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BRPI0922030A2 - regeneração das ilhotas pancreáticas e reversão de diabetes pelos genes do fator de transcrição das ilhotas distribuídos in vivo - Google Patents

regeneração das ilhotas pancreáticas e reversão de diabetes pelos genes do fator de transcrição das ilhotas distribuídos in vivo

Info

Publication number
BRPI0922030A2
BRPI0922030A2 BRPI0922030A BRPI0922030A BRPI0922030A2 BR PI0922030 A2 BRPI0922030 A2 BR PI0922030A2 BR PI0922030 A BRPI0922030 A BR PI0922030A BR PI0922030 A BRPI0922030 A BR PI0922030A BR PI0922030 A2 BRPI0922030 A2 BR PI0922030A2
Authority
BR
Brazil
Prior art keywords
islet
reversal
diabetes
vivo
transcription factor
Prior art date
Application number
BRPI0922030A
Other languages
English (en)
Inventor
Ding Jiahuan
A Grayburn Paul
Chen Shuyuan
Original Assignee
Baylor Res Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor Res Institute filed Critical Baylor Res Institute
Publication of BRPI0922030A2 publication Critical patent/BRPI0922030A2/pt

Links

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BRPI0922030A 2008-11-13 2009-11-13 regeneração das ilhotas pancreáticas e reversão de diabetes pelos genes do fator de transcrição das ilhotas distribuídos in vivo BRPI0922030A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11440708P 2008-11-13 2008-11-13
PCT/US2009/064467 WO2010057045A2 (en) 2008-11-13 2009-11-13 Regeneration of pancreatic islets and reversal of diabetes by islet transcription factor genes delivered in vivo

Publications (1)

Publication Number Publication Date
BRPI0922030A2 true BRPI0922030A2 (pt) 2018-10-16

Family

ID=42170747

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0922030A BRPI0922030A2 (pt) 2008-11-13 2009-11-13 regeneração das ilhotas pancreáticas e reversão de diabetes pelos genes do fator de transcrição das ilhotas distribuídos in vivo

Country Status (14)

Country Link
US (2) US20110287086A1 (pt)
EP (1) EP2350297A4 (pt)
JP (2) JP2012508585A (pt)
KR (1) KR101305931B1 (pt)
CN (1) CN102282263B (pt)
AR (1) AR076445A1 (pt)
AU (1) AU2009313875B2 (pt)
BR (1) BRPI0922030A2 (pt)
CA (1) CA2743668A1 (pt)
IL (1) IL212881A0 (pt)
MX (1) MX2011005047A (pt)
NZ (3) NZ602474A (pt)
TW (1) TW201029669A (pt)
WO (1) WO2010057045A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2370112T3 (en) * 2008-11-24 2017-07-24 Bonus Cellora Ltd IMPLANTABLE LIPOSOM INHIBITED MATRIX COMPOSITION AND APPLICATIONS THEREOF
AR080029A1 (es) * 2010-01-27 2012-03-07 Baylor Res Inst Composicion de microburbujas que comprende un adn plasmidico que codifica un factor de crecimiento del endotelio vascular humano
AR080806A1 (es) * 2010-03-24 2012-05-09 Baylor Res Inst Expresion del gen neurod1 en celulas epiteliales pancreaticas no endocrinas (nepec)
KR20130132795A (ko) 2010-10-08 2013-12-05 미나 테라퓨틱스 리미티드 짧은 rna 분자
GB201205158D0 (en) 2012-03-23 2012-05-09 Univ Leeds Apparatus and method for manipulating entrained particles
WO2015070050A1 (en) 2013-11-08 2015-05-14 Baylor Research Institute Nuclear loclization of glp-1 stimulates myocardial regeneration and reverses heart failure
EP3594348B1 (en) 2013-11-22 2021-09-08 MiNA Therapeutics Limited C/ebp alpha short activating rna compositions and methods of use
KR102814645B1 (ko) * 2018-08-01 2025-05-29 오하이오 스테이트 이노베이션 파운데이션 인슐린 생성 조직으로 피부를 재프로그래밍하기 위한 조성물 및 방법
AU2021301190A1 (en) * 2020-06-29 2023-02-02 The Trustees Of Indiana University Compositions and methods for reprogramming skin tissue to have insulinogenic and delivery functions
CN113122538A (zh) * 2021-04-15 2021-07-16 遵义医科大学附属医院 一种靶向敲减Rip3基因表达的shRNA、重组载体及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911324B2 (en) * 2001-10-18 2005-06-28 The Regents Of The University Of California Induction of beta cell differentiation in human cells
US7141240B2 (en) * 2002-03-12 2006-11-28 Cedars-Sinai Medical Center Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
US20040132679A1 (en) * 2002-09-03 2004-07-08 Baylor College Of Medicine Induction of pancreatic islet formation
CN101389273B (zh) * 2004-08-05 2012-09-05 贝勒研究院 基因或药物递送系统
JP2009514967A (ja) * 2005-11-07 2009-04-09 ザ ジェネラル ホスピタル コーポレーション 幹細胞の加齢化を調節するための方法及び組成物
US20080145937A1 (en) * 2006-09-22 2008-06-19 Baylor Research Institute In Vivo Transformation of Pancreatic Acinar Cells into Insulin-Producing Cells

Also Published As

Publication number Publication date
JP2014168463A (ja) 2014-09-18
IL212881A0 (en) 2011-07-31
WO2010057045A2 (en) 2010-05-20
CN102282263A (zh) 2011-12-14
JP2012508585A (ja) 2012-04-12
CN102282263B (zh) 2015-02-11
AR076445A1 (es) 2011-06-15
TW201029669A (en) 2010-08-16
NZ602474A (en) 2013-02-22
WO2010057045A8 (en) 2011-02-03
AU2009313875A1 (en) 2010-05-20
NZ595273A (en) 2012-10-26
WO2010057045A3 (en) 2010-09-16
KR20110086594A (ko) 2011-07-28
CA2743668A1 (en) 2010-05-20
EP2350297A4 (en) 2012-05-09
AU2009313875B2 (en) 2013-01-10
NZ592821A (en) 2012-06-29
MX2011005047A (es) 2011-07-29
EP2350297A2 (en) 2011-08-03
JP5813161B2 (ja) 2015-11-17
KR101305931B1 (ko) 2013-09-12
US20110287086A1 (en) 2011-11-24
US20140294924A1 (en) 2014-10-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2495 DE 30-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.