[go: up one dir, main page]

BRPI0914092A2 - método de produção de um anticorpo a partir de células plasmáticas, método de produção de um anticorpo monoclonal a partir de células plasmáticas, método de produção de um anticorpo ou de um fragmento de anticorpo, anticorpo isolado ou fragmento de anticorpo, anticorpo ou fragmento de anticorpo e composição farmacêutica - Google Patents

método de produção de um anticorpo a partir de células plasmáticas, método de produção de um anticorpo monoclonal a partir de células plasmáticas, método de produção de um anticorpo ou de um fragmento de anticorpo, anticorpo isolado ou fragmento de anticorpo, anticorpo ou fragmento de anticorpo e composição farmacêutica

Info

Publication number
BRPI0914092A2
BRPI0914092A2 BRPI0914092A BRPI0914092A BRPI0914092A2 BR PI0914092 A2 BRPI0914092 A2 BR PI0914092A2 BR PI0914092 A BRPI0914092 A BR PI0914092A BR PI0914092 A BRPI0914092 A BR PI0914092A BR PI0914092 A2 BRPI0914092 A2 BR PI0914092A2
Authority
BR
Brazil
Prior art keywords
antibody
producing
fragment
plasma cells
antibody fragment
Prior art date
Application number
BRPI0914092A
Other languages
English (en)
Inventor
Antonio Lanzavecchia
David Jarrossay
Original Assignee
Inst Research In Biomedicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0914092(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0819376A external-priority patent/GB0819376D0/en
Priority claimed from US12/509,731 external-priority patent/US9340603B2/en
Application filed by Inst Research In Biomedicine filed Critical Inst Research In Biomedicine
Publication of BRPI0914092A2 publication Critical patent/BRPI0914092A2/pt
Publication of BRPI0914092B1 publication Critical patent/BRPI0914092B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C07K16/108—
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Virology (AREA)
BRPI0914092-1A 2008-10-22 2009-10-22 Método de produção de um anticorpo a partir de células plasmáticas, método de produção de um anticorpo monoclonal a partir de células plasmáticas e método de produção de um anticorpo ou de um fragmento de anticorpo BRPI0914092B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0819376.5 2008-10-22
GB0819376A GB0819376D0 (en) 2008-10-22 2008-10-22 Method for culturing human plasma cells
US18158209P 2009-05-27 2009-05-27
US61/181,582 2009-05-27
US12/509,731 US9340603B2 (en) 2008-07-25 2009-07-27 Neutralizing anti-influenza A virus antibodies and uses thereof
US12.509,731 2009-07-27
PCT/IB2009/006616 WO2010010466A2 (en) 2008-07-25 2009-07-27 Neutralizing anti-influenza a virus antibodies and uses thereof
IBPCT/IB09/006616 2009-07-27
PCT/IB2009/007375 WO2010046775A2 (en) 2008-10-22 2009-10-22 Methods for producing antibodies from plasma cells

Publications (2)

Publication Number Publication Date
BRPI0914092A2 true BRPI0914092A2 (pt) 2015-10-27
BRPI0914092B1 BRPI0914092B1 (pt) 2021-08-31

Family

ID=41796120

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914092-1A BRPI0914092B1 (pt) 2008-10-22 2009-10-22 Método de produção de um anticorpo a partir de células plasmáticas, método de produção de um anticorpo monoclonal a partir de células plasmáticas e método de produção de um anticorpo ou de um fragmento de anticorpo

Country Status (18)

Country Link
US (1) US9347043B2 (pt)
EP (2) EP2350128B1 (pt)
JP (1) JP5837820B2 (pt)
KR (1) KR101606608B1 (pt)
CN (1) CN102282170B (pt)
AU (1) AU2009306010B2 (pt)
BR (1) BRPI0914092B1 (pt)
CA (1) CA2740138C (pt)
CL (1) CL2011000797A1 (pt)
DK (1) DK2350128T3 (pt)
EA (1) EA024586B1 (pt)
ES (1) ES2525346T3 (pt)
IL (1) IL212121A (pt)
MX (1) MX2011003855A (pt)
NZ (1) NZ592036A (pt)
PL (1) PL2350128T3 (pt)
WO (1) WO2010046775A2 (pt)
ZA (1) ZA201102387B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011092593A2 (en) 2010-01-20 2011-08-04 Institute For Research In Biomedicine Hiv-1 neutralizing antibodies and uses thereof
DK2400298T3 (da) * 2010-05-28 2013-09-02 Hoffmann La Roche Enkelt B-celle-dyrkningsfremgangsmåde og specifik antistoffremstilling
US10087408B2 (en) 2010-07-07 2018-10-02 The University Of British Columbia System and method for microfluidic cell culture
US20130115606A1 (en) 2010-07-07 2013-05-09 The University Of British Columbia System and method for microfluidic cell culture
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
EP2703485B1 (en) * 2011-03-30 2018-12-26 National University Corporation University Of Toyama Method for selecting plasma cells and plasmablasts, and method for producing target antigen-specific antibody
SI3418300T1 (sl) 2011-07-18 2021-03-31 Institute For Research In Biomedicine Nevtralizirajoča protitelesa proti virusu influence A in njihove uporabe
CN107880121B (zh) 2012-03-20 2022-02-18 胡默波斯生物医学公司 中和rsv、mpv和pvm的抗体和其应用
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
WO2016075546A2 (en) 2014-11-14 2016-05-19 Antonio Lanzavecchia Antibodies that neutralize ebola virus and uses thereof
HRP20201811T1 (hr) 2014-11-18 2021-01-08 Humabs Biomed S.A. Protutijela koja snažno neutraliziraju virus bjesnoće i druge lyssaviruse i njihova upotreba
EP3313871A1 (en) 2015-06-26 2018-05-02 Institute for Research in Biomedicine Proteins comprising a mutated lair-1 fragment and uses thereof
WO2017059878A1 (en) 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof
US10513553B2 (en) 2015-11-13 2019-12-24 Visterra, Inc. Compositions and methods for treating and preventing influenza
EP3419663A1 (en) 2016-02-24 2019-01-02 Visterra, Inc. Formulations of antibody molecules to influenza virus
CN105950552A (zh) * 2016-05-26 2016-09-21 宁波艾科生物科技有限公司 一种分泌抗原特异性抗体浆细胞的分离方法
WO2018010789A1 (en) 2016-07-13 2018-01-18 Humabs Biomed Sa Novel antibodies specifically binding to zika virus epitopes and uses thereof
WO2018193063A2 (en) 2017-04-19 2018-10-25 Institute For Research In Biomedicine Novel malaria vaccines and antibodies binding to plasmodium sporozoites
WO2019024979A1 (en) 2017-07-31 2019-02-07 Institute For Research In Biomedicine FUNCTIONAL DOMAIN ANTIBODIES IN THE ELBOW REGION
JP6622825B2 (ja) * 2018-01-25 2019-12-18 インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ Ａ型インフルエンザウイルス中和抗体及びその使用法
KR102880569B1 (ko) 2018-12-19 2025-11-06 후맙스 바이오메드 에스에이 B형 간염 바이러스를 중화하는 항체 및 이의 용도
WO2020198329A1 (en) 2019-03-25 2020-10-01 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2020221451A1 (en) 2019-04-30 2020-11-05 Humabs Biomed Sa Antibodies binding to plasmodium circumsporozoite protein and uses thereof
WO2020221450A1 (en) 2019-04-30 2020-11-05 Humabs Biomed Sa Antibodies and methods for treatment of influenza a infection
EP3757127A1 (en) 2019-06-28 2020-12-30 Institute for Research in Biomedicine Deimmunized antibodies binding to alpha-4 integrin and uses thereof
JP2022545920A (ja) 2019-08-29 2022-11-01 ヴィア・バイオテクノロジー・インコーポレイテッド Ｂ型肝炎ウイルス感染を処置するための抗体組成物および方法
WO2021041989A1 (en) 2019-08-29 2021-03-04 Vir Biotechnology, Inc. Compositions and methods for treatment of influenza a infection
JP2020048568A (ja) * 2019-11-22 2020-04-02 インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ Ａ型インフルエンザウイルス中和抗体及びその使用法
AR122722A1 (es) 2020-06-24 2022-09-28 Vir Biotechnology Inc Anticuerpos que neutralizan el virus de la hepatitis b y sus usos
JP2023552846A (ja) 2020-12-08 2023-12-19 フマブス バイオメッド エスアー メタニューモウイルスのｆ－タンパク質に結合する抗体およびその使用
EP4259655A1 (en) 2020-12-08 2023-10-18 VIR Biotechnology, Inc. Antibodies and methods for treatment of influenza a infection
WO2022162012A2 (en) 2021-01-26 2022-08-04 Eth Zurich Antibodies broadly targeting coronaviruses and uses thereof
WO2022161598A1 (en) 2021-01-26 2022-08-04 Eth Zurich Antibodies broadly targeting coronaviruses and uses thereof
WO2022162009A1 (en) 2021-01-26 2022-08-04 Eth Zurich Method for rapid identification of cross-reactive and/or rare antibodies
US20240092872A1 (en) 2021-01-26 2024-03-21 Vir Biotechnology, Inc. Compositions and methods for treating hepatitis b virus infection
WO2022161597A1 (en) 2021-01-26 2022-08-04 Eth Zurich Method for rapid identification of cross-reactive and/or rare antibodies
JP2024535124A (ja) 2021-09-07 2024-09-26 インスティテュート・フォー・リサーチ・イン・バイオメディシン 破傷風毒素に結合する抗体およびその使用
CN114350606A (zh) * 2022-01-05 2022-04-15 上海药明生物医药有限公司 一种富集大鼠浆细胞及建立浆细胞杂交瘤的方法
WO2023230439A1 (en) 2022-05-23 2023-11-30 Vir Biotechnology, Inc. Fc-engineered hepatitis b virus neutralizing antibodies and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1143006T3 (da) 1995-08-18 2008-07-14 Morphosys Ip Gmbh Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker
US7368256B2 (en) * 2001-08-10 2008-05-06 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Antibodies against Stachybotrys chartarum and methods for their use
NZ542784A (en) * 2002-08-19 2008-07-31 Astrazeneca Ab Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
US7318925B2 (en) * 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
AU2003282780A1 (en) * 2003-08-08 2005-03-07 Abgenix, Inc. Antibodies directed to parathyroid hormone (pth) and uses thereof
EP2522678A1 (en) 2006-05-15 2012-11-14 Sea Lane Biotechnologies, LLC Neutralizing antibodies to influenza viruses
EA017203B1 (ru) 2006-09-07 2012-10-30 Круселл Холланд Б.В. Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение
CA2668800A1 (en) 2006-11-08 2008-06-05 Macrogenics West, Inc. Tes7 and antibodies that bind thereto
JP5346820B2 (ja) 2007-03-13 2013-11-20 エイチユーエムエイビーエス・リミテッド・ライアビリティ・カンパニー Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体
WO2010003240A1 (en) * 2008-07-08 2010-01-14 The Royal Institution For The Advancement Of Learning/Mcgill University Gmcsf and truncated ccl2 conjugates and methods and uses thereof

Also Published As

Publication number Publication date
WO2010046775A2 (en) 2010-04-29
EA201100668A1 (ru) 2012-06-29
EP2350128B1 (en) 2014-10-01
JP5837820B2 (ja) 2015-12-24
IL212121A (en) 2016-03-31
EA024586B1 (ru) 2016-10-31
IL212121A0 (en) 2011-06-30
ES2525346T3 (es) 2014-12-22
AU2009306010B2 (en) 2015-12-24
CA2740138C (en) 2017-01-10
JP2012506251A (ja) 2012-03-15
WO2010046775A3 (en) 2010-06-17
US20100145031A1 (en) 2010-06-10
BRPI0914092B1 (pt) 2021-08-31
US9347043B2 (en) 2016-05-24
EP2350128A2 (en) 2011-08-03
NZ592036A (en) 2012-12-21
DK2350128T3 (da) 2014-12-01
CL2011000797A1 (es) 2012-03-16
CN102282170A (zh) 2011-12-14
EP2848630A1 (en) 2015-03-18
AU2009306010A1 (en) 2010-04-29
ZA201102387B (en) 2012-09-26
CN102282170B (zh) 2015-04-08
PL2350128T3 (pl) 2015-03-31
KR20110073506A (ko) 2011-06-29
CA2740138A1 (en) 2010-04-29
KR101606608B1 (ko) 2016-03-25
HK1164899A1 (en) 2012-09-28
MX2011003855A (es) 2011-12-16

