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BRPI0920706A2 - partículas inaláveis compreendendo tiotrópio - Google Patents

partículas inaláveis compreendendo tiotrópio

Info

Publication number
BRPI0920706A2
BRPI0920706A2 BRPI0920706A BRPI0920706A BRPI0920706A2 BR PI0920706 A2 BRPI0920706 A2 BR PI0920706A2 BR PI0920706 A BRPI0920706 A BR PI0920706A BR PI0920706 A BRPI0920706 A BR PI0920706A BR PI0920706 A2 BRPI0920706 A2 BR PI0920706A2
Authority
BR
Brazil
Prior art keywords
tiotropium
inhalable particles
inhalable
particles
Prior art date
Application number
BRPI0920706A
Other languages
English (en)
Inventor
Antonio Sereno Guerra
Karim Amighi
Original Assignee
Laboratórios Liconsa S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40348057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0920706(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratórios Liconsa S A filed Critical Laboratórios Liconsa S A
Publication of BRPI0920706A2 publication Critical patent/BRPI0920706A2/pt
Publication of BRPI0920706B1 publication Critical patent/BRPI0920706B1/pt
Publication of BRPI0920706B8 publication Critical patent/BRPI0920706B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electrolytic Production Of Metals (AREA)
BRPI0920706A 2008-10-02 2009-10-02 partículas inaláveis compreendendo tiotrópio, processos de preparação das mesmas, e composição farmacêutica BRPI0920706B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08382040A EP2172190A1 (en) 2008-10-02 2008-10-02 Inhalable particles comprising tiotropium
EP08382040.7 2008-10-02
US10411308P 2008-10-09 2008-10-09
US61/104,113 2008-10-09
PCT/EP2009/062821 WO2010037845A1 (en) 2008-10-02 2009-10-02 Inhalable particles comprising tiotropium

Publications (3)

Publication Number Publication Date
BRPI0920706A2 true BRPI0920706A2 (pt) 2015-12-29
BRPI0920706B1 BRPI0920706B1 (pt) 2021-02-02
BRPI0920706B8 BRPI0920706B8 (pt) 2021-05-25

Family

ID=40348057

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0920706A BRPI0920706B8 (pt) 2008-10-02 2009-10-02 partículas inaláveis compreendendo tiotrópio, processos de preparação das mesmas, e composição farmacêutica

Country Status (39)

Country Link
US (1) US20110311618A1 (pt)
EP (2) EP2172190A1 (pt)
JP (1) JP5622730B2 (pt)
KR (1) KR101639089B1 (pt)
CN (1) CN102170861B (pt)
AR (1) AR073528A1 (pt)
AU (1) AU2009299801B2 (pt)
BR (1) BRPI0920706B8 (pt)
CA (1) CA2737399C (pt)
CL (1) CL2011000696A1 (pt)
CO (1) CO6361899A2 (pt)
CR (1) CR20110227A (pt)
CY (1) CY1121090T1 (pt)
DK (1) DK2349204T3 (pt)
DO (1) DOP2011000091A (pt)
EC (1) ECSP11010925A (pt)
ES (1) ES2675857T3 (pt)
HN (1) HN2011000864A (pt)
HR (1) HRP20181009T1 (pt)
HU (1) HUE038208T2 (pt)
LT (1) LT2349204T (pt)
MA (1) MA34560B1 (pt)
MX (1) MX2011003491A (pt)
MY (1) MY159172A (pt)
NI (1) NI201100066A (pt)
NZ (1) NZ591923A (pt)
PE (2) PE20110850A1 (pt)
PL (1) PL2349204T3 (pt)
PT (1) PT2349204T (pt)
RU (2) RU2685236C2 (pt)
SI (1) SI2349204T1 (pt)
SM (1) SMT201800350T1 (pt)
SV (1) SV2011003852A (pt)
TR (1) TR201808269T4 (pt)
TW (1) TWI433675B (pt)
UA (1) UA100777C2 (pt)
UY (1) UY32160A (pt)
WO (1) WO2010037845A1 (pt)
ZA (1) ZA201101735B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012023407A2 (pt) * 2010-03-31 2019-09-24 Glenmark Pharmaceuticals Ltd composição em pó farmacêutica para instalação, e, processo para a preparação da mesma.
WO2011152804A2 (en) * 2010-06-03 2011-12-08 Mahmut Bilgic Process for dry powder formulations
WO2011154014A1 (en) * 2010-06-11 2011-12-15 Gea Process Engineering A/S Controlled humidity drying
EP2608769B1 (en) 2010-08-23 2019-11-06 Fraunhofer Gesellschaft zur Förderung der Angewand Humidified particles comprising a therapeutically active substance
WO2013109213A2 (en) * 2012-01-16 2013-07-25 Mahmut Bilgic Pharmaceutical formulations comprising tiotropium
US9387616B2 (en) 2012-08-03 2016-07-12 Otto Männer Innovation GmbH Hot runner injection molding apparatus with additional controller
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
AU2014248455B2 (en) 2013-04-01 2018-12-06 Pulmatrix Operating Company, Inc. Tiotropium dry powders
KR101748796B1 (ko) * 2015-09-30 2017-06-19 한미약품 주식회사 활성성분의 전달량이 향상된 흡입용 캡슐제
WO2018051132A1 (en) * 2016-09-19 2018-03-22 Mexichem Fluor S.A. De C.V. Pharmaceutical composition
EP4108230A1 (en) * 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation
GR1010358B (el) * 2021-09-14 2022-12-16 Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια, Σταθερο φαρμακευτικο σκευασμα που περιεχει βρωμιουχο τιοτροπιο, για χορηγηση απο το αναπνευστικο
CN114191418B (zh) * 2021-12-21 2023-06-09 丽珠医药集团股份有限公司 噻托溴铵双层微球及其制备方法和噻托溴铵缓释吸入剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
ES2192866T3 (es) * 1998-11-13 2003-10-16 Jago Res Ag Polvo seco para inhalacion.
US20020081266A1 (en) * 1999-08-20 2002-06-27 Norton Healthcare Ltd. Spray dried powders for pulmonary or nasal administration
MXPA02005666A (es) 2000-10-12 2002-11-29 Boehringer Ingelheim Pharma Nuevos polvos para anhalacion que contienen tiotropio.
CZ306435B6 (cs) * 2000-12-14 2017-01-25 Ortho-Mcneil Pharmaceutical, Inc. Steroidní hormonální přípravek a způsob jeho přípravy
US6485279B2 (en) * 2000-12-26 2002-11-26 Carrier Corporation Thrust load reliever
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
US7754242B2 (en) * 2002-03-20 2010-07-13 Alkermes, Inc. Inhalable sustained therapeutic formulations
AU2003230689B2 (en) * 2002-03-20 2006-06-29 Alkermes, Inc. Inhalable sustained therapeutic formulations
DE10339197A1 (de) * 2003-08-22 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität
MX2007009988A (es) * 2005-12-19 2008-02-22 Sicor Inc Formas novedosas de bromuro de tiotropio y procesos para su preparacion.
CA2640165A1 (en) * 2006-01-27 2007-08-02 The Provost, Fellows And Scholars Of The College Of The Holy And Undivid Ed Trinity Of Queen Elizabeth Near Dublin A method of producing porous microparticles
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations

Also Published As

Publication number Publication date
DOP2011000091A (es) 2011-04-30
CL2011000696A1 (es) 2011-07-29
TW201018468A (en) 2010-05-16
CA2737399C (en) 2017-02-21
AU2009299801B2 (en) 2014-02-27
MX2011003491A (es) 2011-06-16
SV2011003852A (es) 2011-04-12
ES2675857T3 (es) 2018-07-13
PE20110850A1 (es) 2011-11-25
EP2349204B1 (en) 2018-04-11
AR073528A1 (es) 2010-11-10
RU2014150986A3 (pt) 2018-07-02
NZ591923A (en) 2012-02-24
HN2011000864A (es) 2015-02-09
US20110311618A1 (en) 2011-12-22
LT2349204T (lt) 2018-10-10
RU2011117256A (ru) 2012-11-10
CN102170861B (zh) 2014-05-14
ECSP11010925A (es) 2011-07-29
AU2009299801A1 (en) 2010-04-08
BRPI0920706B8 (pt) 2021-05-25
HUE038208T2 (hu) 2018-10-29
PE20142435A1 (es) 2015-01-11
KR20110081265A (ko) 2011-07-13
ZA201101735B (en) 2012-05-30
PL2349204T3 (pl) 2018-09-28
KR101639089B1 (ko) 2016-07-12
CR20110227A (es) 2011-06-24
PT2349204T (pt) 2018-07-06
SMT201800350T1 (it) 2018-09-13
EP2349204A1 (en) 2011-08-03
CY1121090T1 (el) 2019-12-11
RU2685236C2 (ru) 2019-04-17
UY32160A (es) 2010-04-30
JP5622730B2 (ja) 2014-11-12
TR201808269T4 (tr) 2018-07-23
HRP20181009T1 (hr) 2018-08-24
UA100777C2 (ru) 2013-01-25
MY159172A (en) 2016-12-30
RU2014150986A (ru) 2015-06-10
BRPI0920706B1 (pt) 2021-02-02
SI2349204T1 (en) 2018-08-31
MA34560B1 (fr) 2013-10-02
CA2737399A1 (en) 2010-04-08
CO6361899A2 (es) 2012-01-20
NI201100066A (es) 2012-01-05
TWI433675B (zh) 2014-04-11
WO2010037845A1 (en) 2010-04-08
DK2349204T3 (en) 2018-07-16
CN102170861A (zh) 2011-08-31
EP2172190A1 (en) 2010-04-07
JP2012504580A (ja) 2012-02-23

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/10/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF