[go: up one dir, main page]

BRPI1015558A2 - chip biológico microfluídico, e, método de usar o mesmo. - Google Patents

chip biológico microfluídico, e, método de usar o mesmo.

Info

Publication number
BRPI1015558A2
BRPI1015558A2 BRPI1015558A BRPI1015558A BRPI1015558A2 BR PI1015558 A2 BRPI1015558 A2 BR PI1015558A2 BR PI1015558 A BRPI1015558 A BR PI1015558A BR PI1015558 A BRPI1015558 A BR PI1015558A BR PI1015558 A2 BRPI1015558 A2 BR PI1015558A2
Authority
BR
Brazil
Prior art keywords
same
biological chip
microfluidic biological
microfluidic
chip
Prior art date
Application number
BRPI1015558A
Other languages
English (en)
Inventor
Eric Marijn Wielhouwer
Elwin Xander Vrouwe
Johannes Oonk
Marinus Bernardus Olde Riekerink
Michael Keith Richardson
Original Assignee
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leiden filed Critical Univ Leiden
Publication of BRPI1015558A2 publication Critical patent/BRPI1015558A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C12M1/38—Temperature-responsive control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Thermal Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BRPI1015558A 2009-06-16 2010-06-15 chip biológico microfluídico, e, método de usar o mesmo. BRPI1015558A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0910330.0A GB0910330D0 (en) 2009-06-16 2009-06-16 A biological microfluidics chip and related methods
PCT/EP2010/003579 WO2010149292A1 (en) 2009-06-16 2010-06-15 A biological microfluidics chip and related methods

Publications (1)

Publication Number Publication Date
BRPI1015558A2 true BRPI1015558A2 (pt) 2016-04-26

Family

ID=40940870

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015558A BRPI1015558A2 (pt) 2009-06-16 2010-06-15 chip biológico microfluídico, e, método de usar o mesmo.

Country Status (12)

Country Link
US (1) US9315768B2 (pt)
EP (1) EP2442909A1 (pt)
JP (1) JP2012529896A (pt)
KR (1) KR20120040697A (pt)
CN (1) CN102481571A (pt)
AU (1) AU2010265110A1 (pt)
BR (1) BRPI1015558A2 (pt)
CA (1) CA2765732A1 (pt)
GB (1) GB0910330D0 (pt)
RU (1) RU2012101428A (pt)
SG (1) SG176893A1 (pt)
WO (1) WO2010149292A1 (pt)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
US8999636B2 (en) 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
GB0910330D0 (en) 2009-06-16 2009-07-29 Univ Leiden A biological microfluidics chip and related methods
CN102162140B (zh) * 2011-01-14 2013-03-27 东华大学 一种微流体芯片及其纺丝方法
JP5872776B2 (ja) * 2011-03-04 2016-03-01 株式会社生体分子計測研究所 細胞アッセイ用流路チップ及び検査装置
CN102199529A (zh) * 2011-03-22 2011-09-28 博奥生物有限公司 一种生物芯片杂交系统
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
EP2739587B1 (en) 2011-08-01 2020-05-27 Denovo Sciences Cell capture system
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
ITTO20110990A1 (it) * 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US11430279B2 (en) * 2012-05-09 2022-08-30 Wisconsin Alumni Research Foundation Functionalized microfluidic device and method
US9186670B2 (en) * 2012-05-09 2015-11-17 Wisconsin Alumni Research Foundation Functionalized microfluidic device and method
CN103461279B (zh) * 2012-06-08 2015-11-18 中国科学院上海生命科学研究院 用于线虫培养和/或观察的微流芯片和设备及其应用
US9103468B2 (en) * 2012-07-30 2015-08-11 University Of South Carolina Enhanced flow boiling in microchannels by high frequency microbubble-excited and -modulated oscillations
US9857333B2 (en) * 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
KR101468001B1 (ko) * 2014-05-21 2014-12-02 경북대학교 산학협력단 삼차원 다공성 나노섬유구조체를 포함한 미소유체 기반 조직칩 및 그 제조방법
CN104015366B (zh) * 2014-06-24 2016-05-25 上海大学 生物3d打印用交联凝胶状态监测注射器及方法
TWI561166B (en) * 2014-11-27 2016-12-11 Bo Gang Lin Photosynthesis microfluidic chamber and photosynthesis method
CN105875224B (zh) * 2014-12-09 2019-04-09 林伯刚 光合作用微流道室与光合作用方法
WO2016115457A1 (en) * 2015-01-16 2016-07-21 California Institute Of Technology Methods and devices for micro-isolation, extraction, and/or analysis of microscale components in an array
US12290811B2 (en) 2015-01-23 2025-05-06 Unchained Labs Microfluidic serial dilution platform based well-plate using an oil-free immiscible phase driven by manual or electronic pipettors
CN106148160B (zh) * 2015-03-27 2018-04-20 深圳华大基因科技服务有限公司 细胞分离装置和细胞分离方法
NL2014840B1 (en) * 2015-05-21 2017-01-31 Intecrypt B V Microfluidic device for in vitro 3D cell culture experimentation.
CN108367290B (zh) 2015-10-01 2021-06-04 伯克利之光生命科技公司 井孔板培养器
US10934512B2 (en) 2015-11-26 2021-03-02 Pusan National University Industry-University Cooperation Foundation Microfluidic perfusion cell culture system
WO2017091043A1 (ko) * 2015-11-26 2017-06-01 부산대학교 산학협력단 관류 세포 배양 마이크로 유체 시스템
EP3383992B1 (en) 2015-12-04 2025-02-05 President and Fellows of Harvard College Open-top microfluidic devices and methods for simulating a function of a tissue
GB2560290B (en) 2015-12-04 2022-03-09 Emulate Inc Open-Top Microfluidic Device With Structural Anchors
RU2633655C1 (ru) * 2016-05-17 2017-10-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" Устройство для дозированного вскрытия микрокапсул
EP3472301B1 (en) * 2016-06-15 2023-08-02 Mimetas B.V. Cell culture device and methods
WO2018079866A1 (ko) * 2016-10-25 2018-05-03 서울대학교산학협력단 세포를 공동배양하기 위한 미세유체칩
US10392592B2 (en) 2016-11-09 2019-08-27 University Of Macau Microfluidic screening system
WO2018102781A1 (en) 2016-12-01 2018-06-07 Berkeley Lights, Inc. Well-plate incubator
KR102036922B1 (ko) * 2016-12-05 2019-10-25 (주)옵토레인 분석 모듈 및 이의 제조 방법
CN106861781B (zh) * 2017-04-10 2023-04-11 黑龙江科技大学 一种基于表面纳米气泡降低流体阻力的微通道制备方法
WO2018200896A1 (en) 2017-04-28 2018-11-01 Neofluidics, Llc Fluidic devices with reaction wells and uses thereof
US11745181B2 (en) 2017-08-09 2023-09-05 Unchained Labs Devices and methods for bioassay
CN112980667B (zh) 2017-08-29 2024-09-17 伯乐实验室有限公司 用于分离和分析细胞的系统和方法
US10780436B2 (en) * 2017-09-26 2020-09-22 Advanced NanoBio Technologies Limited Multi-channel microfluidic device and method for using the same
EP3706905A4 (en) 2017-11-10 2021-11-03 Neofluidics, LLC INTEGRATED FLUID CIRCUIT AND DEVICE FOR DROPLET MANIPULATION AND PROCEDURE FOR THIS
RU2675998C1 (ru) * 2018-02-02 2018-12-25 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Микрофлюидный чип для культивирования и/или исследования клеток и заготовка микрофлюидного чипа
WO2020069290A1 (en) * 2018-09-28 2020-04-02 Overture Life, Inc. In vitro fertilization system and components associated therewith
EP3870369A4 (en) 2018-10-26 2022-11-09 Neofluidics, LLC FLUID DEVICES HAVING REACTION WELLS AND THROAT CHANNEL AND USES THEREOF
US11097274B2 (en) * 2018-12-20 2021-08-24 Cerflux, Inc. Biomimetic array device and methods of using same
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
WO2020227309A1 (en) 2019-05-07 2020-11-12 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
KR20250084977A (ko) 2019-06-14 2025-06-11 바이오 래드 래버러토리스 인코오포레이티드 자동화된 단일 세포 처리 및 분석을 위한 시스템 및 방법
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
CN112452362B (zh) * 2020-09-25 2021-09-21 中山大学 一种无泵固定斑马鱼微流体芯片系统及其制备方法与应用
CN115777684B (zh) * 2021-09-10 2025-07-04 深圳拜尔洛克生物技术有限公司 用于生物组织冷冻保存或解冻复苏的装置
CN114134011B (zh) * 2021-11-24 2023-07-21 深圳先进技术研究院 用于培养单层细菌的装置及模具
EP4444910A4 (en) 2021-12-10 2025-11-05 Bio Rad Laboratories Inc Compositions, processes and systems for the treatment of samples with functionalized particles of adjustable morphology
US20250145924A1 (en) * 2022-01-26 2025-05-08 Georgia Tech Research Corporation Cell deactivation device
AU2023370517A1 (en) * 2022-10-24 2025-06-12 Cell Tech Holding Pty Ltd Single cell handling device
TWI849811B (zh) * 2023-03-21 2024-07-21 好孕行生醫股份有限公司 用以提供垂直溫差環境之加熱培養裝置及其使用方法
WO2025171389A1 (en) * 2024-02-09 2025-08-14 Colossal Biosciences Inc. An apparatus and method for a microfluidic culture of non-adherent pre-implantation cells, tissues, organoids, or embryos under environmentally controlled, highly customizable microenvironments

