BRPI1007196A2 - profármacos e derivado de espiroindolinona - Google Patents
profármacos e derivado de espiroindolinonaInfo
- Publication number
- BRPI1007196A2 BRPI1007196A2 BRPI1007196A BRPI1007196A BRPI1007196A2 BR PI1007196 A2 BRPI1007196 A2 BR PI1007196A2 BR PI1007196 A BRPI1007196 A BR PI1007196A BR PI1007196 A BRPI1007196 A BR PI1007196A BR PI1007196 A2 BRPI1007196 A2 BR PI1007196A2
- Authority
- BR
- Brazil
- Prior art keywords
- prodrugs
- spiroindolinone
- derivative
- spiroindolinone derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14717609P | 2009-01-26 | 2009-01-26 | |
| PCT/EP2010/050525 WO2010084097A1 (en) | 2009-01-26 | 2010-01-18 | Spiroindolinone derivative prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1007196A2 true BRPI1007196A2 (pt) | 2016-09-27 |
Family
ID=41683401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1007196A BRPI1007196A2 (pt) | 2009-01-26 | 2010-01-18 | profármacos e derivado de espiroindolinona |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100190814A1 (pt) |
| EP (1) | EP2389381A1 (pt) |
| JP (1) | JP2012515743A (pt) |
| KR (1) | KR20110096174A (pt) |
| CN (1) | CN102292337A (pt) |
| AU (1) | AU2010206192A1 (pt) |
| BR (1) | BRPI1007196A2 (pt) |
| CA (1) | CA2748957A1 (pt) |
| IL (1) | IL213673A0 (pt) |
| MX (1) | MX2011006499A (pt) |
| SG (1) | SG173115A1 (pt) |
| WO (1) | WO2010084097A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8076482B2 (en) * | 2009-04-23 | 2011-12-13 | Hoffmann-La Roche Inc. | 3,3′-spiroindolinone derivatives |
| TWI494312B (zh) | 2011-03-10 | 2015-08-01 | Daiichi Sankyo Co Ltd | 二螺吡咯啶衍生物 |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| US10576064B2 (en) | 2014-07-03 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors |
| PT3183254T (pt) | 2014-08-21 | 2019-08-29 | Boehringer Ingelheim Int | Novos compostos de espiro[3h-indole-3,2¿-pirrolidin]-2(1h)-ona e derivados como inibidores de mdm2-p53 |
| CA2976752C (en) | 2015-02-20 | 2019-12-17 | Daiichi Sankyo Company, Limited | Method for treating cancer by combined use |
| KR20170134462A (ko) | 2015-04-13 | 2017-12-06 | 다이이찌 산쿄 가부시키가이샤 | Mdm2 저해제와 btk 저해제의 병용 치료법 |
| SI3359542T1 (sl) | 2015-10-09 | 2021-08-31 | Boehringer Ingelheim International Gmbh | Spojine in derivati spiro(3H-indol-3,2'-pirolidin)-2(1H)-ona kot MDM2-P53 inhibitorji |
| ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
| CN109843329A (zh) | 2016-10-17 | 2019-06-04 | 第一三共株式会社 | 使用mdm2抑制剂和dna甲基转移酶抑制剂的组合治疗方法 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7495007B2 (en) * | 2006-03-13 | 2009-02-24 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US20070213341A1 (en) * | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
| US7638548B2 (en) * | 2006-11-09 | 2009-12-29 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US7553833B2 (en) * | 2007-05-17 | 2009-06-30 | Hoffmann-La Roche Inc. | 3,3-spiroindolinone derivatives |
| US7776875B2 (en) * | 2007-12-19 | 2010-08-17 | Hoffman-La Roche Inc. | Spiroindolinone derivatives |
-
2010
- 2010-01-12 US US12/685,750 patent/US20100190814A1/en not_active Abandoned
- 2010-01-18 CN CN2010800055146A patent/CN102292337A/zh active Pending
- 2010-01-18 EP EP10700998A patent/EP2389381A1/en not_active Withdrawn
- 2010-01-18 SG SG2011053352A patent/SG173115A1/en unknown
- 2010-01-18 JP JP2011546765A patent/JP2012515743A/ja active Pending
- 2010-01-18 MX MX2011006499A patent/MX2011006499A/es unknown
- 2010-01-18 BR BRPI1007196A patent/BRPI1007196A2/pt not_active IP Right Cessation
- 2010-01-18 CA CA2748957A patent/CA2748957A1/en not_active Abandoned
- 2010-01-18 KR KR1020117017065A patent/KR20110096174A/ko not_active Ceased
- 2010-01-18 AU AU2010206192A patent/AU2010206192A1/en not_active Abandoned
- 2010-01-18 WO PCT/EP2010/050525 patent/WO2010084097A1/en not_active Ceased
-
2011
- 2011-06-20 IL IL213673A patent/IL213673A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010206192A1 (en) | 2011-07-07 |
| JP2012515743A (ja) | 2012-07-12 |
| CA2748957A1 (en) | 2010-07-29 |
| EP2389381A1 (en) | 2011-11-30 |
| WO2010084097A1 (en) | 2010-07-29 |
| IL213673A0 (en) | 2011-07-31 |
| MX2011006499A (es) | 2011-07-12 |
| US20100190814A1 (en) | 2010-07-29 |
| CN102292337A (zh) | 2011-12-21 |
| KR20110096174A (ko) | 2011-08-29 |
| SG173115A1 (en) | 2011-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15I | Others concerning applications: loss of priority | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |