BRPI0822337A2 - Folatos, composições e usos dos mesmos - Google Patents

Folatos, composições e usos dos mesmos

Info

Publication number: BRPI0822337A2
Authority: BR; Brazil
Prior art keywords: folates; compositions
Prior art date: 2008-02-20

Application number

BRPI0822337-8A

Other languages

English (en)

Inventor

Ermanno Valoti

Davide Bianchi

Marco Valetti

Original Assignee

Gnosis Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-02-20

Filing date

2008-02-20

Publication date

2015-06-16

2008-02-20 Application filed by Gnosis Spa filed Critical Gnosis Spa

2015-06-16 Publication of BRPI0822337A2 publication Critical patent/BRPI0822337A2/pt

2019-02-12 Publication of BRPI0822337B1 publication Critical patent/BRPI0822337B1/pt

2021-05-25 Publication of BRPI0822337B8 publication Critical patent/BRPI0822337B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)

BRPI0822337A 2008-02-20 2008-02-20 folatos, composições e usos dos mesmos BRPI0822337B8 (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP2008/052037 WO2009103334A1 (en)	2008-02-20	2008-02-20	Folates, compositions and uses thereof

Publications (3)

Publication Number	Publication Date
BRPI0822337A2 true BRPI0822337A2 (pt)	2015-06-16
BRPI0822337B1 BRPI0822337B1 (pt)	2019-02-12
BRPI0822337B8 BRPI0822337B8 (pt)	2021-05-25

Family

ID=40299393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0822337A BRPI0822337B8 (pt)	2008-02-20	2008-02-20	folatos, composições e usos dos mesmos

Country Status (22)

Country	Link
EP (1)	EP2245032B1 (pt)
JP (1)	JP5856372B2 (pt)
KR (1)	KR101512624B1 (pt)
CN (1)	CN101970439B (pt)
AU (1)	AU2008351242B2 (pt)
BR (1)	BRPI0822337B8 (pt)
CA (1)	CA2712714C (pt)
CY (1)	CY1116343T1 (pt)
DK (1)	DK2245032T3 (pt)
EA (1)	EA017742B1 (pt)
ES (1)	ES2538480T3 (pt)
HR (1)	HRP20150674T1 (pt)
HU (1)	HUE025450T2 (pt)
IL (1)	IL207164A (pt)
MX (1)	MX2010009075A (pt)
NZ (1)	NZ586959A (pt)
PL (1)	PL2245032T3 (pt)
PT (1)	PT2245032E (pt)
SI (1)	SI2245032T1 (pt)
UA (1)	UA103310C2 (pt)
WO (1)	WO2009103334A1 (pt)
ZA (1)	ZA201005278B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103450202B (zh) *	2012-06-04	2015-07-01	南京莱因医药科技有限公司	L-5-甲基四氢叶酸与有机碱加成盐的方法
CN103664945B (zh) *	2012-09-07	2016-01-20	南京莱因医药科技有限公司	L-5-甲基四氢叶酸氨基酸盐的制备方法
JP2015024965A (ja) *	2013-07-24	2015-02-05	株式会社えがお	グルコサミン有機酸抱合物およびその製造方法
CN106455637A (zh) *	2014-05-30	2017-02-22	嘉康利公司	霞多丽葡萄籽提取物
EP3190112A4 (en) *	2014-09-04	2017-09-13	Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd.	Composition of (6s)-5-methyl tetrahydrofolic acid or salt thereof as well as preparation therefor and application thereof
CN106901379B (zh) *	2017-03-11	2021-08-13	深圳奥萨制药有限公司	一种辅助预防心血管疾病的维生素保健食品
CN106974292B (zh) *	2017-03-22	2021-02-26	深圳奥萨制药有限公司	一种由维生素d、e及叶酸组成的维生素组合物保健食品
DK3609894T3 (da)	2017-03-31	2024-09-09	Merck Patent Gmbh	Krystallinsk natriumsalt af 5-methyl-(6s)-tetrahydrofolsyre
EP3609895B1 (en)	2017-03-31	2024-10-16	Merck Patent GmbH	Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
EP3461826A1 (en) *	2017-09-29	2019-04-03	Aprofol AG	Multifunctional folate salts
EP3586849A1 (en) *	2018-06-29	2020-01-01	Aprofol AG	Folate preparations
US11633400B2 (en) *	2018-07-06	2023-04-25	Merck Patent Gmbh	Crystalline salt comprising 5-methyl-(6S)-tetrahydrofolic acid and 4-(2-hydroxyethyl)-morpholine
CA3105531A1 (en)	2018-07-06	2020-01-09	Merck Patent Gmbh	Crystalline salt of 5-methyl-(6s)-tetrahydrofolic acid and l-isoleucine ethyl ester
EP3646873A1 (en)	2018-10-31	2020-05-06	Aprofol AG	Folate salts
CN109748920A (zh) *	2018-12-24	2019-05-14	中健(广州)生物医药研究院有限公司	一种l-5-甲基四氢叶酸氨基葡萄糖盐及其合成方法
CN110313568A (zh) *	2018-12-24	2019-10-11	中健(广州)生物医药研究院有限公司	一种叶酸增强益生菌型固体饮料及其制备方法
CN110302090A (zh) *	2018-12-24	2019-10-08	中健(广州)生物医药研究院有限公司	L-5-甲基四氢叶酸氨基葡萄糖盐在化妆品中的应用
CN110974917A (zh) *	2019-11-25	2020-04-10	垒途智能教科技术研究院江苏有限公司	一种具有辅助防治儿童、青少年心理抑郁的作用的复合制剂
CN115040489B (zh) *	2022-08-17	2022-10-25	北京罗诺强施医药技术研发中心有限公司	具有优良一致性的稳定药物组合物及其制法
EP4501315A1 (en)	2023-08-04	2025-02-05	Lesaffre et Compagnie	Liquid formulations of folates
TW202535359A (zh)	2023-12-20	2025-09-16	法國商樂斯福公司	四氫葉酸鹽固體配方

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2137186A1 (en) *	1971-05-14	1972-12-29	Mauvernay Centre Europ	Folic acid salts - used as neuro-stimulants and for dynamising muscular function
JPS57123140A (en) *	1981-01-23	1982-07-31	Sankyo Co Ltd	Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component
IT1195288B (it) *	1981-11-05	1988-10-12	Zambeletti Spa L	Composizione farmaceutica per la terapia di calcolosi renale infetta
CA2021042A1 (en) *	1989-07-21	1991-01-22	Fabrizio Marazza	Salts of n ,n -methylene-5,6,7,8-tetrahydrofolic acid
IT1245889B (it) *	1991-04-12	1994-10-25	Alfa Wassermann Spa	Formulazioni farmaceutiche per uso orale gastroresistenti contenenti sali di acidi biliari.
CH689831A5 (de) *	1995-11-07	1999-12-15	Eprova Ag	Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de) *	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
JPWO2005112667A1 (ja) *	2004-05-20	2008-03-27	隆史大森	健康食品
JP2006131611A (ja) *	2004-10-07	2006-05-25	Otsuka Pharmaceut Factory Inc	骨代謝・たんぱく質代謝改善用栄養組成物

2008
- 2008-02-20 PL PL08709119T patent/PL2245032T3/pl unknown
- 2008-02-20 ES ES08709119.5T patent/ES2538480T3/es active Active
- 2008-02-20 SI SI200831448T patent/SI2245032T1/sl unknown
- 2008-02-20 MX MX2010009075A patent/MX2010009075A/es active IP Right Grant
- 2008-02-20 UA UAA201009825A patent/UA103310C2/ru unknown
- 2008-02-20 CA CA2712714A patent/CA2712714C/en active Active
- 2008-02-20 HR HRP20150674TT patent/HRP20150674T1/hr unknown
- 2008-02-20 PT PT87091195T patent/PT2245032E/pt unknown
- 2008-02-20 AU AU2008351242A patent/AU2008351242B2/en active Active
- 2008-02-20 HU HUE08709119A patent/HUE025450T2/en unknown
- 2008-02-20 JP JP2010547053A patent/JP5856372B2/ja active Active
- 2008-02-20 NZ NZ586959A patent/NZ586959A/en unknown
- 2008-02-20 EP EP08709119.5A patent/EP2245032B1/en active Active
- 2008-02-20 KR KR1020107020933A patent/KR101512624B1/ko active Active
- 2008-02-20 CN CN200880127258.0A patent/CN101970439B/zh active Active
- 2008-02-20 BR BRPI0822337A patent/BRPI0822337B8/pt active IP Right Grant
- 2008-02-20 EA EA201070966A patent/EA017742B1/ru not_active IP Right Cessation
- 2008-02-20 WO PCT/EP2008/052037 patent/WO2009103334A1/en not_active Ceased
- 2008-02-20 DK DK08709119.5T patent/DK2245032T3/da active
2010
- 2010-07-22 IL IL207164A patent/IL207164A/en active IP Right Grant
- 2010-07-23 ZA ZA2010/05278A patent/ZA201005278B/en unknown
2015
- 2015-05-29 CY CY20151100481T patent/CY1116343T1/el unknown

