BRPI0822237A2 - Compostos de imidazo [1,2-a] piridina - Google Patents

Compostos de imidazo [1,2-a] piridina

Info

Publication number: BRPI0822237A2
Authority: BR; Brazil
Prior art keywords: imidazo; pyridine compounds; pyridine; compounds
Prior art date: 2007-12-21

Application number

BRPI0822237-1A

Other languages

English (en)

Inventor

Robert Ray Singhaus Jr

Jay E Wrobel

Robert J Stefan

Esward M Matelan

Ronald Charles Bernotas

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-21

Filing date

2008-12-19

Publication date

2015-06-30

2008-12-19 Application filed by Wyeth Llc filed Critical Wyeth Llc

2015-06-30 Publication of BRPI0822237A2 publication Critical patent/BRPI0822237A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0822237-1A 2007-12-21 2008-12-19 Compostos de imidazo [1,2-a] piridina BRPI0822237A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1585007P	2007-12-21	2007-12-21
PCT/US2008/087708 WO2009086123A1 (en)	2007-12-21	2008-12-19	Imidazo [1,2-a] pyridine compounds

Publications (1)

Publication Number	Publication Date
BRPI0822237A2 true BRPI0822237A2 (pt)	2015-06-30

Family

ID=40527707

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0822237-1A BRPI0822237A2 (pt)	2007-12-21	2008-12-19	Compostos de imidazo [1,2-a] piridina

Country Status (8)

Country	Link
US (1)	US20110112135A1 (pt)
EP (1)	EP2231660A1 (pt)
JP (1)	JP2011507900A (pt)
CN (1)	CN101945871A (pt)
AU (1)	AU2008345681A1 (pt)
BR (1)	BRPI0822237A2 (pt)
CA (1)	CA2710452A1 (pt)
WO (1)	WO2009086123A1 (pt)

Families Citing this family (39)

