BRPI1003430A2 - synergistic combination of imidacloprid and bifenthrin, their preparation process and uses, and methods of use - Google Patents

Abstract

SYNERGIC COMBINATION OF IMIDACLOPRID AND BIFENTRINE, THEIR PREPARATION PROCESS AND USES, AND METHODS OF USE. The present invention relates to an inorganic agrochemical formulation of imidacloprid and bifenthrin in specific proportions for controlling and / or controlling pests and diseases in plant crops. Their processes of preparation, use and method of use as well as the use of imidacloprid and bifentrin in the preparation of the synergistic agrochemical formulation of the invention are further described.

Description

Patent Descriptive Report for "SYNERGIC COMBINATION OF IMIDACLOPRID AND BIFENTRINE, THEIR PREPARATION PROCESS AND USES, AND METHODS OF USE". BACKGROUND OF THE INVENTION

The present invention relates to the synergistic combination of

active ingredients imidacloprid and bifenthrin for pest control in soybean, cotton, beans, wheat, irrigated rice, potatoes, tomatoes, citrus fruits, tobacco and corn.

Imidacloprid is an insecticide known to control a variety of pests. US Patent 4,742,060 provides a description of imidecoprid and some of its uses. Imidacloprid provides some control of hemiptera insects of the Aphididade family, especially those popularly known as aphids. However, many other pests are part of the pest complex of important crops, such as soybeans, cotton, beans, wheat, rice, potatoes, tomatoes, citrus fruits, tobacco and corn.

Bifenthrin is an insecticide known to control a variety of pests. US 4 238 505 provides a description of bifentry and some of its uses. Bifenthrin is generally known as 2-methylbiphenyl-3-ylmethyl (z) - (1RS, 3RS) -3- (2-chloro-3,3,3-trifluoroprop-1-enyl) -2,2-dimethylcyclopropane carboxylate, CAS Registration Number 82657-04-3. Bisphentrin is described in The Pesticide Manual, page 88 (entry 76), C.D.S. Thomas, 13th edition, 2003. Bifenthrin is known to provide some control over lepidopteran insects of the Noctuidae family, especially those popularly known as caterpillars. The present invention may be used to control the following

pests:

Soybean culture: Euchistus herus, Nezara viridula, Piezodorus guildini, Dichelops furcatus, Edessa media, Anticarsia gemmatalis, Pseudoplusia includens, Tetranichus urticae and Polyphagotersunemus latus. Cotton culture: Anthonomus grandis, Alabama clay,

Pseudoplusia includens, Spodoptera erídanea, Pectinophora gossipiela,

Bean culture: Euchistus herus, Nezara viridula, Piezodorus guidini, Diabrotica speciosa, Empoaska kraemeri, Bemisia tabaci and Pseudoplusia includens,

Wheat crop: Pseudaletia sequax and Dichelops furcatus, Rho-palosiphum graminum, Potato crop: Lyriomyza huidobrertsis, Thripes palmi, Phthorimaea operculella, Tomato crop: Lyriomyza trifolii, Thripes palmi.

Among the pests mentioned above, we can highlight the perception Euchistus heros, which is a phytophagous stinkbug considered one of the main insects that attack soybean crops in Brazil. Their damage is caused by the introduction of their mouthpiece into developing grains or seeds, which harms tissues and causes serious damage to seed supply and quality, resulting in low strength and low seed content. oil in the seeds, and provides the entry of fungi, which can cause other diseases in plants. According to researchers Paulo Degrande and Lucia Vivan (Cul-

Magazine Magazine, 2008), when bed bugs attack pods, losses reach high levels, even over 30%. If the attack occurs during grain formation, the grain will shrink and be stained to a lesser extent due to reduced oil content. In this case, seed germination power losses can reach 50%.

In short, bedbugs cause damage to soybeans due to reduced yield through effects on pods and / or grains, reductions in germination power and seed resistance, reduced protein and oil content in grains and inoculation of soybeans. pathogenic elements in the seed.

SUMMARY OF THE INVENTION

The main object of this invention is to provide a specific synergistic combination (premix) of imidacloprid + bifenthrin, encoded as "BF 404-06", to control a wider spectrum of pests in soybean, cotton, beans, wheat, irrigated rice, potatoes, tomatoes, citrus fruits, tobacco and corn.

Another object of the invention is to reduce the amount of active ingredient per hectare because the synergism of the inventive molecules BF 404-06 (bifenthrin + imidacloprid) provides applications with lower amount of active ingredient per hectare of imidacloprid.

Another important and unexpected technical factor that has been observed by the inventors is related to the increased residual effect of insecticide product BF 404-06 compared to bifenthrin alone. This longer effect reduces the number of insect control applications and reduces the cost / ha for the producer.

The present invention, in addition to offering all the synergistic benefits of pest control premixing, does not cause an imbalance of mites, which always happens when other pyrethroids are applied. According to Valentini etal. (1980), the mite is pyrethroid resistant, and its use irritates females, causes them to spread, encourages oviposition, and eliminates natural enemies such as Thysanoptera, ladybugs, chrysopids, and bed bugs.

The invention BF 404-06 (bifentrin + imidacloprid) is an important tool in the management of insecticide pest resistance as a mixture of two active ingredients from different chemical groups. DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a solid or liquid formulation.

gives. In solid form it should be used as wettable powder (Wettable Powder - PM) and / or Water Dispersible Granules (WDG), and in liquid form which should be used as an emulsifiable concentrate (EC) as Concentrated Suspension. (SC), suspoemulsion (SE) and / or concentrated emulsion (EW), but preferably as SC, not excluding other formulation types.

The ratio between the amount of imidacloprid and the amounts of bifenthrin is about 8-12 parts of imidacloprid to about 1-5 parts of bifenthrin. In one feature of the invention, the ideal ratio of imidacloprid: bifenthrin is about 10: 3. With 1L formulations, the concentration in gia / L (gia = gram

bifenthrin is about 1 for every 699 gia / L and imidacloprid is about 699 to about 1 gia / L. Preferably, the concentration of bifenthrin is about 30 g / l, and that of imidacloprid is around 100 g / l. The sum concentration of the active ingredients in the final formulation may typically range from about 10 gia / l to about 700 gia / l, preferably about 300 gia / l.

The rest of a formulation of up to 1 (one) liter may include vehicles

suitable additives and / or excipients which may be selected from water, surfactants, defoamers, antifreeze, rheology modifying agents, dispersants, humectants, bactericides or bacteriostatic agents, colorants, anti-caking agents and stabilizers and mixtures thereof. The vehicle may normally be inert, of organic material or

inorganic, and of natural or synthetic origin. The carrier, if solid, may be clay, silicates, silica, resins, waxes, cellulosic fibers, fertilizers or the like and may be used alone or in combination. If liquid, the carrier may be water, C1 to C14 chain alcohols, glycols, acetates, ketones, glycerides, saturated or unsaturated hydrocarbons, fatty acid esters, vegetable oils, mineral oils or the like and may be used singly or separately. together. Preferably, water is used as a vehicle.

The surfactants can be ionic, nonionic, cationic or

polymeric.

The anionic surfactants that can be used at present

invention are: linear or branched dodecylbenzenic sulfonic acid, in acid or neutralized form, nitrogenous derivatives, sulfonated aromatic polymers in acid or neutralized form, sulphonated formaldehydes in acid or neutralized form, condensed or not, lignosulfonated. These are preferably sulfated and / or sulfonated surfactants.

Nonionic surfactants which may be used in the present invention are: alkoxylated, such as alkoxylated sorbitan esters, alkoxylated alcohols, alkoxylated vegetable oils, alkoxylated fatty acids, among others; fatty esters, such as polyethylene glycol esters, glycerol or polyglycerol esters, sorbitan esters; amides such as fatty amides of ethanolamine or ethylene amines, fatty imidazolines, among others. Preferably, caprylic, caprylic, isodecyl, isotridecyl, decyl, lauric, stearyl, oleic, nonyl phenyl, alkoxylated alcohols of 1-16 mo of ethylene oxide and / or propene oxide are used. , alkoxylated vegetable oils, such as alkoxylated castor oil with an alkoxylation degree of 5-54 mo of ethylene oxide or propene oxide, alkoxylated sorbitan esters with an alkoxylation degree of between 5 and 80 mo of ethylene oxide and / or oxide of propene.

The cationic surfactants that may be used in the present invention are alkyl trimethyl ammonium hydrochloride, dialkyl dimethyl ammonium hydrochloride, alkyl hydroxyethyl dimethyl ammonium hydrochloride, cetyl trimethyl ammonium hydrochloride, distearyl dimethyl ammonium hydrochloride, and quarten esters, among others.

The polymeric surfactants that may be used in the present invention are ethylene oxide and propylene oxide block copolymers, mainly butyl chain, polyacrylate copolymers, methyl methacrylate copolymers, among others.

The present invention also relates to a process for preparing the formulations of the invention, for example, the concentrated suspension type formulation comprising the following steps:

- water, surfactants and additives are mixed in one container; - add to this mixture of melted bifenthrin which will be under

stirring in a recrystallization process;

- after the recrystallization process is complete, imidecoprid is added;

- After completing the addition of all raw materials, the formulation undergoes a grinding process, where there will be greater interaction between the molecules and particle size reduction of the active ingredients, thus increasing synergism. between molecules and their efficiency in the field;

- after grinding, the formulation still undergoes a deaeration and thickening process to increase its physical stability, obtaining

a stable and synergistic agrochemical formulation is given;

- The product is then bottled in jars and other types of high density polyethylene containers and distributed on the market.

Another embodiment of the invention is the use of imidacloprid and bifentrin in the preparation of formulations for the control and / or control of pests and diseases in plant crops.

The invention also includes the use of the formulations of the invention.

controlling and / or combating pests and diseases in plant crops.

Another embodiment of the invention is a method of controlling and / or controlling pests and diseases in plant crops, including applying the formulations of the invention to these pests, their habitats and / or plant crops.

As mentioned earlier, the invention has wide and efficient application in soybean, cotton, beans, wheat, irrigated rice, tomatoes, citrus fruits, tobacco and maize crops to control and combat Euchistus herus, Nezara viridula, Piezodorus guidini, Dichelops furcatus, Edessa meditabunda Anticarsia gemmatalis, Pseudoplusia inclusis, Anthonomus grandis, Alabama argilacea, Spodoptera eridanea, Peetinophora gossipiela, Diabrotiea speeiosa, Empoaska kraemeri, Rhizophaumidae Lyriomyza huidobrensis, Phthorimaea opereulella, Lyriomyza trifolii and Thripes palmi, without limitation, and the diseases caused by them.

In order to achieve a better understanding of the invention, some examples of formulations used are given below. These examples are intended to illustrate, not limit, the uses of the invention. EXAMPLES:

Example 1 - Formulation of the Invention (BF 404-06):

(components) [concentration (g / 1 OOm Water qsp Silicone emulsion 0.5 EO / PO copolymer 2 Sodium sulfonated naphthalene formaldehyde 1.5 Benzisothiazoline 0.25 Bentonite clay 0.6 Glycerin 6 Gum xanthan 0.3 Imidacloprid 10 Bifenthrin 3

Example 2 - Formulation of the Invention (BF 404-06):

Water qsp Silicone emulsion 0.5 EO / DUST copolymer 4 Sodium sulfonated naphthalene formaldehyde 2.5 Benzisothiazoline 0.25 Bentonite clay 0 Glycerin 8 Xanthan gum 0.4 Imidacloprid 10 Bifentrin 3

Example 3 - Formulation of the Invention (BF 404-06):

(components) _ [concentration (g / 1 OmL)]

Water qsp Silicone emulsion 0.5 EO / POW 3 copolymer Isotridecyl alcohol with 8 mo of ethylene oxide 1.5 Nonylphenol with 10 mo of ethylene oxide 1 Benzisothiazoline 0.25 Clay smectite 0.6 Monoethylene glycol 6 Xanthan gum 0.2 Imidacloprid 10 Bifentrin 3

Example 4 - Formulation of the Invention (BF 404-06):

(components) [concentration (g / 1 OOm Water qsp Silicone based antifoam 0.5 Triestyrylphenol with 54 mo of ethylene oxide 3.5 Lauric alcohol with 10 mo of ethylene oxide 1.5 Dodecylbenzene sodium sulfonate 2 Benzisothiazoline 0, 25 Monoethylene Glycol 7 Xanthan Gum 0.25 Imidacloprid 10 Bifentrin 3

Example 5 - Use of BF 404-06 in soybean crops to combat bed bugs:

BF 404-06 at a dose of 0.5L / ha is applied to a culture of soil

already. At this dose we used 15 gia / ha of bifenthrin + 50 gia / ha of imidacloprid. This dose is equivalent to 0.15L / ha of Talstar® (trade name for bifentrin 100, marketed by FMC Química do Brasil Ltda.). Therefore, the same 15gia / ha of bifenthrin were applied. When the treatments are compared, one can observe a

marked increase in performance with BF 404-06 treatment in proportion to the active ingredient Talstar® to control the bed bug Euchistus heros, a pest on which bifenthrin is not effective when applied alone. These results, which are presented in Tables 1, 2 and 3

below, prove the results already obtained, and show the additive and synergistic effect of the imidacloprid and bifenthrin molecule, a fact that had never been observed in the state of the art for these doses in soybean crops.

The imidacloprid / bifentrin ratio can range from 9: 3 to 11: 3, and the ratio is 10: 3, the exact ratio of tests.

TABLE 1: Summary of the three studies conducted in southern Brazil, focusing on the control of adults and bed bug nymphs Euchistus herus, 2008/09 crop.

Treatments Rate / ha GAl Form 2 DAA% Euchistusherus Control ADULTS & NINFAS 5 DAA S DAA 12 DAA 15 DAA 1 UNTREATED N insects / m} * 6 8 10 8 9 I 2 BF 404-06 65 (15-t> 0) Γ 0.5 77 ί 85 to 69 ab 70 to 62 ab I 3 BF 404-06 78 (18 + 50) 0.6 89 £ 82 to 85 to 69 to 66 a 4 BF 404-06 91 (21 + 70) 0 , 7 78 and 88 to 96 to 77 to 69 to I 5 TALSTAR 0.15 50 53 b 39 c 32 b 32 c I

6 CONNECT 84 (9.3 +75) Γ 0.75 68 ab 49 b 34 C 35 b 41 b and b

7 FULL ENGINE 49.4 (19 + 25) ^ 0.2_68 ab 59 b_43 b and 38 b 39 b and b

5th

TABLE 2: Summary of the three studies carried out in the southern region of Brazil ， focusing on the control of euchistus herus bed bug and nymphs ， highlighting the residual insecticide control, 2008/09 crop.

Treatments

Rate / ha G Ai Form

2 DAA

% Control Euchistus herus NYMPHS DAA 8 DAA 12 DAA

DAA

UNTREATED (N insects / m)

5th

5th

5th

I 2 BF 404-06 65 (15) 50} 0.5 70 ab 85 a 90 a I I 69 ab 78 a I 3 BF 404-06 78 (18 + 60) 0.6 87 a 85 a 94 a 80 a 85 to 4 BF 404-06 91 (21 + 70) 0.7 74 ab 87 to 100 to 79 to 80 to I 5 TALSTAR C, 15 45 b 55 b 41 bcl I 43 b and 19 b and I

6 CONNECT

7 FULL ENGEO

84 (9.3 +75) 49.4 (19 + 25)

0.75 0.2

65 ab

66 ab

53 b 63 b

c 70 ab

39 c 50 b and

44 b 46 b

7 FULL ENGEO 49.4 (19 十 25) 0.2

52 b

59 b and

70 ab

29

36 b

TABLE 3: Summary of the three studies conducted in the central region of Brazil (Cerrado), focusing on the control of bed bug nymphs Euchistus herus, highlighting the residual insecticide control, 2008/09 crop.

Treatments Rate / ha% Control Euchistus herus ADULTS & NINFAS

. _GAI Form IDAA 3 DAA 5 DAA 7 DAA IODAA 15 DAA

1 UNTREATED (N kisects / m) 8 7 9 8 17 9

I 2 BF 404-06 65 (15 ^ 50) 0.5 88 to 91 to 79 to 72 a \ | 60 ab 78 ab]

3 BF 404-06 78 (18-f60) 0.6 91 to 90 to 93 to 79 to 67 ab 83 ab

4 BF 404-06 91 (21 + 70) 0.7 92 to 85 to 94 to 79 to 75 to 92 to

I 5 TAL5TAR 0,15 73 b 55 b 44 b 45 b | | 52 b 69 b |

6 CONNECT 84 (9.3 +75} 0.75 83 ab 72 ab 75 a 63 ab 56 b 69 b

7 FULL ENGINE 49.4 (19 + 25) 0.2 88 a_84 a 83 to 72 a 61 ab 69 b

In order to obtain a better identification and evidence of the new, superior and unexpected effects of the present invention, BF 404-06 has been compared to the standard Connect® trademark (Bayer Cropscience brand), which is composed of Betacyflutrin 12.5 gia / L + 100 gia imidacloprid / L. As BF 404-06 has in its composition one of Connect®'s active ingredients - imidacloprid - this product

was used as standard for the results. - In order to control Euchistus heros, the dose of 70 to 100

Imidacloprid (Connect®) / ha was used. For bifenthrin, when applied alone, doses of 12 to 18 g / ha are used. With these doses, the control provided by both imidacloprid (Connect®) and bifenthrin is generally insufficient and inconsistent.

Thus, for the control of this pest in soybean, by applying 0.5 l / ha of the formulated product BF 404-06 (bifentrin + imidacloprid) against a dose of 0.75 l / ha of the Connect standard commercial product. ®, one can observe the following advantageous and surprising effects for technicians:

When applying BF 404-06 50% less imidacloprid active ingredient is used compared to Connect® commercial product, ie with product BF 404-06 50 gia / ha is applied while with ο Connect®, 75 gi / ha are used to achieve satisfactory control effectiveness of Euchistus herus according to the data in Tables 4, 5 and 6 below.

The reduction in the amount of active ingredient present provides advantages such as: cost reduction and lower environmental impact due to reduction of active ingredient / ha (reduction from 75 gia / ha to 50 gia / ha).

In addition to reducing this active ingredient, we also observed better pest control, especially with insect nymphs (Table 5). The prolonged residual effect brings the benefit of a smaller number of applications during the soybean crop cycle.

Control of the above exemplified bed bugs may include a Kinetic, sequential or simultaneous application of BF 404-06. The results can be seen in Table 5. The objective

so it was exclusively to control Euchistus herus nymphs. At 12 and 15 days after application (DAA) 1 treatment with BF 404-06 shows efficiencies of 70 and 62%, respectively, while with ο Talstar® applied alone, the efficiency is 32% in the same period. To show the consistency of the results, the summary of studies conducted in the Brazilian Cerrado region (Table 6) also shows the same trend as the results.

previously mentioned. Another important factor is the residual effect of the insecticide, which with BF 404-06 is extended. This can be observed by analyzing the data in Tables 4, 5 and 6, on days 12 and 15 after the application (DAA) of the products. Treatment with BF 404-06 showed efficiencies of 70 and 62%, respectively, while with ο Connect®, the control efficiency was 35% and 41% in the same period.

To control this pest, several experiments were performed in different Brazilian regions. During these experiments, 0.5L / ha of the formulated product BF 404-06 (bifentrin + imidacloprid) was applied and the results were compared with ο Talstar® (bifenthrin) at a dose of 0.15L / ha and ο Connect® at 0.75L / ha dose.

TABLE 4: Summary of the five studies conducted in the southern region

do Brasil1 focusing on the control of adults and bed bug nymphs Euchistus herus, 2008/09 crop.

Treatments Rate / ha GAI Form% Euchistusherus Control ADULTS & NINFAS 2 DAA 5 DAA 8 DAA 12 DAA 15 DAA 1 UNTREATED (N insects / m) * 6 8 10 8 9 I 2 BF 404-06 65 (1 ^ -50]) 0, 5 77 to 85 to 69 ab 70 to 62 ab | 3 BF 404-06 4 BF 404-06 5 TALSTAR 78 (18 + 60) 91 (21 + 70) R 15 0.6 0.7 0.15 89 a 78 a 50 b 82 a 88 a 53 b 85 a 96 a 39 c 69 a 77 a 32 b 66 a 69 a 32 c I 6 CONNECT 84 (9,3 & 75]> '0.75 68 ab 49 b 34 c 35 b 41 b and I

7 FULL ENGEO 49.4 (19 + 25) '0.2_68 ab 59 b 43 b and 38 b 39 b and b

TABLE 5: Summary of the five studies carried out in the southern region of Brazil1 focusing on the control of bed bug nymphs Euchistus herus, highlighting the residual insecticide control, 2008/09 crop.

Treatments Rate / Ηέ% Control Euchistus herus NYMPHS

GAI Form 2 DAA 5 DAA 8 DAA 12 DAA 15 DAA

1 UNTREATED (N insects / m) 4 5 5 5 5

I 2 BF 404-06 65 (15 (5φ 0.5 70 ab 85 to 90 to I I 69 ab 78 to I 3 BF 404-06 78 (18 + 60) 0.6 87 to 85 to 94 to 80 to 85 a 4 BF 404-06 91 pl + 70) 0.7 74 ab 87 a 100 a 79 a 80 a TALSTAR 15 0.15 45 b 55 b 41 b and 43 b and 19 b and I 6 CONNECT 84 (9.3C ± 75j> 0.75 65 ab 53 b 35 c I 139 c 44 b I

7 FULL ENGINE 49.4 (19 + 25) 0.2 66 ab 63 b 70 ab 50 b and 46 b

TABLE 6: Summary of the three studies conducted in the central region of Brazil (Cerrado), focusing on the control of European bed bug nymphs.

chistus herus, highlighting ο residual insecticide control, 2008/09 crop. Treatments

Rate / ha GAI Form

% Control Euchistusherus ADULT05 & NINFAS 3 OAA 5 DAA 7 DAA 10 DAA

1 UNTREATED (N insects / m) _

1 2 BF 404-06 65 (15 (50¾0 ~

9th

88 a

91a

79 to

3 BF 404-06

4 BF 404-06

TALSTAR

78 (18 + 60) 0.6 91 (21 + 70) 0.7 0.15

91a 92 to 73 b

90a 85 to 55 b

93 a

94 to 44 b

I 6 CONNECT 84 (9.3 (75 ；) 0.75 83 ab 72 ab 7sT

7 ENGEO Pi £ m 49.4 (19 + 25) 0.2 88 a

84a

83 a

ΈΏί

72 to

60 ab

61 ab

78 ab

79 to 67 ab 83 ab

79 to 75 to 92 to

45 b 52 b 69 b

63 ab | I 56 b 69 b

69 b

Example 5: Effectiveness of BF 404-06 focusing on the control of bedbug adults and nymphs Euchistus herus, Londrina / PR, 2007/08 crop.

This work was carried out in order to verify the efficacy of products to control the stink bug Euschistus heros, which is popularly known as stink bug from soybean. The 0.5L / ha BF 404-06 product (15 + 50 g / ha bifentrin + imidacloprid, respectively) offers 90.1% control 14 days after application (DAA) 1 while ο Tals - tar® (100 gia bifentrin / L) offers, at a dose of 0.15L / ha, control close to 70%. Connect®, which at these doses contains 75 g / l imidacloprid, offers an unsatisfactory result with 36% control.

These results show that ο BF 404-06, even with 50% less imidacloprid, provided final control 150% better than ο Connect®, which contains 75 g / ha of imidacloprid in its formulation and 28% better than ο Talstar® with the same amount of the active ingredient bifenthrin / ha. TABLE 7

Doses N "of insects / m% Control Euchistus herus qAA-" ： ： ： ； ： 14DAA .. 1 UNTREATED 2.5 a 0.0 b 0.0 c 0.0 e 2 BF 404-06 39 0.3 3.0 to 87.5 to 96.9 to 83.2 ab IS 6Ρ4ό4-όέ 65 o, 5 to ^ 00.6 a δό, Ί a I

4 BF 404-06 91 0.7 3.0 to 95.8 to 100.0 to 93.8 to

TALSTAR 15 0.15 2.0 to 57.5 to 64.1 ab 70.3 b and 6 CONNECT 84 0.75 1.3 to 16.7 b 76.6 to 36.7 d

7 FULL ENGEO 44.4 0.18 d.m.s (P = .05) Standard Deviation CV

2.0 a 24.2 b 44.0 b 61.3 2.12 33.20 25.38 15.57 1.43 22.35 17.08 10.48 64.44 41.53 24.83 16, 85

Example 6: Effectiveness of BF 404-06 Focusing on Adult Control

bedbugs and nymphs Euchistus herus, Passo Fundo / PR, crop. 2007/08.

This work was carried out in a region considered cooler to verify the effectiveness of products to control the stink bug Euschistus heros, which is popularly known as brown soybean stink bug.

The product BF 404-06 at a dose of 0.5L / ha (15 + 50 gia / ha of

fentrin + imidacloprid, respectively) offers a 66% control 15 days after application (DAA), while ο Talstar® (100 gia bifentrin / L) provides a dose of close to 60% at 0.15 L / ha . Connect®, which in these doses contains 75 g / L imidacloprid, offers a poor result with 44% control. These results show that BF 404-06, even with 50% less imidacloprid, provided final control 53% better than ο Connect®, which contains 75 g / ha of imidacloprid in its form and is 9% better. than ο Talstar® with the same amount of bifentrin active ingredient / ha. TABLE 8

Dt> ses% Control Euchistus herus § Treatments GIA Formulated 2 DAA 5 DAA 7 DAA 9 DAA 15DAA] 1 UNTREATED 0.0 b 0.0 b 0.0 c 0.0 b 0.0 b 2 BF 404-06 39 0 , 43.6 to 45.3 to 47.7 ab 34.9 to 44.7 ab I 3 BF 404-06 65 0.5 58.1 to 60.2 to 60.0 to 59.7 to 66, 1 to I 4 BF 404-06 91 0.7 59.5 to 54.7 to 62.6 to 68.0 to 60.0 ab TALSTAR 15 0.15 56.3 to 37.5 to 38.0 abc 56 , 1 to 60.7 to 6 CONNECT 84 0.75 64.4 to 56.9 to 36.1 abc 45.8 to 43.8 ab dms (P = .05) 27.36 32.06 28.72 28 .98 39.15 Standard Deviation 18.41 21.58 19.33 19.51 26.35 CV 36.82 48.29 56.96 39.93 54.98

Example 7: Effectiveness of BF 404-06 focusing on the control of adults and nymphs of Iagartas Pseudoplusia includens, Londrina / PR, 2007/08 crop.

This work was carried out with the objective of controlling Iagarta Pseudoplusia includens, which is currently one of the most difficult pests to control in soybean crops, in order to verify the efficacy of products for controlling this pest, which is popularly known as Iagarta fal. - sa-medideira.

BF 404-06 at a dose of 0.5 l / ha (15 + 50 gia / ha of bifenthrin + imidacloprid, respectively) offers 85% control 9 days after application (DAA), while ο Talstar® ( 100 gia bifentrina / L) offers ， at the dose of 0.15l / ha, control close to 65%. Connect®, which in these doses contains 75 g / l imidacloprid, offers a slightly lower result than BF 404-06, in the same proportion as the active ingredient imidacloprid per ha. These results show that ο BF 404-06 ， even with 50% less imidacloprid, provided 4% better final control than ο Connect®, which contains 75 g / ha of imidacloprid in its formulation and 30% better than ο Talstar® with the same amount of active ingredient bifentrin / ha.

TABLE 9

Doses% Control Pseudoplusia includens Treatments GIA Formulated 5 DAA 9 DAA 1 UNTREATED 0.0 b 0.0 c 2 BF 404-06 39 0.3 30.0 ab 65.8 ab | 3 BF 404-06 65 0.5 65 , 0 ab 85 ab I 4 BF 404-06 91 0.7 100.0 to 97.2 a TALSTAR 15 0.15 33.3 ab 65.0 ab 6 CONNECT 84 0.75 36.7 ab 81.7 ab dms (P = .05) 57.50 26.79 Standard Deviation 38.70 18.03 CV 93.42 28.67

Example 8: Summary of the effectiveness of three studies with BF 404-06 focusing on the control of nests and nymphs of the small green stink bug (P / 'ezodorus guidinii), Mato Grosso / MT, 2007/08 crop.

The stink bug Piezodorus guidinii, popularly known as the green soybean bug, is also a species that causes large yield losses in soybean crops, which can reach almost 40% according to studies by Dr. Cecilia Czapak of the Federal University of Goias. , published in Cultivar magazine in January 115, 2009.

The following work shows the synthesized results of 3 experimental studies conducted in the Midwest region of Brazil, regarding the control of this pest. The 0.5L / ha BF 404-06 product (15 + 50 g / ha bifentrin + imidacloprid, respectively) offers 49% control 15 days after application (DAA) 1 while ο Talstar® (100 gia bifentrene / L) offers ， at a dose of 0'15L / ha, control close to 32%. Connect®, which at these doses contains 75 g / l imidacloprid, provides a 40% overall control result. These results show that ο BF 404-06, even with 50% less imidacloprid, provided 22.5% better final control than ο Connect®, which contains 75 g / ha imidacloprid in its formulation and 53% better than ο Talstar® with the same amount of active ingredient bifentrin / ha.

TABLE 10

IatamaiiM

»I» 删 HM 1 UNTREATED Oc Od Od Ob Ob O1Ob 2 BF 404-06 9 + 30 0.3 80b 68 b 68abc 69 to 65a 46a I 3 BF 404-06 15 + 50 0.5 91 ab 78 ab 78 ab 79 a 57 to 49 a I 4 BF 404-06 21 + 70 0.7 85afa 74 ab 74abc 77a 56 a 38ab TALSTAR 15 0.15 91 ab 51c 51c 67 a 55 a 32 ab 6 CONNECT 9.3 + 75 0.75 92 ab 56b and 56b 66a 45 to 40 ab

Example 9: Summary of the effectiveness of 14 studies with BF 404-06 focusing on the control of neotropical marram bed bug nymphs (Euchistus heros), Mato Grosso-Brazil, 2007/08 crop.

The following work shows the synthesized results of 14 experimental studies conducted in the Midwest region of Brazil, which has a warm climate favoring the rapid multiplication of insects considered pests for agriculture. These studies were carried out with the objective of verifying the efficacy of the products for the control of the stink bug Euschistus heros, popularly known as the brown stink bug, evaluating the pest reinfestation.

BF 404-06 at a dose of 0.5L / ha (15 + 50 gia / ha of bifenthrin + imidacloprid, respectively) offers 85% control 20 days after application (DAA) 1 while ο Talstar® ( 100 bifentrin gia / L), at a dose of 0.15L / ha, provides control close to 73%. Connect®, which in these doses contains 75 g / L imidacloprid, offers a poor outcome with 68% control.

These results show that ο BF 404-06 ， even with 50% less imidacloprid, provided 25% better final control than ο Connect®, which contains 75 g / ha of imidacloprid in its formulation and 16%.

better than ο Talstar® with the same amount of active ingredient bisphentine / ha.

Thus1 fewer applications may be used using BF 404-06 treatment at doses of 0.5L / ha (15 + 50gia / ha of bifenthrin + imidaclopyr) because its control of nymphs was better. TABLE 11

1 UNTREATED Ob Oc Oc 0c 0b 0b

2 BF 404-06 9 + 30 0.3 84 to 98 ab 82 ab 79 ab 84 to 83 to 13 BF 404-06 15 + 50 0.5 80 to 83 b 80 ab 90 to 76 to 85 to 4 BF 404- 06 21 + 70 0.7 84 a 89 ab 94a 94 a 89 a 95 a 5TALSTAR 15 0.15 76 a 91 ab 74 b 66 b 70 a 73 a 6 CONNECT 9.3 + 75 0.75 72 a 89 ab 79 ab 80 ab 87 a 68 a 7ENGEO FULL 19 + 25 0.18 44 ab 100 a 77 ab 81 ab 69 a 74 a

Example 10: Effectiveness of BF 404-06 Focusing on Bed Bug Control Euchistus herus, Ibipora / PR, 2008/09 crop.

This work was carried out to verify the effectiveness of products to control the stink bug Euschistus herns, which is popularly known as the brown stink bug.

BF 404-06 at a dose of 0.5L / ha (15 + 50 gia / ha of bifenthrin + imidacloprid, respectively) offers almost 70% control 14 days after application (DAA) 1 while Talstar® (100 gia bifentrina / L) offers ， at the dose of 0.15l / ha, control close to 43%. Connect®, which at these doses contains 75 g / L imidacloprid, offers an unsatisfactory result with 28% control.

These results show that BF 404-06, even with 50% less imidacloprid, provided 150% better final control than Connect®, which contains 75 g / ha of imidacloprid in its formulation and is 62% better than ο Talstar® with the same amount of the active ingredient bifenthrin / ha.

This culture developed under a lot of rain. As bifenthrin has low solubility, the product remains longer on soybean leaves, which provides more time for control and results in major differences compared to standard Connect® and Engeo Pleno® products.

distributed by Syngenta). TABLE 12

Treatments Rate / ha N insects% Control Euchistus herns ADULTS _._ GAI Formulated ODAA 2 DAA 5 DAA 7 DAA 10DAA 14 DAA

1 UNTREATED (N insects / m) 5 to 3 to 7 to 5 to 4 to 4 to

I 2 BF 40Φ06 65 f 15 + 501 0 · 5 4 to 72.9 to 85.6 to 60.4 ab 77.7 to 69.2 to I

3 BF 404-06 78 (18 + 60) 0.6 4 to 91.7 to 71.1 to 59.7 ab 63.1 to 60.8 to

4 BF 404-06_91 (21 + 70) 0.74 to 87.5 to 77.8 to 91.7 to 76.2 to_72.5 to

TALSTAR 15 0.15 4 to 18.8 b 88.7 to 223 b and 30.4 ab 433 ab 6 CONNECT 84 (9.3 +75) 0.75 2 to 75.0 to 82.4 to 27.8 b 34.2 ab 28.3 ab 7 FULL ENGEO 49.4 (19 + 25) 0.2 4 a 18.8 b 44.2 b 22.9 b and 28.9 ab 31.7 ab LSD (P = .05 ) 35.22 19.28 27.18 34.82 36.08 Standard Deviation 23.71 12.98 18.30 23.44 24.28 CV 45.52 20.19 44.87 52.86 55.58

Example 11: Effectiveness of BF 404-06 focusing on bed bug control Euchistus herus, Ibipora / PR. 2008/09 Harvest: The following work proves the excellent results of the BF 404-

06. The study was carried out with the objective of verifying the efficacy of products for the control of bed bug nymphs Euschistus heros, popularly known as bed bug, evaluating pest reinfestation.

In this study, reinfestation was evidenced by 14 DAA, because at 10 DAA there was only one bed bug per square meter on average in the untreated yams, while at 14 DAA infestation increased to an average of 4 bed bugs. per square meter.

BF 404-06 at a dose of 0.5 l / ha (15 + 50 gia / ha of bifenthrin + imidacloprid, respectively) offers 100% control 14 days after application (DAA) while ο Talstar® ( 100 bifenthrin / L) offers ， at a dose of 0.15 l / ha, control close to 10%. Connect®, which at these doses contains 75 g / L imidacloprid, offers an unsatisfactory result with 42.5% control.

These results show that ο BF 404-06, even with 50% less imidacloprid, provided 135% better final control than ο Connect®, which contains 75 g / ha imidacloprid in its formulation and 900% better than ο Talstar® with the same amount of the active ingredient bifenthrin / ha.

Thus, we may have fewer applications using BF 404-06 treatment at doses of 0.5L7ha (15 + 50gia / ha of bifenthrin + imidaclopyr), because its control of nymphs was better. LSD (P = .05) 3.7 30.6 31.60

Standard Deviation 2.5 20.6 21.27

CV 79.2 30.94 31.78

44.88 31.08 30.21 20.92

84.59 39.05

TABLE 13

Treatments Rate / ha% Control Euchtstus herus NYMPHS

._GAI Formulated ODAA 2 DAA 5 DAA 7 DAA 10 DAA 14 DAA

1 UNTREATED f N insects / m) 2 to 3 to 6 to 3 to 1 to 4 ~

I 2 BF 404-06 65 (5 + 50) 0.5 3 to SS to S_SS ab 91.7 to 50.0 to 100 0 3 1

3 BF 404-06 78 (18 + 60) 0.6 3 to 100 to 95.8 to 91.7 to 50.0 to 100.0 to

4 SF 404-06 91 (21 + 70) 0.7 5 at 100 to 87.5 ab 100.0 at 50.0 at 100 a

TALSTAR 15 0.15 2 to 46 b B9A ab 72.9 to 25.0 to 10.0 b 6 CONNECT 84 f9.3 +751 0.75 4 to 63 ab 45.6 b 58.3 to 50.0 to 42.5 b

7 FULL ENGEO 49.4 (19 + 25) 0.2 4 to 71 ab 64.4 ab 85.4 to 25.0 to 22.5 b

2 17 5, 2, 9, 112

3 2

Claims (17)

Synergistic agrochemical formulation, characterized in that it comprises: (i) imidacloprid; (ii) bifenthrin; and (iii) suitable adjuvants, vehicles and / or excipients; wherein the ratio of imidacloprid: bifentrin in the formulation is about 8-12: 1-5 'is preferably about 10: 3. Formulation according to Claim 1, characterized in that it comprises about 1 to about 699 g / l bifentrin and about 699 to about 1 g / l imidacloprid, preferably about 30 gia / l bifentrin and about 100 g / l imidacloprid. Formulation according to claim 1, characterized in that it comprises a total of 10 to about 700 g / L bifentrin and imidacloprid, preferably about 130 g / L. Formulation according to any one of claims 1 to 3, characterized in that suitable adjuvants, vehicles and / or excipients are selected from the group consisting of: water, surfactants, defoamers, rheology modifying agents, dispersants, humectants, bactericides or bacteriostatic agents, dyes, anti-caking agents, stabilizers, antifreeze, clay, silicates, silica, resins, waxes, cellulose fibers, fertilizers, C1-C14 alcohols, glycols, acetates, ketones, glycerides, saturated hydrocarbons and unsaturated, fatty acid esters, vegetable oils, mineral oils and mixtures thereof. Formulation according to any one of Claims 1 to 4, characterized in that it is in solid or liquid form, preferably in solid and wettable form (PM) and / or granules dispersed in water. (WDG) and the liquid form is an emulsifiable concentrate (EC), concentrated suspension (SC), suspoemulse (SE) and / or concentrated emulsion (BN). Formulation according to any one of Claims 1 to 5, characterized in that it comprises: (components) [concentration (g / 1 OOm <table> table see original document page 21 </column> </row> <table > Formulation according to any one of claims 5 to 5, characterized in that it comprises: <table> table see original document page 21 </column> </row> <table> Formulation according to any one of claims 5 to 8, characterized in that it comprises: (components) [concentration (bread (g / 1 OOm <table> table see original document page 21 </column> </row> < table> <table> table see original document page 22 </column> </row> <table> Formulation according to any one of claims 1 to 5, characterized in that it comprises: (components) _ [concentration (g / 100mL)] <table> table see original document page 22 </column> </row> <table> A process for preparing the synergistic agrochemical formulation as defined in any one of claims 1 to 9, characterized in that it comprises the steps of: -water, surfactants and additives are mixed in a container; adding to this mixture of molten bifentrin which will be stirred in a recrystallization process; -after the recrystallization process is complete, ο imidacloprid is added; - Upon completion of the addition of all raw materials, the formulation undergoes a milling process where there will be greater interaction between the molecules and reduction of particle size of the active ingredients, thereby increasing synergism between the two. molecules and their efficiency in the field; -after milling, the formulation further undergoes a deaeration and densification process to increase its physical stability, obtaining a stable and synergistic agrochemical formulation; The product is bottled in vials and other types of high density polyethylene containers and is distributed on the market. 11. Use of imidacloprid and bifenthrin, characterized in that it is in the preparation of a synergistic agrochemical formulation for the control and / or control of pests and diseases caused by them in plant crops. Use of the synergistic agrochemical formulation as defined in any one of claims 1 to 9, characterized in that it is in the control and / or control of pests and diseases caused by them in plant crops. Use according to any one of claims 11 and 12, characterized in that the crops are selected from soybean, corn, beans, wheat, irrigated rice, tomatoes, citrus fruits, tobacco and maize, among others, and pests are selected from Euchistus herus, Nezara viridula, Piezodorus guidini, Dichelops furcatus, Edessa meditabunda antiquias gemmatalis, Pseudoplusia includens, Anthonomus grandis, Alabama argilaceae, Spodoptera eridanea, Pectinophora gossipiela tabaci, Pseudaletia sequax, Dichelops furcatus, Rhopalosiphum graminum, Lyriomyza huidobrensis, Phthorimaea operculella, Lyriomyza trifolii and Thripes palmi. Use according to any one of claims 11 to 13, characterized in that the formulation is employed in a Kinetic, sequential or simultaneous application. A method for controlling and / or controlling pests and diseases in plant crops, comprising the application of the synergistic agrochemical formulation as defined in any one of claims 1 to 9, concerning said pests; their habitats and / or plant crops. Method according to claim 15, characterized in that the crops are selected from soybean, cotton, beans, wheat, irrigated rice, tomatoes, citrus fruits, tobacco and maize, among others, and the pests are selected. from Euchistus herus, Nezara viridula, Piezodorus guidini, Dichelops furcatus, Edessa meditabunda Anticarsia gemmatalis, Pseudoplusia includens, Anthonomus grandis, Alabama argilaceae, Spodopte eridanea, Pectinophora gossipiiosa, Embrotica tabera, Pseudaletia sequax, Dichelops furcatus, Rhopalosifum graminum, Lyriomyza huidobrensis, Phthorimaea operculella, Lyriomyza trifolii and Thripes palmi. Method according to any one of claims 15 and 16, characterized in that the formulation is employed in a single, sequential or simultaneous application.