Similar Documents

Publication Publication Date Title
BRPI0914092A2 (pt) método de produção de um anticorpo a partir de células plasmáticas, método de produção de um anticorpo monoclonal a partir de células plasmáticas, método de produção de um anticorpo ou de um fragmento de anticorpo, anticorpo isolado ou fragmento de anticorpo, anticorpo ou fragmento de anticorpo e composição farmacêutica
IL206715A (en) Anti-mif anti-mif antibodies, medicinal preparations containing them, their use and methods for their preparation
BR112012001171A2 (pt) método de seleção. evolução e expressão de um articorpo ou fragmento de anticorpo, métodos de evolução e expressão de um anticorpo e de uma proteína, método de evolução e de fabricação de uma proteína, método de evolução para expressão intensificada e fabricação de uma proteína, método para identificar e produzir uma proteína,e, método de evolução de uma proteína.
IL260285B (en) Anti-gcc antibody molecules and related compositions and methods
WO2010145792A8 (en) Bispecific antigen binding proteins
NZ606090A (en) Human cgrp receptor binding proteins
BRPI0822447A2 (pt) Anticorpo monoclonal e método do mesmo
BRPI0919377A2 (pt) anticorpo isolado ou um fragmento ligante de antígeno do memso, ácido nucleico isolado, vetor, célula hospedeira, composição farmacêutica, método de produzir o referido anticorpo ou fragmento, uso dos mesmos, e composição compreendendo o referido anticorpo ou fragmento
EP2473525A4 (en) MONOCLONAL ANTIBODIES AGAINST GLYCOPROTEIN OF EBOLA SUDAN BONIFACE VIRUS
EP2647720A4 (en) PEPTIDE LIBRARY MANUFACTURING METHOD, PEPTIDE LIBRARY AND SCREENING METHOD
BRPI0914916A2 (pt) anticorpos de interleucina-20 anti-humanos, assim como método de produção dos mesmos
WO2011131746A3 (en) Heterodimeric antibody fc-containing proteins and methods for production thereof
IL232635A0 (en) Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold and pharmaceutical compostions comprising the same
DE602006006200D1 (de) Antikörper gegen 25-hydroxyvitamin d
IL202232A (en) A method of making a human antibody derived from a rabbit parent antibody that binds to a desired antigen as well as a human antibody or fragment thereof produced by this method
EP2141497B8 (en) Method for the analysis of circulating antibodies
WO2010121093A3 (en) Humanized antibody compositions and methods for binding lysophosphatidic acid
IL205073A (en) 2 bst antibodies, methods of making them, medicinal preparations containing them and their use
IL197823A0 (en) Methods for improving antibody production
BRPI1005176A2 (pt) ensaio de insulina, reagente de ensaio de insulina, anticorpo monoclonal, e, método de triar anticorpos monoclonais.
EP2308899A4 (en) ANTIBODY COMPLEX, ANTIGEN DETECTION METHOD, AND METHOD OF PRODUCING AN ANTIBODY COMPLEX
IL205051A (en) Method for producing antibodies
WO2008110914A3 (en) Methods for producing active scfv antibodies and libraries therefor
WO2010079510A3 (en) Anti-rhd monoclonal antibodies
EP2475383A4 (en) FOR THE PEPTIDE PRODUCED FROM HSP65 6 SPECIFIC HUMANIZED ANTIBODIES AND USES THEREOF

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/10/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: EXTINTA A PATENTE, NOS TERMOS DO ARTIGO 86, DA LPI, E ARTIGO 14 DA PORTARIA 52/2023, REFERENTE AO NAO RECOLHIMENTO DA 16A RETRIBUICAO ANUAL. PARA FINS DE RESTAURACAO CONFORME ARTIGO 87, DA LPI 9.279, E ARTIGO 15, DA PORTARIA 52/2023, VIDE PARECER.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2852 DE 02-09-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.