BRPI0823154A2 - Análogos de insulina com uma porção acila e alquileno glicol - Google Patents

Análogos de insulina com uma porção acila e alquileno glicol

Info

Publication number: BRPI0823154A2
Authority: BR; Brazil
Prior art keywords: alkylene glycol; acyl moiety; insulin analogs; insulin; analogs
Prior art date: 2007-08-15

Application number

BRPI0823154-0A

Other languages

English (en)

Inventor

Peter Madsen

Thomas Borglum Kjeldsen

Thomas Hoeg-Jensen

Tina Moller Tagmose

Palle Jakobsen

Janos Tibor Kodra

Patrick William Garibay

Dorte Xenia Gram

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-15

Filing date

2008-08-18

Publication date

2015-07-07

2008-08-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2015-07-07 Publication of BRPI0823154A2 publication Critical patent/BRPI0823154A2/pt

Links

125000002252 acyl group Chemical group 0.000 title 1
-1 alkylene glycol Chemical compound 0.000 title 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Zoology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

BRPI0823154-0A 2007-08-15 2008-08-18 Análogos de insulina com uma porção acila e alquileno glicol BRPI0823154A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07114386		2007-08-15
PCT/EP2008/060768 WO2009022013A1 (en)	2007-08-15	2008-08-15	Insulin analogues with an acyl and aklylene glycol moiety

Publications (1)

Publication Number	Publication Date
BRPI0823154A2 true BRPI0823154A2 (pt)	2015-07-07

Family

ID=38754600

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0823154-0A BRPI0823154A2 (pt)	2007-08-15	2008-08-18	Análogos de insulina com uma porção acila e alquileno glicol

Country Status (13)

Country	Link
US (1)	US9150633B2 (pt)
EP (2)	EP2178912B1 (pt)
JP (1)	JP5730569B2 (pt)
KR (1)	KR20100053561A (pt)
CN (1)	CN101784562B (pt)
AU (1)	AU2008288413B2 (pt)
BR (1)	BRPI0823154A2 (pt)
CA (1)	CA2695970A1 (pt)
ES (1)	ES2548304T3 (pt)
MX (1)	MX2010001645A (pt)
RU (1)	RU2514430C2 (pt)
WO (2)	WO2009022013A1 (pt)
ZA (1)	ZA201001416B (pt)

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AU2012216723B2 (en) *	2007-11-20	2014-08-28	Ambrx, Inc.	Modified insulin polypeptides and their uses
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
JP5749155B2 (ja) *	2008-03-18	2015-07-15	ノボ・ノルデイスク・エー／エス	プロテアーゼ安定化アシル化インスリンアナログ
AU2013205270B2 (en) *	2008-03-18	2015-01-15	Novo Nordisk A/S	Protease stabilized, acylated insulin analogues
CN102665676B (zh)	2009-11-02	2015-04-01	诺沃-诺迪斯克有限公司	非共价结合的白蛋白和酰化胰岛素的药物溶液
EP2523655A2 (en) *	2010-01-12	2012-11-21	Novo Nordisk A/S	Pharmaceutical compositions for oral administration of insulin peptides
CN104693302A (zh) *	2010-06-23	2015-06-10	诺沃—诺迪斯克有限公司	包含额外的二硫键的胰岛素衍生物
JP2013540771A (ja) *	2010-10-15	2013-11-07	ノヴォノルディスクアー／エス	新規ｎ末端修飾インスリン誘導体
WO2012171994A1 (en) *	2011-06-15	2012-12-20	Novo Nordisk A/S	Multi substituted insulins
BR112014025132A2 (pt)	2012-04-11	2017-07-11	Novo Nordisk As	formulações de insulina
ES2676065T3 (es)	2013-10-07	2018-07-16	Novo Nordisk A/S	Nuevo derivado de un análogo de la insulina
FR3013049B1 (fr) *	2013-11-14	2015-11-13	You-Ping Chan	Analogue de l'insuline glargine
GB201321489D0 (en)	2013-12-05	2014-01-22	Chemical & Biopharmaceutical Lab Of Patras S A	Biologically active insulin derivatives
MA43289B1 (fr)	2014-01-20	2019-12-31	Hanmi Pharm Ind Co Ltd	Insuline à action prolongée et utilisation associée
AR099569A1 (es) *	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
WO2015191705A1 (en) *	2014-06-10	2015-12-17	California Institute Of Technology	Non-canonical insulins and their uses
JP2018531900A (ja) *	2015-08-25	2018-11-01	ノヴォノルディスクアー／エス	新規インスリン誘導体及びその医学的使用
UY36870A (es)	2015-08-28	2017-03-31	Hanmi Pharm Ind Co Ltd	Análogos de insulina novedosos
BR112019005637A2 (pt)	2016-09-23	2019-07-30	Hanmi Pharm Ind Co Ltd	análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso
US11208453B2 (en) *	2016-11-21	2021-12-28	Case Western Reserve University	Rapid-acting insulin analogues of enhanced stability
HUE060149T2 (hu)	2016-12-16	2023-02-28	Novo Nordisk As	Inzulint tartalmazó gyógyászati készítmények
TWI798209B (zh)	2017-03-23	2023-04-11	南韓商韓美藥品股份有限公司	對胰島素受體有降低親和性之胰島素類似物之接合物及其用途
JOP20190273A1 (ar) *	2017-05-26	2019-11-24	Lilly Co Eli	مركب إنسولين معالج بأسيل
MX2020001434A (es)	2017-08-17	2020-03-20	Novo Nordisk As	Analogos de insulina acilados novedosos y usos de estos.
EP3893934B1 (en)	2018-12-11	2025-09-10	Sanofi	Insulin conjugates
CN110041219B (zh) *	2019-05-09	2020-09-25	南京工业大学	一种索马鲁肽侧链的液相合成方法
KR102427426B1 (ko)	2019-12-11	2022-08-01	노보 노르디스크 에이/에스	신규한 인슐린 유사체 및 이의 용도
BR112022013009A2 (pt) *	2019-12-30	2022-09-06	Gan & Lee Pharmaceuticals Co Ltd	Derivados de insulina, composição farmacêutica, uso do derivado da insulina e métodos para tratar ou prevenir diabetes, para aumentar a capacidade de um derivado de insulina e para aumentar a potência de um derivado de insulina
JP2023510218A (ja) *	2019-12-30	2023-03-13	ガンアンドリーファーマスゥーティカルズカンパニーリミテッド	長時間作用型ｇｌｐ－１化合物
CN114075273A (zh) *	2020-08-17	2022-02-22	四川科伦药物研究院有限公司	一种glp-1类似物片段活化酯的制备方法
JP2024521757A (ja) *	2021-05-24	2024-06-04	サンシャイン・レイク・ファーマ・カンパニー・リミテッド	新規なアシル化インスリンアナログ
US20250340610A1 (en) *	2022-01-28	2025-11-06	Gan & Lee Pharmaceuticals Co., Ltd.	Acylated insulin
CN115894719B (zh) *	2022-11-24	2023-10-20	武汉禾元生物科技股份有限公司	一种人血清白蛋白胰岛素偶联物及其制备方法
AU2024232757A1 (en)	2023-03-06	2025-08-21	Ascendis Pharma A/S	Drug compounds comprising albumin-binding moieties
WO2026013135A1 (en)	2024-07-10	2026-01-15	Ascendis Pharma A/S	Albumin-binding reagents
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ES2307544T3 (es)	1999-12-29	2008-12-01	Novo Nordisk A/S	Metodo de produccion de precursores de insulina y analogos de precursores de insulina.
SK2432004A3 (sk) *	2001-12-20	2005-04-01	Eli Lilly And Company	Inzulínová zlúčenina s protrahovaným účinkom
BR0314289B8 (pt) *	2002-09-25	2021-07-27	Novo Nordisk As	método para produzir um peptídeo n-acilado
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ES2428510T3 (es)	2005-02-02	2013-11-08	Novo Nordisk A/S	Derivados de insulina
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WO2008015099A2 (en)	2006-07-31	2008-02-07	Novo Nordisk A/S	Pegylated, extended insulins
EP2178912B1 (en)	2007-08-15	2015-07-08	Novo Nordisk A/S	Insulin analogues with an acyl and aklylene glycol moiety