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
AU3649199A (en) 1998-04-17 1999-11-08 Ljl Biosystems, Inc. Sample-holding devices and systems
US7033840B1 (en) * 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
GB0321158D0 (en) * 2003-09-10 2003-10-08 Central Research Lab Ltd Apparatus and method for handling cells,embryos or oocytes
EP1702052A4 (en) * 2003-12-19 2009-02-18 Univ Waterloo CULTIVATED CELL AND METHOD AND DEVICE FOR CELL CULTURE
GB0505378D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Fluidic devices for cell and embryo culture
WO2008035074A2 (en) 2006-09-19 2008-03-27 Bg Research Ltd. Improvements in reaction apparatus
EP1970121A1 (en) * 2006-12-15 2008-09-17 Universiteit Leiden A microfluidic chip design comprising capillaries
CN101827931A (zh) 2008-08-29 2010-09-08 北京大学 用于可准确控制的细胞培养的微流体芯片
GB0910330D0 (en) 2009-06-16 2009-07-29 Univ Leiden A biological microfluidics chip and related methods

Also Published As

Publication number Publication date
SG176893A1 (en) 2012-01-30
EP2442909A1 (en) 2012-04-25
JP2012529896A (ja) 2012-11-29
US9315768B2 (en) 2016-04-19
US20120164679A1 (en) 2012-06-28
KR20120040697A (ko) 2012-04-27
CA2765732A1 (en) 2010-12-23
AU2010265110A1 (en) 2012-02-09
RU2012101428A (ru) 2013-07-27
CN102481571A (zh) 2012-05-30
GB0910330D0 (en) 2009-07-29
WO2010149292A1 (en) 2010-12-29

Similar Documents

Publication Publication Date Title
BRPI1015558A2 (pt) chip biológico microfluídico, e, método de usar o mesmo.
BRPI1007996A2 (pt) fluido de tratamento, e, método
BRPI0913292A2 (pt) método de hidroconversão, e, zona de reação de hidroconversão.
FR2929502B1 (fr) Implant nucleique.
LTC2358756I2 (lt) Žmogaus antikūnai, pasižymintys dideliu giminingumu pcsk9
BRPI0807473A2 (pt) Recipiente, javre e conjunto de recipiente e javre
BRPI1015087A2 (pt) fluido de perfuração, e, método.
BRPI0917120A2 (pt) método, e, meio legível por computador.
BRPI0905853A2 (pt) Meios de fermentação e processos destes.
BRPI0722004A2 (pt) Posto de saúde.
BRPI0915433A2 (pt) método, e, dispositivo.
BR112012002116A2 (pt) análise pvt de fluídos pressurizados.
BR112012000025A2 (pt) polipeptídos e processo de tratamento.
BRPI0922440A2 (pt) dispositivo protético e método de fabricação do mesmo .
BRPI1007477A2 (pt) método, e, composição de tratamento de poço
BRPI1011256A2 (pt) "fluido de perfuração, e, método."
BRPI0814941A2 (pt) Composição de tratamentode semente, e, método de tratamento de semente.
BRPI0920779A2 (pt) método de produção de óleo biológico.
BRPI0814466A2 (pt) Método.
BRPI0822633A2 (pt) Desinfetante, e, método de esterilização.
BRPI0913227A2 (pt) método, e objeto
BRPI0922312A2 (pt) método, e, meio legível por computador
BRPI0923412A2 (pt) método, e, produto de programa de computador.
BRPI0811755A2 (pt) Amplificação específica de senquência de dna específicas de tumor.
BRPI1014516A2 (pt) Biorreator de estado sólido, estático, e método para usar o mesmo

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.