BRPI0908229A2 - método para dispensar iontoforeticamente um corticoesteróide, derivado de corticoesteróide, pró-droga ou sal no olho de um paciente, kit para dispensar iontoforeticamente dexametasona no olho de um paciente, formulação de dexametasona, dispositivo para dispensar dexametasona, e, método para tratar uma doença oftálmica sensível a corticoesteróide em um mamífero. - Google Patents
método para dispensar iontoforeticamente um corticoesteróide, derivado de corticoesteróide, pró-droga ou sal no olho de um paciente, kit para dispensar iontoforeticamente dexametasona no olho de um paciente, formulação de dexametasona, dispositivo para dispensar dexametasona, e, método para tratar uma doença oftálmica sensível a corticoesteróide em um mamífero.Info
- Publication number
- BRPI0908229A2 BRPI0908229A2 BRPI0908229A BRPI0908229A BRPI0908229A2 BR PI0908229 A2 BRPI0908229 A2 BR PI0908229A2 BR PI0908229 A BRPI0908229 A BR PI0908229A BR PI0908229 A BRPI0908229 A BR PI0908229A BR PI0908229 A2 BRPI0908229 A2 BR PI0908229A2
- Authority
- BR
- Brazil
- Prior art keywords
- corticosteroid
- dexamethasone
- dispensing
- iontophoretically
- eye
- Prior art date
Links
- 239000003246 corticosteroid Substances 0.000 title 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 title 3
- 229960003957 dexamethasone Drugs 0.000 title 3
- 238000000034 method Methods 0.000 title 2
- 241000124008 Mammalia Species 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3126708P | 2008-02-25 | 2008-02-25 | |
| US4795008P | 2008-04-25 | 2008-04-25 | |
| PCT/US2009/034977 WO2009108626A2 (en) | 2008-02-25 | 2009-02-24 | Enhanced delivery of a therapeutic to ocular tissues through iontophoresis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0908229A2 true BRPI0908229A2 (pt) | 2017-06-13 |
| BRPI0908229A8 BRPI0908229A8 (pt) | 2017-10-10 |
Family
ID=41016683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908229A BRPI0908229A8 (pt) | 2008-02-25 | 2009-02-24 | Uso de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste, kit e dispositivo para dispensar iontoforeticamente um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente para tratar um distúrbio ocular mediado por inflamação no referido paciente, e, formulação apropriada para dispensação iontoforética ocular de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20090306579A1 (pt) |
| EP (1) | EP2249921B1 (pt) |
| JP (1) | JP2011512903A (pt) |
| CN (1) | CN101970042A (pt) |
| AU (1) | AU2009219426B2 (pt) |
| BR (1) | BRPI0908229A8 (pt) |
| CA (1) | CA2716390C (pt) |
| IL (1) | IL207014A0 (pt) |
| MX (1) | MX2010009157A (pt) |
| WO (1) | WO2009108626A2 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101970042A (zh) | 2008-02-25 | 2011-02-09 | 眼门药品公司 | 经由离子电渗法增强递送治疗药物至眼部组织 |
| WO2010078246A1 (en) * | 2008-12-31 | 2010-07-08 | Eyegate Pharma S.A.S. | System and method for ocular iontophoresis with buffering |
| WO2012095877A1 (en) * | 2011-01-12 | 2012-07-19 | Sooft Italia Spa | Corneal delivery of cross-linking agents by iontophoresis for the treatment of keratoconus and related ophthalmic compositions |
| WO2012162459A1 (en) * | 2011-05-26 | 2012-11-29 | Pepose Jay | Device and method for administering eye medications |
| JP5463511B1 (ja) * | 2013-05-13 | 2014-04-09 | 株式会社メディカル・アート | イオン泳動式皮膚感染症治療装置 |
| WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2015164626A2 (en) * | 2014-04-23 | 2015-10-29 | Seros Medical, Llc | Vacuum-assisted drug delivery device and method |
| KR20170046146A (ko) * | 2014-08-13 | 2017-04-28 | 더 존스 홉킨스 유니버시티 | 각막 동종이식 거부 및 신혈관 형성의 예방을 위한 글루코 코르티코이드-로딩된 나노입자 |
| ES2874562T3 (es) * | 2014-12-19 | 2021-11-05 | Kemin Ind Inc | Suministro intraocular de moléculas bioactivas mediante el uso de iontoforesis |
| EP3247452A4 (en) | 2015-01-22 | 2018-11-14 | Eyegate Pharmaceuticals, Inc. | Iontophoretic contact lens |
| MY186271A (en) | 2015-03-05 | 2021-07-01 | Auckland Uniservices Ltd | Ophthalmic compositions and methods of use therefor |
| WO2019089537A1 (en) | 2017-10-31 | 2019-05-09 | Tusker Medical, Inc. | Systems, apparatus, and methods for delivery of therapeutic substance to nasal cavity |
| EP3883562A4 (en) | 2018-11-21 | 2022-08-03 | Tremeau Pharmaceuticals, Inc. | PURIFIED FORMS OF ROFECOXIB AND METHODS OF MAKING AND USING |
| US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
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| US4221787A (en) * | 1978-03-28 | 1980-09-09 | Interx Research Corporation | Esteramide prodrugs of anti-inflammatory corticosteroids |
| US4279900A (en) * | 1978-07-13 | 1981-07-21 | Intrex Research Corporation | Prodrugs for the improved delivery of halogen-containing glucocorticosteroids |
| US4456602A (en) * | 1982-08-23 | 1984-06-26 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4472392A (en) * | 1983-01-21 | 1984-09-18 | The Upjohn Company | Sulfonate containing ester prodrugs of corticosteroids |
| US4469689A (en) * | 1983-03-30 | 1984-09-04 | The Upjohn Company | Sulfonate containing ester prodrugs of corticosteroids |
| US4588718A (en) * | 1984-03-28 | 1986-05-13 | The Upjohn Company | Carboxy containing ester prodrugs of corticosteroids |
| GB9024005D0 (en) * | 1990-11-05 | 1990-12-19 | British Bio Technology | Process for amplifying nucleic acid |
| US5222936A (en) * | 1991-09-25 | 1993-06-29 | Stephen Robert L | Intracorporeal iontophoretic method |
| DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| EP0647450A1 (en) * | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| CA2172983A1 (en) * | 1993-09-29 | 1995-04-06 | Kei Sugai | 21-substituted steroid compound |
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| JP2006518769A (ja) * | 2003-02-21 | 2006-08-17 | サン・ファーマシューティカル・インダストリーズ・リミテッド | 安定な眼科用組成物 |
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| CN101970042A (zh) | 2008-02-25 | 2011-02-09 | 眼门药品公司 | 经由离子电渗法增强递送治疗药物至眼部组织 |
| CA2723458C (en) * | 2008-05-14 | 2014-01-28 | Otonomy, Inc. | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
-
2009
- 2009-02-24 CN CN2009801063912A patent/CN101970042A/zh active Pending
- 2009-02-24 EP EP09714994.2A patent/EP2249921B1/en not_active Not-in-force
- 2009-02-24 US US12/391,836 patent/US20090306579A1/en not_active Abandoned
- 2009-02-24 AU AU2009219426A patent/AU2009219426B2/en not_active Ceased
- 2009-02-24 MX MX2010009157A patent/MX2010009157A/es active IP Right Grant
- 2009-02-24 JP JP2010547849A patent/JP2011512903A/ja active Pending
- 2009-02-24 WO PCT/US2009/034977 patent/WO2009108626A2/en not_active Ceased
- 2009-02-24 BR BRPI0908229A patent/BRPI0908229A8/pt not_active Application Discontinuation
- 2009-02-24 CA CA2716390A patent/CA2716390C/en not_active Expired - Fee Related
-
2010
- 2010-07-15 IL IL207014A patent/IL207014A0/en active IP Right Grant
-
2012
- 2012-05-11 US US13/469,481 patent/US10376463B2/en not_active Expired - Fee Related
-
2013
- 2013-10-22 US US14/060,055 patent/US9149525B2/en not_active Expired - Fee Related
-
2016
- 2016-03-10 US US15/066,689 patent/US9820935B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009219426B2 (en) | 2015-12-03 |
| AU2009219426A1 (en) | 2009-09-03 |
| BRPI0908229A8 (pt) | 2017-10-10 |
| US20090306579A1 (en) | 2009-12-10 |
| MX2010009157A (es) | 2010-09-24 |
| US20140046242A1 (en) | 2014-02-13 |
| US10376463B2 (en) | 2019-08-13 |
| WO2009108626A2 (en) | 2009-09-03 |
| JP2011512903A (ja) | 2011-04-28 |
| EP2249921B1 (en) | 2020-06-17 |
| US9820935B2 (en) | 2017-11-21 |
| CN101970042A (zh) | 2011-02-09 |
| US20120283231A1 (en) | 2012-11-08 |
| IL207014A0 (en) | 2010-12-30 |
| CA2716390C (en) | 2016-08-23 |
| US20160263024A1 (en) | 2016-09-15 |
| EP2249921A4 (en) | 2015-02-11 |
| US9149525B2 (en) | 2015-10-06 |
| EP2249921A2 (en) | 2010-11-17 |
| CA2716390A1 (en) | 2009-09-03 |
| WO2009108626A3 (en) | 2010-01-07 |
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