BRPI0915460A2 - métodos e composições para a liberação intensificada de macromoléculas - Google Patents

métodos e composições para a liberação intensificada de macromoléculas

Info

Publication number: BRPI0915460A2
Authority: BR; Brazil
Prior art keywords: macromolecules; compositions; methods; enhanced release; enhanced
Prior art date: 2008-07-10

Application number

BRPI0915460A

Other languages

English (en)

Inventor

David Urech

Esther Furrer

Valerie Hulmann-Cottier

Original Assignee

Esbatech Alcon Biomed Res Unit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-10

Filing date

2009-07-10

Publication date

2015-11-10

2009-07-10 Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit

2015-11-10 Publication of BRPI0915460A2 publication Critical patent/BRPI0915460A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pain & Pain Management (AREA)
Mycology (AREA)
Microbiology (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Endocrinology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Inorganic Chemistry (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)

BRPI0915460A 2008-07-10 2009-07-10 métodos e composições para a liberação intensificada de macromoléculas BRPI0915460A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7958608P	2008-07-10	2008-07-10
PCT/CH2009/000248 WO2010003268A2 (en)	2008-07-10	2009-07-10	Methods and compositions for enhanced delivery of macromolecules

Publications (1)

Publication Number	Publication Date
BRPI0915460A2 true BRPI0915460A2 (pt)	2015-11-10

Family

ID=41328751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0915460A BRPI0915460A2 (pt)	2008-07-10	2009-07-10	métodos e composições para a liberação intensificada de macromoléculas

Country Status (12)

Country	Link
US (2)	US8697074B2 (pt)
EP (2)	EP2769711A1 (pt)
JP (2)	JP5579713B2 (pt)
KR (1)	KR20110031373A (pt)
CN (2)	CN104800147A (pt)
BR (1)	BRPI0915460A2 (pt)
CA (1)	CA2730178A1 (pt)
HK (1)	HK1201201A1 (pt)
MX (1)	MX2011000009A (pt)
RU (1)	RU2522245C2 (pt)
WO (1)	WO2010003268A2 (pt)
ZA (1)	ZA201008597B (pt)

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KR20180005753A (ko) *	2008-06-25	2018-01-16	에스바테크 - 어 노바티스 컴파니 엘엘씨	Ｖｅｇｆ를 억제하는 안정하고 가용성인 항체
EP2307457B2 (en) *	2008-06-25	2022-06-22	Novartis AG	Stable and soluble antibodies inhibiting tnf
CA2730178A1 (en)	2008-07-10	2010-01-14	Esbatech, An Alcon Biomedical Research Unit Llc	Methods and compositions for enhanced delivery of macromolecules
UY33679A (es) *	2010-10-22	2012-03-30	Esbatech	Anticuerpos estables y solubles
US10583171B2 (en) *	2015-11-30	2020-03-10	INSERM (Institut National de la Santé et de la Recherche Médicale)	NMDAR antagonists for the treatment of diseases associated with angiogenesis
CA3011502A1 (en)	2016-03-17	2017-09-21	Numab Innovation Ag	Anti-tnf.alpha.-antibodies and functional fragments thereof
CN109153718B (zh)	2016-03-17	2022-02-08	努玛治疗有限公司	抗TNFα抗体及其功能片段
EP3219727B1 (en)	2016-03-17	2020-12-16	Tillotts Pharma AG	Anti-tnf alpha-antibodies and functional fragments thereof
SI3219726T1 (sl)	2016-03-17	2021-02-26	Tillotts Pharma Ag	Anti-TNF alfa protitelesa in njihovi funkcionalni fragmenti
JP7049311B2 (ja)	2016-03-17	2022-04-06	ヌマブイノヴェイションアーゲー	抗ＴＮＦα抗体およびそれらの機能的断片
MA45684A (fr)	2016-07-14	2019-05-22	Bioarctic Neuroscience Ab	Protéine d'apport du cerveau
EP3409688A1 (en)	2017-05-31	2018-12-05	Tillotts Pharma Ag	Topical treatment of inflammatory bowel disease using anti-tnf-alpha antibodies and fragments thereof
EP3456739A1 (en)	2017-09-19	2019-03-20	Tillotts Pharma Ag	Use of anti-tnfalpha antibodies for treating wounds
ES2938609T3 (es)	2017-09-20	2023-04-13	Tillotts Pharma Ag	Preparación de formas farmacéuticas sólidas que comprenden anticuerpos mediante estratificación de solución/suspensión
EP3459529A1 (en)	2017-09-20	2019-03-27	Tillotts Pharma Ag	Preparation of sustained release solid dosage forms comprising antibodies by spray drying
EP3459527B1 (en)	2017-09-20	2022-11-23	Tillotts Pharma Ag	Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization
WO2020114616A1 (en)	2018-12-07	2020-06-11	Tillotts Pharma Ag	Topical treatment of immune checkpoint inhibitor induced diarrhoea, colitis or enterocolitis using antibodies and fragments thereof
IL320091A (en)	2019-01-31	2025-06-01	Numab Therapeutics AG	Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof
CN116096412A (zh)	2020-04-10	2023-05-09	因维德公司	对冠状病毒s蛋白质具有特异性的化合物及其用途
WO2024200722A1 (en)	2023-03-28	2024-10-03	Tillotts Pharma Ag	Solid oral dosage form comprising antibodies for sustained release in the lower gastrointestinal tract

