010885A2 BRPI1010885A BRPI1010885A BRPI1010885A2 BR PI1010885 A2 BRPI1010885 A2 BR PI1010885A2 BR PI1010885 A BRPI1010885 A BR PI1010885A BR PI1010885 A BRPI1010885 A BR PI1010885A BR PI1010885 A2 BRPI1010885 A2 BR PI1010885A2
- Authority
- BR
- Brazil
- Prior art keywords
- mirna
- chemical modification
- modification motifs
- mimetic inhibitors
- mimetic
- Prior art date
Links
- 238000007385 chemical modification Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108091070501 miRNA Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18503309P | 2009-06-08 | 2009-06-08 | |
| PCT/US2010/037821 WO2010144485A1 (en) | 2009-06-08 | 2010-06-08 | CHEMICAL MODIFICATION MOTIFS FOR miRNA INHIBITORS AND MIMETICS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1010885A2 true BRPI1010885A2 (pt) | 2015-09-22 |
Family
ID=43309198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1010885A BRPI1010885A2 (pt) | 2009-06-08 | 2010-06-08 | motivos de modificação química para inibidores mirna e miméticos. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20120148664A1 (pt) |
| EP (1) | EP2440566A4 (pt) |
| JP (1) | JP2012529295A (pt) |
| KR (1) | KR20120047892A (pt) |
| CN (1) | CN102803284B (pt) |
| AU (1) | AU2010258875A1 (pt) |
| BR (1) | BRPI1010885A2 (pt) |
| CA (1) | CA2765129A1 (pt) |
| EA (1) | EA022757B1 (pt) |
| GE (1) | GEP20156329B (pt) |
| MA (1) | MA33488B1 (pt) |
| MX (1) | MX2011013176A (pt) |
| NZ (1) | NZ597078A (pt) |
| SG (1) | SG176716A1 (pt) |
| UA (1) | UA105390C2 (pt) |
| WO (1) | WO2010144485A1 (pt) |
| ZA (1) | ZA201109319B (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2660523C (en) | 2006-08-11 | 2019-03-19 | Prosensa Technologies B.V. | Methods and means for treating dna repeat instability associated genetic disorders |
| PL2203173T3 (pl) | 2007-10-26 | 2016-06-30 | Academisch Ziekenhuis Leiden | Środki i sposoby przeciwdziałania zaburzeniom mięśni |
| AU2011219029B2 (en) | 2010-02-26 | 2017-02-02 | Columbia University | Methods and compositions for the detection and treatment of cancer involving miRNAs and miRNA inhibitors and targets |
| US20120116381A1 (en) | 2010-11-05 | 2012-05-10 | Houser Kevin L | Surgical instrument with charging station and wireless communication |
| US8642751B2 (en) | 2010-12-15 | 2014-02-04 | Miragen Therapeutics | MicroRNA inhibitors comprising locked nucleotides |
| CN102643807B (zh) * | 2011-02-18 | 2015-06-03 | 中国科学院上海药物研究所 | 人miR-484的反义寡聚核苷酸及其应用 |
| CA2833223A1 (en) * | 2011-04-22 | 2012-10-26 | Prosensa Technologies B.V. | New compounds for treating, delaying and/or preventing a human genetic disorder such as myotonic dystrophy type 1 (dm1) |
| SI2702155T1 (sl) * | 2011-04-25 | 2017-07-31 | Regulas Therapeutics Inc. | Spojine MicroRNA in postopki za modulacijo aktivnosti MIR-21 |
| WO2012149646A1 (en) * | 2011-05-05 | 2012-11-08 | Sunnybrook Research Institute | Mirna inhibitors and their uses |
| KR20140037868A (ko) * | 2011-05-09 | 2014-03-27 | 더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우 | 폐동맥 고혈압의 치료에서 마이크로rna를 조절하는 방법 |
| AU2013201303C1 (en) | 2011-10-06 | 2016-06-23 | MiRagen Therapeutics, Inc. | Control of whole body energy homeostasis by microRNA regulation |
| BR112014018427B1 (pt) | 2012-01-27 | 2021-11-03 | Biomarin Technologies B.V. | Oligonucleotídeos moduladores de rna com características melhoradas para o tratamento da distrofia muscular de duchenne e becker |
| RS56319B1 (sr) | 2012-04-23 | 2017-12-29 | Biomarin Tech Bv | Oligonukleotidi koji moduliraju rnk sa poboljšanim karakteristikama za lečenje neuromišićnih poremećaja |
| AU2013251696B2 (en) | 2012-04-25 | 2018-11-15 | Sanofi | MicroRNA compounds and methods for modulating miR-21 activity |
| CN102703456B (zh) * | 2012-05-15 | 2014-04-02 | 武汉生命之美科技有限公司 | DAPK3基因hsa-miR-20a的作用靶位点 |
| US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
| EP3354734B1 (en) | 2012-06-21 | 2020-06-10 | Miragen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| CA2902623A1 (en) | 2013-03-15 | 2014-09-25 | MiRagen Therapeutics, Inc. | Locked nucleic acid inhibitor of mir-145 and uses thereof |
| SG11201508925WA (en) | 2013-05-01 | 2015-11-27 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| CN103290011B (zh) * | 2013-05-16 | 2015-09-16 | 南京市妇幼保健院 | 与胎儿先天性心脏病相关的母体血清/血浆miRNA标志物mir-29c及其应用 |
| CN103667441B (zh) * | 2013-09-10 | 2016-10-19 | 山西医科大学第一医院 | 一种Hsa-miR-145-5p试剂盒及其成熟体模拟物的应用 |
| GB201400598D0 (en) | 2014-01-14 | 2014-03-05 | Univ Glasgow | Materials and methods for modulation of tendon healing |
| CN104083761A (zh) * | 2014-06-25 | 2014-10-08 | 北京大学第三医院 | microRNA-101抑制剂在制备预防或治疗骨关节炎药物中的应用 |
| BR112017001931A2 (pt) | 2014-08-07 | 2017-11-28 | Regulus Therapeutics Inc | direcionamento de micrornas para distúrbios metabólicos |
| SG11201705907XA (en) | 2015-01-20 | 2017-08-30 | Miragen Therapeutics Inc | Mir-92 inhibitors and uses thereof |
| AU2016315584B2 (en) * | 2015-09-02 | 2022-07-14 | Alnylam Pharmaceuticals, Inc. | Programmed cell death 1 ligand 1 (PD-L1) iRNA compositions and methods of use thereof |
| WO2017043490A1 (ja) * | 2015-09-07 | 2017-03-16 | 協和発酵バイオ株式会社 | 自然免疫誘導効果が増強した二重鎖リボ核酸 |
| DK3426781T3 (da) | 2016-03-07 | 2024-09-30 | Us Health | Mikro-rna'er og fremgangsmåder til anvendelse deraf |
| EP3449001B1 (en) | 2016-04-29 | 2021-12-08 | Aptamir Therapeutics, Inc. | Inhibition of mir-22 mirna by apt-110 |
| CA3041761A1 (en) * | 2016-10-31 | 2018-05-03 | Gifu University | Double-stranded nucleic acid molecule and use thereof |
| US20180193270A1 (en) | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| RU2020131372A (ru) | 2018-03-14 | 2022-04-14 | Бет Израэль Диконесс Медикал Сентр | ИНГИБИТОРЫ микроРНК 22 |
| EP3790972A1 (en) | 2018-05-08 | 2021-03-17 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect |
| US11015197B2 (en) | 2018-08-29 | 2021-05-25 | Korea Institute Of Science And Technology | Therapeutic agent for treating cancer comprising anti-miRNA-albumin composite |
| AU2021246530A1 (en) | 2020-04-02 | 2022-11-03 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
| EP4185694A1 (en) * | 2020-07-23 | 2023-05-31 | Johann Wolfgang Goethe-Universität Frankfurt | Combinatorial inhibition of mirnas for treatment of heart failure |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5840710A (en) | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| DE10049549A1 (de) * | 2000-10-06 | 2002-05-02 | Markus Hecker | Modulation der Transkription pro-inflammatorischer Genprodukte |
| US7683036B2 (en) * | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| JP5192234B2 (ja) * | 2004-08-10 | 2013-05-08 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 化学修飾オリゴヌクレオチド |
| CN101426912A (zh) * | 2005-08-17 | 2009-05-06 | 瑟纳治疗公司 | 介导rna干扰的化学修饰短干扰核酸分子 |
| US20080287383A1 (en) * | 2007-03-02 | 2008-11-20 | Nastech Pharmaceutical Company Inc. | Nucleic acid compounds for inhibiting erbb gene expression and uses thereof |
| CA2701547C (en) * | 2007-10-04 | 2020-03-10 | Santaris Pharma A/S | Oligonucleotides which target and inhibit micrornas |
| CA2705325C (en) * | 2007-11-09 | 2016-11-01 | The Board Of Regents Of The University Of Texas System | Micro-rnas of the mir-15 family modulate cardiomyocyte survival and cardiac repair |
-
2010
- 2010-06-08 SG SG2011090529A patent/SG176716A1/en unknown
- 2010-06-08 MA MA34505A patent/MA33488B1/fr unknown
- 2010-06-08 CN CN201080035109.9A patent/CN102803284B/zh not_active Expired - Fee Related
- 2010-06-08 CA CA2765129A patent/CA2765129A1/en not_active Abandoned
- 2010-06-08 EA EA201171493A patent/EA022757B1/ru not_active IP Right Cessation
- 2010-06-08 EP EP20100786712 patent/EP2440566A4/en not_active Withdrawn
- 2010-06-08 KR KR1020127000345A patent/KR20120047892A/ko not_active Ceased
- 2010-06-08 BR BRPI1010885A patent/BRPI1010885A2/pt not_active IP Right Cessation
- 2010-06-08 NZ NZ597078A patent/NZ597078A/xx not_active IP Right Cessation
- 2010-06-08 MX MX2011013176A patent/MX2011013176A/es active IP Right Grant
- 2010-06-08 WO PCT/US2010/037821 patent/WO2010144485A1/en not_active Ceased
- 2010-06-08 UA UAA201200188A patent/UA105390C2/ru unknown
- 2010-06-08 AU AU2010258875A patent/AU2010258875A1/en not_active Abandoned
- 2010-06-08 US US13/377,076 patent/US20120148664A1/en not_active Abandoned
- 2010-06-08 JP JP2012515076A patent/JP2012529295A/ja active Pending
- 2010-06-08 GE GEAP201012527A patent/GEP20156329B/en unknown
-
2011
- 2011-12-19 ZA ZA2011/09319A patent/ZA201109319B/en unknown
-
2013
- 2013-08-22 US US13/973,594 patent/US20140066491A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011013176A (es) | 2012-04-30 |
| EA022757B1 (ru) | 2016-02-29 |
| EA201171493A1 (ru) | 2012-06-29 |
| JP2012529295A (ja) | 2012-11-22 |
| CN102803284B (zh) | 2015-11-25 |
| WO2010144485A1 (en) | 2010-12-16 |
| ZA201109319B (en) | 2013-02-27 |
| NZ597078A (en) | 2013-11-29 |
| KR20120047892A (ko) | 2012-05-14 |
| CN102803284A (zh) | 2012-11-28 |
| EP2440566A1 (en) | 2012-04-18 |
| UA105390C2 (ru) | 2014-05-12 |
| EP2440566A4 (en) | 2013-10-16 |
| US20140066491A1 (en) | 2014-03-06 |
| MA33488B1 (fr) | 2012-08-01 |
| US20120148664A1 (en) | 2012-06-14 |
| AU2010258875A1 (en) | 2012-01-19 |
| SG176716A1 (en) | 2012-01-30 |
| CA2765129A1 (en) | 2010-12-16 |
| GEP20156329B (en) | 2015-07-27 |
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