BRPI0918038A2 - Processos para preparar um composto e um sal, e, composto - Google Patents
Processos para preparar um composto e um sal, e, compostoInfo
- Publication number
- BRPI0918038A2 BRPI0918038A2 BRPI0918038-9A BRPI0918038A BRPI0918038A2 BR PI0918038 A2 BRPI0918038 A2 BR PI0918038A2 BR PI0918038 A BRPI0918038 A BR PI0918038A BR PI0918038 A2 BRPI0918038 A2 BR PI0918038A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- salt
- preparing
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9534108P | 2008-09-09 | 2008-09-09 | |
| US61/095,341 | 2008-09-09 | ||
| PCT/SE2009/050999 WO2010030224A1 (en) | 2008-09-09 | 2009-09-08 | A process for preparing [1s- [1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0918038A2 true BRPI0918038A2 (pt) | 2015-08-04 |
| BRPI0918038B1 BRPI0918038B1 (pt) | 2021-07-13 |
Family
ID=42005334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0918038-9A BRPI0918038B1 (pt) | 2008-09-09 | 2009-09-08 | Processo para preparar um composto |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8563755B2 (pt) |
| EP (1) | EP2340252B1 (pt) |
| JP (1) | JP5656837B2 (pt) |
| KR (1) | KR101669297B1 (pt) |
| CN (1) | CN102149716A (pt) |
| AU (1) | AU2009292269B2 (pt) |
| BR (1) | BRPI0918038B1 (pt) |
| CA (1) | CA2734454C (pt) |
| CL (1) | CL2011000496A1 (pt) |
| DK (1) | DK2340252T3 (pt) |
| ES (1) | ES2558843T3 (pt) |
| HR (1) | HRP20160018T1 (pt) |
| IL (1) | IL211191A (pt) |
| MX (1) | MX2011002505A (pt) |
| MY (1) | MY156796A (pt) |
| RU (1) | RU2509082C2 (pt) |
| SG (1) | SG196805A1 (pt) |
| SI (1) | SI2340252T1 (pt) |
| WO (1) | WO2010030224A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| CA2768043A1 (en) | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
| US8859769B2 (en) | 2010-02-16 | 2014-10-14 | Actavis Group Ptc Ehf | Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
| AU2011244023A1 (en) | 2010-04-20 | 2012-10-25 | Actavis Group Ptc Ehf | Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates |
| CA2803354A1 (en) | 2010-06-30 | 2012-01-05 | Actavis Group Ptc Ehf | Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor |
| WO2012063126A2 (en) | 2010-11-09 | 2012-05-18 | Actavis Group Ptc Ehf | Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material |
| US20130317220A1 (en) | 2010-12-20 | 2013-11-28 | Actavis Group Ptc Ehf | NOVEL PROCESSES FOR PREPARING TRIAZOLO[4, 5-d]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF |
| WO2012138981A2 (en) * | 2011-04-06 | 2012-10-11 | Teva Pharmaceutical Industries Ltd. | New intermediates and processes for preparing ticagrelor |
| CA2839057A1 (en) | 2011-06-15 | 2012-12-20 | Actavis Group Ptc Ehf | Improved process for preparing cyclopentylamine derivatives and intermediates thereof |
| US9221829B2 (en) | 2011-09-14 | 2015-12-29 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
| EP2570405A1 (en) | 2011-09-14 | 2013-03-20 | LEK Pharmaceuticals d.d. | Synthesis of Triazolopyrimidine Compounds |
| EP2586773A1 (en) | 2011-10-27 | 2013-05-01 | LEK Pharmaceuticals d.d. | Synthesis of Triazolopyrimidine Compounds |
| HUE036244T2 (hu) | 2011-10-27 | 2018-06-28 | Lek Pharmaceuticals | Triazolo-pirimidin vegyületek szintézise |
| JP2015500219A (ja) | 2011-11-30 | 2015-01-05 | アクタビス・グループ・ピーティーシー・イーエイチエフ | 新規な結晶形を有するチカグレロル及びその調製方法 |
| EP2607355A1 (en) * | 2011-12-23 | 2013-06-26 | LEK Pharmaceuticals d.d. | Synthesis of triazolopyrimidine compounds |
| CN104114542B (zh) * | 2011-12-23 | 2017-11-14 | 力奇制药公司 | 三唑并嘧啶化合物的合成 |
| EP2628721A1 (en) | 2012-02-20 | 2013-08-21 | LEK Pharmaceuticals d.d. | Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid |
| US9233966B2 (en) | 2012-04-05 | 2016-01-12 | Dr. Reddy's Laboratories Limited | Preparation of ticagrelor |
| WO2014006091A1 (en) | 2012-07-04 | 2014-01-09 | Lek Pharmaceuticals D.D. | Ticagrelor adducts with divalent metal salts |
| CN103626743B (zh) * | 2012-08-23 | 2018-06-08 | 广东东阳光药业有限公司 | 替卡格雷的新型中间体及其制备方法 |
| WO2014083139A1 (en) | 2012-11-29 | 2014-06-05 | Actavis Group Ptc Ehf | Novel amorphous form of ticagrelor |
| WO2014102830A1 (en) * | 2012-12-31 | 2014-07-03 | Megafine Pharma (P) Ltd. | A process for preparation of ticagrelor and intermediates thereof |
| CN103965198A (zh) * | 2013-02-05 | 2014-08-06 | 郝聪梅 | 替卡格雷的中间体及其制备方法以及利用该中间体制备替卡格雷的方法 |
| CN104045620B (zh) * | 2013-03-12 | 2017-05-10 | 博瑞生物医药（苏州）股份有限公司 | 一种替卡格雷中间体的制备方法 |
| CN107573333B (zh) | 2013-04-10 | 2019-10-18 | 江苏恒瑞医药股份有限公司 | 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法 |
| CN106496234B (zh) * | 2013-06-03 | 2019-08-30 | 杭州领业医药科技有限公司 | 结晶形态的三唑[4,5-d]嘧啶化合物及其制备方法和用途 |
| CN104230818B (zh) * | 2013-06-06 | 2018-01-12 | 郝聪梅 | 替卡格雷中间体的改进制备方法 |
| WO2014206187A1 (zh) | 2013-06-24 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替卡格雷及其中间体的制备方法 |
| CN103275087A (zh) * | 2013-06-28 | 2013-09-04 | 南京工业大学 | 一种三氮唑并嘧啶类衍生物及其制备方法 |
| CN104059069B (zh) * | 2013-08-22 | 2016-08-10 | 北京康立生医药技术开发有限公司 | 一种替卡格雷的制备方法 |
| WO2015037016A2 (en) * | 2013-09-10 | 2015-03-19 | Laurus Labs Private Limited | An improved process for the preparation of ticagrelor and intermediates thereof |
| CN104592237A (zh) * | 2013-10-31 | 2015-05-06 | 徐州万邦金桥制药有限公司 | 一种抗凝血药替格瑞洛的合成方法 |
| CN103588712B (zh) * | 2013-11-08 | 2016-06-08 | 南京欧信医药技术有限公司 | 一种嘧啶类化合物及其制备方法、和应用 |
| WO2015162630A1 (en) | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
| CN103992277A (zh) * | 2014-05-16 | 2014-08-20 | 苏州天马精细化学品股份有限公司 | 一种替卡格雷中间体4,6-二氯-5-氨基-2-丙硫基嘧啶的制备方法 |
| US10011605B2 (en) | 2014-06-18 | 2018-07-03 | Flamma Spa | Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds |
| CN104311560B (zh) * | 2014-09-16 | 2017-04-26 | 北京红太阳药业有限公司 | 一种替格瑞洛的制备方法 |
| CN104788458A (zh) * | 2015-03-21 | 2015-07-22 | 北京工业大学 | 一种替格瑞洛的制备方法 |
| CN105294573B (zh) * | 2015-06-16 | 2018-07-10 | 厦门医学院 | 一种合成4,6-二氯-2-(丙硫基)-5-氨基嘧啶的方法 |
| CN105153167B (zh) * | 2015-09-06 | 2017-09-19 | 惠州信立泰药业有限公司 | 一种替格瑞洛结晶及含有该结晶的药物组合物 |
| CN105237540B (zh) * | 2015-09-21 | 2017-10-03 | 南京正大天晴制药有限公司 | 一种替格瑞洛有关物质的制备方法、检测方法及用途 |
| WO2017072790A1 (en) * | 2015-10-26 | 2017-05-04 | Avra Laboratories Pvt. Ltd. | An improved process for synthesis of ticagrelor |
| CN105669681A (zh) * | 2016-04-11 | 2016-06-15 | 成都华宇制药有限公司 | 一种替格瑞洛的合成方法 |
| CN106866682A (zh) * | 2017-04-14 | 2017-06-20 | 上海华源医药科技发展有限公司 | 一种适用于替格瑞洛工业化生产的工艺 |
| WO2020231723A1 (en) | 2019-05-13 | 2020-11-19 | Ecolab Usa Inc. | 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor |
| CN115160320B (zh) * | 2022-06-27 | 2024-05-07 | 南通常佑药业科技有限公司 | 一种手性嘧啶并三唑类替格瑞洛的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975434A (en) * | 1986-05-27 | 1990-12-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antiviral and anticancer cyclopentenyl cytosine |
| MY104575A (en) | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| BR9712108A (pt) | 1996-09-23 | 1999-08-31 | Novartis Ag | Processo para a preparação de compostos amino aromáticos substituidos. |
| US5962741A (en) | 1996-11-19 | 1999-10-05 | Novartis Ag | Process for the production of aromatic halogen-amino compounds |
| TW530058B (en) | 1997-07-22 | 2003-05-01 | Astra Pharma Prod | Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation |
| CA2316264A1 (en) * | 1998-02-17 | 1999-08-19 | Brian Springthorpe | Novel triazolo(4,5-d)pyrimidine compounds |
| TWI229674B (en) * | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| GB0013407D0 (en) | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
| AR028110A1 (es) | 2000-06-02 | 2003-04-23 | Astrazeneca Ab | Nuevo proceso |
| GB0013488D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| MXPA03009946A (es) * | 2001-05-10 | 2005-03-07 | Aventis Pharma Gmbh | Nuevos procedimientos para la preparacion de compuestos de adenosina e intermedios para los mismos. |
| EP1574508A1 (de) * | 2004-01-30 | 2005-09-14 | Lonza AG | Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen |
| SE0401001D0 (sv) | 2004-03-31 | 2004-03-31 | Astrazeneca Ab | Chemical process |
| GB0615620D0 (en) | 2006-08-05 | 2006-09-13 | Astrazeneca Ab | A process for the preparation of optically active intermediates |
| GB0615619D0 (en) | 2006-08-05 | 2006-09-13 | Astrazeneca Ab | Chemical process for preparation of intermediates |
-
2009
- 2009-09-08 MY MYPI2011001023A patent/MY156796A/en unknown
- 2009-09-08 WO PCT/SE2009/050999 patent/WO2010030224A1/en not_active Ceased
- 2009-09-08 DK DK09813307.7T patent/DK2340252T3/en active
- 2009-09-08 SG SG2014001895A patent/SG196805A1/en unknown
- 2009-09-08 AU AU2009292269A patent/AU2009292269B2/en active Active
- 2009-09-08 ES ES09813307.7T patent/ES2558843T3/es active Active
- 2009-09-08 JP JP2011526012A patent/JP5656837B2/ja active Active
- 2009-09-08 MX MX2011002505A patent/MX2011002505A/es active IP Right Grant
- 2009-09-08 KR KR1020117006117A patent/KR101669297B1/ko active Active
- 2009-09-08 BR BRPI0918038-9A patent/BRPI0918038B1/pt active IP Right Grant
- 2009-09-08 CA CA2734454A patent/CA2734454C/en not_active Expired - Fee Related
- 2009-09-08 SI SI200931352T patent/SI2340252T1/sl unknown
- 2009-09-08 HR HRP20160018TT patent/HRP20160018T1/hr unknown
- 2009-09-08 EP EP09813307.7A patent/EP2340252B1/en active Active
- 2009-09-08 CN CN2009801359324A patent/CN102149716A/zh active Pending
- 2009-09-08 US US13/062,728 patent/US8563755B2/en active Active
- 2009-09-08 RU RU2011109436/04A patent/RU2509082C2/ru active
-
2011
- 2011-02-10 IL IL211191A patent/IL211191A/en active IP Right Grant
- 2011-03-08 CL CL2011000496A patent/CL2011000496A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102149716A (zh) | 2011-08-10 |
| US20120101274A1 (en) | 2012-04-26 |
| HK1159103A1 (zh) | 2012-07-27 |
| KR101669297B1 (ko) | 2016-10-25 |
| AU2009292269A1 (en) | 2010-03-18 |
| MY156796A (en) | 2016-03-31 |
| EP2340252A4 (en) | 2012-08-01 |
| KR20110063460A (ko) | 2011-06-10 |
| DK2340252T3 (en) | 2016-01-18 |
| JP2012502024A (ja) | 2012-01-26 |
| CL2011000496A1 (es) | 2011-08-26 |
| BRPI0918038B1 (pt) | 2021-07-13 |
| IL211191A (en) | 2015-07-30 |
| CA2734454C (en) | 2016-09-13 |
| SI2340252T1 (sl) | 2016-02-29 |
| ES2558843T3 (es) | 2016-02-09 |
| US8563755B2 (en) | 2013-10-22 |
| CA2734454A1 (en) | 2010-03-18 |
| MX2011002505A (es) | 2011-04-07 |
| RU2509082C2 (ru) | 2014-03-10 |
| AU2009292269B2 (en) | 2012-11-01 |
| SG196805A1 (en) | 2014-02-13 |
| EP2340252B1 (en) | 2015-11-11 |
| RU2011109436A (ru) | 2012-10-20 |
| JP5656837B2 (ja) | 2015-01-21 |
| HRP20160018T1 (hr) | 2016-02-12 |
| EP2340252A1 (en) | 2011-07-06 |
| WO2010030224A1 (en) | 2010-03-18 |
| IL211191A0 (en) | 2011-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/09/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |