BRPI0918718A2 - síntese de acetato de glatirâmero - Google Patents

síntese de acetato de glatirâmero

Info

Publication number: BRPI0918718A2
Authority: BR; Brazil
Prior art keywords: glatiramer acetate; acetate synthesis; synthesis; glatiramer; acetate
Prior art date: 2008-08-07

Application number

BRPI0918718A

Other languages

English (en)

Inventor

Meng-Fen Ho

Tsung-Yu Hsiao

Original Assignee

Scinopharm Taiwan Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-08-07

Filing date

2009-08-05

Publication date

2015-12-01

2009-08-05 Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd

2015-12-01 Publication of BRPI0918718A2 publication Critical patent/BRPI0918718A2/pt

Links

108010072051 Glatiramer Acetate Proteins 0.000 title 1
FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
229960003776 glatiramer acetate Drugs 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Water Supply & Treatment (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Polyamides (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0918718A 2008-08-07 2009-08-05 síntese de acetato de glatirâmero BRPI0918718A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18821608P	2008-08-07	2008-08-07
PCT/US2009/052845 WO2010017292A1 (en)	2008-08-07	2009-08-05	Synthesis of glatiramer acetate

Publications (1)

Publication Number	Publication Date
BRPI0918718A2 true BRPI0918718A2 (pt)	2015-12-01

Family

ID=41653533

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0918718A BRPI0918718A2 (pt)	2008-08-07	2009-08-05	síntese de acetato de glatirâmero

Country Status (12)

Country	Link
US (1)	US8212002B2 (pt)
EP (1)	EP2326657B1 (pt)
JP (1)	JP2011530523A (pt)
KR (1)	KR20110059606A (pt)
CN (1)	CN102112485B (pt)
AR (1)	AR072974A1 (pt)
AU (1)	AU2009279636A1 (pt)
BR (1)	BRPI0918718A2 (pt)
CA (1)	CA2733500A1 (pt)
IL (1)	IL211052A (pt)
NZ (1)	NZ590872A (pt)
WO (1)	WO2010017292A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2277050B2 (en)	2008-04-16	2022-09-28	Momenta Pharmaceuticals, Inc.	Analysis of amino acid copolymer compositions
US8399600B2 (en) *	2008-08-07	2013-03-19	Sigma-Aldrich Co. Llc	Preparation of low molecular weight polylysine and polyornithine in high yield
RU2011144566A (ru)	2009-04-03	2013-05-10	Момента Фармасьютикалз, Инк.	Контроль сополимерных композиций
WO2012114167A1 (en) *	2011-02-24	2012-08-30	Biocon Limited	Processes for the preparation of glatiramer acetate
GB2478837A (en) *	2011-03-14	2011-09-21	Cipla Ltd	Preparation of glatiramer
WO2013009885A2 (en)	2011-07-11	2013-01-17	Momenta Pharmaceuticals, Inc.	Evaluation of copolymer diethylamide
WO2013009864A1 (en)	2011-07-11	2013-01-17	Momenta Pharmaceuticals, Inc.	Structure assessment of heterogeneous polypeptide mixtures
US8575198B1 (en)	2011-09-07	2013-11-05	Momenta Pharmaceuticals, Inc.	In-process control for the manufacture of glatiramer acetate
CN104844697B (zh) *	2014-09-26	2018-10-23	深圳翰宇药业股份有限公司	醋酸格拉替雷的制备方法
CN105884866B (zh) *	2015-01-26	2021-04-20	漳州未名博欣生物医药有限公司	格拉替雷的化学合成方法
JP2020525459A (ja)	2017-06-26	2020-08-27	アンスティテュ・パストゥール	Ｈｉｖリザーバーを排除し、ウイルス負荷を低減する処置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL36670A (en) *	1971-04-21	1974-09-10	Sela M	Therapeutic basic copolymers of amino acids
IL113812A (en) *	1994-05-24	2000-06-29	Yeda Res & Dev	Copolymer-1 pharmaceutical compositions containing it and its use
US6013764A (en) *	1996-07-17	2000-01-11	Ortho Pharmaceutical Corp.	Liquid phase peptide synthesis of KL-4 pulmonary surfactant
US7495072B2 (en) *	2004-09-09	2009-02-24	Teva Pharmaceutical Industries, Ltd.	Process for preparation of mixtures of polypeptides using purified hydrobromic acid
DK1797109T3 (en) *	2004-09-09	2016-04-11	Yeda Res & Dev	MIXTURES OF POLYPEPTIDES, compositions containing them and methods for their preparation, and uses thereof
CA2583589C (en) *	2004-10-29	2012-04-24	Sandoz Ag	Processes for preparing glatiramer
ZA200705874B (en) *	2005-02-02	2009-04-29	Teva Pharma	Process for producing polypeptide mixtures using hydrogenolysis
WO2007022193A2 (en) *	2005-08-15	2007-02-22	Wai Hong Chan	Process for the preparation of copolymer-1
US20090035816A1 (en) *	2007-08-02	2009-02-05	Scinopharm Taiwan Ltd.	Process for the preparation of a polypeptide
BRPI1011434A2 (pt) *	2009-05-08	2016-03-15	Scinopharm Taiwan Ltd	metodos de analisar misturas de peptideo

2009
- 2009-08-05 AU AU2009279636A patent/AU2009279636A1/en not_active Abandoned
- 2009-08-05 NZ NZ590872A patent/NZ590872A/xx not_active IP Right Cessation
- 2009-08-05 EP EP09805500.7A patent/EP2326657B1/en not_active Not-in-force
- 2009-08-05 KR KR1020117005133A patent/KR20110059606A/ko not_active Withdrawn
- 2009-08-05 CA CA2733500A patent/CA2733500A1/en not_active Abandoned
- 2009-08-05 US US12/536,023 patent/US8212002B2/en not_active Expired - Fee Related
- 2009-08-05 CN CN2009801308021A patent/CN102112485B/zh not_active Expired - Fee Related
- 2009-08-05 BR BRPI0918718A patent/BRPI0918718A2/pt not_active Application Discontinuation
- 2009-08-05 JP JP2011522216A patent/JP2011530523A/ja active Pending
- 2009-08-05 WO PCT/US2009/052845 patent/WO2010017292A1/en not_active Ceased
- 2009-08-06 AR ARP090103027A patent/AR072974A1/es unknown
2011
- 2011-02-03 IL IL211052A patent/IL211052A/en active IP Right Grant

Also Published As

Publication number	Publication date
EP2326657A4 (en)	2012-10-31
IL211052A0 (en)	2011-04-28
JP2011530523A (ja)	2011-12-22
CA2733500A1 (en)	2010-02-11
US8212002B2 (en)	2012-07-03
KR20110059606A (ko)	2011-06-02
US20100036092A1 (en)	2010-02-11
EP2326657B1 (en)	2017-09-27
AR072974A1 (es)	2010-10-06
AU2009279636A1 (en)	2010-02-11
NZ590872A (en)	2012-10-26
CN102112485B (zh)	2013-11-27
IL211052A (en)	2016-05-31
EP2326657A1 (en)	2011-06-01
WO2010017292A1 (en)	2010-02-11
CN102112485A (zh)	2011-06-29

Publication	Publication Date	Title
BRPI0918718A2 (pt)	2015-12-01	síntese de acetato de glatirâmero
DE602009000580D1 (de)	2011-03-03	Endoskopsystem
BR112012007164A2 (pt)	2016-03-29	"veículo"
DE602008000562D1 (de)	2010-03-11	Fahrzeugrad
BRPI0811014A2 (pt)	2015-01-27	Veículo
EP2246950A4 (en)	2012-10-31	EYELET
PL2414015T4 (pl)	2022-06-13	System laryngoskopowy
DE602007004361D1 (de)	2010-03-11	Endoskopsystem
BR112012003787A2 (pt)	2017-07-04	variantes de glicoamilase
EP2128012A4 (en)	2012-04-11	VEHICLE
BRPI0920521A2 (pt)	2018-01-16	combinação farmacêutica
EP2177425A4 (en)	2014-06-18	Vehicle
SMT201600372B (it)	2017-01-10	Compresse di ulipristal acetato
DK2035451T3 (da)	2010-06-07	Insulinoptrop peptidsyntese
DE602008001297D1 (de)	2010-07-01	Fahrzeugrad
EP2164080A4 (en)	2011-08-10	EYELET
EP2334686A4 (en)	2012-05-02	CORTISTATIN ANALOGUE AND ITS SYNTHESIS
BRPI0811864A2 (pt)	2014-11-18	Derivados de ácido cistéico de peptídeos antivirais
CR10675A (es)	2009-04-17	Analogos de 2-fenoxipirimidinona
DE602008000034D1 (de)	2009-08-13	Rollerartiges Fahrzeug
BRPI0922716A2 (pt)	2016-11-01	purificação de polipeptídeo
DK2147106T3 (da)	2013-09-08	Expressionssystem
EP2264026A4 (en)	2012-03-28	ALKYLAMINOPYRIDINDERIVATE
BRPI0817451A2 (pt)	2015-06-16	Veículo pequeno
DE602008006114D1 (de)	2011-05-26	Fahrzeugrad

Legal Events

Date	Code	Title	Description
2016-04-12	B11A	Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
2016-08-02	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]