BRPI1015921A2 - agonistas de gpr119 - Google Patents

agonistas de gpr119

Info

Publication number: BRPI1015921A2
Authority: BR; Brazil
Prior art keywords: gpr119 agonists; gpr119; agonists
Prior art date: 2009-07-15

Application number

BRPI1015921A

Other languages

English (en)

Inventor

Ana Belen Bueno Melendo

Bin Liu

David Gene Barrett

Jeffry Bernard Franciskovich

Kumiko Takeuchi

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-15

Filing date

2010-07-12

Publication date

2016-04-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43449712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1015921(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-07-12 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2016-04-26 Publication of BRPI1015921A2 publication Critical patent/BRPI1015921A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

BRPI1015921A 2009-07-15 2010-07-12 agonistas de gpr119 BRPI1015921A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP09382114		2009-07-15
US24544509P	2009-09-24	2009-09-24
PCT/US2010/041645 WO2011008663A1 (en)	2009-07-15	2010-07-12	Gpr119 agonists

Publications (1)

Publication Number	Publication Date
BRPI1015921A2 true BRPI1015921A2 (pt)	2016-04-26

Family

ID=43449712

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1015921A BRPI1015921A2 (pt)	2009-07-15	2010-07-12	agonistas de gpr119

Country Status (24)

Country	Link
US (1)	US8207344B2 (pt)
EP (1)	EP2454251A1 (pt)
JP (1)	JP5715127B2 (pt)
KR (1)	KR101365854B1 (pt)
CN (1)	CN102471313B (pt)
AR (1)	AR077638A1 (pt)
AU (1)	AU2010273642B2 (pt)
BR (1)	BRPI1015921A2 (pt)
CA (1)	CA2764906C (pt)
CO (1)	CO6480977A2 (pt)
CR (1)	CR20120012A (pt)
DO (1)	DOP2012000006A (pt)
EA (1)	EA020540B1 (pt)
EC (1)	ECSP12011606A (pt)
IL (1)	IL216776A0 (pt)
MA (1)	MA33428B1 (pt)
MX (1)	MX2012000704A (pt)
NZ (1)	NZ597125A (pt)
PE (1)	PE20121045A1 (pt)
SG (1)	SG177646A1 (pt)
TN (1)	TN2012000002A1 (pt)
TW (1)	TWI429634B (pt)
WO (1)	WO2011008663A1 (pt)
ZA (1)	ZA201200227B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2295816T3 (es)	2003-01-14	2008-04-16	Arena Pharmaceuticals, Inc.	Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia.
EP2146210A1 (en)	2008-04-07	2010-01-20	Arena Pharmaceuticals, Inc.	Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
WO2011113947A1 (en)	2010-03-18	2011-09-22	Boehringer Ingelheim International Gmbh	Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions
EP2619198A1 (en)	2010-09-22	2013-07-31	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140018371A1 (en) *	2011-04-01	2014-01-16	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
AU2012240122B2 (en)	2011-04-08	2016-08-25	Merck Sharp & Dohme Corp.	Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
WO2012170702A1 (en) *	2011-06-08	2012-12-13	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
ES2602813T3 (es)	2011-06-09	2017-02-22	Rhizen Pharmaceuticals S.A.	Nuevos compuestos como moduladores de GPR-119
WO2012173917A1 (en)	2011-06-16	2012-12-20	Merck Sharp & Dohme Corp.	Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment
US9422266B2 (en)	2011-09-30	2016-08-23	Merck Sharp & Dohme Corp.	Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
WO2013062835A1 (en) *	2011-10-24	2013-05-02	Merck Sharp & Dohme Corp.	Substituted piperidinyl compounds useful as gpr119 agonists
US9018200B2 (en)	2011-10-24	2015-04-28	Merck Sharp & Dohme Corp.	Substituted piperidinyl compounds useful as GPR119 agonists
AU2012339870B2 (en)	2011-11-15	2017-06-29	Merck Sharp & Dohme Corp.	Substituted cyclopropyl compounds useful as GPR119 agonists
JP2015522559A (ja) *	2012-06-12	2015-08-06	チョンクンダンファーマシューティカルコーポレーション	Ｇｐｒ１１９アゴニストとしてのピペリジン誘導体
CA2878625A1 (en)	2012-07-11	2014-01-16	Elcelyx Therapeutics, Inc.	Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
WO2014052619A1 (en) *	2012-09-27	2014-04-03	Irm Llc	Piperidine derivatives and compositions as modulators of gpr119 activity
RU2642429C2 (ru)	2013-11-26	2018-01-25	Чон Кун Тан Фармасьютикал Корп.	Амидные производные в качестве агонистов grp119
KR101651505B1 (ko) *	2014-05-02	2016-08-29	현대약품 주식회사	싸이클로 헥센 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
PL3242666T3 (pl)	2015-01-06	2025-02-17	Arena Pharmaceuticals, Inc.	Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
JP6838744B2 (ja)	2015-06-22	2021-03-03	アリーナファーマシューティカルズ，インコーポレイテッド	Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
AU2018220521A1 (en)	2017-02-16	2019-09-05	Arena Pharmaceuticals, Inc.	Compounds and methods for treatment of primary biliary cholangitis
KR102859841B1 (ko)	2018-06-06	2025-09-12	아레나 파마슈티칼스, 인크.	S1p1 수용체와 관련된 병태의 치료 방법
CA3173731A1 (en)	2020-02-28	2021-09-02	Kallyope, Inc.	Gpr40 agonists
KR20230012597A (ko)	2020-05-19	2023-01-26	칼리오페, 인크.	Ampk 활성화제
AU2021297323A1 (en)	2020-06-26	2023-02-16	Kallyope, Inc.	AMPK activators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2295816T3 (es) *	2003-01-14	2008-04-16	Arena Pharmaceuticals, Inc.	Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia.
CA2661371A1 (en) *	2006-08-30	2008-03-06	Biovitrum Ab (Publ)	Pyrimidine compounds for treating gpr119 related disorders
US7638541B2 (en) *	2006-12-28	2009-12-29	Metabolex Inc.	5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
CN101801954B (zh) *	2007-09-20	2013-10-09	Irm责任有限公司	作为gpr119活性调节剂的化合物和组合物

2010
- 2010-07-06 AR ARP100102424A patent/AR077638A1/es not_active Application Discontinuation
- 2010-07-08 TW TW099122534A patent/TWI429634B/zh not_active IP Right Cessation
- 2010-07-12 WO PCT/US2010/041645 patent/WO2011008663A1/en not_active Ceased
- 2010-07-12 MX MX2012000704A patent/MX2012000704A/es active IP Right Grant
- 2010-07-12 CA CA2764906A patent/CA2764906C/en not_active Expired - Fee Related
- 2010-07-12 PE PE2012000041A patent/PE20121045A1/es not_active Application Discontinuation
- 2010-07-12 EP EP10734412A patent/EP2454251A1/en not_active Withdrawn
- 2010-07-12 US US12/834,054 patent/US8207344B2/en not_active Expired - Fee Related
- 2010-07-12 AU AU2010273642A patent/AU2010273642B2/en not_active Ceased
- 2010-07-12 CN CN201080031375.4A patent/CN102471313B/zh not_active Expired - Fee Related
- 2010-07-12 BR BRPI1015921A patent/BRPI1015921A2/pt not_active IP Right Cessation
- 2010-07-12 KR KR1020127000996A patent/KR101365854B1/ko not_active Expired - Fee Related
- 2010-07-12 EA EA201270169A patent/EA020540B1/ru not_active IP Right Cessation
- 2010-07-12 SG SG2012002523A patent/SG177646A1/en unknown
- 2010-07-12 MA MA34531A patent/MA33428B1/fr unknown
- 2010-07-12 NZ NZ597125A patent/NZ597125A/xx not_active IP Right Cessation
- 2010-07-12 JP JP2012520691A patent/JP5715127B2/ja not_active Expired - Fee Related
2011
- 2011-12-05 IL IL216776A patent/IL216776A0/en unknown
- 2011-12-29 CO CO11181048A patent/CO6480977A2/es active IP Right Grant
2012
- 2012-01-02 TN TNP2012000002A patent/TN2012000002A1/en unknown
- 2012-01-09 CR CR20120012A patent/CR20120012A/es unknown
- 2012-01-11 ZA ZA2012/00227A patent/ZA201200227B/en unknown
- 2012-01-11 DO DO2012000006A patent/DOP2012000006A/es unknown
- 2012-01-13 EC EC2012011606A patent/ECSP12011606A/es unknown

Also Published As

Publication number	Publication date
KR101365854B1 (ko)	2014-02-21
CA2764906C (en)	2014-06-10
EA020540B1 (ru)	2014-11-28
MA33428B1 (fr)	2012-07-03
JP2012533546A (ja)	2012-12-27
CN102471313A (zh)	2012-05-23
NZ597125A (en)	2013-08-30
KR20120024964A (ko)	2012-03-14
US8207344B2 (en)	2012-06-26
TW201114757A (en)	2011-05-01
US20110015199A1 (en)	2011-01-20
TWI429634B (zh)	2014-03-11
SG177646A1 (en)	2012-02-28
TN2012000002A1 (en)	2013-09-19
AU2010273642A1 (en)	2012-01-19
EP2454251A1 (en)	2012-05-23
EA201270169A1 (ru)	2012-06-29
ZA201200227B (en)	2013-06-26
AR077638A1 (es)	2011-09-14
AU2010273642B2 (en)	2014-03-13
IL216776A0 (en)	2012-03-01
CA2764906A1 (en)	2011-01-20
MX2012000704A (es)	2012-03-07
PE20121045A1 (es)	2012-08-09
JP5715127B2 (ja)	2015-05-07
DOP2012000006A (es)	2012-01-31
CR20120012A (es)	2012-03-28
ECSP12011606A (es)	2012-02-29
WO2011008663A1 (en)	2011-01-20
CO6480977A2 (es)	2012-07-16
CN102471313B (zh)	2014-06-04

Publication	Publication Date	Title
FIC20250029I1 (fi)	2025-08-29	neratinibi
BRPI1015921A2 (pt)	2016-04-26	agonistas de gpr119
FIC20230025I1 (fi)	2023-07-19	neratinibi
DK2506745T3 (da)	2013-12-16	Patron-ekstraktionsindretning
BR112012004536A2 (pt)	2019-09-24	dispositivo
BRPI1008774A2 (pt)	2016-03-08	espiroamida substituída
UA19989S (uk)	2010-02-25	Пристрій гіпертермомасажний
EP2474540A4 (en)	2013-03-13	GPR119 AGONIST
DK2511282T3 (da)	2014-07-07	Uracylspirooxetannukleosider
BR112012010974A2 (pt)	2017-12-12	dispositivo
BRPI1008827A2 (pt)	2016-02-23	deisobutenizador
BRPI0807911A2 (pt)	2014-06-17	Agonistas de alfa2c adrenorreceptor
BRPI1014968A2 (pt)	2016-12-13	subalargador
BRPI1008070A2 (pt)	2016-03-15	tricianoboratos
BR112012004964A2 (pt)	2016-04-05	girocóptero
DK2493768T3 (da)	2014-08-04	Etiketfjernelses-indretning
BR112012002883A2 (pt)	2016-03-22	dispositivo
FR2947857B1 (fr)	2012-03-30	Agencement de deshuileur
EP2509287A4 (en)	2014-11-05	SLIDING AND TILTING MECHANISM
EP2479211A4 (en)	2013-06-05	FLUOR RUBBER COMPOSITION
BRPI1010159A2 (pt)	2016-03-29	bistuti
BR112012007885A2 (pt)	2019-09-24	dispositivo de retensão
BR112012002889A2 (pt)	2016-03-22	dispositivo
EP2448583A4 (en)	2012-12-05	Substituted 4-hydroxypyrimidine-5-carboxamides
BRPI0917563A2 (pt)	2015-11-17	porta-objeto

Legal Events

Date	Code	Title	Description
2017-05-23	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-09-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]