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EP2307457B2 (en)	2008-06-25	2022-06-22	Novartis AG	Stable and soluble antibodies inhibiting tnf
TR201808591T4 (tr) *	2008-06-25	2018-07-23	Esbatech Alcon Biomed Res Unit	Bir evrensel bir antikor iskeleti kullanılarak tavşan antikorların insanlaştırılması.
US8637022B2 (en) *	2008-06-30	2014-01-28	Esbatech, An Alcon Biomedical Research Unit Llc	Functionalized polypeptides
CA2730178A1 (en)	2008-07-10	2010-01-14	Esbatech, An Alcon Biomedical Research Unit Llc	Methods and compositions for enhanced delivery of macromolecules

2009
- 2009-07-10 CA CA2730178A patent/CA2730178A1/en not_active Abandoned
- 2009-07-10 MX MX2011000009A patent/MX2011000009A/es active IP Right Grant
- 2009-07-10 BR BRPI0915460A patent/BRPI0915460A2/pt not_active IP Right Cessation
- 2009-07-10 CN CN201510138310.4A patent/CN104800147A/zh active Pending
- 2009-07-10 CN CN2009801262475A patent/CN102088958A/zh active Pending
- 2009-07-10 JP JP2011516941A patent/JP5579713B2/ja active Active
- 2009-07-10 EP EP14162656.4A patent/EP2769711A1/en not_active Withdrawn
- 2009-07-10 KR KR1020117002959A patent/KR20110031373A/ko not_active Ceased
- 2009-07-10 WO PCT/CH2009/000248 patent/WO2010003268A2/en not_active Ceased
- 2009-07-10 US US13/000,533 patent/US8697074B2/en active Active
- 2009-07-10 EP EP09775745A patent/EP2303230A2/en not_active Withdrawn
- 2009-07-10 RU RU2011104816/15A patent/RU2522245C2/ru not_active Application Discontinuation
2010
- 2010-11-30 ZA ZA2010/08597A patent/ZA201008597B/en unknown
2014
- 2014-02-12 JP JP2014024529A patent/JP2014122230A/ja not_active Withdrawn
- 2014-02-26 US US14/190,788 patent/US20140212421A1/en not_active Abandoned
2015
- 2015-02-18 HK HK15101810.9A patent/HK1201201A1/en unknown

Also Published As

Publication number	Publication date
US20140212421A1 (en)	2014-07-31
EP2303230A2 (en)	2011-04-06
EP2769711A1 (en)	2014-08-27
US8697074B2 (en)	2014-04-15
JP2011527289A (ja)	2011-10-27
CA2730178A1 (en)	2010-01-14
US20110135644A1 (en)	2011-06-09
MX2011000009A (es)	2011-08-15
HK1201201A1 (en)	2015-08-28
RU2011104816A (ru)	2012-08-20
WO2010003268A2 (en)	2010-01-14
RU2522245C2 (ru)	2014-07-10
JP5579713B2 (ja)	2014-08-27
WO2010003268A3 (en)	2011-01-13
AU2009267729A1 (en)	2010-01-14
CN104800147A (zh)	2015-07-29
ZA201008597B (en)	2012-05-30
KR20110031373A (ko)	2011-03-25
JP2014122230A (ja)	2014-07-03
CN102088958A (zh)	2011-06-08

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