Also Published As

Publication number	Publication date
KR20110011602A (ko)	2011-02-08
EA201070966A1 (ru)	2011-02-28
JP5856372B2 (ja)	2016-02-09
IL207164A (en)	2015-01-29
EA017742B1 (ru)	2013-02-28
AU2008351242A2 (en)	2010-09-09
IL207164A0 (en)	2010-12-30
WO2009103334A1 (en)	2009-08-27
NZ586959A (en)	2012-04-27
AU2008351242B2 (en)	2012-12-20
EP2245032A1 (en)	2010-11-03
CN101970439A (zh)	2011-02-09
BRPI0822337B8 (pt)	2021-05-25
MX2010009075A (es)	2010-11-26
PT2245032E (pt)	2015-07-21
CA2712714A1 (en)	2009-08-27
HUE025450T2 (en)	2016-04-28
PL2245032T3 (pl)	2015-08-31
ES2538480T3 (es)	2015-06-22
UA103310C2 (en)	2013-10-10
KR101512624B1 (ko)	2015-04-16
DK2245032T3 (da)	2015-06-22
CA2712714C (en)	2015-05-12
BRPI0822337B1 (pt)	2019-02-12
HRP20150674T1 (hr)	2015-07-31
JP2011512366A (ja)	2011-04-21
AU2008351242A1 (en)	2009-08-27
SI2245032T1 (sl)	2015-08-31
ZA201005278B (en)	2011-09-28
CY1116343T1 (el)	2017-02-08
CN101970439B (zh)	2014-11-12
EP2245032B1 (en)	2015-03-25

Publication	Publication Date	Title
BRPI0822337A2 (pt)	2015-06-16	Folatos, composições e usos dos mesmos
BRPI0910503A2 (pt)	2015-09-29	compostos, composições farmacêuticas e respectivos usos.
BRPI0920927A2 (pt)	2019-09-24	derivados de azaquinolinona e usos dos mesmos
PT2963031T (pt)	2019-03-20	Pró-fármacos de tetrahidrocanabinol, composições compreendendo pró-fármacos de tetrahidrocanabinol e métodos de utilização dos mesmos
BRPI1013943A2 (pt)	2015-09-01	Composto cetais e usos dos mesmos.
BRPI0915897A2 (pt)	2015-11-03	compostos derivados triazóis, composições farmacêuticas e combinações dos mesmos e seus usos
BRPI0914682A2 (pt)	2015-10-20	compostos de heteroarila e usos dos mesmos
BRPI0918652A2 (pt)	2015-08-25	Composições farmacêuticas e métodos de libração relacionadas.
BRPI1009372A2 (pt)	2016-05-31	compostos, composição farmacêutica e respectivos usos
BRPI0908906A2 (pt)	2019-09-24	compostos heterocíclicos e usos dos mesmos
BRPI0906962A2 (pt)	2015-07-14	Composto, e, composição farmacêutica
BRPI0906556A2 (pt)	2015-07-07	Composto, e, composição farmacêutica
BRPI0912198A2 (pt)	2019-09-24	anticorpos anti-fn14 e usos dos mesmos
BRPI0813627A2 (pt)	2014-12-23	Peptídio antimicrobiano, composições e métodos de uso
BRPI1014997A2 (pt)	2019-09-24	compostos heteroarila e usos dos mesmos
BRPI0906973A2 (pt)	2015-07-14	Compostos e composições como inibidores de cinase.
BRPI1011404A2 (pt)	2016-03-15	mutantes e usos dos mesmos
BRPI1008709A2 (pt)	2016-03-08	composições e usos das mesmas.
PL2356462T3 (pl)	2017-07-31	Kompozycje anty-CXCR1 oraz sposoby
BRPI0818477A2 (pt)	2015-04-14	Dc-sign, icam-3 e lsectin porcinos e usos dos mesmos
BRPI0909770A2 (pt)	2015-08-11	Vacina, e, kit
BRPI0907453A2 (pt)	2015-07-14	Compostos, uso e preparação dos mesmos
EP2240022A4 (en)	2012-04-25	PHARMACEUTICAL COMPOSITIONS
BRPI1011970A2 (pt)	2015-09-22	compostos pirazolil-acrilonitrila e usos dos mesmos.
BRPI0819909A2 (pt)	2017-12-19	anticorpos antimesotelina e usos dos mesmos

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-07-31	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-10-02	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2018-12-26	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-02-12	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/02/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/02/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/02/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF