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BRPI0917017B8 - inibidores de pirrol de s-nitrosoglutationa redutase como agentes terapêuticos - Google Patents

inibidores de pirrol de s-nitrosoglutationa redutase como agentes terapêuticos

Info

Publication number
BRPI0917017B8
BRPI0917017B8 BRPI0917017A BRPI0917017A BRPI0917017B8 BR PI0917017 B8 BRPI0917017 B8 BR PI0917017B8 BR PI0917017 A BRPI0917017 A BR PI0917017A BR PI0917017 A BRPI0917017 A BR PI0917017A BR PI0917017 B8 BRPI0917017 B8 BR PI0917017B8
Authority
BR
Brazil
Prior art keywords
therapeutic agents
inhibitors
nitrosoglutathione reductase
pyrrole
pyrrole inhibitors
Prior art date
Application number
BRPI0917017A
Other languages
English (en)
Inventor
J Rosenthal Gary
Wasley Jan
Qiu Jian
Strong Sarah
Sun Xicheng
Original Assignee
N30 Pharmaceuticals Inc
N30 Pharmaceuticals Llc
Nivalis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N30 Pharmaceuticals Inc, N30 Pharmaceuticals Llc, Nivalis Therapeutics Inc filed Critical N30 Pharmaceuticals Inc
Publication of BRPI0917017A2 publication Critical patent/BRPI0917017A2/pt
Publication of BRPI0917017B1 publication Critical patent/BRPI0917017B1/pt
Publication of BRPI0917017B8 publication Critical patent/BRPI0917017B8/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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Abstract

inibidores de pirrol de s-nitrosoglutationa redutase como agentes terapêuticos. a presente invenção refere-se a inibidores de s-nitrosoglutationa redutase (gsnor), composições farmacêuticas compreendendo tais inibidores de gsnor, e métodos de preparação e uso das mesmas.
BRPI0917017A 2008-08-15 2009-08-14 inibidores de pirrol de s-nitrosoglutationa redutase como agentes terapêuticos BRPI0917017B8 (pt)

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PCT/US2009/053931 WO2010019910A1 (en) 2008-08-15 2009-08-14 Novel pyrrole inhibitors of s-nitrosoglutathione reductase as therapeutic agents

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