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BRPI0919932A8 - Pirrolina-carbóxi-lisina gerada biossinteticamente, bem como processo para preparar método para derivatizar uma proteína - Google Patents

Pirrolina-carbóxi-lisina gerada biossinteticamente, bem como processo para preparar método para derivatizar uma proteína

Info

Publication number
BRPI0919932A8
BRPI0919932A8 BRPI0919932A BRPI0919932A BRPI0919932A8 BR PI0919932 A8 BRPI0919932 A8 BR PI0919932A8 BR PI0919932 A BRPI0919932 A BR PI0919932A BR PI0919932 A BRPI0919932 A BR PI0919932A BR PI0919932 A8 BRPI0919932 A8 BR PI0919932A8
Authority
BR
Brazil
Prior art keywords
pcl
lysine
carboxy
polypeptides
peptides
Prior art date
Application number
BRPI0919932A
Other languages
English (en)
Inventor
Geierstanger Bernhard
Ou Weijia
E Cellitti Susan
Crossgrove Tiffany
Chiu Hsien-Po
Grunewald Jan
Hao Xueshi
Uno Tetsuo
Original Assignee
Novartis Ag
Irm Llc
Novartis Int Pharmaceutical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Irm Llc, Novartis Int Pharmaceutical Ltd filed Critical Novartis Ag
Publication of BRPI0919932A2 publication Critical patent/BRPI0919932A2/pt
Publication of BRPI0919932A8 publication Critical patent/BRPI0919932A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PIRROLINA-CARBÓXI-LISINA GERADA BIOSSINTETICAMENTE,BEM COMO PROCESSO PARA PREPARAR MÉTODO PARA DERIVATIZAR UMA PROTEÍNA. A presente invenção refere-se a uma pirrolino-carbóxi-lisina (PCL), um análogo de pirrolisina, que é um aminoácido natural, biossinteticamente gerado e métodos para gerar biossinteticamente PCL. Também são descritas aqui proteínas, polipeptídeos e peptídeos que possuem PCL incorporada e métodos para incorporar PCL em tais proteínas, poIipeptídeos e peptídeos. Também é descrita aqui a derivatização sítio-específica de proteínas, polipeptídeos e peptídeos que possuem PCL ou pirrolisina incorporada neles. Também é descrita a reticulação de proteínas, polipeptídeos e peptídeos que possuem PCL ou pirrolisina incorporada neles.
BRPI0919932A 2008-10-24 2009-10-23 Pirrolina-carbóxi-lisina gerada biossinteticamente, bem como processo para preparar método para derivatizar uma proteína BRPI0919932A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10843408P 2008-10-24 2008-10-24
PCT/US2009/061954 WO2010048582A1 (en) 2008-10-24 2009-10-23 Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues

Publications (2)

Publication Number Publication Date
BRPI0919932A2 BRPI0919932A2 (pt) 2017-10-24
BRPI0919932A8 true BRPI0919932A8 (pt) 2018-02-06

Family

ID=41479140

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919932A BRPI0919932A8 (pt) 2008-10-24 2009-10-23 Pirrolina-carbóxi-lisina gerada biossinteticamente, bem como processo para preparar método para derivatizar uma proteína

Country Status (12)

Country Link
US (2) US8785151B2 (pt)
EP (1) EP2356092B1 (pt)
JP (1) JP5542832B2 (pt)
KR (2) KR20130086386A (pt)
CN (1) CN102264697B (pt)
AU (1) AU2009308163B2 (pt)
BR (1) BRPI0919932A8 (pt)
CA (2) CA2742043C (pt)
EA (1) EA021001B1 (pt)
ES (1) ES2477543T3 (pt)
MX (1) MX342677B (pt)
WO (1) WO2010048582A1 (pt)

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KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
AU2015229463A1 (en) * 2014-03-12 2016-09-15 Novartis Ag Specific sites for modifying antibodies to make immunoconjugates
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WO2017109706A1 (en) 2015-12-22 2017-06-29 Novartis Ag Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
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CN113698468B (zh) * 2021-09-01 2022-10-11 浙江新码生物医药有限公司 人白细胞介素2-聚乙二醇偶联物及其应用
CN116626180B (zh) * 2022-02-11 2025-12-02 北京大学 一种卤代有机物的高灵敏高通量扫描分析方法
CN115928111A (zh) * 2022-11-23 2023-04-07 华南理工大学 一种电化学合成7-硫氰基-3,4-二氢喹喔啉-2(1h)-酮类化合物的方法
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Also Published As

Publication number Publication date
CA2742043C (en) 2014-11-25
KR101316159B1 (ko) 2013-10-15
CA2742043A1 (en) 2010-04-29
MX342677B (es) 2016-10-07
CN102264697A (zh) 2011-11-30
WO2010048582A1 (en) 2010-04-29
JP5542832B2 (ja) 2014-07-09
JP2012506869A (ja) 2012-03-22
BRPI0919932A2 (pt) 2017-10-24
MX2011004246A (es) 2011-07-13
US8785151B2 (en) 2014-07-22
EA201100659A1 (ru) 2011-12-30
AU2009308163A1 (en) 2010-04-29
KR20110089145A (ko) 2011-08-04
US9624520B2 (en) 2017-04-18
EP2356092A1 (en) 2011-08-17
EA021001B1 (ru) 2015-03-31
ES2477543T3 (es) 2014-07-17
CA2871855C (en) 2017-08-15
US20140302553A1 (en) 2014-10-09
AU2009308163B2 (en) 2013-01-10
KR20130086386A (ko) 2013-08-01
US20110262963A1 (en) 2011-10-27
CN102264697B (zh) 2015-09-09
CA2871855A1 (en) 2010-04-29
EP2356092B1 (en) 2014-04-16

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM)

B25A Requested transfer of rights approved

Owner name: NOVARTIS AG (CH)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2485 DE 21-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.