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US20110071197A1 (en) *	2008-04-16	2011-03-24	Peter Nilsson	Bis-aryl compounds for use as medicaments
CA2766100C (en)	2009-06-29	2018-05-22	Incyte Corporation	Pyrimidinones as pi3k inhibitors
BR112012010041A2 (pt)	2009-10-30	2016-05-24	Janssen Pharmaceutica Nv	derivados de imidazo [1,2-b] piridazina e seu uso como inibidores de pde10
EP2518066B1 (en) *	2009-12-18	2016-05-18	Mitsubishi Tanabe Pharma Corporation	Novel anti-platelet agent
WO2011075643A1 (en)	2009-12-18	2011-06-23	Incyte Corporation	Substituted heteroaryl fused derivatives as pi3k inhibitors
EP2338888A1 (en) *	2009-12-24	2011-06-29	Almirall, S.A.	Imidazopyridine derivatives as JAK inhibitors
UY33213A (es)	2010-02-18	2011-09-30	Almirall Sa	Derivados de pirazol como inhibidores de jak
AR080754A1 (es)	2010-03-09	2012-05-09	Janssen Pharmaceutica Nv	Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
WO2011130342A1 (en)	2010-04-14	2011-10-20	Incyte Corporation	FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS
WO2011163195A1 (en)	2010-06-21	2011-12-29	Incyte Corporation	Fused pyrrole derivatives as pi3k inhibitors
ES2526675T3 (es)	2010-07-09	2015-01-14	Pfizer Limited	N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje
EP2463289A1 (en)	2010-11-26	2012-06-13	Almirall, S.A.	Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
ES2764848T3 (es)	2010-12-20	2020-06-04	Incyte Holdings Corp	N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
WO2012125629A1 (en)	2011-03-14	2012-09-20	Incyte Corporation	Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en)	2011-03-25	2015-09-08	Incyte Holdings Corporation	Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
US9029389B2 (en) *	2011-04-21	2015-05-12	Institut Pasteur Korea	Anti-inflammation compounds
WO2013000924A1 (en)	2011-06-27	2013-01-03	Janssen Pharmaceutica Nv	1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
EP2554544A1 (en)	2011-08-01	2013-02-06	Almirall, S.A.	Pyridin-2(1h)-one derivatives as jak inhibitors
KR20140051998A (ko)	2011-08-03	2014-05-02	교와 핫꼬 기린 가부시키가이샤	디벤조옥세핀 유도체
KR102131612B1 (ko)	2011-09-02	2020-07-08	인사이트 홀딩스 코포레이션	Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
CA2866113C (en)	2012-03-02	2020-05-12	Alexar Therapeutics, Inc.	Pyrazolyl derivatives as liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
AR090548A1 (es)	2012-04-02	2014-11-19	Incyte Corp	Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
ES2855575T3 (es)	2012-06-26	2021-09-23	Janssen Pharmaceutica Nv	Combinaciones que comprenden compuestos de 4-metil-[1,2,4]triazolo[4,3-a]quinoxalina como inhibidores de PDE2 e inhibidores de PDE10 para su uso en el tratamiento de trastornos neurológicos o metabólicos
EP2869822B1 (en)	2012-07-09	2016-09-14	Janssen Pharmaceutica, N.V.	Inhibitors of phosphodiesterase 10 enzyme
EP2882496B1 (en)	2012-08-13	2019-10-09	The Rockefeller University	Treatment and diagnosis of melanoma
MX2016002930A (es)	2013-09-04	2016-12-02	Ralexar Therapeutics Inc	Moduladores del receptor x hepatico (lxr).
BR112016004904B1 (pt)	2013-09-04	2023-01-24	Ellora Therapeutics, Inc.	Compostos moduladores de receptor x do fígado (lxr), seu uso e composição farmaceutica compreendendo os mesmos
US10774072B2 (en)	2014-06-10	2020-09-15	Ube Industries, Ltd.	Crystal of N-substituted sulfonamide compound
US10428046B2 (en)	2014-06-10	2019-10-01	Ube Industries, Ltd.	N-substituted sulfonamide compound and method for producing same
WO2015191677A1 (en)	2014-06-11	2015-12-17	Incyte Corporation	Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
KR101480674B1 (ko) *	2014-07-03	2015-01-09	주식회사 큐리언트	화합물 및 염증성 질환 치료용 약학적 조성물
SI3831833T1 (sl)	2015-02-27	2023-03-31	Incyte Holdings Corporation	Postopki za pripravo inhibitorja PI3K
WO2016183060A1 (en)	2015-05-11	2016-11-17	Incyte Corporation	Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2016183063A1 (en)	2015-05-11	2016-11-17	Incyte Corporation	Crystalline forms of a pi3k inhibitor
WO2017123568A2 (en)	2016-01-11	2017-07-20	The Rockefeller University	Methods for the treatment of myeloid derived suppressor cells related disorders
AU2018373028A1 (en)	2017-11-21	2020-04-30	Inspirna, Inc.	Polymorphs and uses thereof
IL278889B2 (en)	2018-06-01	2025-11-01	Incyte Corp	Dosing regimen for the treatment of pi3k related disorders
WO2020221380A1 (en) *	2019-04-30	2020-11-05	Ustav Organicke Chemie A Biochemie Av Cr, V. V. I.	Selective ligands of human constitutive androstane receptor
HUE067466T2 (hu)	2019-12-13	2024-10-28	Inspirna Inc	Fémsók és alkalmazásuk

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FR2696745B1 (fr) *	1992-10-12	1995-05-12	Synthelabo	Procédé de préparation de dérivés de phényltétrazole.
GB9927687D0 (en) *	1999-11-23	2000-01-19	Merck Sharp & Dohme	Therapeutic agents
GB0128499D0 (en) *	2001-11-28	2002-01-23	Merck Sharp & Dohme	Therapeutic agents
JP2003313126A (ja) *	2002-04-23	2003-11-06	Sankyo Co Ltd	イミダゾピリジン誘導体を有効成分とする医薬
GB0212048D0 (en) *	2002-05-24	2002-07-03	Merck Sharp & Dohme	Therapeutic agents
GB0217783D0 (en) *	2002-07-31	2002-09-11	Glaxo Group Ltd	Compounds
US20040259948A1 (en) *	2003-01-10	2004-12-23	Peter Tontonoz	Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
CA2512886A1 (en) *	2003-02-28	2004-09-10	Galderma Research & Development, S.N.C.	Ligands that modulate lxr-type receptors
US20080070883A1 (en) *	2006-09-19	2008-03-20	Wyeth	Use of LXR modulators for the prevention and treatment of skin aging
CA2690192A1 (en) *	2007-06-26	2008-12-31	Gilead Colorado, Inc.	Imidazopyridinyl thiazolyl histone deacetylase inhibitors

2008
- 2008-12-19 US US12/809,893 patent/US20110112135A1/en not_active Abandoned
- 2008-12-19 BR BRPI0822237-1A patent/BRPI0822237A2/pt not_active IP Right Cessation
- 2008-12-19 CA CA2710452A patent/CA2710452A1/en not_active Abandoned
- 2008-12-19 WO PCT/US2008/087708 patent/WO2009086123A1/en not_active Ceased
- 2008-12-19 AU AU2008345681A patent/AU2008345681A1/en not_active Abandoned
- 2008-12-19 CN CN2008801273719A patent/CN101945871A/zh active Pending
- 2008-12-19 EP EP08866385A patent/EP2231660A1/en not_active Withdrawn
- 2008-12-19 JP JP2010539879A patent/JP2011507900A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO2009086123A1 (en)	2009-07-09
EP2231660A1 (en)	2010-09-29
CA2710452A1 (en)	2009-07-09
WO2009086123A8 (en)	2009-10-15
US20110112135A1 (en)	2011-05-12
CN101945871A (zh)	2011-01-12
AU2008345681A1 (en)	2009-07-09
JP2011507900A (ja)	2011-03-10

Publication	Publication Date	Title
BRPI0822237A2 (pt)	2015-06-30	Compostos de imidazo [1,2-a] piridina
DK2137184T3 (da)	2013-07-22	Imidazo[1,2-a]pyridinforbindelser som receptor-tyrosinkinaseinhibitorer
DK2384326T3 (da)	2014-05-05	Pyrrolo[2,3-d]pyrimidinforbindelser
DK1904494T3 (da)	2011-02-21	Imidazo[1,2-A]pyridin-forbindelser som VEGF-R2-inhibitorer
BRPI0722088A2 (pt)	2016-03-22	derivados de pirrolo[2,3-b]piridina como moduladores de cinase
IL204720A0 (en)	2010-11-30	Imidazo [1, 2 - a] pyridine derivatives useful as alk inhibitors
BRPI0919948A2 (pt)	2015-08-25	Pirido[4,3-b]indois contendo porções rígidas
DOP2007000080A (es)	2007-11-15	Piridin [3,4-b] pirazinonas
IL206330A (en)	2015-06-30	Pyrido [3,2– b] pyrazine compounds maintained in position 8 as anti-proliferative agents
ATE463498T1 (de)	2010-04-15	Imidazo-verbindungen
EP1928237A4 (en)	2011-03-09	NEW HETEROCYCLES BASED ON IMIDAZO
ZA201204028B (en)	2013-11-27	Imidazo[1.2-a]pyridine compounds, sysnthesis thereof, and methods of using same
BR112013015959A2 (pt)	2018-07-10	Derivados de 2-arilimidazo [1,2-b] piridazina, 2- fenilimidazo [1,2-a] piridina, e 2-fenilimidazo [1,2-a] pirazina.
DK2124944T3 (da)	2012-04-23	Pyrazolo[3,4-b]pyridinderivater som phosphodiesteraseinhibitorer
BRPI0819831A2 (pt)	2019-09-24	derivados de amidas de áciodo 6,7-diidro-5h-imidazo[1,2-a]imidazol-3-carboxílico
BRPI1014459A2 (pt)	2016-04-05	derivados de 3-(1,2,3-triazol-4-il)pirrolo[2,3-b]-piridina"
EP2142542A4 (en)	2011-06-22	NEW IMIDAZO [4,5-B] PYRIDINE-7-CARBOXYLAMIDEAMIDE 704
BRPI0914665A2 (pt)	2015-10-20	derivados de pirimido[2,1-a]isoquinolin-4-ona substituída
BRPI0822239A2 (pt)	2015-06-30	Composto de pirazolo[1,5-a] pirimidina
DK2167470T3 (da)	2011-06-27	Triazolo-[1,5A]-chinoliner som adenosin-A3-receptor ligander
EP2511276A4 (en)	2012-12-19	Pyrrolo [2,3-D] pyrimidine derivative
IL206666A0 (en)	2010-12-30	N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
EP2565194A4 (en)	2013-09-11	IMIDAZO [1,2-a] PYRIDINE DERIVATIVE
IL206668A0 (en)	2010-12-30	N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
ATE489386T1 (de)	2010-12-15	Naphthyridin-derivate

Legal Events

Date	Code	Title	Description
2015-12-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.