2008
- 2008-08-15 EP EP08803059.8A patent/EP2178912B1/en not_active Not-in-force
- 2008-08-15 JP JP2010520597A patent/JP5730569B2/ja not_active Expired - Fee Related
- 2008-08-15 AU AU2008288413A patent/AU2008288413B2/en not_active Ceased
- 2008-08-15 US US12/673,516 patent/US9150633B2/en not_active Expired - Fee Related
- 2008-08-15 CN CN200880102999.3A patent/CN101784562B/zh not_active Expired - Fee Related
- 2008-08-15 WO PCT/EP2008/060768 patent/WO2009022013A1/en not_active Ceased
- 2008-08-15 ES ES08803059.8T patent/ES2548304T3/es active Active
- 2008-08-15 CA CA2695970A patent/CA2695970A1/en not_active Abandoned
- 2008-08-15 KR KR1020107003525A patent/KR20100053561A/ko not_active Withdrawn
- 2008-08-15 MX MX2010001645A patent/MX2010001645A/es active IP Right Grant
- 2008-08-15 RU RU2010107788/04A patent/RU2514430C2/ru not_active IP Right Cessation
- 2008-08-15 EP EP13180261.3A patent/EP2708554A1/en not_active Withdrawn
- 2008-08-15 WO PCT/EP2008/060733 patent/WO2009022005A1/en not_active Ceased
- 2008-08-18 BR BRPI0823154-0A patent/BRPI0823154A2/pt not_active IP Right Cessation
2010
- 2010-02-26 ZA ZA2010/01416A patent/ZA201001416B/en unknown

Also Published As

Publication number	Publication date
WO2009022013A1 (en)	2009-02-19
MX2010001645A (es)	2010-03-10
KR20100053561A (ko)	2010-05-20
JP5730569B2 (ja)	2015-06-10
EP2178912B1 (en)	2015-07-08
ES2548304T3 (es)	2015-10-15
CN101784562A (zh)	2010-07-21
US9150633B2 (en)	2015-10-06
AU2008288413B2 (en)	2013-09-26
CN101784562B (zh)	2016-07-13
RU2514430C2 (ru)	2014-04-27
US20110098440A1 (en)	2011-04-28
WO2009022005A1 (en)	2009-02-19
RU2010107788A (ru)	2011-09-20
EP2708554A1 (en)	2014-03-19
EP2178912A1 (en)	2010-04-28
JP2010535851A (ja)	2010-11-25
ZA201001416B (en)	2011-06-29
CA2695970A1 (en)	2009-02-19
AU2008288413A1 (en)	2009-02-19

Publication	Publication Date	Title
BRPI0823154A2 (pt)	2015-07-07	Análogos de insulina com uma porção acila e alquileno glicol
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Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application fees: dismissal - article 86 of industrial property law	Free format text: REFERENTE A 8A ANUIDADE.
2017-01-10	B08K	Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.