[go: up one dir, main page]

BRPI0821779A2 - tratamento terapêutico de câncer - Google Patents

tratamento terapêutico de câncer

Info

Publication number
BRPI0821779A2
BRPI0821779A2 BRPI0821779A BRPI0821779A BRPI0821779A2 BR PI0821779 A2 BRPI0821779 A2 BR PI0821779A2 BR PI0821779 A BRPI0821779 A BR PI0821779A BR PI0821779 A BRPI0821779 A BR PI0821779A BR PI0821779 A2 BRPI0821779 A2 BR PI0821779A2
Authority
BR
Brazil
Prior art keywords
cancer
therapeutic treatment
therapeutic
treatment
Prior art date
Application number
BRPI0821779A
Other languages
English (en)
Inventor
Grayzel David
Macdougall John
Ross Robert
Original Assignee
Infinity Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40824720&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0821779(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US11/965,688 external-priority patent/US7812164B2/en
Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of BRPI0821779A2 publication Critical patent/BRPI0821779A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
BRPI0821779A 2007-12-27 2008-12-23 tratamento terapêutico de câncer BRPI0821779A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1716007P 2007-12-27 2007-12-27
US11/965,688 US7812164B2 (en) 2006-12-28 2007-12-27 Cyclopamine analogs
US11896908P 2008-12-01 2008-12-01
PCT/US2008/088222 WO2009086416A1 (en) 2007-12-27 2008-12-23 Therapeutic cancer treatments

Publications (1)

Publication Number Publication Date
BRPI0821779A2 true BRPI0821779A2 (pt) 2019-09-24

Family

ID=40824720

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0821779A BRPI0821779A2 (pt) 2007-12-27 2008-12-23 tratamento terapêutico de câncer

Country Status (16)

Country Link
US (1) US20090181997A1 (pt)
EP (1) EP2225254A4 (pt)
JP (1) JP2011522773A (pt)
KR (1) KR20100137416A (pt)
CN (1) CN101918420A (pt)
AR (1) AR070047A1 (pt)
AU (1) AU2008345151A1 (pt)
BR (1) BRPI0821779A2 (pt)
CA (1) CA2710377A1 (pt)
CL (1) CL2008003901A1 (pt)
IL (1) IL206632A0 (pt)
MX (1) MX2010006991A (pt)
PE (1) PE20091180A1 (pt)
TW (1) TW200934784A (pt)
WO (1) WO2009086416A1 (pt)
ZA (1) ZA201004403B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
EP2224807B1 (en) 2007-12-27 2016-11-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
US20100297118A1 (en) * 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
US20120020876A1 (en) * 2009-01-23 2012-01-26 Kenneth Paul Olive Hedgehog pathway inhibitors
JP6141015B2 (ja) 2009-08-05 2017-06-07 インフィニティ ファーマスーティカルズ、インク． シクロパミン類似体の酵素によるアミノ基転移
DK2470173T3 (en) 2009-08-25 2016-06-06 Abraxis Bioscience Llc Combination therapy of nanoparticle composition of the taxane and the hedgehog inhibitors
WO2011088404A1 (en) * 2010-01-15 2011-07-21 Infinity Pharmaceuticals , Inc Treatment of fibrotic conditions using hedgehog inhibitors
WO2012006584A2 (en) * 2010-07-08 2012-01-12 Infinity Pharmaceuticals, Inc. Therapeutic regimens for hedgehog-associated cancers
US20120010230A1 (en) * 2010-07-08 2012-01-12 Macdougall John R Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling
US9376447B2 (en) 2010-09-14 2016-06-28 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
RU2492855C2 (ru) * 2011-02-15 2013-09-20 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии" СО РАМН (ФГБУ "НИИ онкологии" СО РАМН) Способ комбинированного лечения немелкоклеточного рака легкого ii и iii стадии с пред- и послеоперационной химиотерапией
CA2752008A1 (en) 2011-09-13 2013-03-13 Universite De Montreal Combination therapy using ribavirin as elf4e inhibitor
RU2704811C2 (ru) * 2014-07-17 2019-10-31 БайоКьюрити Фармасьютикалз Инк. Лечение рака комбинацией лучевой терапии, наночастиц оксида церия и химиотерапевтического средства
WO2016172160A1 (en) * 2015-04-21 2016-10-27 Genentech, Inc. Compositions and methods for prostate cancer analysis
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos
CN107137406B (zh) * 2016-03-01 2021-07-02 江苏恒瑞医药股份有限公司 一种Hedgehog信号通路抑制剂在制备治疗EGFR过度表达的癌症的药物中的用途
WO2018031658A1 (en) * 2016-08-10 2018-02-15 Celgene Corporation Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
AU2018247767B2 (en) 2017-04-03 2025-01-30 F. Hoffmann-La Roche Ag Antibodies binding to STEAP-1
AU2019314819A1 (en) * 2018-07-31 2020-10-22 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
GEAP202215446A (en) 2018-07-31 2022-08-25 Ascentage Pharma Suzhou Co Ltd Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/or bendamustine or bcl-2 inhibitor combined with chop
KR20210003731A (ko) 2018-07-31 2021-01-12 어센테지 파마 (쑤저우) 컴퍼니 리미티드 Bcl-2 억제제와 MDM2 억제제의 병용 제품 및 질환의 예방 및/또는 치료에 있어서 이의 용도
CN114522167A (zh) 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CN115282133A (zh) * 2021-12-06 2022-11-04 温州医科大学 竹红菌乙素在制备抗结肠癌药物中的应用
WO2024150234A1 (en) * 2023-01-12 2024-07-18 Sol-Gel Technologies Ltd. Treatment and prevention of basal cell carcinoma with topical composition comprising patidegib

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US7709454B2 (en) * 1997-06-20 2010-05-04 New York University Methods and compositions for inhibiting tumorigenesis
US7741298B2 (en) * 1997-06-20 2010-06-22 New York University Method and compositions for inhibiting tumorigenesis
US6238876B1 (en) * 1997-06-20 2001-05-29 New York University Methods and materials for the diagnosis and treatment of sporadic basal cell carcinoma
US7291626B1 (en) * 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
US6867216B1 (en) * 1998-04-09 2005-03-15 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signal pathways, compositions and uses related thereto
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
CA2339330A1 (en) * 1998-08-13 2000-02-24 University Of Southern California Methods to increase blood flow to ischemic tissue
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
US20070021493A1 (en) * 1999-09-16 2007-01-25 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
JP5420128B2 (ja) * 1999-10-13 2014-02-19 ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン ヘッジホッグ経路の調節物質、並びにそれに関する組成物及び利用法
US6552016B1 (en) * 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US6893637B1 (en) * 1999-10-21 2005-05-17 Zymogenetics, Inc. Method of treating fibrosis
IL133809A0 (en) * 1999-12-30 2001-04-30 Yeda Res & Dev Steroidal alkaloids and pharmaceutical compositions comprising them
US6613798B1 (en) * 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
WO2002080952A2 (en) * 2001-04-09 2002-10-17 Lorantis Limited Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways
AUPR602401A0 (en) * 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release delivery system
EP1411938B1 (en) * 2001-07-02 2005-07-06 Tas, Sinan Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
JP2003192919A (ja) * 2001-10-17 2003-07-09 Asahi Denka Kogyo Kk 難燃性合成樹脂組成物
GB0221539D0 (en) * 2002-09-17 2002-10-23 Medical Res Council Methods of treatment
FR2850022B1 (fr) * 2003-01-22 2006-09-08 Centre Nat Rech Scient Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications
WO2005013800A2 (en) * 2003-07-15 2005-02-17 The Johns Hopkins University Elevated hedgehog pathway activity in digestive system tumors, and methods of treating digestive system tumors having elevated hedgehog pathway activity
US20070231828A1 (en) * 2003-10-01 2007-10-04 Johns Hopkins University Methods of predicting behavior of cancers
US20080095761A1 (en) * 2003-10-01 2008-04-24 The Johns Hopkins University Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis
WO2005042700A2 (en) * 2003-10-20 2005-05-12 The Johns Hopkins University Use of hedgehog pathway inhibitors in small-cell lung cancer
JP5204486B2 (ja) * 2004-08-27 2013-06-05 インフィニティ ファーマスーティカルズ、インク． シクロパミンアナログ及びその使用方法
JP2008514726A (ja) * 2004-09-30 2008-05-08 ザ ユニヴァーシティー オヴ シカゴ ヘッジホッグ阻害剤、放射線及び化学療法薬の併用療法
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
US8668905B2 (en) * 2005-05-12 2014-03-11 University Of South Florida P53 vaccines for the treatment of cancers
JP2009513672A (ja) * 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
WO2007056135A1 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Method of treating cancers with saha and pemetrexed
WO2007076294A2 (en) * 2005-12-15 2007-07-05 Wei Chen Method of screening the activity of the smoothened receptor to identify theraputic modulation agents or diagnose disease
CA2635718A1 (en) * 2005-12-27 2007-08-09 Genentech, Inc. Methods of using hedgehog kinase antagonists to inhibit hedgehog signaling and to treat hedgehog mediated disorders
EP1998785A4 (en) * 2006-02-21 2009-06-17 Univ Michigan TREATMENT OF CANCER BY AN ANTAGONIST OF THE HEDGEHOG SIGNALING PATH
WO2007123511A2 (en) * 2006-03-24 2007-11-01 Infinity Pharmaceuticals, Inc. Dosing regimens for the treatment of cancer
KR101563010B1 (ko) * 2006-10-31 2015-10-26 더 가버먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤 휴먼 서비씨즈 평활화 폴리펩티드 및 사용 방법
WO2008057497A2 (en) * 2006-11-02 2008-05-15 Curis, Inc. Small organic molecule regulators of cell proliferation
TWI433674B (zh) * 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
NZ579356A (en) * 2007-03-07 2012-04-27 Infinity Pharmaceuticals Inc Cyclopamine lactam analogs and methods of use thereof
AU2008223355B2 (en) * 2007-03-07 2014-03-20 Infinity Discovery, Inc. Heterocyclic cyclopamine analogs and methods of use thereof
AR066063A1 (es) * 2007-04-18 2009-07-22 Merck & Co Inc Derivados de triazol que son antagonistas de smo
US7867492B2 (en) * 2007-10-12 2011-01-11 The John Hopkins University Compounds for hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies
BRPI0820856A2 (pt) * 2007-12-13 2019-05-14 Siena Bhiotech.S.P.A. anatagonista da série de reação de hedgehog e aplicações terapêuticas dos mesmos
US20100222287A1 (en) * 2007-12-27 2010-09-02 Mcgovern Karen J Therapeutic Cancer Treatments
US20100297118A1 (en) * 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
EP2224807B1 (en) * 2007-12-27 2016-11-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
CL2009001479A1 (es) * 2008-07-02 2010-01-04 Infinity Pharmaceuticals Inc Metodo para aislar un alcaloide del veratrum desglicosilado que comprende proporcionar un material de planta veratrum, poner en contacto con una solucion acuosa y extraer el material de la planta veratrum con un solvente para proporcionar un extracto que comprende dicho alcaloide.
WO2011088404A1 (en) * 2010-01-15 2011-07-21 Infinity Pharmaceuticals , Inc Treatment of fibrotic conditions using hedgehog inhibitors
WO2012006584A2 (en) * 2010-07-08 2012-01-12 Infinity Pharmaceuticals, Inc. Therapeutic regimens for hedgehog-associated cancers
US20120010230A1 (en) * 2010-07-08 2012-01-12 Macdougall John R Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling

Also Published As

Publication number Publication date
AU2008345151A1 (en) 2009-07-09
TW200934784A (en) 2009-08-16
WO2009086416A1 (en) 2009-07-09
CA2710377A1 (en) 2009-07-09
ZA201004403B (en) 2012-02-29
CN101918420A (zh) 2010-12-15
US20090181997A1 (en) 2009-07-16
JP2011522773A (ja) 2011-08-04
KR20100137416A (ko) 2010-12-30
EP2225254A4 (en) 2011-03-30
CL2008003901A1 (es) 2009-07-24
IL206632A0 (en) 2010-12-30
MX2010006991A (es) 2010-09-30
AR070047A1 (es) 2010-03-10
PE20091180A1 (es) 2009-08-26
EP2225254A1 (en) 2010-09-08

Similar Documents

Publication Publication Date Title
BRPI0821779A2 (pt) tratamento terapêutico de câncer
BRPI0821660A2 (pt) Combinações de agentes terapêuticos para tratamento de câncer
CY2014006I1 (el) Μεθοδοι θεραπευτικης αγωγης χρησιμοποιωντας γλυκοπεγκυλιωμενο g-csf
HUE054495T2 (hu) Rák kezelésére szolgáló készítmény
BR112012005594A2 (pt) tratamento de câncer
IL197315A0 (en) Treatment of cancer
DK2121139T3 (da) Formulations for cancer treatment
BRPI0810206A2 (pt) Método de tratar câncer
BRPI0811265A2 (pt) Tratamento de sinucleinopatias
BRPI0815551A2 (pt) Tratamento através de hucbc de doença beta-amiloide
BRPI0908026A2 (pt) Métodos para o tratamento de doenças do intestino
DK2056842T3 (da) Modificeret galactosylceramid til behandling af cancerøse sygdomme
EP2310006A4 (en) CANCER TREATMENT
BRPI1006438A2 (pt) terapia adjuvante de cancer
EP2049139A4 (en) TREATMENT OF TUMORS EXPRESSING RAS
BRPI0912683A2 (pt) tratamento de tumores metastáticos
ME03508B (me) Kombinovana terapija za liječenje dijabetesa
EP2125002A4 (en) TREATMENT OF SKIN CANCER
HUE054196T2 (hu) Terápiás szerek nemkívánatos sejtproliferációhoz kapcsolódó betegségek kezelésére
HUE036490T2 (hu) Tumorok kezelése anti-L1 antitest alkalmazásával
BRPI0922884A2 (pt) compostos para tratamento de câncer
DK2147122T3 (da) Enzymatisk kræftbehandling
EP3381471C0 (en) PAIN TREATMENT
IL200525A0 (en) Methods of treating cancer by administering human il-18 combinations
BRPI0812932A2 (pt) Composições e métodos de tratar câncer

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.