BRPI1015203A2 - agentes antimicrobianos - Google Patents
agentes antimicrobianosInfo
- Publication number
- BRPI1015203A2 BRPI1015203A2 BRPI1015203A BRPI1015203A BRPI1015203A2 BR PI1015203 A2 BRPI1015203 A2 BR PI1015203A2 BR PI1015203 A BRPI1015203 A BR PI1015203A BR PI1015203 A BRPI1015203 A BR PI1015203A BR PI1015203 A2 BRPI1015203 A2 BR PI1015203A2
- Authority
- BR
- Brazil
- Prior art keywords
- antimicrobial agents
- antimicrobial
- agents
- Prior art date
Links
- 239000004599 antimicrobial Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09163955 | 2009-06-26 | ||
| EP09163955.9 | 2009-06-26 | ||
| PCT/EP2010/059152 WO2010149795A1 (en) | 2009-06-26 | 2010-06-28 | Antimicrobial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1015203A2 true BRPI1015203A2 (pt) | 2016-08-02 |
| BRPI1015203B1 BRPI1015203B1 (pt) | 2021-06-01 |
Family
ID=42537604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1015203-2A BRPI1015203B1 (pt) | 2009-06-26 | 2010-06-28 | Proteína de fusão composta por uma endolisina e uma extensão de peptídeo anfifática, usos da mesma e composição farmacêutica que compreende a dita proteína |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20120195872A1 (pt) |
| EP (2) | EP2446028B1 (pt) |
| JP (2) | JP6034188B2 (pt) |
| KR (1) | KR101701890B1 (pt) |
| CN (1) | CN102482655B (pt) |
| AU (1) | AU2010264659B2 (pt) |
| BR (1) | BRPI1015203B1 (pt) |
| CA (1) | CA2765810C (pt) |
| EA (1) | EA038542B1 (pt) |
| IL (1) | IL217121B (pt) |
| MX (1) | MX2011013453A (pt) |
| SG (1) | SG177704A1 (pt) |
| WO (1) | WO2010149795A1 (pt) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101711062B1 (ko) | 2009-06-26 | 2017-02-28 | 카톨리에케 유니버시테이트 루벤 | 항균제 |
| EP2446028B1 (en) | 2009-06-26 | 2018-04-04 | Lysando Aktiengesellschaft | Antimicrobial agents |
| CN102575240B (zh) | 2009-08-24 | 2016-01-13 | 勒芬天主教大学，K.U.勒芬R&D | 新的细胞内溶素OBPgpLYS |
| SG188566A1 (en) * | 2010-09-17 | 2013-04-30 | Tecnifar Ind Tecnica Farmaceutica S A | Antibacterial phage, phage peptides and methods of use thereof |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| CN102766196B (zh) * | 2011-05-06 | 2014-10-29 | 上海医药工业研究院 | 一组阳离子抗菌肽及其制备方法和应用 |
| CN103361341B (zh) * | 2012-03-26 | 2015-09-02 | 复旦大学附属华山医院 | 杀菌肽ll-37的基因工程的表达及其制备方法和用途 |
| EP2679232A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria vaccination |
| US9388400B2 (en) | 2012-06-29 | 2016-07-12 | Lysando Ag | Composition for use in mycobacteria diagnosis |
| EP2679677A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
| US11155801B2 (en) * | 2013-08-06 | 2021-10-26 | Trustees Of Dartmouth College | Unglycosylated lysostaphin variant protein |
| WO2015070911A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| WO2015070912A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| EP2904912A1 (en) * | 2014-02-07 | 2015-08-12 | Hyglos Invest GmbH | Novel high pressure method with endolysin for processing of foods |
| EP3105322B1 (en) | 2014-02-14 | 2018-12-12 | Lysando AG | Antimicrobial agents |
| EP3185882B1 (en) | 2014-08-29 | 2019-10-09 | Aarhus Universitet | Positively charged co-polymers for use as antimicrobial agents |
| WO2016130024A1 (en) * | 2015-02-13 | 2016-08-18 | Supreme Biotechnologies Limited | Endolysin expression platform |
| CA3022334A1 (en) * | 2016-04-28 | 2017-11-02 | Lysando Ag | Antimicrobial agents against salmonella bacteria |
| EP3528837A1 (en) * | 2016-10-20 | 2019-08-28 | Lysando AG | New antimicrobial agents against enterococcus bacteria |
| WO2018185634A1 (en) * | 2017-04-03 | 2018-10-11 | Sasinapas Co., Ltd. | Engineered gram-negative endolysins |
| CN108018271B (zh) * | 2018-01-31 | 2020-08-11 | 武汉核圣生物技术有限公司 | 单亚基rna聚合酶、其纯化方法及在rna合成中的应用 |
| WO2019191633A2 (en) * | 2018-03-29 | 2019-10-03 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| US11958890B2 (en) | 2018-05-30 | 2024-04-16 | Lysando Ag | Antimicrobial proteins |
| AU2019327378A1 (en) * | 2018-08-23 | 2020-10-29 | Contrafect Corporation | Lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| WO2021087415A1 (en) * | 2019-10-31 | 2021-05-06 | University Of Maryland, College Park | Method of treating infections by bacteriolytic enzymes and manufacture thereof |
| CN115461034B (zh) * | 2020-03-02 | 2024-09-27 | 联合利华知识产权控股有限公司 | 一种有效的抗痤疮个人护理组合物 |
| US20230140823A1 (en) | 2020-03-19 | 2023-05-04 | Micreos Human Health B.V. | A stabilized protein of interest. |
| US20250288652A1 (en) | 2021-02-08 | 2025-09-18 | Wuhan Lysigen Bio-Tech Company Limited | Bacteriophage lysine, chimera thereof and application thereof |
| KR102547393B1 (ko) * | 2021-04-19 | 2023-06-23 | 엠브릭스 주식회사 | 보툴리늄 독소 전위 도메인 및 엔도라이신을 포함하는 단백질 복합체 및 이를 포함하는 항균 조성물 |
| WO2023168418A1 (en) * | 2022-03-03 | 2023-09-07 | Massachusetts Institute Of Technology | Cell-wall binding protein specifically targeting cutibacterium acnes |
| CN114349870B (zh) * | 2022-03-21 | 2022-06-03 | 天津辅元生物医药科技有限公司 | 一种兼具防粘连功效的重组抗菌肽及其制备方法和应用 |
| CN114540385B (zh) * | 2022-03-21 | 2023-06-23 | 齐鲁工业大学 | 一种利用大肠杆菌产溶葡萄球菌酶的方法 |
| WO2024241070A1 (en) | 2023-05-22 | 2024-11-28 | L'oreal | Cosmetic composition comprising an endolysin and a polyvinyl alcohol |
| FR3149202A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et une huile. |
| FR3149203A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition anhydre comprenant une endolysine et de l’hydroxypropylmethylcellulose et/ou du pullulane |
| FR3152395A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et la 4-hydroxyacetophenone |
| FR3149208A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique, notamment aqueuse, comprenant une endolysine et un pullulane |
| CN121358455A (zh) | 2023-06-02 | 2026-01-16 | 莱雅公司 | 包含衍生自金黄色葡萄球菌噬菌体的内溶素和芳族醇的化妆品组合物 |
| FR3149209A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique |
| FR3149207A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un composé de formule (I) |
| FR3149205A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un agent de charge organique |
| FR3149204A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un tensioactif non ionique comprenant un résidu carbohydrate |
| FR3149206A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique aqueuse comprenant une endolysine et du tréhalose |
| FR3152394A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine et des particules d’aérogel de silice hydrophobe |
| FR3152396A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un polyhydroxyalcane |
| FR3152393A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée d’un phage de Staphylococcus aureus et une charge minérale |
| WO2025093666A1 (en) | 2023-11-01 | 2025-05-08 | University Of Copenhagen | Treatment of lymphoma |
| CN118421604B (zh) * | 2024-05-27 | 2024-10-22 | 小白鲸(中山)生物医药有限公司 | 一种重组溶葡萄球菌酶突变体及其制备方法和应用 |
| CN119799685A (zh) * | 2024-12-27 | 2025-04-11 | 深圳先进技术研究院 | 一种靶向闪烁梭菌的抗菌蛋白及其制备方法与应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0383770B1 (en) | 1987-07-06 | 1995-09-13 | Louisiana State University and Agricultural and Mechanical College | Inhibition of eucaryotic pathogens and neoplasms with lytic peptides |
| GB8816693D0 (en) | 1988-07-13 | 1988-08-17 | Agricultural & Food Res | Viral enzyme & gene |
| GB2255561B (en) | 1991-04-20 | 1995-06-21 | Agricultural & Food Res | Lysins from bacteriophages |
| ATE233817T1 (de) | 1992-08-21 | 2003-03-15 | Univ British Columbia | Kationische peptide und verfahren zu deren herstellung |
| AU3341995A (en) | 1994-09-01 | 1996-03-22 | Novo Nordisk A/S | A basic protein composition for killing or inhibiting microbial cells |
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
| US6428784B1 (en) | 1997-10-31 | 2002-08-06 | New Horizons Diagnostics Corp | Vaginal suppository for treating group B Streptococcus infection |
| US20030113298A1 (en) | 1997-10-31 | 2003-06-19 | Vincent Fischetti | Use of bacterial phage associated lysing proteins for the prophylactic and therapeutic treatment of various illnesses |
| US6288212B1 (en) | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| US5993809A (en) * | 1998-11-18 | 1999-11-30 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| WO2001000855A1 (en) | 1999-06-23 | 2001-01-04 | Ppl Therapeutics (Scotland) Ltd. | Fusion proteins incorporating lysozyme |
| US7338936B2 (en) | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| JP4472998B2 (ja) | 2002-04-22 | 2010-06-02 | ダウ グローバル テクノロジーズ インコーポレイティド | 低コストのペプチド製造 |
| US7566447B2 (en) | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
| NZ545564A (en) | 2003-09-11 | 2008-07-31 | Novozymes As | Recombinant production of antimicrobial agents |
| WO2005108563A2 (en) | 2004-04-19 | 2005-11-17 | University Of Chicago | Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4 |
| US7572602B1 (en) | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DE102005040347A1 (de) | 2005-08-25 | 2007-03-01 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von Listerien |
| ATE470451T1 (de) | 2006-03-31 | 2010-06-15 | Univ St Andrews | Antimikrobielle zusammensetzungen mit einem kationischen peptid und glycylglycin- endopeptidase |
| DE102006061002A1 (de) | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
| AR068552A1 (es) * | 2007-09-25 | 2009-11-18 | Pastoral Greenhouse Gas Res Lt | Polipeptidos y polinucleotidos del fago omegamru y sus usos para detectar, apuntar e inhibir celulas microbianas metanogenicas |
| EP2225263A1 (en) | 2007-11-26 | 2010-09-08 | Plant Bioscience Limited | Novel polypeptides having endolysin activity and uses thereof |
| EP2318531A4 (en) | 2008-07-24 | 2011-11-09 | Us Agriculture | TO RESISTANCE DEVELOPMENT REFRACTORY ANTIMICROBIAL ACTIVE SUBSTANCES |
| EP2157100A1 (en) * | 2008-08-19 | 2010-02-24 | Profos AG | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
| GB0815484D0 (en) * | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| US8389679B2 (en) * | 2009-02-05 | 2013-03-05 | The Regents Of The University Of California | Targeted antimicrobial moieties |
| DE102010014867A1 (de) * | 2009-04-17 | 2010-11-18 | Sms Siemag Ag | Verfahren zum Bereitstellen mindestens einer Arbeitswalze zum Walzen eines Walzguts |
| US8383102B2 (en) | 2009-05-21 | 2013-02-26 | The United States Of America As Represented By The Secretary Of Agriculture | Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens |
| EP2446028B1 (en) | 2009-06-26 | 2018-04-04 | Lysando Aktiengesellschaft | Antimicrobial agents |
| KR101711062B1 (ko) | 2009-06-26 | 2017-02-28 | 카톨리에케 유니버시테이트 루벤 | 항균제 |
| CN102575240B (zh) | 2009-08-24 | 2016-01-13 | 勒芬天主教大学，K.U.勒芬R&D | 新的细胞内溶素OBPgpLYS |
| CA2794603C (en) | 2010-04-27 | 2019-05-21 | Lysando Ag | Method of reducing biofilms |
| US9388400B2 (en) * | 2012-06-29 | 2016-07-12 | Lysando Ag | Composition for use in mycobacteria diagnosis |
-
2010
- 2010-06-28 EP EP10727421.9A patent/EP2446028B1/en active Active
- 2010-06-28 KR KR1020127002109A patent/KR101701890B1/ko active Active
- 2010-06-28 WO PCT/EP2010/059152 patent/WO2010149795A1/en not_active Ceased
- 2010-06-28 AU AU2010264659A patent/AU2010264659B2/en active Active
- 2010-06-28 EP EP18165516.8A patent/EP3363896A1/en active Pending
- 2010-06-28 JP JP2012516777A patent/JP6034188B2/ja active Active
- 2010-06-28 EA EA201270082A patent/EA038542B1/ru unknown
- 2010-06-28 US US13/380,329 patent/US20120195872A1/en not_active Abandoned
- 2010-06-28 SG SG2012003745A patent/SG177704A1/en unknown
- 2010-06-28 MX MX2011013453A patent/MX2011013453A/es active IP Right Grant
- 2010-06-28 CN CN201080037886.7A patent/CN102482655B/zh active Active
- 2010-06-28 BR BRPI1015203-2A patent/BRPI1015203B1/pt active IP Right Grant
- 2010-06-28 CA CA2765810A patent/CA2765810C/en active Active
-
2011
- 2011-12-21 IL IL217121A patent/IL217121B/en active IP Right Grant
-
2016
- 2016-07-01 JP JP2016131194A patent/JP2017018092A/ja active Pending
-
2019
- 2019-01-29 US US16/260,407 patent/US11136570B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2765810A1 (en) | 2010-12-29 |
| EA201270082A1 (ru) | 2012-06-29 |
| IL217121B (en) | 2019-08-29 |
| AU2010264659A1 (en) | 2011-12-15 |
| AU2010264659B2 (en) | 2016-08-04 |
| BRPI1015203B1 (pt) | 2021-06-01 |
| EP2446028B1 (en) | 2018-04-04 |
| US11136570B2 (en) | 2021-10-05 |
| CN102482655A (zh) | 2012-05-30 |
| CN102482655B (zh) | 2018-04-10 |
| KR101701890B1 (ko) | 2017-02-02 |
| EP2446028A1 (en) | 2012-05-02 |
| JP2012530510A (ja) | 2012-12-06 |
| MX2011013453A (es) | 2012-04-11 |
| US20120195872A1 (en) | 2012-08-02 |
| SG177704A1 (en) | 2012-02-28 |
| CA2765810C (en) | 2018-10-16 |
| US20190218538A1 (en) | 2019-07-18 |
| JP2017018092A (ja) | 2017-01-26 |
| WO2010149795A1 (en) | 2010-12-29 |
| EA038542B1 (ru) | 2021-09-13 |
| EP3363896A1 (en) | 2018-08-22 |
| JP6034188B2 (ja) | 2016-11-30 |
| KR20120061802A (ko) | 2012-06-13 |
| IL217121A0 (en) | 2012-02-29 |
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